KEGG   Eumetopias jubatus (Steller sea lion): 114206954
Entry
114206954         CDS       T07240                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
eju  Eumetopias jubatus (Steller sea lion)
Pathway
eju00562  Inositol phosphate metabolism
eju01100  Metabolic pathways
eju01521  EGFR tyrosine kinase inhibitor resistance
eju01522  Endocrine resistance
eju01524  Platinum drug resistance
eju04012  ErbB signaling pathway
eju04014  Ras signaling pathway
eju04015  Rap1 signaling pathway
eju04024  cAMP signaling pathway
eju04062  Chemokine signaling pathway
eju04066  HIF-1 signaling pathway
eju04068  FoxO signaling pathway
eju04070  Phosphatidylinositol signaling system
eju04071  Sphingolipid signaling pathway
eju04072  Phospholipase D signaling pathway
eju04081  Hormone signaling
eju04140  Autophagy - animal
eju04150  mTOR signaling pathway
eju04151  PI3K-Akt signaling pathway
eju04152  AMPK signaling pathway
eju04210  Apoptosis
eju04211  Longevity regulating pathway
eju04213  Longevity regulating pathway - multiple species
eju04218  Cellular senescence
eju04360  Axon guidance
eju04370  VEGF signaling pathway
eju04380  Osteoclast differentiation
eju04510  Focal adhesion
eju04550  Signaling pathways regulating pluripotency of stem cells
eju04611  Platelet activation
eju04613  Neutrophil extracellular trap formation
eju04620  Toll-like receptor signaling pathway
eju04625  C-type lectin receptor signaling pathway
eju04630  JAK-STAT signaling pathway
eju04650  Natural killer cell mediated cytotoxicity
eju04660  T cell receptor signaling pathway
eju04662  B cell receptor signaling pathway
eju04664  Fc epsilon RI signaling pathway
eju04666  Fc gamma R-mediated phagocytosis
eju04668  TNF signaling pathway
eju04670  Leukocyte transendothelial migration
eju04722  Neurotrophin signaling pathway
eju04725  Cholinergic synapse
eju04750  Inflammatory mediator regulation of TRP channels
eju04810  Regulation of actin cytoskeleton
eju04910  Insulin signaling pathway
eju04914  Progesterone-mediated oocyte maturation
eju04915  Estrogen signaling pathway
eju04917  Prolactin signaling pathway
eju04919  Thyroid hormone signaling pathway
eju04923  Regulation of lipolysis in adipocytes
eju04926  Relaxin signaling pathway
eju04929  GnRH secretion
eju04930  Type II diabetes mellitus
eju04931  Insulin resistance
eju04932  Non-alcoholic fatty liver disease
eju04933  AGE-RAGE signaling pathway in diabetic complications
eju04935  Growth hormone synthesis, secretion and action
eju04960  Aldosterone-regulated sodium reabsorption
eju04973  Carbohydrate digestion and absorption
eju05010  Alzheimer disease
eju05017  Spinocerebellar ataxia
eju05020  Prion disease
eju05100  Bacterial invasion of epithelial cells
eju05132  Salmonella infection
eju05135  Yersinia infection
eju05142  Chagas disease
eju05146  Amoebiasis
eju05160  Hepatitis C
eju05161  Hepatitis B
eju05162  Measles
eju05163  Human cytomegalovirus infection
eju05164  Influenza A
eju05165  Human papillomavirus infection
eju05166  Human T-cell leukemia virus 1 infection
eju05167  Kaposi sarcoma-associated herpesvirus infection
eju05168  Herpes simplex virus 1 infection
eju05169  Epstein-Barr virus infection
eju05170  Human immunodeficiency virus 1 infection
eju05171  Coronavirus disease - COVID-19
eju05200  Pathways in cancer
eju05203  Viral carcinogenesis
eju05205  Proteoglycans in cancer
eju05206  MicroRNAs in cancer
eju05207  Chemical carcinogenesis - receptor activation
eju05208  Chemical carcinogenesis - reactive oxygen species
eju05210  Colorectal cancer
eju05211  Renal cell carcinoma
eju05212  Pancreatic cancer
eju05213  Endometrial cancer
eju05214  Glioma
eju05215  Prostate cancer
eju05218  Melanoma
eju05220  Chronic myeloid leukemia
eju05221  Acute myeloid leukemia
eju05222  Small cell lung cancer
eju05223  Non-small cell lung cancer
eju05224  Breast cancer
eju05225  Hepatocellular carcinoma
eju05226  Gastric cancer
eju05230  Central carbon metabolism in cancer
eju05231  Choline metabolism in cancer
eju05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
eju05415  Diabetic cardiomyopathy
eju05417  Lipid and atherosclerosis
eju05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:eju00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114206954 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114206954 (PIK3CA)
   04014 Ras signaling pathway
    114206954 (PIK3CA)
   04015 Rap1 signaling pathway
    114206954 (PIK3CA)
   04370 VEGF signaling pathway
    114206954 (PIK3CA)
   04630 JAK-STAT signaling pathway
    114206954 (PIK3CA)
   04668 TNF signaling pathway
    114206954 (PIK3CA)
   04066 HIF-1 signaling pathway
    114206954 (PIK3CA)
   04068 FoxO signaling pathway
    114206954 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    114206954 (PIK3CA)
   04072 Phospholipase D signaling pathway
    114206954 (PIK3CA)
   04071 Sphingolipid signaling pathway
    114206954 (PIK3CA)
   04024 cAMP signaling pathway
    114206954 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    114206954 (PIK3CA)
   04152 AMPK signaling pathway
    114206954 (PIK3CA)
   04150 mTOR signaling pathway
    114206954 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    114206954 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114206954 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    114206954 (PIK3CA)
   04218 Cellular senescence
    114206954 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114206954 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    114206954 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114206954 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114206954 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    114206954 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    114206954 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    114206954 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    114206954 (PIK3CA)
   04660 T cell receptor signaling pathway
    114206954 (PIK3CA)
