Escherichia coli clone D i14: i14_0001
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Entry
i14_0001 CDS
T02003
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
elc
Escherichia coli clone D i14
Pathway
elc00260
Glycine, serine and threonine metabolism
elc00261
Monobactam biosynthesis
elc00270
Cysteine and methionine metabolism
elc00300
Lysine biosynthesis
elc01100
Metabolic pathways
elc01110
Biosynthesis of secondary metabolites
elc01120
Microbial metabolism in diverse environments
elc01230
Biosynthesis of amino acids
Module
elc_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
elc_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
elc_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
elc00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
i14_0001 (thrA)
00270 Cysteine and methionine metabolism
i14_0001 (thrA)
00300 Lysine biosynthesis
i14_0001 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
i14_0001 (thrA)
Enzymes [BR:
elc01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
i14_0001 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
i14_0001 (thrA)
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Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
AER87519
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All DBs
Position
336..2798
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AA seq
820 aa
AA seq
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MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDNLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDSNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccatctggtagcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttctgacgggactcgccgcc
gcccagccgggatttccgctggcacaattgaaaactttcgtcgaccaggaatttgcccaa
ataaaacatgtcctgcatggcatcagtttgttggggcagtgcccggatagcatcaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtgttagaagcg
cgtggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtgggtcattac
ctcgaatctaccgttgatattgctgaatccacccgccgtattgcggcaagccgcattccg
gctgaccacatggtgctgatggctggtttcactgccggtaatgaaaaaggcgagctggtg
gttctgggacgcaacggttccgactactccgctgcggtgctggcggcctgtttacgcgcc
gattgttgcgagatctggacggatgttgacggtgtttatacctgcgatccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctatcaggaagcgatggagctttcttacttc
ggcgctaaagttcttcacccccgcaccatcacccccatcgcccagtttcagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagccgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaagggatggttggcatggcggcgcgcgtctttgcagcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccgcaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggtttactggagccgttggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttacgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgccattgctcagggatcttctgaacgctcaatctct
gtcgtggtcaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcagcaaagctggttgaagaataaacatatcgacttacgtgtc
tgcggtgttgctaactcgaaggcactcctcaccaatgtacatggccttaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgtacttccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgttacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatcagttgcgttatgcggcggaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttatcgagaacctgcaa
aatctgctcaatgctggtgatgaattgatgaagttctccggcattctttcaggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacactggcg
cgggaaatgggttataccgaaccggacccgcgagatgatctttctggtatggatgtggcg
cgtaagctattgattctcgctcgtgaaacgggacgtgaactggagctggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgccgagggtgatgtcgccgcttttatggcg
aatctgtcacagctcgacaatctctttgccgcgcgtgtggcgaaggcccgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggcgtctgccgcgtgaagattgcc
gaagtggatagtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttc
tatagccactattatcagccgctgccgttggtactgcgcggatatggtgcgggcaatgac
gttacagctgccggtgtctttgctgatctgctacgtaccctctcatggaagttaggagtc
tga
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