Esox lucius (northern pike): 105015717 Help Entry 105015717         CDS       T04894                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism els  Esox lucius (northern pike) Pathway els04020   Calcium signaling pathway els04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:els00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105015717    04020 Calcium signaling pathway     105015717  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:els04040]     105015717 Ion channels [BR:els04040]  Voltage-gated cation channels   Ryanodine receptor    105015717 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  105015717 NCBI-ProteinID:  XP_019909871 LinkDB All DBs Position LG15:13635155..13752404 Genome browser AA seq 4922 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGQNSEGRLLRKAAQGGGHRTLLYGHAILLRHSFSA MYLTCLKTSRSQTDKLSFDVGLQEDSSGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLTIP GFDQNDDQQRIVNYETGNAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTSGHYLAL TEETGVVLQDREKSDTASTSFCFRASKEKLESSPKRDIEGMGVAEIKYGDSICFVMHVAT GLWLSYQAPDVKSSRLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSH FIRDLDSLGGKNRASVALPIEEVLQTLNDLITYFQLPDAELEHEEKQIMLRSLKNRQNLF KQEGMLTLVSCCIDRLNVYNSAAHFGECAGAEAGASWKDILNLLYELLAALIRGNRNNCT QFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVSEGSAQ YKKWYYELMIDHVDHFLTADPSHLRVGWAHKGYAPYPGGGEGWGGNGVGDDLYSYGFDGL HLWSGRISRAVASINQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFFP VVSFSAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMKVEPVKEYKRDIDGVRDL LGTTQFMSQASFIPTPVETSQIVMPPYLEKVRDRLAENIHELWGMNKIELGWSYGKIRDD NKRQHPCLVDFSKLPETEKNYNLQMSTETFKTLLALGCHVVQVNVNAEEDLKKIKLPKNY MMSNGYKPTPLELSDVKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYHIEPPDQEGAAHVMERLSIDKIRFFRVE RTYAVLTGKWYFEFEAVTGGDMRVGWARPGCRPDVELGTDQLAFVFDGYRGHRLNMGSRF FGRCWRAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFTDFETEDGFIPVCSLGLSQ VGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKNHSHIMVT RIDGTIDSPPCLKVSHKTFGTQNSNGDMVYCRLSMPVEFHSFFKTSSVIDMNGVNEEHQS LKLRHLPKSMRHSHDGIRGSDYSHITTYYYSVRVFAGQDPNCVWVGWVTPDYHYYSNHFN LSKNRTVTVTLGDERGRVHESVRRSNCYMVWGGDVTSSGHSSSRSNVDLEIGCLIDLATG LVTFSANGKELATSYQVEPNTKLFPSVFVRPTSPSLFQFELAKIKNAMPLSAAIFKSEHR NPVPQCPPRLDVQTITSVLWSRMPNTFLKVETSRVSERHGWLVQCLEPLQMLAVHIPEEN RCVDVMELSEQEDLRTFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSG VLREGFYNVLISVHLETAKEARLMMNNEFIIPVTEETRSIRLFCDSSKHHSPPGVDLSTS LKPRLNFSPPCFISTKREPHLYSPQIPVDVLKEKAITMLTEAVQGGGHHIRDPVGGSVEY QFVPILRLIGTLLTMGVLGSQDVNKILLLIDPNVFMEHPEGTVAAVTEATEKEGLTGAEE KAVEAGEEEVAKEAKQPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSF VSKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGEDCPCPEDIQ EELYDFHNELRLHCGIPMEEEEEQQDTSIKGRLLALVYKIKGQPLKMEEEPAEHEQQAPS NLKELISQTMVSWAQECHIQDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAGSIKDT INLLASLGQIRSLLSVRMGKEEEKLMMDGLGDIMNNKIFYQHPNLMRVLGMHETVMEVMV NVLGGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRG STPLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWNPIEGE RYLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISEN PALDLPSAAQGISSDASAEDEEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGE ALRIRAILRSLVPTEDLVGIISIPLKMPVVHKDGTVTEPDMAASFCPDHKAPMVLFLDRV YGIEDQSFLLHLLEVGFLPDLQASTSLDTEALSTTETALAMNRYIGSAMLPLLTRCAPHF AGTEHYAALMDSTLLTVYRLSKGRSLTKAQRDAIEECLLAACKYLRPSMLQQLLRRLVFD VPLLTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLDSLSQR KYDADLFKMAMPCLSAIAGALPPDYMDATISTNLEKPVSVDAQGNFEPKPISTANIALPE KLEHFANKYAAHCHDKWSAEKVMLGWKYGDCIDDKAKTHPQLRTYKGLTEKVDFSTTHHR RRLNHVRMKFHNASVSWCVSSNVPQEKEIYRWPVRETLKSMLAMGWNIDRTKDGETMSQR ETEKMRKISQSSSQANGFNPTPIDTSSVVLSRELQGMVEVVAENYHNIWAKKKKNDLGIR GGATHPLLVPYDTLTAKEKAKDREKAQDLFRFLQINGFAITRGLKDMERDSSSMEKRFAY KFLKKLLKYVNSAQEFIAHLEVMATTGKTEKSPHEQEIKFFAKVLLPLIDQYFKNHSLYF LSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSDSTTMVSCLHILAHTLDT RTVMKSGSELVKAGLRTFFENAAEDLEKTFENLKLGKFTHSRSQMKGVSQNINYTTVALL PILTALFQHITQHHFGVDLLLDDVQVSCYRILTSLYALGTGKNIYVERQLPALGECLATL AGAMPVAFLEPLLNALNPCSVFNTKTARERAILGMPETVEELCPDMPQLDVLMKDINDIS ESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQAPQHSAVFCTTVTSEHLSLILGNIL KILNSNLGIDEASWMKRIAVYAQPIISKARADLLKSHFLPTLEKLKKKTVKVVTEEELLK ADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSNELFRMVAE IFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKTKISKSGGQDQERKHKRKRGEFYSV QTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYLLKDTDEEVKDHVRRNLHLQEKSED PAVRWQLNLYKDVMVKNEGPPDPENTVCRVQSISAAVFHLEQVEQPLRSKKCVWQKLLSK QRKRAVVACFRMAPLYNLPRHRSINLFLLGYQRIWIETETYSFEEKLVQDLAKTQLKVEE EEEEEAERQPDPLHQLILHFSHNALTERSSLEEDPLYIAYADMMAKSCAEDEEEEDGEGK EKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQMISASKGSLGPMVTFTLKLGISILNGGN IVVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSINVSE RGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQES ISDFYWYYSGRDIMDEAGQRNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMIVMMLSLLEGNVVNGTIGKQMVDTLV ESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPDSKGVISKKEFQKSMENQKQYSQSEIE FLLSCAEADENDMFNYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDARLATFLDLAES VINYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGESE KMELFVNFCEDTIFEMQLASQISEPDAMERPEEDEDDRQSLEEELDEEDEERRMESHSAF TNSCVSMRKNLSSFRQLLTFRSMRRQYRRFRRMSVRELVRGFFSFFWMIITGLFRFLYNL VWGFFHILWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVLEAEKMDASEASSVA EMGHMAQGDKAEADLMAELLNIPTKSQGGKHGAEPGLGDMGEVVGVDAPSLASAVKQKKA KEAATKEHSNGDHKAEPEKADAEDEEKKDKDKAKEEAPPETPPEERKAAKKRPGLKKEPP EAFMASFCAGLEIYQTKMLNYLARNFYNLRFLALFVAFAINFILLFYKVTGDDDDPDPWN GGRGTDEEDEGGMEYFVLQESTGYMAPTLRFLAILHTIISFLCVVGYYYLKVPLVVFKRE KEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGA ERIAELLGLDKSALDFNPTEETVVKEASLLSWLGSIDTKYHCWKMGVVFTDNSFLYLVWY TTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVA FNFFRKFYNKSEDEDQPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRIL FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGF ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQ LG NT seq 14769 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaagatgaaatccaattcttgagaactgatgatgaagtg gttctccagtgtgtcgcctgcatccacaaggaaaatcgcaagttctgccttaccgcagag gggctcggcaatcgactgtgttacctggaacccacatcagaggcaaagtatgtcccgcca gacctgtgcatctgtaactttgtgctggagcagtctctgtctgtgcgagccttacaggag atgctggctaagactgggcagaacagtgaggggaggctcttgaggaaggcagcccaggga ggtggacacaggacacttctgtatggacacgctatcctccttaggcactctttcagtgct atgtatcttacctgtttgaagacatcaaggtcccagacagataagctgtcctttgatgtg ggactgcaggaggattcatcaggcgaggcttgttggtggaccattcacccagcctccaag cagaggtcggagggcgagaaggtacgcatcggtgatgaccttatccttgtcagtgtatca tcagaacgataccttcacctgtccatctctaatggcaacatccaggtggacgcatcattc atgcagactctgtggaatgtccaccccacctgctctggcagcaacgtggaggagggttat cttctgggtgggcatgtgttgcgtctgttccacggtcatgatgaagttctgaccatccca gggtttgaccagaatgatgaccaacagaggatagtgaactatgagacgggcaatgcagga gccaaggccaggtctctgtggaggctggagcctcttagaatcagctggagtgggagtcac attcgctgggggcagccctttcgtctccgtcacctcacctctggtcactacctggccctg acggaggaaacgggagtggtactgcaggaccgggagaaatctgacacagcatccacctcc ttctgctttagagcctccaaggagaagctggagtccagcccgaagcgggacatcgagggc atgggagtggcagagattaagtatggggactcaatctgtttcgtcatgcatgtggccaca ggactctggctctcctaccaggcacctgatgtaaaatcttctcgcttgggccccttaaag agacgggcctgcctccactctgagggtcacatggatgatgggttgaccctgcagcggtgt cagcatgaagagtctcgtgctgctcgcataatccgaaacactactcgcctcttcagccac ttcatcagagacctggactctctgggaggcaagaaccgtgcatcagtagccctgcccatc gaggaggtcctccagaccctcaacgacctcatcacctacttccagctgcctgacgctgag ctagagcacgaggagaaacagatcatgctgcgctcgctcaagaatcgacagaacctcttc aaacaggaaggcatgctaactctggtgtcctgctgcatcgaccgcctcaacgtgtacaac agtgccgcccacttcggggagtgtgctggggcggaggctggagcgtcctggaaggacatc ctcaatcttctgtatgagctactagcggcactgatccgaggtaacagaaacaactgtacc cagttctccaacaatcttgactggctggtcagcaagctggagagactggagtcctcctca ggcatactggaggttctccactgcatcctaattgagagcccagaggctttaaatatcatc cagagaggacacatcaagtccatcatctccctgctctacaaacatggacgtaaccacaag attctggatgtgctctgctccctctgtgtctgtaatggggtggctgtgagagccaatcag aacctcatctgcgatcacctgctccccaaaagagatcttcttctccaaacccgattggtc