Eumetopias jubatus (Steller sea lion): 114221310 Help Entry 114221310         CDS       T07240                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju04020   Calcium signaling pathway eju04371   Apelin signaling pathway eju04713   Circadian entrainment eju04921   Oxytocin signaling pathway eju04970   Salivary secretion eju05010   Alzheimer disease eju05012   Parkinson disease eju05020   Prion disease eju05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:eju00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     114221310 (RYR3)    04020 Calcium signaling pathway     114221310 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     114221310 (RYR3)   09154 Digestive system    04970 Salivary secretion     114221310 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     114221310 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     114221310 (RYR3)    05012 Parkinson disease     114221310 (RYR3)    05020 Prion disease     114221310 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     114221310 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:eju04040]     114221310 (RYR3) Ion channels [BR:eju04040]  Voltage-gated cation channels   Ryanodine receptor    114221310 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  114221310 NCBI-ProteinID:  XP_027975230 LinkDB All DBs Position Unknown AA seq 4886 aa AA seqDB search MSISCRFAEVVGAKTGTGCRFRCCLQPGQHGASSVSQHGEESDSEDEVVLQCIANIHKEQ RKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGSEG AAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIH PASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSI EEGYLLGGHVVRLFHGHDECLTIPSTDQNDAQHRRIFYEAGGAGTRARSLWRVEPLRISW SGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKEIKEKLDSS HKRDIEGMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDD GLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPP EEEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAW KEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEAL NLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQT RLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPY PGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSI SFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEAL LPKEKMRLEPVKEYKRDAEGIRDLLGTTQSLSQASFIPCPIDTSQVILPPHLEKIRDRLA ENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLAL GCHIAHVNPAAEEDLKKVKLPKNYMMSNGYRPAPLDLSDVKLLPPQEILVDKLAENAHNV WAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP SDQELADPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIE LGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKG SELAFADYEIENGFVPICSLGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDV AMWFSKRLPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMP VECHSSFSHSPCLDSDAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYH LYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGC LVDLAMGMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNSMPLSAA IFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMA LHIPEENRCVDVLELCEQEDLMQFHYHTLRLYSAVCALGNSRVAYALCGHVDLSQLFYAI DNKYLPGLLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSTTGKIRLYPDESKRHGLP