Eumetopias jubatus (Steller sea lion): 114205853 Help Entry 114205853         CDS       T07240                                  Symbol ADCY3 Name (RefSeq) adenylate cyclase type 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju00230   Purine metabolism eju01100   Metabolic pathways eju01522   Endocrine resistance eju04015   Rap1 signaling pathway eju04020   Calcium signaling pathway eju04022   cGMP-PKG signaling pathway eju04024   cAMP signaling pathway eju04062   Chemokine signaling pathway eju04072   Phospholipase D signaling pathway eju04081   Hormone signaling eju04082   Neuroactive ligand signaling eju04114   Oocyte meiosis eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04261   Adrenergic signaling in cardiomyocytes eju04270   Vascular smooth muscle contraction eju04371   Apelin signaling pathway eju04540   Gap junction eju04611   Platelet activation eju04713   Circadian entrainment eju04714   Thermogenesis eju04723   Retrograde endocannabinoid signaling eju04724   Glutamatergic synapse eju04725   Cholinergic synapse eju04727   GABAergic synapse eju04740   Olfactory transduction eju04750   Inflammatory mediator regulation of TRP channels eju04911   Insulin secretion eju04912   GnRH signaling pathway eju04913   Ovarian steroidogenesis eju04914   Progesterone-mediated oocyte maturation eju04915   Estrogen signaling pathway eju04916   Melanogenesis eju04918   Thyroid hormone synthesis eju04921   Oxytocin signaling pathway eju04923   Regulation of lipolysis in adipocytes eju04925   Aldosterone synthesis and secretion eju04926   Relaxin signaling pathway eju04927   Cortisol synthesis and secretion eju04928   Parathyroid hormone synthesis, secretion and action eju04934   Cushing syndrome eju04935   Growth hormone synthesis, secretion and action eju04962   Vasopressin-regulated water reabsorption eju04970   Salivary secretion eju04971   Gastric acid secretion eju04972   Pancreatic secretion eju04976   Bile secretion eju05032   Morphine addiction eju05163   Human cytomegalovirus infection eju05166   Human T-cell leukemia virus 1 infection eju05200   Pathways in cancer eju05207   Chemical carcinogenesis - receptor activation eju05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:eju00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     114205853 (ADCY3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     114205853 (ADCY3)    04371 Apelin signaling pathway     114205853 (ADCY3)    04020 Calcium signaling pathway     114205853 (ADCY3)    04072 Phospholipase D signaling pathway     114205853 (ADCY3)    04024 cAMP signaling pathway     114205853 (ADCY3)    04022 cGMP-PKG signaling pathway     114205853 (ADCY3)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     114205853 (ADCY3)    04081 Hormone signaling     114205853 (ADCY3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     114205853 (ADCY3)   09144 Cellular community - eukaryotes    04540 Gap junction     114205853 (ADCY3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     114205853 (ADCY3)    04062 Chemokine signaling pathway     114205853 (ADCY3)   09152 Endocrine system    04911 Insulin secretion     114205853 (ADCY3)    04923 Regulation of lipolysis in adipocytes     114205853 (ADCY3)    04912 GnRH signaling pathway     114205853 (ADCY3)    04913 Ovarian steroidogenesis     114205853 (ADCY3)    04915 Estrogen signaling pathway     114205853 (ADCY3)    04914 Progesterone-mediated oocyte maturation     114205853 (ADCY3)    04921 Oxytocin signaling pathway     114205853 (ADCY3)    04926 Relaxin signaling pathway     114205853 (ADCY3)    04935 Growth hormone synthesis, secretion and action     114205853 (ADCY3)    04918 Thyroid hormone synthesis     114205853 (ADCY3)    04928 Parathyroid hormone synthesis, secretion and action     114205853 (ADCY3)    04916 Melanogenesis     114205853 (ADCY3)    04925 Aldosterone synthesis and secretion     114205853 (ADCY3)    04927 Cortisol synthesis and secretion     114205853 (ADCY3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     114205853 (ADCY3)    04270 Vascular smooth muscle contraction     114205853 (ADCY3)   09154 Digestive system    04970 Salivary secretion     114205853 (ADCY3)    04971 Gastric acid secretion     114205853 (ADCY3)    04972 Pancreatic secretion     114205853 (ADCY3)    04976 Bile secretion     114205853 (ADCY3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     114205853 (ADCY3)   09156 Nervous system    04724 Glutamatergic synapse     114205853 (ADCY3)    04727 GABAergic synapse     114205853 (ADCY3)    04725 Cholinergic synapse     114205853 (ADCY3)    04723 Retrograde endocannabinoid signaling     114205853 (ADCY3)   09157 Sensory system    04740 Olfactory transduction     114205853 (ADCY3)    04750 Inflammatory mediator regulation of TRP channels     114205853 (ADCY3)   09149 Aging    04211 Longevity regulating pathway     114205853 (ADCY3)    04213 Longevity regulating pathway - multiple species     114205853 (ADCY3)   09159 Environmental adaptation    04713 Circadian entrainment     114205853 (ADCY3)    04714 Thermogenesis     114205853 (ADCY3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     114205853 (ADCY3)    05207 Chemical carcinogenesis - receptor activation     114205853 (ADCY3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     114205853 (ADCY3)    05163 Human cytomegalovirus infection     114205853 (ADCY3)   09165 Substance dependence    05032 Morphine addiction     114205853 (ADCY3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     114205853 (ADCY3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     114205853 (ADCY3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     114205853 (ADCY3) Enzymes [BR:eju01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      114205853 (ADCY3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N HNOBA Peptidase_S49_N Motif Other DBs NCBI-GeneID:  114205853 NCBI-ProteinID:  XP_027955225 LinkDB All DBs Position Unknown AA seq 1145 aa AA seqDB search MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGGGRTHEISVRNSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVLVMCALVFSGDKLAPLLVAAVGLLLDTV LFVLCKEGLLPDRITRKVVPYLLWLLITAQIFSYLGLNFARAHAASDTVGWQAFFVFSFF ITLPLSLSPIVVISVVSCVVHTLVLGVTVAQQQQDGLRGMHLLREILANVFLYLCAIAVG IMSYYMADRKLRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTLDCLKGEFDVEPGDGGSRCE YLDEKGIETYLIIASKPEVKKTATQHGLGSPALRNGAPASSKPSSPALIETKEPNGSTHT SGSTSGEPEEQGGQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN YMTFVVGEVLLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN VVDMLSCLQYYTGPNNSTAGLEVEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM LLVTGAVAVINIYAWRPIFDEYDRRRFQEHDFPAVALEKMQGFSTPGLNGTGRLPLVPSK YSMTVMIFIMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH VARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEEKSDKERWQHLADLADF ALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGV MGNIQVVEETQAILREYGFRFVRRGPIFVKGKGELLTFFLKGREKPAAFPNGSSVTLPHQ VVDNS NT seq 3438 nt NT seq  +upstreamnt  +downstreamnt atgccaaggaaccagggcttctccgagcccgaatactcggccgagtactccgccgagtac