KEGG   Eumetopias jubatus (Steller sea lion): 114218424
Entry
114218424         CDS       T07240                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
eju  Eumetopias jubatus (Steller sea lion)
Pathway
eju01522  Endocrine resistance
eju04010  MAPK signaling pathway
eju04015  Rap1 signaling pathway
eju04068  FoxO signaling pathway
eju04071  Sphingolipid signaling pathway
eju04114  Oocyte meiosis
eju04148  Efferocytosis
eju04218  Cellular senescence
eju04261  Adrenergic signaling in cardiomyocytes
eju04370  VEGF signaling pathway
eju04380  Osteoclast differentiation
eju04517  IgSF CAM signaling
eju04550  Signaling pathways regulating pluripotency of stem cells
eju04611  Platelet activation
eju04613  Neutrophil extracellular trap formation
eju04620  Toll-like receptor signaling pathway
eju04621  NOD-like receptor signaling pathway
eju04622  RIG-I-like receptor signaling pathway
eju04625  C-type lectin receptor signaling pathway
eju04657  IL-17 signaling pathway
eju04658  Th1 and Th2 cell differentiation
eju04659  Th17 cell differentiation
eju04660  T cell receptor signaling pathway
eju04664  Fc epsilon RI signaling pathway
eju04668  TNF signaling pathway
eju04670  Leukocyte transendothelial migration
eju04714  Thermogenesis
eju04722  Neurotrophin signaling pathway
eju04723  Retrograde endocannabinoid signaling
eju04728  Dopaminergic synapse
eju04750  Inflammatory mediator regulation of TRP channels
eju04912  GnRH signaling pathway
eju04914  Progesterone-mediated oocyte maturation
eju04917  Prolactin signaling pathway
eju04926  Relaxin signaling pathway
eju04932  Non-alcoholic fatty liver disease
eju04933  AGE-RAGE signaling pathway in diabetic complications
eju04935  Growth hormone synthesis, secretion and action
eju04936  Alcoholic liver disease
eju05014  Amyotrophic lateral sclerosis
eju05020  Prion disease
eju05022  Pathways of neurodegeneration - multiple diseases
eju05132  Salmonella infection
eju05133  Pertussis
eju05135  Yersinia infection
eju05140  Leishmaniasis
eju05142  Chagas disease
eju05145  Toxoplasmosis
eju05152  Tuberculosis
eju05161  Hepatitis B
eju05163  Human cytomegalovirus infection
eju05167  Kaposi sarcoma-associated herpesvirus infection
eju05169  Epstein-Barr virus infection
eju05170  Human immunodeficiency virus 1 infection
eju05171  Coronavirus disease - COVID-19
eju05205  Proteoglycans in cancer
eju05208  Chemical carcinogenesis - reactive oxygen species
eju05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
eju05415  Diabetic cardiomyopathy
eju05417  Lipid and atherosclerosis
eju05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:eju00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114218424 (MAPK12)
   04015 Rap1 signaling pathway
    114218424 (MAPK12)
   04370 VEGF signaling pathway
    114218424 (MAPK12)
   04668 TNF signaling pathway
    114218424 (MAPK12)
   04068 FoxO signaling pathway
    114218424 (MAPK12)
   04071 Sphingolipid signaling pathway
    114218424 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    114218424 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    114218424 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    114218424 (MAPK12)
   04218 Cellular senescence
    114218424 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    114218424 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114218424 (MAPK12)
   04613 Neutrophil extracellular trap formation
    114218424 (MAPK12)
   04620 Toll-like receptor signaling pathway
    114218424 (MAPK12)
   04621 NOD-like receptor signaling pathway
    114218424 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    114218424 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    114218424 (MAPK12)
   04660 T cell receptor signaling pathway
    114218424 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    114218424 (MAPK12)
   04659 Th17 cell differentiation
    114218424 (MAPK12)
   04657 IL-17 signaling pathway
    114218424 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    114218424 (MAPK12)
   04670 Leukocyte transendothelial migration
    114218424 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    114218424 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    114218424 (MAPK12)
   04917 Prolactin signaling pathway
    114218424 (MAPK12)
   04926 Relaxin signaling pathway
    114218424 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    114218424 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114218424 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    114218424 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    114218424 (MAPK12)
   04722 Neurotrophin signaling pathway
    114218424 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114218424 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114218424 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    114218424 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    114218424 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    114218424 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114218424 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    114218424 (MAPK12)
   05161 Hepatitis B
    114218424 (MAPK12)
   05171 Coronavirus disease - COVID-19
    114218424 (MAPK12)
   05163 Human cytomegalovirus infection
    114218424 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114218424 (MAPK12)
   05169 Epstein-Barr virus infection
    114218424 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114218424 (MAPK12)
   05135 Yersinia infection
    114218424 (MAPK12)
   05133 Pertussis
    114218424 (MAPK12)
   05152 Tuberculosis
    114218424 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    114218424 (MAPK12)
   05140 Leishmaniasis
    114218424 (MAPK12)
   05142 Chagas disease
    114218424 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    114218424 (MAPK12)
   05020 Prion disease
    114218424 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    114218424 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114218424 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    114218424 (MAPK12)
   05415 Diabetic cardiomyopathy
    114218424 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    114218424 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    114218424 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114218424 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    114218424 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:eju01001]
    114218424 (MAPK12)
Enzymes [BR:eju01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     114218424 (MAPK12)
Protein kinases [BR:eju01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   114218424 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase
Other DBs
NCBI-GeneID: 114218424
NCBI-ProteinID: XP_027971334
LinkDB
Position
Unknown
AA seq 367 aa
MSSPPPARRGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSAGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSADAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAERRV
TAAEALTHPYFESLQDTEDEPKAQKYDESFDDMDRTLDEWKRVTYKEVLSFKPPRQLGTK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccaccgcccgcccgccggggcttttaccgccaggaggtgaccaagacggct
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctccggcgcctacggcgcg
gtgtgctcggccgtggacagccgcactggcgccaaggtggccatcaagaaactgtaccgg
cccttccagtcggagctcttcgccaagcgcgcctaccgcgaactgcgcctcctcaagcac
atgcgccacgagaacgtcatcgggctgctggacgtgttcacccctgatgaaaccctggat
gatttcacagacttttacctggtgatgccgttcatggggactgacctgggcaagctcatg
aagcatgagaagctgagtgaggaccgaatccagttccttgtctaccagatgctgaagggg
ctaaagtacatccatgctgctggcatcatccatagggacctgaagcccggcaatctggca
gtgaatgaggactgtgagctgaagatcctggacttcggcctggcgaggcaggcagacagc
gagatgactgggtatgtggtgactcggtggtaccgggcacctgaggtcatcttgaattgg
atgcgctacacgcagacggtggatatctggtcggcgggctgcatcatggcggagatgatt
acagggaagacgctgttcaagggcagtgaccacctggaccagctgaaggagatcatgaag
gtgacagggacgcctcccgctgagtttgtgcagaggctgcagagtgccgatgcgaagaac
tacatgaagggcctccccgagttggagaagaaggatttcgcatccatcctgactaatgca
agtcctctggctgtgaacctcctggagaaaatgcttgtgctagatgcagagcggcgggtg
actgcggccgaggcgctgacccacccctacttcgagtcactgcaggacacggaggatgag
cccaaggcccagaagtacgacgagtcctttgatgatatggaccgcacgctggatgagtgg
aaacgtgtcacatataaagaagtgctcagcttcaagcctccccggcagctggggaccaag
gtctccaaggagacggccctctga

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