GVGLRTCLKPGFRFSTPCFVVTSEEHQKQSPEIPLEILKTKALSMLTEAVQHSGAHIRDP VGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSAETEDRAEKEEVTQ VEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSHLCDCELQHRVEAIVAFGDIY VSKLQANQKSRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIR EELYDFHEDLLLHCGVPLEEEEEVEEDTSWTGKLRALVYKIKGPPKPEKEQPTEEEERSP TTLKELISQTMIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSD TINLLAALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVM VNVLGAEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRG STPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGE RYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISEN PALDLPSQGYKREVLEDNEDEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIR IRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKASMVLFLDRVYGI KDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEVALALNRYLCSAVLPLLTRCAPLFAGT EHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQ LNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYD PDLFRMALPCLSAIAGALPPDYLDTRISATLEKQISVDADGNFDPKPINTMNFSLPEKWE YIVTKYAEHSHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARES LKTMLAVGWSVERTKEGEALVQQRENEKLRSMSQASQGNSYSPAPLDLSNVVLSRELQGM VEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNG IVVSRGMKDLELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQE IKFFAKVLLPLVDQYFTNHHLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRI SLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGK FTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYS LGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPD TVEEMCPDVPQLEGLMKDISDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPP STGPWCTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKSHF IPTLEKLKKKAVKTVQEEEQLKADTRGDTQEAELLILDEFAVLCRDLYAFYPLLIRYVDN SRSNWLKSPNADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKM SKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYR DTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFH LEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHKINNFFLSTFQRVWLEKV NEKTQYDRLIPILMKSPKVEEEEEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTS YSSMMAKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKG EMSLMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFE RQNKAEGLGMVTEEGTREKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTIN VIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCI GNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGN VVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQ KAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVNRFHEPAKDIGFNVAVLLTNLSEHM PNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESK RQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPDEEEEEDEDSSYML EIEGEEEDAKSFESASAFAMACASVKRNVANFLKKATLKNLRKQYRRVKKMTVKELVKVF FSFFWMLLVGLFQLFFTILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIH DDALDAERAEVTEPGVPPELIHFVKGDKGDADIMSDLFGFRPKKEGGLKHGPEGGLGDLS EIIGEDEPPTLESTVQKKRKAQVAEMKAAHEAEGRVEHEKTDLEDGEKEDTAKEEEQAEA LWADMTKKKKRRRGQKVEKPEAFMANFFKGLEVYQTKLLHYLARNFYNLRFLALFVAFAI NFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIH TIISLLCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPS FPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSI DMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGV RAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVR EDMETKCFICGIGNDYFDTIPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVW KMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14661 nt NT seq  +upstreamnt  +downstreamnt atgtccatctcttgcaggtttgcagaggtggtcggtgcgaagacaggcacgggctgccgc ttcaggtgttgtctgcagccaggtcagcatggagcatccagtgtcagccagcatggggaa gaaagtgacagtgaagatgaggtggttctccagtgcatcgcaaacattcacaaggagcaa aggaagttctgcctggcagccgagggccttgggaaccgcttgtgcttcttggaacccact tcagaagccaagtatgttcctccagatctctgcgtctgcaattttgtgctggaacagtcc ctctctgtgagagccctacaggaaatgcttgccaacacaggtgaaaatggcagcgaaggg gcagcacaagggggtggccacaggaccctgctatatggccacgcgattctcctgcggcac tccttcagcggaatgtatctaacatgtttgaccacatcaagatcccagacagataaactt gcctttgatgtaggtctacgagaacatgccacaggagaagcctgttggtggaccatacat cccgcttccaaacagagatctgagggagagaaagttcgaattggtgatgacctcatcctc gtgagcgtgtcctctgaaagataccttcatctctcagtatcaaatgggaacatacaagtg gacgcctcttttatgcaaacactctggaatgtacatcctacgtgctcaggaagcagcatt gaagaaggatacctacttggtgggcatgtagtacgtctcttccacggtcacgatgagtgc ttgacgataccatctacagaccagaatgatgctcagcacaggaggatattctatgaagct gggggagctgggacacgagccagatctctgtggagagtggaaccccttcggataagttgg agtggcagtaacatcagatggggccaggctttccggctccggcatctcaccacaggccac tacctggccttgacagaggaccagggccttatactgcaggaccgggcgaagtcagacacc aagtccacagccttctctttccgggcctccaaggaaatcaaggagaaattggattccagt cacaagcgagatatagaaggcatgggcgttccagaaatcaagtatggagattcggtctgc tttgtgcaacatatagccagtggtctgtgggtgacctacaaagcacaagatgccaagacc tcccgccttggacctctgaaaagaaaggtcatactccatcaggaaggccacatggatgac gggttaaccctgcagagatgccagcgcgaggagtcacaggctgctcggatcatccggaac acaacagccttattcagccagtttgtaagtggaaacaatcgcacagctgcccctgtcacc ctgccgattgaagaggtcctgcagaccttacaggacttgattgcctactttcagccccca gaggaggagatgcagcacgaagacaaacagaacaagctccgctcactcaagaacagacag aaccttttcaaggaagaaggaatgttggcccttgtgttaaactgcattgaccgcttaaat atctacaacagtgtagcacactttgcagggattgcaagggaggagagtggcatggcttgg aaagagatcctgaacctcctgtacaaactgctggctgctctcattcgtggaaacagaaac aactgtgctcaattctctaacaacctggattggctaatcagcaaactggacagactagaa tcttcctcaggtatcttggaagttttacactgcatcttgattgaaagcccagaagcctta aacctgatagccgagggccacatcaagtccatcatctcgttattggataagcatggacgg aatcacaaggttctcgatgtgttgtgctccctctgtctctgcaatggggttgcagtcaga gccaaccagaatctgatttgtgataatttgctgccccggagaaacctgctcctgcagaca cggctgattaatgatgtgaccagcattcggcccaacatcttcctgggagtcgccgagggc tcggcgcagtacaagaagtggtacttcgagctgatcatcgaccaggtggaccccttccta acagctgagcccacacacctgcgggtgggctgggcctcttcctcaggctatgctccgtac cctggcggaggagaaggatggggaggcaatggtgtcggcgatgacctgtactcttatggc tttgatggacttcacctttggtcaggccgcatacccagagccgtagcgtccatcaatcag cacctcctgagatcagatgacgtggtgagctgttgcctcgacctcggagtgcccagcatc tccttccgcatcaacgggcagcctgtgcaggggatgtttgagaacttcaacacagatggg ctcttcttccctgtggtgagcttctcagcaggtgtcaaagtgcgtttcctgatgggtgga cgtcatggagaatttaagttcctgcctccctctggctatgccccttgctatgaagcctta cttccaaaagaaaagatgagattggagcctgtgaaagaatataaacgtgacgctgaaggc attagagatctgctgggtaccacccagtccctctcccaagcctctttcatcccttgcccc