KEGG   Eptesicus fuscus (big brown bat): 103296401
Entry
103296401         CDS       T09083                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
efus  Eptesicus fuscus (big brown bat)
Pathway
efus01521  EGFR tyrosine kinase inhibitor resistance
efus01522  Endocrine resistance
efus04010  MAPK signaling pathway
efus04012  ErbB signaling pathway
efus04068  FoxO signaling pathway
efus04270  Vascular smooth muscle contraction
efus04650  Natural killer cell mediated cytotoxicity
efus04720  Long-term potentiation
efus04726  Serotonergic synapse
efus04730  Long-term depression
efus04810  Regulation of actin cytoskeleton
efus04910  Insulin signaling pathway
efus04914  Progesterone-mediated oocyte maturation
efus04928  Parathyroid hormone synthesis, secretion and action
efus05010  Alzheimer disease
efus05022  Pathways of neurodegeneration - multiple diseases
efus05034  Alcoholism
efus05160  Hepatitis C
efus05161  Hepatitis B
efus05200  Pathways in cancer
efus05205  Proteoglycans in cancer
efus05208  Chemical carcinogenesis - reactive oxygen species
efus05210  Colorectal cancer
efus05211  Renal cell carcinoma
efus05212  Pancreatic cancer
efus05213  Endometrial cancer
efus05214  Glioma
efus05215  Prostate cancer
efus05218  Melanoma
efus05219  Bladder cancer
efus05220  Chronic myeloid leukemia
efus05221  Acute myeloid leukemia
efus05223  Non-small cell lung cancer
efus05224  Breast cancer
efus05225  Hepatocellular carcinoma
efus05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:efus00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103296401 (ARAF)
   04012 ErbB signaling pathway
    103296401 (ARAF)
   04068 FoxO signaling pathway
    103296401 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103296401 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103296401 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103296401 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    103296401 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    103296401 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103296401 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    103296401 (ARAF)
   04720 Long-term potentiation
    103296401 (ARAF)
   04730 Long-term depression
    103296401 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103296401 (ARAF)
   05205 Proteoglycans in cancer
    103296401 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    103296401 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103296401 (ARAF)
   05212 Pancreatic cancer
    103296401 (ARAF)
   05225 Hepatocellular carcinoma
    103296401 (ARAF)
   05226 Gastric cancer
    103296401 (ARAF)
   05214 Glioma
    103296401 (ARAF)
   05221 Acute myeloid leukemia
    103296401 (ARAF)
   05220 Chronic myeloid leukemia
    103296401 (ARAF)
   05218 Melanoma
    103296401 (ARAF)
   05211 Renal cell carcinoma
    103296401 (ARAF)
   05219 Bladder cancer
    103296401 (ARAF)
   05215 Prostate cancer
    103296401 (ARAF)
   05213 Endometrial cancer
    103296401 (ARAF)
   05224 Breast cancer
    103296401 (ARAF)
   05223 Non-small cell lung cancer
    103296401 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103296401 (ARAF)
   05160 Hepatitis C
    103296401 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103296401 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    103296401 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    103296401 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103296401 (ARAF)
   01522 Endocrine resistance
    103296401 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:efus01001]
    103296401 (ARAF)
Enzymes [BR:efus01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103296401 (ARAF)
Protein kinases [BR:efus01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103296401 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 103296401
NCBI-ProteinID: XP_027983478
LinkDB
Position
1:complement(130772695..130783914)
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQYYHSIQDLSGGYRQHEAPSNRPLNEPL
TPQGSSSSSQHRDPEHFPFPATANAPLQRIRSTSTPNVHMVSTTTPLDSGLFQLAAQSFN
ADAAGSRGGGDGVPRGSPSPASVSSGRKSPHSKSPSEQRERKSVGDDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcagcgcacagtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggctctcaaggtgcggggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaagggcgaaagacagtcactgcctgggacacagccattgccccg
ctggatggcgaggagctcattgttgaggtccttgaagacgtcccactgactatgcacaat
tttgtacggaagacattcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaggtc
cccaccgtctgtgttgacatgagtaccaactgccgacagtactaccacagtatccaggat
ttgtccggaggctacagacagcacgaggctccttccaaccgtcctttgaatgagccgcta
acccctcagggttccagctccagctcccagcaccgagaccctgagcacttcccctttcct
gccacggccaacgcccccctgcagcgcatccgctccacgtctactcccaacgtccatatg
gtcagcaccaccacccccctggactccggtctcttccagctcgctgcccagagtttcaac
gctgatgctgctggtagtagaggtggcggtgatggagtgccccgggggagccccagcccg
gctagtgtgtcctcggggaggaagtccccacattccaagtccccatccgaacagcgggag
aggaagtccgtgggtgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcacgtcaacatcttgctgttcatgggcttcatgacccggccggggttcgccatc
atcacacagtggtgtgagggctccagcctctaccaccacctgcatgtggccgacacacgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgggatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagatcggtgacttcggcctggccacggtgaagacgagatggagcggggct
cagcccttggagcagccctcaggctctgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcggatgtctacgcctatggggttgtgctctac
gagctcatgaccggctccttgccttatagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgattgcctcaagtttcagcgagaggagcggcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcatcgcacccaggctgatgagttgcccgcctgcctactcagc
gcagcccgccttgtgccttag

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