tcggtcagcttgccctctgaccctgaccgtggcgggggccgaacccatgaaatctcggtc cggaactcgggatcctgcctctgcctgccgcggttcatgcggctgaccttcgtgcctgag tccctggagaacttgtaccagacctacttcaaacggcagcgccatgagacccttttggtg ctggtggtgttcgcggccctcttcgactgctatgtgctggtcatgtgtgccctggtcttc tccggcgacaagctggctcccctcctcgtggccgcggtggggctgctgttggacaccgtc ctcttcgtgctctgcaaagaggggctgttgcccgaccgcatcacccggaaagtggtgccc tacctgctgtggctgctgataactgcccagattttctcctacctgggcctgaactttgcg cgagcccacgcggccagcgacacggtgggctggcaggccttctttgtcttctccttcttc atcacgctgccgctcagcctcagccccatcgtggtcatctctgtggtctcctgcgtcgtg cacacgctcgtcttgggggtcaccgtggcccagcagcagcaggacgggctgaggggcatg cacttgctaagggagatcctggccaacgtcttcctctacctgtgtgccatcgccgtgggc atcatgtcctactacatggcggaccgcaagctccgcaaggccttcctggaggcccgccag tcgctggaggtgaagatgaacctggaggagcagagccagcagcaggagaaccttatgctt tccatcctgcccaagcacgtggctgacgaaatgctgaaggacatgaagaaggacgagagc cagaaggaccagcagcagttcaacaccatgtacatgtatcggcacgagaacgtcagcatc ctctttgcggacatcgtgggcttcacccagctgtcttctgcctgcagtgcccaggagctc gtgaagctgctcaacgagctctttgcccgcttcgacaagctggccgccaaataccaccag ctgcggattaagatcctgggcgactgttactactgcatctgcggcctgcccgactaccgg gaggaccacgccgtctgctccatcctcatggggctcgctatggtggaggccatctcgtac gtgcgggagaagacgaagacgggggtggacatgcgtgtgggggtgcacacgggcaccgtg ctggggggcgtcctgggccagaagcgctggcagtacgacgtgtggtctaccgacgtcact gtggccaacaagatggaggccggtggcatccccgggcgtgtgcacatctcccagagcacc ctggactgcctgaagggcgagttcgacgtggagccgggcgacgggggcagccgctgtgag tacctggacgagaagggcatcgagacctacctcatcatcgcgtccaagccagaggtgaag aaaacagccacgcagcacggcctcggcagcccggccctgcgaaacggagcgccagcttcc tccaagcccagctcccccgccctcatcgagaccaaggagcccaacgggagcacccacacc agcggctccacatcgggggagcctgaggagcagggtggtcaggctgacaatccctcgttc cccaacccacgccggaggctgcgccttcaggacctggctgaccgagtggtggacgcctct gaggacgagcatgagctcaaccagctactcaacgaggccctgcttgagcgagagtctgcc caggtagtgaagaagagaaataccttcctcctttccatgaggttcatggaccccgagatg gaaacccgctactcagtggagaaggagaagcagagcggggctgccttcagctgctcctgc gttgtcctgctctgcaccgccctggtcgagatactcatcgacccctggctaatgacaaac tacatgacctttgtggtcggggaggttctacttctgatcctgacaatctgctcgctggcc gccatctttccccgggcctttcctaagaagcttgttgccttctcgacttggatcgaccgg acccgctgggccaggaacacctgggccatgttagccatcttcattctcgtcatggcaaat gtcgtggacatgctcagctgtctccagtactacaccggaccgaacaacagcactgcaggg ctggaggtggaggatggctgtgtagagaaccccaagtattacaactatgtcgccgtgctg tccctcattgccaccatcatgctggtgcaggtcagccacatggtgaagctcacactcatg ctgctcgtcaccggggccgtggccgtcatcaacatctatgcctggcgccccatctttgat gaatacgaccgcaggcgttttcaggaacatgactttcccgcggtcgccttagagaagatg cagggattttccacccctgggctcaacggcactggcaggctgcccctggtgccttctaag tactccatgaccgtgatgatcttcatcatgatgctaagcttctactacttctcgcgccac gtagaaaaactggcaaggacactgttcttatggaagatcgaggtccacgaccagaaggaa cgtgtctacgagatgcggcgctggaatgaggccttggtcaccaacatgttgcctgagcac gtggcacgccatttcctggggtccaagaagagagatgaggagctgtacagccagtcttac gatgagattggagtcatgtttgcctccctgcccaactttgccgacttctacacagaggag agcatcaataatggtggcattgagtgtctgcgcttcctcaatgagatcatctcagatttt gattctctcctggacaatcccaaattccgggtcatcaccaagatcaaaaccattggcagc acctatatggcagcttcaggagtcaccccagatgtcaacaccaacggctttgccagctcc aacaaggaggaaaagtcagacaaggagcgctggcagcacctggccgatctggcggacttt gctctggccatgaaggatacgctcacaaacatcaacaaccagtccttcaacaacttcatg ctgcgcatcggcatgaacaaaggaggggtcctggctggggtcattggagcccgcaaacca cactatgacatctggggcaatacggtcaatgtggccagcaggatggagtccacaggggtc atgggcaacattcaggtggtggaagaaacacaagccatccttcgagagtacggcttccgc tttgtgaggcgagggcccatctttgtgaaagggaagggggaactgctaacctttttcctg aaggggcgtgagaagccagctgccttccctaatggctcctcggtcaccctgccccaccag gtggtggacaactcctga

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