atagacactagtcaggtcattttgccccctcacctagaaaagatccgagacagactggct gaaaacattcacgagctttggggaatgaataaaatagagcttggctggacttttggcaag atacgggacgacaataaaagacaacacccctgtcttgtggagttttcaaagctgcctgaa actgagaagaattataacctacaaatgtcaactgaaaccttaaaaaccctcctggccctg gggtgccacattgctcatgtgaatccagctgctgaggaggatctcaagaaggtcaaattg cccaaaaactatatgatgtccaatggctacaggccagcccctttggatctgtctgatgtg aagctgttacctcctcaagaaattttagtggataagcttgcagaaaatgcacataacgtt tgggccaaagacagaataaaacaaggatggacctatggcatccaacaggatctgaagaac aaaagaaatccccggctggtgccatatgcattactggatgagcgtaccaagaagtccaat agggacagccttcgtgaagctgttcgcacatttgtcggttatggctataacattgagccg tcggaccaagaactggctgatccagctgtggagaaagtcagcatagacaagattcgattt ttccgggtagagcggtcttatgcagtgagatctggaaagtggtattttgagtttgaggtg gtgaccggaggagacatgcgcgtcggctgggccaggccgggctgtcggcctgacattgag ctgggcgctgatgaccaagcctttgtgttcgaaggcagcaggggccagcggtggcatcag ggcagcgggtattttggacgtacgtggcagccaggagatgtggttggctgtatgattaac ctggatgatgcttcgatgatcttcacactgaatggggagctgctgatcaccaacaaaggc tctgaactcgccttcgctgattacgagattgagaatggctttgtgcccatctgctctctc ggactgtctcagatcggccgcatgaatctcgggatggatgccagtaccttcaagttttat accatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaaccgtgatgtg gcgatgtggttcagcaagcgcctcccgacgtttgtcaacgtgccaaaggatcatccccat atagaggtcgtgaggatcgatggcaccatggacagccctccatgcctcaaggtgacccac aagacattcggcacacagaacagcaatgccaacatgatctactgccgcttgagcatgccc gtcgagtgccactcctccttcagccacagcccctgtctggacagcgacgctttccagaaa aggaaacagatgcaagaaatactctctcatacaacaacacagtgttactacgcaatccgc atctttgctggacaggacccctcctgtgtctgggtcggatgggtgacaccagactatcac ttatacagtgagaagtttgacctgaataaaaactgtacggtgactgttaccctaggggat gaaagaggccgggtccacgaaagtgtgaaacgcagtaactgctacatggtgtggggtggg gatattgtggccacttcccaaagatcaagtcggagcaacgtggacctggagatcggctgc ctcgtggatctggcgatgggcatgttgtctttctccgccaatgggcgagaactcggcaca tgttaccaggtggagcccaataccaaagtgtttccagcagtcttcctgcagcctacgagc acgtccttgtttcagtttgaacttgggaagctgaagaactcaatgcccctgtcggcggcc atatttaagagtgaagagaagaacccagttccgcagtgtccacctcggctggatgtgcag accatccaacccgtgctctggagccgcatgcccagcagcttcctgaaggtggagacagag cgggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatgatggca ctccacatcccggaggagaacaggtgtgtggacgtcctggagctctgtgagcaggaggac ctgatgcagttccattaccacacgctgcgactctacagtgccgtgtgcgccctgggaaac agccgggtggcctacgccctgtgtggccacgtcgacctctcccagctcttctatgccatc gacaacaagtacctccctggcctccttcgctctggtttctatgacctgctcatcagcatc cacctggccaatgctaaggagaggaagctaatgatgaagaatgagtacatcattcccatc accagcaccaccgggaaaatccgcctgtacccagacgagtccaagaggcacgggctgccg ggggtgggcctgagaacatgtctcaagccagggttcaggttctccaccccttgctttgtt gtgaccagtgaggagcaccagaagcagagccctgagatccccttggagattctcaagacg aaggcactgagcatgctgacggaggcagtgcagcacagcggggctcacatccgggaccct gtcggcgggtctgtggagttccagtttgtgcctgtgctgaaactcatcgggaccctgctg gtcatgggggtgtttgatgatgatgatgtccggcagatcctcctcctgatcgatccctct gtgtttggggagcacagtgcagagacagaggacagagcagagaaggaggaagtgacccag gtggaggagaaggcagtggaggctggggaaaaggccggcaaggaggctccagtcaaaggc ttgttgcagacccgactgccagagtcagtcaagctgcagatgtgtgagctcctcagccat ctctgtgactgcgagctgcaacatcgagtggaggccattgtagcatttggcgacatttat gtctccaaactccaggcaaatcagaagtcccgctacaatgagctcatgcaggccttgaac