KEGG   Enhydra lutris kenyoni (northern sea otter): 111155003
Entry
111155003         CDS       T05871                                 
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
elk  Enhydra lutris kenyoni (northern sea otter)
Pathway
elk00562  Inositol phosphate metabolism
elk01100  Metabolic pathways
elk01521  EGFR tyrosine kinase inhibitor resistance
elk01522  Endocrine resistance
elk01524  Platinum drug resistance
elk04012  ErbB signaling pathway
elk04014  Ras signaling pathway
elk04015  Rap1 signaling pathway
elk04024  cAMP signaling pathway
elk04062  Chemokine signaling pathway
elk04066  HIF-1 signaling pathway
elk04068  FoxO signaling pathway
elk04070  Phosphatidylinositol signaling system
elk04071  Sphingolipid signaling pathway
elk04072  Phospholipase D signaling pathway
elk04081  Hormone signaling
elk04140  Autophagy - animal
elk04150  mTOR signaling pathway
elk04151  PI3K-Akt signaling pathway
elk04152  AMPK signaling pathway
elk04210  Apoptosis
elk04211  Longevity regulating pathway
elk04213  Longevity regulating pathway - multiple species
elk04218  Cellular senescence
elk04360  Axon guidance
elk04370  VEGF signaling pathway
elk04380  Osteoclast differentiation
elk04510  Focal adhesion
elk04550  Signaling pathways regulating pluripotency of stem cells
elk04611  Platelet activation
elk04613  Neutrophil extracellular trap formation
elk04620  Toll-like receptor signaling pathway
elk04625  C-type lectin receptor signaling pathway
elk04630  JAK-STAT signaling pathway
elk04650  Natural killer cell mediated cytotoxicity
elk04660  T cell receptor signaling pathway
elk04662  B cell receptor signaling pathway
elk04664  Fc epsilon RI signaling pathway
elk04666  Fc gamma R-mediated phagocytosis
elk04668  TNF signaling pathway
elk04670  Leukocyte transendothelial migration
elk04722  Neurotrophin signaling pathway
elk04725  Cholinergic synapse
elk04750  Inflammatory mediator regulation of TRP channels
elk04810  Regulation of actin cytoskeleton
elk04910  Insulin signaling pathway
elk04914  Progesterone-mediated oocyte maturation
elk04915  Estrogen signaling pathway
elk04917  Prolactin signaling pathway
elk04919  Thyroid hormone signaling pathway
elk04923  Regulation of lipolysis in adipocytes
elk04926  Relaxin signaling pathway
elk04929  GnRH secretion
elk04930  Type II diabetes mellitus
elk04931  Insulin resistance
elk04932  Non-alcoholic fatty liver disease
elk04933  AGE-RAGE signaling pathway in diabetic complications
elk04935  Growth hormone synthesis, secretion and action
elk04960  Aldosterone-regulated sodium reabsorption
elk04973  Carbohydrate digestion and absorption
elk05010  Alzheimer disease
elk05017  Spinocerebellar ataxia
elk05020  Prion disease
elk05100  Bacterial invasion of epithelial cells
elk05132  Salmonella infection
elk05135  Yersinia infection
elk05142  Chagas disease
elk05146  Amoebiasis
elk05160  Hepatitis C
elk05161  Hepatitis B
elk05162  Measles
elk05163  Human cytomegalovirus infection
elk05164  Influenza A
elk05165  Human papillomavirus infection
elk05166  Human T-cell leukemia virus 1 infection
elk05167  Kaposi sarcoma-associated herpesvirus infection
elk05168  Herpes simplex virus 1 infection
elk05169  Epstein-Barr virus infection
elk05170  Human immunodeficiency virus 1 infection
elk05171  Coronavirus disease - COVID-19
elk05200  Pathways in cancer
elk05203  Viral carcinogenesis
elk05205  Proteoglycans in cancer
elk05206  MicroRNAs in cancer
elk05207  Chemical carcinogenesis - receptor activation
elk05208  Chemical carcinogenesis - reactive oxygen species
elk05210  Colorectal cancer
elk05211  Renal cell carcinoma
elk05212  Pancreatic cancer
elk05213  Endometrial cancer
elk05214  Glioma
elk05215  Prostate cancer
elk05218  Melanoma
elk05220  Chronic myeloid leukemia
elk05221  Acute myeloid leukemia
elk05222  Small cell lung cancer
elk05223  Non-small cell lung cancer
elk05224  Breast cancer
elk05225  Hepatocellular carcinoma
elk05226  Gastric cancer
elk05230  Central carbon metabolism in cancer
elk05231  Choline metabolism in cancer
elk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
elk05415  Diabetic cardiomyopathy
elk05417  Lipid and atherosclerosis
elk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:elk00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    111155003