aatgacgttcaaagcatgaggcccaacatcttcctgggggtgagtgagggctcggcacag tataagaagtggtactacgagctgatgattgaccatgtggaccacttcttgaccgccgac ccatctcacctgcgcgttggctgggcccataagggttatgccccttaccctggtgggggg gaaggctggggtggcaacggggtgggggatgacctctactcctatggctttgatggactt catctctggtcaggtcgtatttcccgggcggtggcttccattaaccagcacatcctgacc tcagaggacgtggtgagctgttgtctggatctgggagctcccagcatctccttcaggatc aacggacaacccgtccagggcatgttcgagaacttcaacatcgatggactcttcttccct gttgtcagcttctccgctggggtcaaggtccgtttcctgttggggggacgtcacggcgac ttcaagttcctgcctccgtcgggctacgccccgtgttacgaggccttgcttcccaaggag aagatgaaggtggagccggtgaaggagtataagagggatatagacggggttcgagacctg ctggggaccactcagtttatgtcccaggcttccttcatacccacccctgtagagaccagc cagatcgtcatgccgccataccttgagaaagtccgggatagactggctgagaatatccat gagctttggggcatgaacaagatcgagctgggctggtcttatgggaagatacgggacgat aataaacgccagcacccatgccttgtggatttttccaagctgcctgaaaccgaaaagaat tataacctgcagatgtcaacggaaacctttaaaaccctgctggcattaggatgccatgtt gtccaagtaaatgtcaatgcagaagaggacctgaagaagatcaaactcccaaagaactac atgatgtcgaatggttacaagcccacgccactggagttgtctgatgtgaaactgacccca ggtcaggagctcctggtagataaactggcagagaatgcccacaatgtgtgggcgaaagac aggatcaaacaaggttggacctatggcattcagcaggatctgaagagcaagcggaaccca cgtctggtgccgtatgctttattagatgaacgcaccaagaagtccaacagggacagcctc cgcgaggccatccgcactctgattggatacggataccacattgaacctcccgaccaggag ggcgcagcccacgtgatggagaggctgagcatcgacaaaattcgcttcttccgtgtggag aggacgtacgccgtgctgacggggaagtggtactttgagtttgaggcagtgacgggggga gacatgcgtgtgggctgggccagacccggatgtaggcctgatgtcgagctgggtactgac cagctggcctttgtcttcgacggatacaggggtcaccgtctgaacatgggcagccgtttc tttggtcggtgttggcgcgcgggggatgtggtgggatgcatgattaacatggaggacaag tctatgatcttcaccctgaacggagagatcctcatcaccaataaaggctcggagctctgc ttcaccgatttcgagacagaggacggttttatcccagtgtgtagtctgggtctgtcgcag gtgggccgtatgaacctggggaaggacgccagcacctttaagtactacaccatgtgtggt ctccaggagggcttcgaaccgtttgcggtcaatatgaaccgagaggtcaccatgtggttc agcaaacgtctccccacctttgtcaatgtgccaaagaaccacagtcatataatggtgacc agaattgatggcaccattgacagccctccctgtctgaaagtgagccataaaacgtttggg acccagaatagtaatggtgacatggtgtactgtcgtctgagcatgcctgtggagttccac tccttcttcaagaccagctctgtcatcgacatgaacggcgtgaacgaggaacaccagtcc ctcaaactcagacatctgcccaagtcgatgagacacagtcatgatggaattagaggatcg gattacagccacatcaccacgtactactactctgtgagggttttcgctggtcaggatcca aactgtgtatgggtgggctgggtaacccctgattaccattattatagcaaccacttcaac ctcagtaagaacaggacagtgacggttaccctgggtgacgagcgtgggcgggtccacgag agtgtgaggaggagtaactgctacatggtgtgggggggtgacgtcaccagctcgggccac tcgtccagtcgcagtaatgtggatctagagataggctgtctaattgacctggccactggc ctggtgaccttcagtgccaatgggaaggagctggccacttcctaccaggtggaacccaac accaagctgtttccctccgtgttcgtgcgaccgaccagccccagtctcttccagtttgag ctggccaagataaagaacgccatgcccctttcggcggccatttttaagagtgaacaccgg