atgtccgcagccctgactgcccggaagaccagggagttccgctcccccccacaggagcag atcaacatgcttcttaactttcaactgggagagaattgcccctgcccagaggagatacgg gaggagctctatgacttccatgaggaccttctccttcactgtggggtccccctggaggag gaggaagaggtggaggaggacacctcctggactgggaagctccgtgccttggtgtataaa atcaaaggccctcccaagcctgagaaggaacagccaacagaagaggaagagagatcgcct acaaccctgaaggagctcatctcacagaccatgatccgctgggcccaggaggaccagatc caagacgcggagttggtccggatgatgttcaacctcctccggagacagtacgacagcatt ggggagttgctgcaggccctgcggaagacctacaccatcagtcaggcctccgtgagcgac accatcaacctgctggctgctctgggccagatccgctgcctgctcagtgtcaggatgggc aaggaagaggagctgctcatgatcaatggcctgggagacattatgaacaacaaggtgttt taccagcatcccaacctcatgcgagtccttggcatgcacgagacggtgatggaggtgatg gtgaacgtgttgggcgcggagaagtctcagattgcttttccaaaaatggttgctagctgt tgccgtttcctctgctatttctgtcgaattagccggcaaaatcagaaggccatgtttgag catctaagttacctgctggagaatagcagtgttggcctagcctccccttcgatgagagga tctacccccctggatgtggcagcttcctccgtgatggacaacaacgagttagcgctgggc ttagaagaaccggacctcgagaaggtggtgacctacttggcaggctgtggcctgcagagc tgccccatgcttctagccaaaggataccctgatgtcggctggaaccccattgaaggggaa cgttacctgtccttcctgaggtttgccgtctttgtgaacagcgaaagtgtggaagaaaat gctagtgtcgtggtcaagctgctcatcagacgcccggagtgcttcggcccagcccttcga ggtgaaggaggaaacggtctattggcagccatgcagggcgccattaagatctctgagaac ccagccctcgacctcccctctcagggatacaagagagaagtcttggaggacaatgaagat gaagagatcgtgcacatgggcaacgcaattatgtctttttattcagctcttatagatctc ctgggccgctgtgcgcctgaaatgcatcttatccagacaggaaagggggaagccatccga atcaggtcaatcctgcgctccctcgtcccgacggaggacctggtcggtatcatcagcatc cccttgaagctgccctccctgaacaaagacgggtccgttagcgagccagatatggcagcc aacttctgccctgaccacaaggcatccatggtgctgttcttggatcgtgtttatggcatt aaggatcaaacttttctgctccacttgctagaggttggatttttacccgacttaagagcc tctgcctctctagatacagtttccctgagcaccacagaggtagcacttgccctaaatagg tatttatgttctgccgtgctcccgctcctcacaagatgcgcccctctctttgccggaaca gaacactacacgtctctgatcgattctacactacagacaatatacaggctttccaaggga cggtccctcacaaaagctcagagggacaccatagaagaatgtttgcttgccatttgcaat cacttgaggccttccatgttacagcaactcttgcgacgtctggtttttgacgtgccccag ctcaacgaatactgcaaaatgcctcttaagcttctgacgaatcactatgaacagtgctgg aagtattactgtctgccttcaggatgggggagctacgggctagctgtggaagaagaattg cacctgacagagaagctcttctgggggatttttgactccctctcccacaagaagtatgac ccagaccttttccgaatggcccttccttgtctcagtgctatagcaggggccctaccaccg gattatttagataccagaatctcagccacattagagaaacagatctcagtagatgcagat ggcaactttgaccccaaacccatcaacaccatgaatttctccttgcctgaaaaatgggaa tacattgtcaccaagtatgcggagcattcacatgataaatgggcctgtgacaagagtcag aatggatggaaatatggaatttccctggatgaaaatgtgaagacccatccactgatcagg cctttcaagacattaacggaaaaggagaaggaaatttaccgctggcctgccagagagtcc ctgaaaaccatgctggctgtgggctggtctgtggagaggaccaaagagggagaggccctg gttcaacagcgggaaaatgagaagcttcggagcatgtcccaggccagccagggcaacagc tacagccctgctcccctggacctctccaacgtggtgctctccagggagctccagggaatg gtggaggtcgtggctgaaaactatcacaacatctgggccaagaagaagaagctggagctg gagagcaaaggtggtggcagtcaccctctgttggtaccatatgacaccttgacagccaag gagaagttcagagaccgagagaaggcacaggacctgtttaaattcctccaagtgaacggc atcgtggtttctagaggtatgaaggatctggagctggatgcctcctccatggaaaagagg tttgcctataaatttttgaagaagatcctgaaatatgttgattccgcccaggagtttatt gcccatttggaagccattgtcagcagtgggaaaacggaaaagtctccccacgaccaggag atcaaattctttgccaaagttctcctcccactggttgaccagtacttcaccaatcaccat