KEGG   Eumetopias jubatus (Steller sea lion): 114216801
Entry
114216801         CDS       T07240                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
eju  Eumetopias jubatus (Steller sea lion)
Pathway
eju01521  EGFR tyrosine kinase inhibitor resistance
eju01522  Endocrine resistance
eju04010  MAPK signaling pathway
eju04012  ErbB signaling pathway
eju04068  FoxO signaling pathway
eju04270  Vascular smooth muscle contraction
eju04650  Natural killer cell mediated cytotoxicity
eju04720  Long-term potentiation
eju04726  Serotonergic synapse
eju04730  Long-term depression
eju04810  Regulation of actin cytoskeleton
eju04910  Insulin signaling pathway
eju04914  Progesterone-mediated oocyte maturation
eju04928  Parathyroid hormone synthesis, secretion and action
eju05010  Alzheimer disease
eju05022  Pathways of neurodegeneration - multiple diseases
eju05034  Alcoholism
eju05160  Hepatitis C
eju05161  Hepatitis B
eju05200  Pathways in cancer
eju05205  Proteoglycans in cancer
eju05208  Chemical carcinogenesis - reactive oxygen species
eju05210  Colorectal cancer
eju05211  Renal cell carcinoma
eju05212  Pancreatic cancer
eju05213  Endometrial cancer
eju05214  Glioma
eju05215  Prostate cancer
eju05218  Melanoma
eju05219  Bladder cancer
eju05220  Chronic myeloid leukemia
eju05221  Acute myeloid leukemia
eju05223  Non-small cell lung cancer
eju05224  Breast cancer
eju05225  Hepatocellular carcinoma
eju05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:eju00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114216801 (ARAF)
   04012 ErbB signaling pathway
    114216801 (ARAF)
   04068 FoxO signaling pathway
    114216801 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114216801 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    114216801 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114216801 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    114216801 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    114216801 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    114216801 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    114216801 (ARAF)
   04720 Long-term potentiation
    114216801 (ARAF)
   04730 Long-term depression
    114216801 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114216801 (ARAF)
   05205 Proteoglycans in cancer
    114216801 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    114216801 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114216801 (ARAF)
   05212 Pancreatic cancer
    114216801 (ARAF)
   05225 Hepatocellular carcinoma
    114216801 (ARAF)
   05226 Gastric cancer
    114216801 (ARAF)
   05214 Glioma
    114216801 (ARAF)
   05221 Acute myeloid leukemia
    114216801 (ARAF)
   05220 Chronic myeloid leukemia
    114216801 (ARAF)
   05218 Melanoma
    114216801 (ARAF)
   05211 Renal cell carcinoma
    114216801 (ARAF)
   05219 Bladder cancer
    114216801 (ARAF)
   05215 Prostate cancer
    114216801 (ARAF)
   05213 Endometrial cancer
    114216801 (ARAF)
   05224 Breast cancer
    114216801 (ARAF)
   05223 Non-small cell lung cancer
    114216801 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    114216801 (ARAF)
   05160 Hepatitis C
    114216801 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114216801 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    114216801 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    114216801 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114216801 (ARAF)
   01522 Endocrine resistance
    114216801 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:eju01001]
    114216801 (ARAF)
Enzymes [BR:eju01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     114216801 (ARAF)
Protein kinases [BR:eju01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   114216801 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 114216801
NCBI-ProteinID: XP_027969277
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSHRPLNEPL
TPQGPSSCTQHREPEHFPFPATANAPLQRIRSTSTPNVHMVSTTAPMDSSLVQLAAPSFS
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccgccacggggcccccctgccaacggggccgagccatcccgggcagtgggcact
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcatcgaggggcgaaagacagtcaccgcctgggacacggccattgccccg
ctggatggagaggagctcatcgtagaggtccttgaagacgtcccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaagctccctcacaccgccccctgaacgagccgtta
acccctcagggtcccagctcctgcacccagcaccgcgagcctgagcactttcccttcccc
gccactgccaacgcccctctccagcgcatccgctccacgtccactcccaacgtccacatg
gtcagcaccacagcccccatggactccagccttgtccagctcgccgccccgagtttcagc
accgatgctgccggtagtagaggtggtggcgatggagccccccgggggagccccagcccg
gccagcgtgtcctcggggaggaagtctccccattccaagtccccgtcagaacagcgggag
cggaagtccgtggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccgcccagtgaggtgcagctgctgaagaggatcgggacaggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacggcacgtcaacatcttgctgttcatgggcttcatgacgcggccgggcttcgccatc
atcacgcaatggtgcgagggctccagcctctaccaccacctgcatgtggccgacacgcgc
ttcgacatggtccagctcattgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagatcggtgactttggcctggccacggtgaagacacgatggagtggggcc
cagcccttggagcagccctcaggctccgtgctatggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcggatgtctacgcctatggggtcgtgctctat
gagctcatgaccggctcgctgccttacagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcgtcccctcttc
ccccagatcctggccaccattgagctgctgcagcggtcactccccaagattgagcggagt
gcctctgaaccctccttgcatcgcacccaggccgatgagctgcctgcctgcctgctcagc
gcagcccgccttgtgccttag

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