Esox lucius (northern pike): 105025293 Help Entry 105025293         CDS       T04894                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism els  Esox lucius (northern pike) Pathway els04020   Calcium signaling pathway els04260   Cardiac muscle contraction els04261   Adrenergic signaling in cardiomyocytes els04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:els00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105025293 (ryr2)    04020 Calcium signaling pathway     105025293 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     105025293 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     105025293 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:els04040]     105025293 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:els04990]     105025293 (ryr2) Ion channels [BR:els04040]  Voltage-gated cation channels   Ryanodine receptor    105025293 (ryr2) Domain-containing proteins not elsewhere classified [BR:els04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    105025293 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 DUF7053 Motif Other DBs NCBI-GeneID:  105025293 NCBI-ProteinID:  XP_028976022 LinkDB All DBs Position LG06:7081013..7265144 Genome browser AA seq 5085 aa AA seqDB search MAEGGEAGEDEIQFLRTDDEVVLQCSATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVP PDLSICTFVLEQSLSVRALQEMLANTEEKAEGQVDVEKWKFMMKTAQGGGHRTLLYGHAV LLRHSYSGMYLCCLGTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGD DLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVATVCSGSEVAQGFMIGGDVLRLLHG HMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRH VTTGKYLSIMEDKGLLLMDKEKADVKSTAFCFRPSKEKLDLGAKKEVDGMGVPDIKYGDS VCYIQHVDTCLWLTYQAMDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVI RSTVFLFNRFIRGLDALSKKGKTPTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRL RALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFAEVAGREAGEAWRSILNSLYELLAA LIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIIS LLDKHGRNHKVLDVLCSLCLCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNI FLGVSEGSAQYRKWYYELIVDQVVPFVTAEATHLRVGWATTDGYQPYPGGGEGWGGNGVG DDLYSYGFDGLHLWSGCIARTVSSPNQHLLRVDDVVSCCLDLGAPSISFRINGQPVQGMF ENFNSDGLFFPVASFSAGVKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPREKLRVEHSHE YKEDHSDTRNLLGPIITLSQAAFTPTPVDTSQIVLPPHLEKIREKLAENIHELWVMNKID LGWTYGAVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVE KVMNLQLSDTYELSSGYKPAPMDLSHIKLASSQEAMVDKLAENAHNVWARDRIRQGWTYG IQQVCHPKDVKNRRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAR ADFSNMSAERFRIFRAEKTYSVNTGKWYFEFEVVTAGEMRVGWARPSCLPDQELGSDEHA FVFDGFKAQLWHQGNEHFGRSWSAGDVVGCMVDLNEHTMMFTHNGEVLLDDSGSELAFKD FEVWEGFVPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWLSKR LPQFIPVPQNHEHIEVTRIDGTVESAPCLKVTQRSFGSQNSNPDITFYRLSMPIECNEVL MKSPGGTLPAGGGNFSFTSKKDLLDFETVSDFEVLMKSAHGTLGSSVDKERDEFNNHKDY TQEKPSKLKQRFMLKRTKPEFNTSSSSARLSEEVLADDRDDYDYLMQTSTYYYSVRIFPG QEPSSVWVGWVTSDFHQYDTAFDLDKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESMS PGQGRNNNGLEIGCLVDTANGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPSIFQF ELGRIKNVMPLSAGLFKSERRNPNPQCPPRLHVQFLTSVLWSRVPNHFLKVDVSRVNDRH GWLVTCSEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHA LCSHADEAQLLYAIENKYMAGLLRTGYYDLLIDIHLSTYATARLMMNNEYIVPMTDETKS ITLFPDEKKKHGLPGIGLSTSLRPRMLFSSPSFICSGADCFQYSPEFPLDLLKTKTIEML TEAVREGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKNILQLIEPSVFSEGA