Eumetopias jubatus (Steller sea lion): 114225777 Help Entry 114225777         CDS       T07240                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju00230   Purine metabolism eju01100   Metabolic pathways eju01522   Endocrine resistance eju04015   Rap1 signaling pathway eju04022   cGMP-PKG signaling pathway eju04024   cAMP signaling pathway eju04062   Chemokine signaling pathway eju04072   Phospholipase D signaling pathway eju04081   Hormone signaling eju04082   Neuroactive ligand signaling eju04114   Oocyte meiosis eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04261   Adrenergic signaling in cardiomyocytes eju04270   Vascular smooth muscle contraction eju04371   Apelin signaling pathway eju04540   Gap junction eju04611   Platelet activation eju04713   Circadian entrainment eju04714   Thermogenesis eju04723   Retrograde endocannabinoid signaling eju04724   Glutamatergic synapse eju04725   Cholinergic synapse eju04727   GABAergic synapse eju04742   Taste transduction eju04750   Inflammatory mediator regulation of TRP channels eju04911   Insulin secretion eju04912   GnRH signaling pathway eju04913   Ovarian steroidogenesis eju04914   Progesterone-mediated oocyte maturation eju04915   Estrogen signaling pathway eju04916   Melanogenesis eju04918   Thyroid hormone synthesis eju04921   Oxytocin signaling pathway eju04923   Regulation of lipolysis in adipocytes eju04924   Renin secretion eju04925   Aldosterone synthesis and secretion eju04926   Relaxin signaling pathway eju04927   Cortisol synthesis and secretion eju04928   Parathyroid hormone synthesis, secretion and action eju04934   Cushing syndrome eju04935   Growth hormone synthesis, secretion and action eju04961   Endocrine and other factor-regulated calcium reabsorption eju04962   Vasopressin-regulated water reabsorption eju04970   Salivary secretion eju04971   Gastric acid secretion eju04972   Pancreatic secretion eju04976   Bile secretion eju05032   Morphine addiction eju05163   Human cytomegalovirus infection eju05166   Human T-cell leukemia virus 1 infection eju05200   Pathways in cancer eju05207   Chemical carcinogenesis - receptor activation eju05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:eju00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     114225777 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     114225777 (ADCY6)    04371 Apelin signaling pathway     114225777 (ADCY6)    04072 Phospholipase D signaling pathway     114225777 (ADCY6)    04024 cAMP signaling pathway     114225777 (ADCY6)    04022 cGMP-PKG signaling pathway     114225777 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     114225777 (ADCY6)    04081 Hormone signaling     114225777 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     114225777 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     114225777 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     114225777 (ADCY6)    04062 Chemokine signaling pathway     114225777 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     114225777 (ADCY6)    04923 Regulation of lipolysis in adipocytes     114225777 (ADCY6)    04912 GnRH signaling pathway     114225777 (ADCY6)    04913 Ovarian steroidogenesis     114225777 (ADCY6)    04915 Estrogen signaling pathway     114225777 (ADCY6)    04914 Progesterone-mediated oocyte maturation     114225777 (ADCY6)    04921 Oxytocin signaling pathway     114225777 (ADCY6)    04926 Relaxin signaling pathway     114225777 (ADCY6)    04935 Growth hormone synthesis, secretion and action     114225777 (ADCY6)    04918 Thyroid hormone synthesis     