KEGG   Enhydra lutris kenyoni (northern sea otter): 111153517
Entry
111153517         CDS       T05871                                 
Name
(RefSeq) tyrosine-protein kinase JAK2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
elk  Enhydra lutris kenyoni (northern sea otter)
Pathway
elk01521  EGFR tyrosine kinase inhibitor resistance
elk04062  Chemokine signaling pathway
elk04081  Hormone signaling
elk04148  Efferocytosis
elk04151  PI3K-Akt signaling pathway
elk04217  Necroptosis
elk04550  Signaling pathways regulating pluripotency of stem cells
elk04630  JAK-STAT signaling pathway
elk04658  Th1 and Th2 cell differentiation
elk04659  Th17 cell differentiation
elk04725  Cholinergic synapse
elk04917  Prolactin signaling pathway
elk04920  Adipocytokine signaling pathway
elk04933  AGE-RAGE signaling pathway in diabetic complications
elk04935  Growth hormone synthesis, secretion and action
elk05140  Leishmaniasis
elk05145  Toxoplasmosis
elk05152  Tuberculosis
elk05161  Hepatitis B
elk05164  Influenza A
elk05167  Kaposi sarcoma-associated herpesvirus infection
elk05168  Herpes simplex virus 1 infection
elk05200  Pathways in cancer
elk05207  Chemical carcinogenesis - receptor activation
elk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
elk05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:elk00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    111153517
   04151 PI3K-Akt signaling pathway
    111153517
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    111153517
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    111153517
  09143 Cell growth and death
   04217 Necroptosis
    111153517
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    111153517
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    111153517
   04659 Th17 cell differentiation
    111153517
   04062 Chemokine signaling pathway
    111153517
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    111153517
   04917 Prolactin signaling pathway
    111153517
   04935 Growth hormone synthesis, secretion and action
    111153517
  09156 Nervous system
   04725 Cholinergic synapse
    111153517
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111153517
   05207 Chemical carcinogenesis - receptor activation
    111153517
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    111153517
  09172 Infectious disease: viral
   05161 Hepatitis B
    111153517
   05164 Influenza A
    111153517
   05168 Herpes simplex virus 1 infection
    111153517
   05167 Kaposi sarcoma-associated herpesvirus infection
    111153517
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    111153517
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    111153517
   05140 Leishmaniasis
    111153517
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111153517
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    111153517
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    111153517
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:elk01001]
    111153517
Enzymes [BR:elk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     111153517
Protein kinases [BR:elk01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   111153517
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr FERM_F2 FERM_F1 SH2_1 Pkinase Jak1_Phl SH2 FERM_C_FAK1 FERM_M
Other DBs
NCBI-GeneID: 111153517
NCBI-ProteinID: XP_022368281
UniProt: A0A2Y9K4R8
LinkDB
Position
Unknown
AA seq 974 aa
MGMACLTMTEMEGTSVSPVHQNGDIPGNANPVKQIDPLLQVYLYHSLEKAEGEYLKFPTG
EYVAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PYWYCNGSNRTYRYGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVAIHKQDGKNLEIELSSLK
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENAIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTSGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKALVHGNVCAKNILLIREEDRKTGNLPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKFVCYRYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPP
AEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRD
LALRVDQIRDNMAG
NT seq 2925 nt   +upstreamnt  +downstreamnt
atggggatggcttgccttacaatgacagaaatggaaggaacgtccgtatctcctgtacat
cagaatggtgatattcctggaaatgctaatccggtgaagcaaatagatccactcctgcag
gtgtatctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggg
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcttgtggaatcacaccagtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatttggtatccgcccaaccat
gtcttccatatagatgaatcaaccaggcacaatgtactctacagaataagattttacttt
ccttactggtattgtaacggcagcaacagaacctatcggtatgggatatctcgaggtgct
gaagctcctcttcttgacgactttgtcatggcctacctttttgctcagtggcggcatgat
tttttacatggatggataaaaatacccgtgactcatgaaacacaagaagagtgtcttgga
atggctgtattagatatgatgagactagccaaagagaaggatcagaccccattggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaaacgaataaggtacagatttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttc
cctgatattattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtaga
attgtagctatacataagcaagatggtaaaaatctggaaattgaacttagctcattaaaa
gaagctttgtcctttgtgtcattaattgatggctattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgt
catggcccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagact
ggactctacgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgct
gttgagcgagaaaatgccatcgaatataagcactgtttgattacaaagaatgagaatgga
gaatacaacctcagtgggaccaagaagaacttcagtaaccttaaagatcttttgaattgc
taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgttgtccc
ccaaagttgaaagataaatcaaaccttctagtcttcagaaccagtggcgtttctgatgtt
cccacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatgtttaatgaaagccttggccaaggcacttttacaaaaattttt
aaaggtataaggagagaagtaggagattatggtcaactacatgaaacagaagttctttta
aaagttctggataaagctcacagaaactattccgagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcatctagttttaaattatggagtgtgtgtctgtggggag
gagaatattctggttcaagagtttgtaaaatttggatccttagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcacttgttcatggaaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcttcctttcatcaaacttagtgatcct
ggtattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataaacctctgagtgctttggattctcaa
agaaagctacagttttacgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagatttcagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgat
atgttaccaaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagac
cctacacaatttgaagagagacacttgaaatttctacagcaacttggcaagttcgtatgt
tataggtatgctccagaatcattgacagagagcaagttttctgtggcttcagatgtttgg
agctttggagtggttctctatgaacttttcacatatattgagaagagtaaaagtccccca
gcggaatttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttg
atagaactcctaaagaataacggaagattaccaagaccagatggatgcccagatgagatt
tatttgatcatgacggaatgctggaataataatgtcaatcaacgcccctcttttagagac
ctagctcttcgagttgatcaaataagggacaacatggctggatga

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