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    111155003
   04014 Ras signaling pathway
    111155003
   04015 Rap1 signaling pathway
    111155003
   04370 VEGF signaling pathway
    111155003
   04630 JAK-STAT signaling pathway
    111155003
   04668 TNF signaling pathway
    111155003
   04066 HIF-1 signaling pathway
    111155003
   04068 FoxO signaling pathway
    111155003
   04070 Phosphatidylinositol signaling system
    111155003
   04072 Phospholipase D signaling pathway
    111155003
   04071 Sphingolipid signaling pathway
    111155003
   04024 cAMP signaling pathway
    111155003
   04151 PI3K-Akt signaling pathway
    111155003
   04152 AMPK signaling pathway
    111155003
   04150 mTOR signaling pathway
    111155003
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    111155003
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    111155003
  09143 Cell growth and death
   04210 Apoptosis
    111155003
   04218 Cellular senescence
    111155003
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    111155003
   04550 Signaling pathways regulating pluripotency of stem cells
    111155003
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    111155003
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    111155003
   04613 Neutrophil extracellular trap formation
    111155003
   04620 Toll-like receptor signaling pathway
    111155003
   04625 C-type lectin receptor signaling pathway
    111155003
   04650 Natural killer cell mediated cytotoxicity
    111155003
   04660 T cell receptor signaling pathway
    111155003
   04662 B cell receptor signaling pathway
    111155003
   04664 Fc epsilon RI signaling pathway
    111155003
   04666 Fc gamma R-mediated phagocytosis
    111155003
   04670 Leukocyte transendothelial migration
    111155003
   04062 Chemokine signaling pathway
    111155003
  09152 Endocrine system
   04910 Insulin signaling pathway
    111155003
   04923 Regulation of lipolysis in adipocytes
    111155003
   04929 GnRH secretion
    111155003
   04915 Estrogen signaling pathway
    111155003
   04914 Progesterone-mediated oocyte maturation
    111155003
   04917 Prolactin signaling pathway
    111155003
   04926 Relaxin signaling pathway
    111155003
   04935 Growth hormone synthesis, secretion and action
    111155003
   04919 Thyroid hormone signaling pathway
    111155003
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    111155003
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    111155003
  09156 Nervous system
   04725 Cholinergic synapse
    111155003
   04722 Neurotrophin signaling pathway
    111155003
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    111155003
  09158 Development and regeneration
   04360 Axon guidance
    111155003
   04380 Osteoclast differentiation
    111155003
  09149 Aging
   04211 Longevity regulating pathway
    111155003
   04213 Longevity regulating pathway - multiple species
    111155003
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111155003
   05206 MicroRNAs in cancer
    111155003
   05205 Proteoglycans in cancer
    111155003
   05207 Chemical carcinogenesis - receptor activation
    111155003
   05208 Chemical carcinogenesis - reactive oxygen species
    111155003
   05203 Viral carcinogenesis
    111155003
   05230 Central carbon metabolism in cancer
    111155003
   05231 Choline metabolism in cancer
    111155003
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    111155003
  09162 Cancer: specific types
   05210 Colorectal cancer
    111155003
   05212 Pancreatic cancer
    111155003
   05225 Hepatocellular carcinoma
    111155003
   05226 Gastric cancer
    111155003
   05214 Glioma
    111155003
   05221 Acute myeloid leukemia
    111155003
   05220 Chronic myeloid leukemia
    111155003
   05218 Melanoma
    111155003
   05211 Renal cell carcinoma
    111155003
   05215 Prostate cancer
    111155003
   05213 Endometrial cancer
    111155003
   05224 Breast cancer
    111155003
   05222 Small cell lung cancer
    111155003
   05223 Non-small cell lung cancer
    111155003
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    111155003
   05170 Human immunodeficiency virus 1 infection
    111155003
   05161 Hepatitis B
    111155003
   05160 Hepatitis C
    111155003
   05171 Coronavirus disease - COVID-19
    111155003