aaccccgtgccccagtgccctcccaggctggacgtccagaccatcacctcagtgctgtgg agccgcatgcccaacaccttcctgaaggtggagacctccagggtcagcgagagacacggc tggttggtccagtgtctggagcccctgcagatgctggccgtccacatacccgaggagaac aggtgtgttgacgtgatggagctttcagagcaggaggacctgaggaccttccactaccac actctgaagctctactgtgccctgtgcgccctgggaaacacccgcgtggcccacgccctc tgctcgcacctcgaccagtcacagttgctctacaccatcgacaaccagtatctctcaggc gtactgcgcgagggcttctacaacgtcctcatcagcgttcacctggagacggccaaggaa gcccgcctcatgatgaacaacgagttcatcatccccgtcaccgaggagacgcgcagcatc cgcctgttctgtgattcctctaagcatcactcccctcccggggtggacctgagcacctcc ctgaagccccggctcaacttctccccgccctgcttcatcagcaccaagcgggagccacac ctgtacagtccccagatccctgtggacgtcctcaaggagaaggccatcaccatgttgacc gaagccgtgcagggtggtgggcaccacatcagagaccctgtggggggcagtgtggagtac cagtttgtgcccatactaaggctgatcggcacactgctcaccatgggcgtgctgggcagc caggacgtcaataagatcctgctgctcatcgaccccaacgtgttcatggagcaccctgag gggacggtcgccgccgtgacggaggccacagagaaggaggggctgacgggcgcggaggag aaggcggtggaggccggggaggaggaggtggccaaggaggccaagcagccaatgaaaggg ctcctggagaagaggcttcctgagccagtcaagcgacagatgtgtgagctactccactac ttctgtgactgtgagctgaaacatcgtattgaggccatcgtgtccttctcagacagcttt gtctccaagctgcagtacaatcagaagtttaggtacaacgagctcatgctggcactcaac atgtctgctgctgtcaccgccaagaaaaccaaggagttccgctcccctccccaagaacag attaacatgctgttgaacttcagtatgggggaggactgcccatgtccagaggacatccag gaggagctctatgacttccacaatgagctgcggctgcactgtggaatcccaatggaggaa gaagaagaacaacaagacacgtctattaaaggccgtctgctggccctggtctataagatc aaaggtcaacctctgaagatggaggaggagccagcggagcatgaacagcaagccccctcc aacctgaaagagctcatcagccagaccatggtgagctgggctcaggagtgccacatccag gatcccgagctggtcagagtaatgttcagcctgcttaggagacagtacgacagtatcggt gagctgctgagggccatgaggaagagctacaccatcagtgctggctccataaaggacacc atcaacctgctggcctcgctgggtcagatcagatcactgctctctgtacgaatgggcaaa gaggaggagaagctaatgatggacgggctgggtgacatcatgaataacaagatattttac cagcaccccaacctgatgcgcgtgctgggtatgcatgagacggtgatggaggttatggtc aacgtgcttgggggaggcaagtcacaggagattgccttccccaagatggtggcaagctgc tgccgcttcttgtgctacttctgccggatcagtcgtcagaatcagaaggccatgtttgac cacctcagctaccttctggaaaacagcagtgtggggctggcatctccggccatgcggggc tccactcccctagacgtggcggcctcctctgtgatggacaacaatggcctggctttggcc ctggaggagccggacctggataaggtggtgacgtacctggcaggctgtgggctgcagagc tgtcctatgcttttggacaagggctaccctgacattggctggaaccccattgagggggag cgctacctctccttcctgagattcgctgtctttgtcaatggtgagagtgtggaggagaac tccagtgtggtggtgaagcttctgatcagacgtccagagtgttttggtccggcgctgaga ggcgaggggggtaacgggctactggcagccatgaaggaggccatcaagatctcggagaac cctgctctggacttgccctctgccgcccagggaatcagctcggatgcatccgctgaggat gaggaggaggaagaggtggtgcatatgggcaatgccatcatgtccttctactctgccctc atcgacctactgggacgctgtgccccagagatgcaccttatcaacaagggtaaaggagag gctctgcgtatccgtgccatcctgcgttccctagtgcccaccgaagacctggtgggcatc