ctctacttcctgtcatcccccctgaagccccttagcagcagcggctatgcctctcataag gagaaagaaatggtggccagcctcttctgcaaactcgctgctcttgttcgacacaggatt tccctcttcggcagcgattctactacaatggtgagctgtcttcacatcttagctcagaca cttgacacaaggacggtcatgaagtcaggctcagagttggtcaaggccgggttacgagca ttctttgaaaatgctgcagaagacttagagaagacttcagaaaacctgaagctggggaag tttacccattccagaacacagattaaaggcgtgtctcagaatattaactataccacggtg gctctgctccccatcttgacgtccatctttgagcacgttgctcagcatcagtttggggtg gatttactcttaggtgatgtgcagatttcatgctaccacatactgtgcagcctctactcc cttgggactggaaagaatatctatgttgaaaggcaacgtcctgcccttggagaatgtctg gcctcattggcagctgccatcccagtggcgttcctggagcccacccttaaccgctacaat ccactctcagtcttcaacactaaaacccccagggagaggtctattctgggcatgccggac acagtggaagagatgtgtcctgacgtcccacagctagaaggcctgatgaaggacatcagc gacctggccgagtcgggggcccggtacacggagatgcctcacgtcatcgaggtcatcttg cccatgctctgcaactacctgtcctactggtgggagcgggggcctgagcacctgcccccc agcacagggccatggtgcaccaaggtcacctctgaacacctcagtgtcatcctgggaaac attctgaaaatcatcaacaacaatctgggcatcgacgaggcgtcctggatgaagcgcatc gcagtgtacgcccagccaatcatcagcaaagcccggccggacctgctgaaaagccacttc atcccaactctggagaagctgaagaaaaaggcggtgaagacggtgcaggaggaggagcag ctgaaagccgacaccagaggagacactcaggaggcggagctcctcatcctggatgagttt gcagtcctctgcagagacctgtacgccttctaccccctgctcatccgctacgtggacaac agcagatctaactggcttaaaagtcctaatgctgactctgaccagctcttccgcatggtg gcagaggtcttcatcctgtggtgtaaatctcacaacttcaagagggaagagcaaaatttt gtgattcagaatgaaattaataatttggcatttttaactggagacagcaaaagcaagatg tcgaaatctggaggacaggaccaggaacggaagaagacaaagcggaggggagacttgtat tccatccagacctctctcatcgtggctgcgctcaagaaaatgctgcccattggtttgaat atgtgcacgccaggcgatcaggagctaatctccctggccaaatctcgatacagctatagg gacacagatgaagaggtgaaggaacatctgcggaataacctgcacctgcaggagaagtct gatgacccagcagtaaagtggcagctgaacctctacaaagatgttttaaagagtgaagaa cctttcaatccagaaaagactgtagagcgtgttcagagaatttcggcagctgtcttccac ctggagcaggtggaacagcctttgaggtccaagaaggcagtctggcacaaactgttgtca aagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacctgccc agacacaaaattaacaatttcttcctgagcacctttcaacgggtttggctggaaaaggtt aatgaaaaaactcagtatgacaggcttatacccattttaatgaaatcccccaaggtggaa gaggaggaggaagaggagacagaaaagcaaccagacccacttcatcagatcattctccat tttagccgcaatgctctcacagagaggagcaaattggaagacgaccccttgtacacgtcc tattccagcatgatggctaagagttgtcagagtggggaggacgaagaagaggaggaagac aaggagaaaacatttgaagagaaagaaatggaaaagcagaaaaccctctaccaacaagcg cggctgcatgagcgtggagctgcagagatggtccttcagatgataagcgccagcaaaggt gagatgagcctcatggtggttgagactctgaagctggggatcgccattctgaatgggggc aacgctggtgtacaacagaaaatgctagattacctaaaggagaaaaaggatgctggattc tttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgaa aggcagaataaagctgaaggcctggggatggttactgaggaaggaacacgtgaaaaagta ctccagaatgatgagtttacacgagatctctttcgattcctgcagttactttgtgaagga cataacagtgactttcagaacttcctgcggactcagatgggcaataccaccaccataaat gtcatcatcagtactgtggactacctcctacgtctgcaggaatcaatcagtgatttctac tggtattattcagggaaggacatcattgatgaatctggacagcacaatttttccaaagct ctggcagtcacgaagcagattttcaattctcttacagaatacatccagggcccttgcatt gggaaccaacagagcctggctcacagcaggctgtgggacgcggtggtcggcttcctccat gtgtttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaag gaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaat gtggtaaatggaactattggcaagcagatggttgacacactggtagagtcatctaccaat gtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacctaaccagctca gacaccttcaaagaatatgacccagatggtaaagggattatctccaaaaaagagttccag aaggccatggaagggcaaaaacagtacacacagtcagagattgactttctcctttcgtgc gcagaagctgatgagaatgatatgtttaattacattgattttgtaaaccggttccatgag ccagccaaggacatagggtttaatgtggcagtgttactgacaaatctctccgaacatatg ccaaatgattctcgccttaagtgtctgttggacccagcagaaagcgtactaaattacttc gaaccctacctgggacgcattgagatcatgggtggggccaagaaaattgagcgcgtttat ttcgaaatcagtgaatccagtcgaactcaatgggagaagccccaagtgaaggaatcgaag cggcagttcatttttgatgtggtcaatgaaggtggagagcaagaaaagatggaactgttt gtgaacttctgtgaggataccatctttgaaatgcagttagcctctcagatctccgaatct gactcggcagacaggcccgacgaggaggaggaagaagatgaagattcatcttatatgtta gaaattgagggtgaagaggaggatgccaagtcttttgagtctgcctctgcatttgccatg gcctgtgcctcagtgaagaggaatgtcgccaactttctgaagaaggcaaccttgaagaat ctcaggaagcagtacaggagggtgaaaaagatgactgtgaaggagctagtgaaggtgttc ttctctttcttctggatgttgcttgtggggctcttccagttgttcttcaccatattggga ggaatctttcagatcctctggaacacagtgtttggagggggcctagtggaaggggcaaag aacatcagagtgaccaagatcctgggtgacatgcctgacccaacccagtttggtatccat gatgatgctctggatgccgagcgggcagaggtgactgagccaggtgtgccacctgaacta attcacttcgtgaaaggtgacaagggagatgcagatattatgtccgatctctttggattc cgcccaaagaaggaaggtggcttaaagcatgggcccgaagggggtttgggtgacctctct gagattattggcgaggatgaaccccctacactagagagtaccgtccagaagaaaaggaaa gcacaggtagcagagatgaaagcagcacatgaagcagaagggagagtggagcacgagaag acagacctggaagacggggagaaggaggatacagccaaagaggaagagcaagccgaggcc ctgtgggcagacatgacaaagaagaagaagcgacggcggggccagaaagtcgagaagcct gaagctttcatggctaattttttcaaagggctggaagtctatcagaccaagttactgcat tacctggccaggaatttctacaacctgaggttcctcgctctgtttgtagccttcgcgatc aacttcatcctactcttttataaggtcactgaagaacctttagaagaagagacagaggac gttgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcgatggtgttcttt gtcctgcaggagagcactgggtatatggcaccaacgttgcgggccttggccattatccac accatcatctctttactctgtgtggtgggctattactgcctgaaggtccctctcgtggta ttcaaaagggaaaaagaaattgccaggaagctggagttcgatggcctgtatatcactgaa cagccctctgaagatgacatcaaggggcagtgggaccgcctggtaatcaacacaccatct tttcctaataactactgggacaagtttgtcaagagaaaggtgatcaacaagtacggagat ctctacggagcagaacgcattgctgaactcctgggtttggacaaaaatgcccttgatttc agcccagtcgaagagagcaaagcagaggcggcctctctggtgtcatggctgagttccatc gacatgaagtaccatatctggaagctgggagttgtttttaccgacaactcctttctctac cttgcctggtatacaaccatgtcagtcttgggccactacaacaacttcttcttcgctgct catctgctggacattgcaatgggcttcaagacactgaggactattctgtcatctgtaact cacaatggcaagcagctggttctgactgtcggtctcctggccgtggtggtttacctctac accgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagatgacgatgag cccgatatgaagtgtgacgacatgatgacgtgttacctgttccacatgtacgtgggagtg agagccggagggggcattggagacgaaattgaagaccctgctggtgacccttacgagatg taccgcattgtctttgacattaccttcttcttcttcgtcattgtcatcttgctggccatc attcagggtcttattattgatgcttttggagagctaagagaccagcaggagcaagtgcga gaagatatggagactaaatgtttcatctgtgggattggtaatgactattttgacacgatt cctcatggctttgaaacacacaccttacaagagcacaacttagccaactatttgttcttc ctgatgtatctgattaataaagatgaaacagaacacacgggtcaggaatcttacgtctgg aagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgctttcggaaacaa tatgaagatcagcttggataa

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