   05164 Influenza A
    111155003
   05162 Measles
    111155003
   05168 Herpes simplex virus 1 infection
    111155003
   05163 Human cytomegalovirus infection
    111155003
   05167 Kaposi sarcoma-associated herpesvirus infection
    111155003
   05169 Epstein-Barr virus infection
    111155003
   05165 Human papillomavirus infection
    111155003
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    111155003
   05135 Yersinia infection
    111155003
   05100 Bacterial invasion of epithelial cells
    111155003
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    111155003
   05142 Chagas disease
    111155003
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    111155003
   05017 Spinocerebellar ataxia
    111155003
   05020 Prion disease
    111155003
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111155003
   05418 Fluid shear stress and atherosclerosis
    111155003
   05415 Diabetic cardiomyopathy
    111155003
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    111155003
   04932 Non-alcoholic fatty liver disease
    111155003
   04931 Insulin resistance
    111155003
   04933 AGE-RAGE signaling pathway in diabetic complications
    111155003
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    111155003
   01524 Platinum drug resistance
    111155003
   01522 Endocrine resistance
    111155003
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:elk04131]
    111155003
Enzymes [BR:elk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     111155003
Membrane trafficking [BR:elk04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    111155003
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 111155003
NCBI-ProteinID: XP_022370703
UniProt: A0A2Y9KC41
LinkDB
Position
Unknown
AA seq 1070 aa
MCVSFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSVLENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDQPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIRFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcgtcagtttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagctggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagttcttataggaaaaggtctacatgaatttgatgcactg
aaggatcccgaagtgaatgagttccgaataaaaatgcgcaaattcagtgaggaaaagatt
cagtcgcttgtgggattgtcttggatggattggctaaagcagacatacccaccagaacat
gaaccatcggtccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagtccctatgactatgtgttgcaagtaagtgggagagtagaatatgtgtttggtgat
cagccactcattcagttccagtatattcggaactgtgtaatgaacaggaccttgccccat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgagcaggaaatgattgccata
gaggctgccataaatcgaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccagattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
actgaactcctctgtaaaaccattgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatacttgtgatctgccacgaatggctcgatta
tgttttgctgtttatgcagttctggataaagtgaaaacaaaaaagtctactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtgaatacgatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcagattcccagaaaataaaaaa
caaccttattattatcctcccttcgataagataattgagaaggcagctgagattgcaagc
agtgacagtgccaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactaaaagaa
atcttggacagggatcccttgtctcaattgtgtgagaatgaaatggatcttatttggact
ctgcggcaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggcgttagagcttctggatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagagctctctcaatatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcactggctaatcggaggatagggcagtttctcttttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacaatttggtgttatccttgaagcatactgccgg
ggaagtgttgggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
actttaaatagcttaatcaaactgaatgcaatgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctttctgacctgcagtcg
cctctgaatccatgtgttatcctctcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtttacaacaacaaagtgtttggtgaagattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccaaatgctg
cgcttgatggatttactttggaaagaagctggtttggatcttcggatgctgccttatggc
tgcttagcgacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctagaccgagccattgaggag
tttaccctgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacattatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgggtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagagaagtttggc
cgcttccgccagtgttgtgaggatgcatatctgattttacgacggcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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