114225777 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     114225777 (ADCY6)    04916 Melanogenesis     114225777 (ADCY6)    04924 Renin secretion     114225777 (ADCY6)    04925 Aldosterone synthesis and secretion     114225777 (ADCY6)    04927 Cortisol synthesis and secretion     114225777 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     114225777 (ADCY6)    04270 Vascular smooth muscle contraction     114225777 (ADCY6)   09154 Digestive system    04970 Salivary secretion     114225777 (ADCY6)    04971 Gastric acid secretion     114225777 (ADCY6)    04972 Pancreatic secretion     114225777 (ADCY6)    04976 Bile secretion     114225777 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     114225777 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     114225777 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     114225777 (ADCY6)    04727 GABAergic synapse     114225777 (ADCY6)    04725 Cholinergic synapse     114225777 (ADCY6)    04723 Retrograde endocannabinoid signaling     114225777 (ADCY6)   09157 Sensory system    04742 Taste transduction     114225777 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     114225777 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     114225777 (ADCY6)    04213 Longevity regulating pathway - multiple species     114225777 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     114225777 (ADCY6)    04714 Thermogenesis     114225777 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     114225777 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     114225777 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     114225777 (ADCY6)    05163 Human cytomegalovirus infection     114225777 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     114225777 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     114225777 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     114225777 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     114225777 (ADCY6) Enzymes [BR:eju01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      114225777 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA GBR2_CC TBK1_ULD Motif Other DBs NCBI-GeneID:  114225777 NCBI-ProteinID:  XP_027981331 LinkDB All DBs Position Unknown AA seq 1161 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRTSGFCTPRYMSCLRDAQPPSPTPAAPP RCPWQDEAFVRRGGPGKGPELGLRAVALGFEDPEATAAVAPDVTAGRRRSCWRRLAQVFQ SKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLAAVLLAFHAAPARPQPAYVALLAGA ATLFVALMVLCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAATPRSPSVGLWCPVFFVY ITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQLGASMLLFICTNIIGICTH YPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMF HKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG DCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGL RKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHI ETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAYSRTKDSKAFRQMGIDDS SKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDP RFGAYVACALLVFCFICFIQLLVFPHSTLLLGIYAGIFLLLLTTVLTCAVPSCGSLFPKA LRRLSRSIVRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNVTPADITAC HLQHLNYSLGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAMIFVLGL IYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFAL ALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRN DELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQL EKIKTIGSTYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGL NMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRG VVKVKGKGEMTTYFLNGGPPS NT seq 3486 nt NT seq  +upstreamnt  +downstreamnt