Escherichia coli O55 H7 RM12579 (EPEC): ECO55CA74_00010
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Entry
ECO55CA74_00010 CDS
T02066
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
elr
Escherichia coli O55:H7 RM12579 (EPEC)
Pathway
elr00260
Glycine, serine and threonine metabolism
elr00261
Monobactam biosynthesis
elr00270
Cysteine and methionine metabolism
elr00300
Lysine biosynthesis
elr01100
Metabolic pathways
elr01110
Biosynthesis of secondary metabolites
elr01120
Microbial metabolism in diverse environments
elr01230
Biosynthesis of amino acids
Module
elr_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
elr_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
elr_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
elr00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
ECO55CA74_00010 (thrA)
00270 Cysteine and methionine metabolism
ECO55CA74_00010 (thrA)
00300 Lysine biosynthesis
ECO55CA74_00010 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
ECO55CA74_00010 (thrA)
Enzymes [BR:
elr01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
ECO55CA74_00010 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
ECO55CA74_00010 (thrA)
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Paralog
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Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
AEZ38636
LinkDB
All DBs
Position
336..2798
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LVQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHLLRHAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccacctggtggcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttctgacgggactcgccgcc
gcccagccgggattcccgctggcgcaattgaaaactttcgtcgaccaggaatttgcccaa
ataaaacatgtcctgcatggcattagtttgttagggcagtgcccggatagcattaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtattagaagcg
cgcggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtggggcattac
ctcgaatctactgtcgatattgcagagtccacccgccgtattgcggcaagtcgtattccg
gctgatcacatggtgctgatggcaggtttcaccgccggtaatgaaaaaggcgaactggtg
gtacttggacgcaacggttccgactactccgcggcggtgctggctgcctgtttacgcgcc
gattgttgcgagatttggacggacgttgacggggtatatacctgcgacccgcgtcaggtg
cccgatgcgaggttgttgaaatcgatgtcctaccaggaagcgatggagctttcctacttc
ggcgctaaagttcttcacccccgcaccattacccccatcgcccagttccagatcccttgc
ctgattaaaaataccggaaatcctcaagctccaggtacgctcattggtgccagtcgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataatatggcaatgttcagcgtt
tccggcccggggatgaaaggaatggtcggcatggcggcgcgcgtctttgctgcaatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccgcaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggcttactggagccgctggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttgcgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgctattgctcagggatcttctgaacgctcaatctct
gtcgtggtaaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcactg
ctggtgcaactgaagcgtcagcaaagctggttgaagaataaacatatcgacttacgtgtc
tgcggtgttgctaactcgaaggctctgctcaccaatgtgcatggcctaaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgcacctccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgtcacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatctgttgcgtcatgcggctgaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttattgagaacctgcaa
aatctgctcaatgctggtgatgaattgatgaagttctccggcattctttcaggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgactacgctggcg
cgggaaatgggttataccgaaccggatccgcgagatgatctttctggtatggatgtagcg
cgtaaactattaattctcgctcgtgaaacgggacgtgaactggagctggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgctgagggtgatgttgccgcttttatggcg
aatctgtcacagctcgacgatctctttgccgcgcgcgtggcgaaggcccgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggcgtctgccgcgtgaagattgcc
gaagtggatggtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttt
tatagccactattatcagccgctgccgttggtgctgcgcggatatggtgcgggcaatgac
gttaccgctgccggtgtctttgccgatctgctacgtaccctctcatggaagttaggagtc
tga
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