atcagcatacccctgaaaatgcccgtcgtccacaaagatggcactgtcacagagcctgat atggcagcaagtttctgcccggaccacaaggctcccatggtattgtttctggaccgtgtc tatggtattgaggaccaaagctttttacttcacctgctggaggtgggcttcctgcccgac ctgcaagcgtccacttccctggacacggaggcgctgagcaccacagagacagccctggcc atgaacagatacatcggctctgccatgctgcccctgctcacccgctgcgccccccacttc gccggcaccgagcactacgctgctctcatggactccacgctgctcacggtctaccggctg tccaagggccgctcgctcaccaaggcacagagggacgccattgaggagtgtctgctggcc gcctgcaagtacctgcgcccctctatgctgcagcagctcctgcgacgcctcgtcttcgac gtgcccttgctgacagagtactgcaagatgcctctcaggctcttgaccaaccactacgag cagagctggaagtattactgtctgccatcaggctggggcagctacggcatggcctcagac gaggagctgctcctcacaaagaagatcttctggggtgttttggactctctctcacagagg aaatacgacgcagatctctttaagatggccatgccttgtctgagtgccatagctggggct ctaccgcctgactacatggacgccaccatcagcaccaacctggagaaacctgtgtctgtg gacgctcagggcaacttcgagcccaaacccatcagcacagccaacattgctcttccagag aaactggaacacttcgccaacaaatatgcagcgcactgccatgacaaatggtcagcagag aaggtgatgttgggatggaagtacggggattgtatagacgacaaggccaagactcaccct cagctcaggacatacaaaggcctcacggagaaggttgatttctctacaacacaccacaga agaagactaaaccatgtgaggatgaagttccataacgcctctgtctcctggtgtgtgtcc tctaatgttccacaggagaaggagatttacaggtggcctgtgagggagactttgaagagc atgctggccatgggctggaacattgacaggaccaaggacggagagaccatgtcccaacgg gagaccgagaaaatgcgcaagatctcgcagtcctcctctcaggctaatgggttcaaccca actccaatagacaccagcagtgtggttctgtctagagagttacagggcatggtggaagtt gtggctgagaattaccacaacatttgggcaaagaagaaaaaaaatgatcttggaattaga ggtggggcgactcaccccctacttgtgccctatgacaccctgactgccaaagagaaggcc aaagacagagagaaggcccaagacctcttccgcttcctccagatcaacggctttgccatc accagagggctgaaggacatggagcgggactcgtcgtccatggagaagagatttgcctac aagttccttaagaaactgctgaagtatgtgaactcagcccaggagttcatcgcccacctc gaggtaatggctacgacagggaagacagaaaagtcaccccatgagcaagaaatcaagttc tttgccaaagtcctcctacccctgatagaccagtactttaagaaccacagtctctacttc ctgtcttcacccagtaagaacctgagtagtagcggctatgcctctaataaggagaaggag atggtgaccagcctgttctgtaaactggcagctcttgtcagacacaggatttccctcttt gggagtgactccaccaccatggtgagctgtcttcacatcctggcccacacactggacacc aggacagtgatgaagtctggttcagagctggtgaaggcagggctgaggacgttctttgag aacgccgcagaggatctggagaagacctttgagaacctgaagctggggaagttcacccat tcccgctcccagatgaagggcgtgtcccagaacatcaactacaccacggtggccctgctg cccatcctcactgccctgttccaacacatcacccagcaccactttggagtggacctgctc ttggatgacgtccaagtgtcatgctatcgtatcctgacaagcctctatgcactcgggact gggaaaaacatctatgtggagaggcagcttccggccctgggggagtgtctggccacccta gcaggggcaatgcctgtggctttcctggagcccctgctcaacgcgctcaacccctgttct gtctttaacaccaagaccgcccgggaacgtgccatcctaggaatgccggaaaccgtggag gagctgtgtccggatatgccccagctggatgtgctcatgaaggacatcaacgacatttcg gagtcgggggcgcgctacaccgagatgccccacgtcattgaggtggtgctgcctatgttg tgtaactatctgtcctactggtgggagaggggcccagagaaccaggcaccccagcacagc