atgtcgtggtttagtggcctcctggtccccaaagtggatgaacggaaaacagcctggggt gagcgcaatgggcagaagcgtccacgccgtgggactcggaccagtggcttctgcacgccc cgctatatgagctgcctccgggatgcacagccccccagtcccacccctgcagcgccccct cggtgcccctggcaggacgaggccttcgtccggaggggtggcccgggcaagggcccagag ctggggctgcgagcggtggccctgggctttgaggacccggaggcgacggccgccgtggcc cctgacgtgacagccgggcgtcggcggtcctgctggcggcgcctggcccaggtgttccag tcgaagcagttccgctcggccaagctggagcgcctgtaccagcggtacttcttccagatg aaccagagcagcctgacgctgctgatggccgtgctggtgctgttggcagccgtgctgctc gccttccacgcggcgcccgcccgcccccagcccgcctacgtggccctgctggccggcgcc gccaccctgttcgtggcgctcatggtgctgtgcaaccggcacagcttccgtcaggactcc atgtgggtggtgagctacgtggtgctgggcatcctggccgctgtgcaggttgggggggcc ctggcagccaccccccgcagcccctccgtgggcctctggtgccctgtgttttttgtctac atcacctacacgctcctacccatccgcatgcgcgcagctgtcttcagtggcctgggcctg tccaccctgcatttgatcttggcctggcagctcaaccgtggcgacgccttcctctggaag cagctgggtgccagcatgttgctgttcatctgcaccaacatcatcggcatctgcacgcac tacccggctgaggtgtctcagcgccaggcctttcaggagacccgtggttacatccaggcc cggctgcacctgcagcatgagaatcggcagcaggaacggctgctgctgtccgtgttgccc cagcatgttgccatggagatgaaagaagatatcaacacaaagaaggaagacatgatgttc cacaagatctacatccagaagcatgacaatgtcagcatcctgtttgcagatattgaaggc ttcaccagcctggcatcccagtgcaccgcacaggagctggtcatgaccctgaacgagctc tttgcccggtttgacaagctggctgcggaaaatcactgcctgaggatcaagatcttaggg gactgttactactgtgtgtcggggctgccggaggcccgggcagatcatgcccactgctgt gtggagatgggggtggacatgatcgaggccatctcgctggtacgtgaggtgaccggtgtg aacgtgaacatgcgcgtgggcatccacagcgggcgtgtgcactgtggcgtccttggcctg cggaagtggcagttcgatgtgtggtccaatgacgtgacgctggccaaccacatggaggcg gggggccgggccggccgaatccatatcacccgggccacgctgcagtacctgaatggggac tatgaggtggagccaggccgcggcggtgagcgtaacgcctacctcaaggagcagcacatt gagaccttcctcatcctgggagccagccagaaacggaaagaggagaaggccatgctggcc aagctgcagcggacacgggccaactccatggaagggctgatgccccgctgggtgcctgac cgcgcctactcccggaccaaggactccaaggctttccgccagatgggcattgatgactcc agcaaagacaaccggggtgcccaagatgccctgaaccccgaggatgaggtagatgagttc ctgggccgtgccatcgatgcccgcagcattgatcagctacggaaggaccatgtgcgccgc ttcctgctcaccttccagagagaggatcttgaaaagaagtactcacggaaggtggacccc cgcttcggagcctacgtggcctgtgcgctgctggtcttctgcttcatctgctttatccag ctcctcgtcttcccacattcaaccctgctgcttgggatctatgccggtatcttcctgctg ttgctgaccaccgtgctgacctgtgccgtgccctcctgcggctctctcttccccaaggcc ctgcgacgtctttcccgcagcattgtccgctctcgggcacacagcactgtggttggcatc ttttcagtcttgcttgtgttcacctctgccatcgccaacatgtttacctgtaaccacacc cccatacggacctgcgcagcccggatgctgaatgtaacacccgctgacatcaccgcctgc cacctgcagcacctcaattactctctgggcctggatgctcccctgtgtgagggcaccgca cccacttgcagcttccctgagtacttcgttgggaacatgctgctgagtctcttggccagc tctgtcttcctgcacatcagtagcatcgggaagttggccatgatctttgtcctggggctc atctatttggtgctgcttctgctgggccccccagccaccatctttgacaactatgacctg ctgcttggtgtccatggcttggcttcttccaatgagactttcgatgggctggactgccca gctgcggggagggtggcgctcaagtacatgacccccgtgattctgctggttttcgcactg gcgctgtatctgcacgcccagcaggtggaatcgactgcgcgtctggactttctctggaag ctgcaggcaacaggggagaaggaggagatggaggaactccaggcttacaaccgaaggctg ctgcacaacattctgcccaaggacgtggctgcccacttcctggcccgggagcgccggaac gacgagctctactatcagtcgtgcgagtgcgtggccgtcatgttcgcctccatcgccaac ttctccgagttttacgtggagctggaggccaacaacgagggcgtcgagtgcctgcggctg ctcaacgagatcatcgccgacttcgatgagatcatcagcgaggagcggttccggcagctg gagaagatcaagaccatcggtagcacctacatggcggcctcagggctgaacgccagcacc tacgatcaggcaggccgctcccacatcaccgccctggccgactacgccatgcggctcatg gagcagatgaaacacatcaatgagcactccttcaacaatttccagatgaagattgggctg aacatgggcccagtcgtggcaggtgtcattggggctcggaagccgcagtatgacatctgg gggaacacagtgaatgtctctagccgtatggacagcacgggggtccctgaccgaatccag gtgaccacggacttgtaccaggttctagctgccaaaggctaccagctggagtgtcgaggg gtggtcaaggtgaagggcaaaggggagatgaccacctacttcctcaacgggggccccccc agttaa

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