   04662 B cell receptor signaling pathway
    114206954 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    114206954 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    114206954 (PIK3CA)
   04670 Leukocyte transendothelial migration
    114206954 (PIK3CA)
   04062 Chemokine signaling pathway
    114206954 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114206954 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    114206954 (PIK3CA)
   04929 GnRH secretion
    114206954 (PIK3CA)
   04915 Estrogen signaling pathway
    114206954 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    114206954 (PIK3CA)
   04917 Prolactin signaling pathway
    114206954 (PIK3CA)
   04926 Relaxin signaling pathway
    114206954 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    114206954 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    114206954 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    114206954 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    114206954 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    114206954 (PIK3CA)
   04722 Neurotrophin signaling pathway
    114206954 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114206954 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    114206954 (PIK3CA)
   04380 Osteoclast differentiation
    114206954 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    114206954 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    114206954 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114206954 (PIK3CA)
   05206 MicroRNAs in cancer
    114206954 (PIK3CA)
   05205 Proteoglycans in cancer
    114206954 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    114206954 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    114206954 (PIK3CA)
   05203 Viral carcinogenesis
    114206954 (PIK3CA)
   05230 Central carbon metabolism in cancer
    114206954 (PIK3CA)
   05231 Choline metabolism in cancer
    114206954 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114206954 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114206954 (PIK3CA)
   05212 Pancreatic cancer
    114206954 (PIK3CA)
   05225 Hepatocellular carcinoma
    114206954 (PIK3CA)
   05226 Gastric cancer
    114206954 (PIK3CA)
   05214 Glioma
    114206954 (PIK3CA)
   05221 Acute myeloid leukemia
    114206954 (PIK3CA)
   05220 Chronic myeloid leukemia
    114206954 (PIK3CA)
   05218 Melanoma
    114206954 (PIK3CA)
   05211 Renal cell carcinoma
    114206954 (PIK3CA)
   05215 Prostate cancer
    114206954 (PIK3CA)
   05213 Endometrial cancer
    114206954 (PIK3CA)
   05224 Breast cancer
    114206954 (PIK3CA)
   05222 Small cell lung cancer
    114206954 (PIK3CA)
   05223 Non-small cell lung cancer
    114206954 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114206954 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    114206954 (PIK3CA)
   05161 Hepatitis B
    114206954 (PIK3CA)
   05160 Hepatitis C
    114206954 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    114206954 (PIK3CA)
   05164 Influenza A
    114206954 (PIK3CA)
   05162 Measles
    114206954 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    114206954 (PIK3CA)
   05163 Human cytomegalovirus infection
    114206954 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114206954 (PIK3CA)
   05169 Epstein-Barr virus infection
    114206954 (PIK3CA)
   05165 Human papillomavirus infection
    114206954 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114206954 (PIK3CA)
   05135 Yersinia infection
    114206954 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    114206954 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114206954 (PIK3CA)
   05142 Chagas disease
    114206954 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114206954 (PIK3CA)
   05017 Spinocerebellar ataxia
    114206954 (PIK3CA)
   05020 Prion disease
    114206954 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114206954 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    114206954 (PIK3CA)
   05415 Diabetic cardiomyopathy
    114206954 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114206954 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    114206954 (PIK3CA)
   04931 Insulin resistance
    114206954 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114206954 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114206954 (PIK3CA)
   01524 Platinum drug resistance
    114206954 (PIK3CA)
   01522 Endocrine resistance
    114206954 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:eju04131]
    114206954 (PIK3CA)
Enzymes [BR:eju01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     114206954 (PIK3CA)
Membrane trafficking [BR:eju04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    114206954 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 114206954
NCBI-ProteinID: XP_027956648
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagttgaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggcttttccaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
cgaaatattcttaatgtttgtaaagaagctgtggatcttcgggatcttaactcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagcatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcgacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgcgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagctattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gcgcagatgtactgcttagtaaaagactggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaactgtt
agtcagaggtttggccttcttttggagtcctattgtcgtgcatgcgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctacaaggtttcctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgaccttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgcgaaattctcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggtgctctgcagttcaacagccacacactgcatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggttattgtgtcgctactttcattctgggcattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatatcgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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