gccgtcttctgcaccacggtcacctcggaacacctcagtctcatcctagggaacatcctg aagatcctcaacagcaacctgggcatcgacgaggcctcatggatgaagaggatcgctgtc tatgcccagcccatcatcagtaaggccagggctgatctgttgaaaagtcacttccttcct acgctggagaagctgaagaagaaaacagtgaaggtggtgacggaggaggagttactgaaa gctgacagtaaaggagacacccaggaggctgagctactcatcctggatgagtttgcagtc ctctgcagagacctctatgccttctacccaatgctaatccgctatgtagacaacaacagg tccaggtggctgaaagagccagacgctgactccaatgaactctttagaatggttgctgag atctttatcctctggtgcaaatcacataattttaaaagggaggagcagaattttgtggtt cagaatgaaatcaacaacctgtccttcctgactggcgataacaagacaaagatttcaaag tcaggaggtcaggaccaggagaggaagcataagaggaagcgaggagagttctactcggtc cagacctccctgatcgtggctgcactgaagaagatgctgcccatcggactgaacatgtgc accccgggagaccaggagctcatctccctggccaagacgcgctaccttctgaaagacaca gacgaagaagtgaaggaccatgtaaggaggaatctgcatctgcaagagaagtccgaggac cccgccgtgcgctggcagctgaacttgtataaagatgtgatggtaaagaacgaaggcccc ccagatcctgagaacacagtctgccgtgtccaaagcatctcagctgcggtctttcatctg gagcaggtggagcagccgttgaggtctaagaagtgtgtgtggcagaagctcctgtccaaa cagagaaagcgtgcggtggtggcctgcttccgcatggctccgctgtacaacctgcccagg catcgctctattaacctcttcctcctgggctatcagagaatatggatagagacagagacg tactcttttgaagagaagctagttcaggacctggcaaagacccaactgaaggtggaggag gaggaagaggaggaggcagagaggcagccagaccctcttcatcagctcatcctgcatttc agtcacaatgcgctcactgagcggagttctttggaggaggaccctttatatattgcatat gcagacatgatggcaaagagttgtgcagaagatgaagaggaggaagacggagaaggaaaa gagaaaacatttgaggaaaaagagatggagaagcagaagacactgtatcagcaggccagg ctgcatgacaggggagcagctgagatggtgttgcagatgatcagtgcgagcaaaggttct cttgggcccatggtgacctttactctgaagctgggcatctccattctgaacggggggaac attgtggtgcagcagaaaatgcttgactatctgaaggaaaaaagagatgctggctttttc aaaagtctgtcaggacttatgcagtcttgcagtgtcctggatttgaatgcgttcgaaagg caaaacaaagcggaaggccttgggatggtgactgaagaaggatcaatcaacgtgagtgag cggggttccaaggtactgcagaacgatgagttcacaaaggacctctttaggtttctgcag ctgctctgtgagggacacaacaacgatttccagaacttcttgcggacacagacagggaac accaccacagtaaatatcataatcagcaccgtggattacctgctccgtctgcaggaatcg atcagtgatttctactggtactactctgggagagacatcatggatgaggctggtcagagg aacttctcaaaggccctggctgtggccaagcagattttcaactctctcactgagtacata cagggcccatgtattggaaaccaacagagcctggctcacagcaggctatgggatgcagtg gtgggcttcctgcatgtgtttgccaacatgcagatgaagctgtcacaggactcgagtcag attgaattattaaaggagctgctggacctgcagaaagacatgatcgtgatgatgctctcc cttctggaaggtaatgttgtcaatggaaccatcggcaaacagatggtggacacattggta gagtcatcaagcaatgtggaaatgattctcaagttctttgacatgttcctcaaactcaaa gacttaaccacctctgacaactttaaggagtatgacccagacagcaagggagtgatctcc aagaaggagtttcaaaagtccatggagaaccagaaacagtattctcagtcagagatcgag ttcctgctctcctgcgcagaggctgatgagaatgacatgttcaactacgaggagtttgtg gagcgttttcatgaaccagccaaggacattggatttaatgtggcagttctgctcaccaac ttatcagaacacatgcctcacgatgcccgtctagccaccttcctggacctggcagagagc