KEGG   Eumetopias jubatus (Steller sea lion): 114205461
Entry
114205461         CDS       T07240                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
eju  Eumetopias jubatus (Steller sea lion)
Pathway
eju01522  Endocrine resistance
eju04010  MAPK signaling pathway
eju04012  ErbB signaling pathway
eju04014  Ras signaling pathway
eju04024  cAMP signaling pathway
eju04068  FoxO signaling pathway
eju04071  Sphingolipid signaling pathway
eju04137  Mitophagy - animal
eju04140  Autophagy - animal
eju04141  Protein processing in endoplasmic reticulum
eju04210  Apoptosis
eju04215  Apoptosis - multiple species
eju04217  Necroptosis
eju04310  Wnt signaling pathway
eju04380  Osteoclast differentiation
eju04510  Focal adhesion
eju04530  Tight junction
eju04620  Toll-like receptor signaling pathway
eju04621  NOD-like receptor signaling pathway
eju04622  RIG-I-like receptor signaling pathway
eju04625  C-type lectin receptor signaling pathway
eju04657  IL-17 signaling pathway
eju04658  Th1 and Th2 cell differentiation
eju04659  Th17 cell differentiation
eju04660  T cell receptor signaling pathway
eju04664  Fc epsilon RI signaling pathway
eju04668  TNF signaling pathway
eju04722  Neurotrophin signaling pathway
eju04723  Retrograde endocannabinoid signaling
eju04728  Dopaminergic synapse
eju04750  Inflammatory mediator regulation of TRP channels
eju04910  Insulin signaling pathway
eju04912  GnRH signaling pathway
eju04914  Progesterone-mediated oocyte maturation
eju04917  Prolactin signaling pathway
eju04920  Adipocytokine signaling pathway
eju04926  Relaxin signaling pathway
eju04930  Type II diabetes mellitus
eju04931  Insulin resistance
eju04932  Non-alcoholic fatty liver disease
eju04933  AGE-RAGE signaling pathway in diabetic complications
eju04935  Growth hormone synthesis, secretion and action
eju04936  Alcoholic liver disease
eju05010  Alzheimer disease
eju05012  Parkinson disease
eju05016  Huntington disease
eju05017  Spinocerebellar ataxia
eju05020  Prion disease
eju05022  Pathways of neurodegeneration - multiple diseases
eju05132  Salmonella infection
eju05133  Pertussis
eju05135  Yersinia infection
eju05142  Chagas disease
eju05145  Toxoplasmosis
eju05152  Tuberculosis
eju05161  Hepatitis B
eju05162  Measles
eju05166  Human T-cell leukemia virus 1 infection
eju05167  Kaposi sarcoma-associated herpesvirus infection
eju05169  Epstein-Barr virus infection
eju05170  Human immunodeficiency virus 1 infection
eju05171  Coronavirus disease - COVID-19
eju05200  Pathways in cancer
eju05208  Chemical carcinogenesis - reactive oxygen species
eju05210  Colorectal cancer
eju05212  Pancreatic cancer
eju05231  Choline metabolism in cancer
eju05415  Diabetic cardiomyopathy
eju05417  Lipid and atherosclerosis
eju05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:eju00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    114205461 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114205461 (MAPK8)
   04012 ErbB signaling pathway
    114205461 (MAPK8)
   04014 Ras signaling pathway
    114205461 (MAPK8)
   04310 Wnt signaling pathway
    114205461 (MAPK8)
   04668 TNF signaling pathway
    114205461 (MAPK8)
   04068 FoxO signaling pathway
    114205461 (MAPK8)
   04071 Sphingolipid signaling pathway
    114205461 (MAPK8)
   04024 cAMP signaling pathway
    114205461 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114205461 (MAPK8)
   04137 Mitophagy - animal
    114205461 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    114205461 (MAPK8)
   04215 Apoptosis - multiple species
    114205461 (MAPK8)
   04217 Necroptosis
    114205461 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114205461 (MAPK8)
   04530 Tight junction
    114205461 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    114205461 (MAPK8)
   04621 NOD-like receptor signaling pathway
    114205461 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    114205461 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    114205461 (MAPK8)
   04660 T cell receptor signaling pathway
    114205461 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    114205461 (MAPK8)
   04659 Th17 cell differentiation
    114205461 (MAPK8)
   04657 IL-17 signaling pathway
    114205461 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    114205461 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114205461 (MAPK8)
   04920 Adipocytokine signaling pathway
    114205461 (MAPK8)
   04912 GnRH signaling pathway
    114205461 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    114205461 (MAPK8)
   04917 Prolactin signaling pathway
    114205461 (MAPK8)
   04926 Relaxin signaling pathway
    114205461 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    114205461 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    114205461 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    114205461 (MAPK8)
   04722 Neurotrophin signaling pathway
    114205461 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114205461 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114205461 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114205461 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    114205461 (MAPK8)
   05231 Choline metabolism in cancer
    114205461 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114205461 (MAPK8)
   05212 Pancreatic cancer
    114205461 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114205461 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    114205461 (MAPK8)
   05161 Hepatitis B
    114205461 (MAPK8)
   05171 Coronavirus disease - COVID-19
    114205461 (MAPK8)
   05162 Measles
    114205461 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114205461 (MAPK8)
   05169 Epstein-Barr virus infection
    114205461 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114205461 (MAPK8)
   05135 Yersinia infection
    114205461 (MAPK8)
   05133 Pertussis
    114205461 (MAPK8)
   05152 Tuberculosis
    114205461 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    114205461 (MAPK8)
   05142 Chagas disease
    114205461 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114205461 (MAPK8)
   05012 Parkinson disease
    114205461 (MAPK8)
   05016 Huntington disease
    114205461 (MAPK8)
   05017 Spinocerebellar ataxia
    114205461 (MAPK8)
   05020 Prion disease
    114205461 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    114205461 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114205461 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    114205461 (MAPK8)
   05415 Diabetic cardiomyopathy
    114205461 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114205461 (MAPK8)
   04936 Alcoholic liver disease
    114205461 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    114205461 (MAPK8)
   04931 Insulin resistance
    114205461 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114205461 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    114205461 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:eju01001]
    114205461 (MAPK8)
Enzymes [BR:eju01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     114205461 (MAPK8)
Protein kinases [BR:eju01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   114205461 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 114205461
NCBI-ProteinID: XP_027954751
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagactctacgttt
acagtcttgaaacggtatcagaatttgaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccggcca
tttcagaatcagactcatgctaaacgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcgaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacctaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacagccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaattgatgcatctaaaaggatctctgtagatgaagctctccagcacccgtat
atcaatgtttggtatgatccttctgaggcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacatacaatagaagaatggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttataagggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcgtcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagacacagacagcagtctagaagcatcagcc
ggacctctgggctgctgtagatga

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