KEGG   Eptesicus fuscus (big brown bat): 103294085
Entry
103294085         CDS       T09083                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
efus  Eptesicus fuscus (big brown bat)
Pathway
efus01521  EGFR tyrosine kinase inhibitor resistance
efus01522  Endocrine resistance
efus04010  MAPK signaling pathway
efus04012  ErbB signaling pathway
efus04015  Rap1 signaling pathway
efus04024  cAMP signaling pathway
efus04062  Chemokine signaling pathway
efus04068  FoxO signaling pathway
efus04150  mTOR signaling pathway
efus04270  Vascular smooth muscle contraction
efus04510  Focal adhesion
efus04650  Natural killer cell mediated cytotoxicity
efus04720  Long-term potentiation
efus04722  Neurotrophin signaling pathway
efus04726  Serotonergic synapse
efus04730  Long-term depression
efus04810  Regulation of actin cytoskeleton
efus04910  Insulin signaling pathway
efus04914  Progesterone-mediated oocyte maturation
efus04928  Parathyroid hormone synthesis, secretion and action
efus04934  Cushing syndrome
efus05010  Alzheimer disease
efus05022  Pathways of neurodegeneration - multiple diseases
efus05034  Alcoholism
efus05160  Hepatitis C
efus05161  Hepatitis B
efus05200  Pathways in cancer
efus05205  Proteoglycans in cancer
efus05208  Chemical carcinogenesis - reactive oxygen species
efus05210  Colorectal cancer
efus05211  Renal cell carcinoma
efus05212  Pancreatic cancer
efus05213  Endometrial cancer
efus05214  Glioma
efus05215  Prostate cancer
efus05216  Thyroid cancer
efus05218  Melanoma
efus05219  Bladder cancer
efus05220  Chronic myeloid leukemia
efus05221  Acute myeloid leukemia
efus05223  Non-small cell lung cancer
efus05224  Breast cancer
efus05225  Hepatocellular carcinoma
efus05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:efus00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103294085 (BRAF)
   04012 ErbB signaling pathway
    103294085 (BRAF)
   04015 Rap1 signaling pathway
    103294085 (BRAF)
   04068 FoxO signaling pathway
    103294085 (BRAF)
   04024 cAMP signaling pathway
    103294085 (BRAF)
   04150 mTOR signaling pathway
    103294085 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103294085 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103294085 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103294085 (BRAF)
   04062 Chemokine signaling pathway
    103294085 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103294085 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    103294085 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    103294085 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103294085 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    103294085 (BRAF)
   04720 Long-term potentiation
    103294085 (BRAF)
   04730 Long-term depression
    103294085 (BRAF)
   04722 Neurotrophin signaling pathway
    103294085 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103294085 (BRAF)
   05205 Proteoglycans in cancer
    103294085 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    103294085 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103294085 (BRAF)
   05212 Pancreatic cancer
    103294085 (BRAF)
   05225 Hepatocellular carcinoma
    103294085 (BRAF)
   05226 Gastric cancer
    103294085 (BRAF)
   05214 Glioma
    103294085 (BRAF)
   05216 Thyroid cancer
    103294085 (BRAF)
   05221 Acute myeloid leukemia
    103294085 (BRAF)
   05220 Chronic myeloid leukemia
    103294085 (BRAF)
   05218 Melanoma
    103294085 (BRAF)
   05211 Renal cell carcinoma
    103294085 (BRAF)
   05219 Bladder cancer
    103294085 (BRAF)
   05215 Prostate cancer
    103294085 (BRAF)
   05213 Endometrial cancer
    103294085 (BRAF)
   05224 Breast cancer
    103294085 (BRAF)
   05223 Non-small cell lung cancer
    103294085 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103294085 (BRAF)
   05160 Hepatitis C
    103294085 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103294085 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    103294085 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    103294085 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103294085 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103294085 (BRAF)
   01522 Endocrine resistance
    103294085 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:efus01001]
    103294085 (BRAF)
Enzymes [BR:efus01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103294085 (BRAF)
Protein kinases [BR:efus01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103294085 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 103294085
NCBI-ProteinID: XP_008148690
LinkDB
Position
14:53231439..53361167
AA seq 763 aa
MAALSGDGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEAL
LDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSSS
SSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKA
LMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFT
LAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEE
ASFAETTLTSGSSPSTHSSDSFGPQMLTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSS
SAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQR
ERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKM
LNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII
ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW
SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ
IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI
HRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2292 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggcgacggcggcgcggagcagggccaggctctgttcaacggggac
atggagcccgaggccggcgccggcgccgcggcctcttcggctgcggaccccgccatcccc
gaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcgtta
ttggataaatttggtggggagcataatccaccatcaatatatctggaggcctatgaagaa
tacaccagcaagctagatgccctccaacaaagagaacaacaattattggaatccctgggg
aatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcttcc
tcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccacagatgtg
tcacggagcaaccctaagtcaccacaaaaacctattgttagagtcttcctgcccaacaaa
cagaggacagtggtacctgcaaggtgtggagttacagtccgggacagtctaaagaaagca
ttgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggatggagag
aagaaaccaattggatgggacactgatatttcctggcttactggagaggaattgcatgtt
gaagtattggaaaatgttccacttacaacacacaactttgtacggaaaacttttttcact
ttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaaacatgt
ggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattatgac
caacttgatttgctgtttgtctccaagttttttgaacaccacccaataccacaggaggag
gcctcctttgcagagactacccttacatctggatcatccccttccacacactcctccgat
tcctttgggccccaaatgctcaccagtccgtctccttcaaaatccattccaattccacag
cctttccgaccagcagatgaagaccatcgaaatcagtttggacaacgagatcggtcctca
tcggctccaaatgtgcatataaacacaatagaacctgtcaatattgatgacttgattaga
gaccaagggtttcgtagtgacggagggtcaactacaggtttatccgccaccccccctgcc
tcattacctggctcactcactaatgtgaaagcattacagaaatctccaggacctcagcgg
gaaagaaaatcatcttcatcctcagaagacaggaatcgaatgaaaacacttggtagacgg
gattcaagtgacgattgggagattcctgatgggcagatcacagtgggacaaagaattggt
tccgggtcatttgggacagtctacaaggggaagtggcatggtgatgtggcagtgaaaatg
ttgaatgtgacagcaccgacacctcagcagttacaagccttcaaaaatgaagtaggagta
ctcaggaaaactcgacatgtgaatattctactcttcatgggctattcaacaaagccacaa
ctggctattgttacccagtggtgtgagggctccagcttatatcaccatctccacatcatt
gagaccaaatttgagatgatcaaacttatagatattgcacggcagactgcacagggcatg
gattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatttttctt
catgaagacctcacagtaaaaataggtgactttggtctagccacagtgaaatctcgatgg
agtgggtcccatcagtttgaacagttgtctggatccattctgtggatggcaccagaagta
atcagaatgcaagacaaaaacccttatagctttcagtcagatgtatatgcatttgggatt
gttctgtatgaattgatgactggacaattaccttattcaaacatcaacaacagggaccag
ataatttttatggtgggacgaggatatctatctccagatctcagtaaggtacgaagtaac
tgtccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaagagatgagaga
ccactctttccccaaattcttgcctctattgagctgttggcccgctcattgccaaaaatt
caccgcagtgcatcagaaccctccttgaatcgggctggcttccaaacagaggattttagt
ctatatgcttgtgcttctccaaaaacacccatccaggcagggggatatggagaatttgca
gccttcaagtag

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