gtgatcaactactttgagccttacctgggccgcatcgagatcatgggtggagctaagcgc atagagagggtttactttgagatcagtgagtccagccgaacgcagtgggagaagcctcag gtcaaagagtccaagagacagttcatctttgacgtggtcaatgagggcggagagagcgag aagatggaattgtttgtcaacttctgtgaggacaccatttttgagatgcagctcgcctcc cagatctctgagcctgatgcaatggagcgtccggaggaggacgaggacgacagacagagt ttggaggaggagctggatgaggaagatgaggagagaaggatggagtctcactcagcgttc accaactcgtgcgtctccatgagaaaaaacctgtccagcttccgccagctgctcaccttc cggagcatgcgacggcagtaccgaaggtttaggaggatgagtgtgagagagttggtccga ggcttcttctccttcttctggatgataatcacgggcctcttccgctttctctacaacctg gtgtggggttttttccacatcctgtggtcctccatgttcggagggggcctagtggaaggg gccaaaaacatgaaggttacggacatcctggggaacatgccagaccccacccagtttggt atccatggcgatgtgctggaggcggagaagatggatgccagcgaggcgtcttcagtggct gagatgggccacatggcccagggggacaaggcagaggcagacctaatggctgagttgctc aacatcccaaccaagagccagggaggcaagcacggggccgaaccaggcctcggggacatg ggggaagtagttggggtcgacgccccctctttagccagcgccgtcaagcagaagaaggcc aaggaggctgcaactaaagagcatagcaacggagatcacaaagctgagccagaaaaagca gacgcagaggatgaggagaagaaggacaaggacaaagccaaagaggaggcaccacctgag accccaccagaggagagaaaggctgccaagaaaagaccaggactgaagaaagaaccgcct gaggcttttatggcaagcttctgcgctggcctggaaatctaccagaccaagatgctgaac tatctggccagaaacttctacaaccttcgtttcttggcgttgtttgttgctttcgccatc aactttattctcctcttctacaaggtgactggggatgacgatgacccagacccctggaat ggaggaagaggtactgacgaagaggatgaaggtgggatggagtatttcgtcctgcaggag agcacgggttacatggcacccaccttgcgcttcctggccatactccacactatcatctca ttcctctgtgtggtgggatactactacctaaaggtgcccctggtggtgttcaagagagag aaggagattgccagaaagctggagtttgatggcctctatataacggagcagccgtcggat gatgacatcaaaggacagtgggatcgcctcgtcatcaacacgccttctttccctaataac tactgggacaagtttgtgaaacgcaaagtcatcaataagtatggggatctgtatggtgca gagaggatagcagagctgctgggtctggataagagtgccctggacttcaaccccacagag gagactgtggtgaaggaggcgtcgctgctgtcctggttgggctccatcgacaccaagtac cactgctggaaaatgggtgtggtattcacagacaattctttcctatacctggtgtggtac accaccatgtccatcctggggcactacaacaacttctttttcgctgcccatctgcttgac attgcgatgggattcaagaccctccggaccatcctgtcctcggtcacccacaatggcaaa cagctggtcctgaccgtaggtctactggcggtggtggtctatctgtacacagtggtggcc ttcaacttcttccgcaagttctacaacaagagtgaggacgaggaccagcctgatatgaag tgtgatgacatgatgacttgttacctgttccatatgtacgttggtgtgagggcagggggt ggcatcggagacgagatagaggacccagcgggggacccatatgagctctaccgcatccta tttgacattacgttcttcttctttgtcatcgtcattcttctggccatcatccagggtctg atcattgatgcttttggagagctaagagaccaacaagagcaagtgaaagaggatatggag accaaatgcttcatctgtgggatcggtaatgactactttgacaccacgcctcacggcttt gagacacacacattacaagagcacaacttggctaactacctgtttttcctgatgtacctt atcaacaaagatgagacagagcacactggtcaggagtcctatgtgtggaagatgtaccag gagaggtgctgggactttttccctgctggagactgtttcagaaagcagtatgaggatcag cttggatag

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