GPPADTPESDVTKGGGGAEGAGGEERAGKVPKGLLQMKLPEPVKLQMCHLLQYLCDCQVR HRIEAVVGFSDDFVAHLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNF KDDKQDCPCPEEIREQLLDFHEDLMTHCGIEMDEDKLNEADSDFTIRGRLMSLVEKVVYL KKKMTFMPKNKKKAKKASTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQ VRALPKAYTINSVSVEDTIKLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQH PNLMRALGMHETVMEVMVNVLSGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHL SYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCS MLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGE GGNGLLAAMIEAIKISEDPSRDGPSPTSEARRTLSDVLLEEEEEDDTIHMGNAIMTFYAA LIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGSVLEP DMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMAL ALNRYLCTAVLPLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLL ATCSKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLTGGWGSFGASS DEELHLSRKLFSGIFDALSRKRYDQELFKLALPCLSAVAGALPPDYMESSYVTMMEKQSS MDSEGNFTPQPADTNHVNVPEKLDYFVNKYAEHSHEKWSMDKLADGWVHGDQFSESSKTQ PLLKPYKSLSEKDKEIYRWPIKESLKTMVAWGWSIERTREGDPAGLHNRARRISQISQQH SLEGAPGFSPRPIDMSNVTLSRDLHSMAELLAENYHNIWAKKKKLELEAKGGGSHPLLVP YDTLTAKEKSKDREKAQDILKFFQINGYCVSRAMKEQELDTPSIEKRFAYTFLQQLITYV DEAHEHMLEFDIGTRPKGEKIPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAIRPISSG GHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLETV KAALRGFFDNAAEDLEKTLENLKQGQFTHSRTQPKGVTQIINYTTVALLPVLSSLFEHIG QNLFGEDLILDDVQVSCYRILNSLYGLGTNKSIYVERQRPALGESLAAFSGAFPVAFLEP ELNKFNSYSIYITKSSRDRAALGLPSQVGQMCPLIPSLEKSLEEIMDLAESGLRYTQMPH VMEVVLPMLCSYMSHWWEHGPENNPPERADGCCTNLTSDHMNNLLGNILKIIYNNLGIDE GAWMKRLAVFSQPIISKAKAGLLKTHFLPLMEKLRKKAATVLLDEEHMKAEGRGEMSEAE LLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNF KREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKRKGDRYSMQTSLIVAALKR LLPVGLNICAPGDHELIALAKNRFTQKDTEDEVREIIRNNLHLQGKYRVFHFKKLVKRLI IVMKWMKSRQACKPLALDTPTGHKRLSSTRKRSATMESSYAYRPTRTTLAGVKRASSVDY AKPQGHGQLEDPAIRWQMALYKELPNRSEDTSDPEKTVERVLDIAHVLFHLDQVEHPQRS KKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEHYFEDKLIE DLAKPGGEEPPEEDEGAKRIDPLHQLIQLFSRTALTEKCKLEEDILYMAYADIMAKSCHD EEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLG IAVLNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTE EGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVD YLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLA HSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIG KQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHK HYTQSETEFLLSCAEPDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQ TFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDV VNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDIGERSTVKEESEKERPEEESPEMGFFSV TTVRTALMALRYNVVFLMNVLSMKSLKKQMKRMKKMTVKDMVMTLVTFYWSVIMGLFHIT FNVSRGFCRIMYNTFLGGSLVEGAKTMKVSDLLANMPDPTQDEVRGEGEDGEKVLAARAS AEKDLADLAVPADGTEVLSDIFGLDLRRGEGGQYKITAHNPNAILTDLLNSPVPVPAPSP ELRRRRQAKSSLEDLEEGPEEMKESVSEPEKAEGENGEKQEEERRKEEDLKRKEKEKRKL EKKEEKPKPKVRHHHTSRTDEPDMQESAFWKKIIAYQRKLLNYFARNFYNMRMLALFVAF AINFILLFYKVSSSSAVVHDKARSPQSGSSLRWDPLMESSEAQGPQDPEQGPVFVNFVLE ESTGYMEPTLRILAILHTVISFCCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPS EDDIKGQWDRLVINTGSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDA HEKKKPKKDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAH LLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESP DMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAII QGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFV MYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15258 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaagctggcgaagatgaaatccagttcttacgaactgatgatgag gtggtgctacagtgttctgccaccgtccacaaagagcagcagaagttgtgtctcgctgct gagggctttgggaatcgactctgtttcctcgaatccacgtccaactctaagaacgtcccc ccagacctgtccatctgtacctttgtcctggagcagtctctctcagttcgggccctgcag gagatgctggccaacacagaggagaaggctgagggccaggttgatgtggaaaaatggaaa ttcatgatgaagacggcccagggtgggggtcaccgcaccttgctctatggacacgccgtc ctgctacgccactcctacagcggcatgtatctctgttgtctgggcacctcgcgatcctca accgacaaactggcgtttgatgtcggactgcaagaagacacgacaggtgaagcctgttgg tggacgatccacccagcctccaagcagagatcggagggagagaaggtcagagtcggcgat gacctcatcctggtcagcgtgtcatcagaacgttacctgcatctgtcatacggtaatggc agcctgcacgtggacgctgccttccagcagacactctggagcgtggcgaccgtatgctct ggcagcgaggtggcccaagggttcatgataggtggggatgtgctgaggctgcttcatggt cacatggatgagtgtctgacggtgccatcaggagaacacggggaggagcagcgcaggacg gtgcactatgaggggggtgcagtttccatccacgcccgctccctctggagactggagacg ctacgggttgcgtggagcggaagccacacgcgctggggccaaccgttccgactccgtcac gtgactacagggaagtacctgagtatcatggaggataagggtctgttgttgatggataag gagaaggctgatgtcaagtcaacggctttctgctttcgcccctccaaggaaaagctggac ctgggtgcgaagaaggaggtggacggcatgggtgttcctgacattaaatacggcgactcg gtgtgttacattcagcacgtggacacctgcctgtggctgacgtaccaggccatggacgcc aagtgcgcgcgtatgggcggcgtgcagagaaaggccatcatgcaccatgagggtcacatg gacgatggtctgaccctgtcccgctctcagcacgaggagtctcgaactgcacgggttata cgtagcacggtcttcctgttcaaccgcttcatcaggggcctggacgccctcagtaaaaaa gggaaaaccccaacactggacctgccaatcgaatcggtcagtctgagtctacaggatctg attggctacttccagccccctgatgagcacctggagcatgaggacaaacagaaccgcctc cgagccctgaagaaccgacagaacctctttcaggaagagggtatgattaacctggtgttg gagtgtatcgaccgtctccacgtgtacagcagcgcagctcattttgctgaggtggcgggg agggaggccggtgaggcctggaggtccatactaaactcattatacgagctactggctgca ttgataagggggaacaggaagaactgtgcccagttctctggctctctggactggttgatc agccgtttagagagattagaggcctcgtctggtatcttggaggtgcttcactgtgtcctt gttgaaagtcctgaagccctgaatatcatcaaggaaggacacatcaagtccatcatctcc ttgttggacaagcatggacgcaaccacaaggttctggatgtgctgtgttctctgtgcttg tgtcacggcgtggcggtacggtccaatcagcacctgatctgtgacaacctcctgcccggc cgggatctgctgctccagacacgccttgtcaaccatgtcagcagcatgaggcccaacatc ttcctgggggtgagcgaaggctccgcccagtacaggaagtggtactacgagctgatcgtg gaccaggtggtgccgttcgtaacagccgaggccacacacctgagagtgggctgggccacc acggacggctaccagccctaccctggtggaggagagggctgggggggcaacggggtcggg gatgacctctactcctacggcttcgacggcctgcacctctggtcaggctgcattgccagg acggtgagctcgcccaatcagcatttactgcgtgtggatgatgttgtcagctgttgcctg gatctcggcgctcccagtatctcgttccgtatcaatggtcagcctgtccagggcatgttc gagaacttcaactctgatggactcttctttcctgtagccagcttctctgccggggtcaag gtgcgtttcctgttgggaggtcgccatggagagttcaagttcctcccgccgccgggctac gccccgtgtttcgaggcggtgctgcccagggagaagctcagagtggaacacagccatgaa tacaaggaggaccacagtgacaccaggaacttactgggtcccattatcaccttgtcacag gctgccttcaccccgacacccgtcgacaccagccagatcgttctgcctccccacctggag aagatcagagagaagctagcggagaacattcacgaactctgggtgatgaacaagatagac ctgggctggacctatggagctgtacgggacgacaacaagcgtcagcacccgtgtctggtg gagttctccaagctcccggagcaggagaggagctacaacctacagatgtctctggagact ctcaagactctgctggccttgggttgtcatgtgggtcttgccgatgagcatgctgtggag aaggtgatgaatctccagctatctgacacatatgagctgtctagtgggtacaagccggcc ccaatggacctcagccacattaagctggcttcttcccaggaggccatggtggacaagctg gcagagaatgctcacaatgtgtgggccagggaccggatccgccagggctggacctacggc atccagcaggtgtgtcacccaaaggatgtgaagaatcgtaggaaccctcgcttggtcccg tacgcgctgctggacgagagaacaaagaagagcaacaaggacagcttgagggaggcagtt cgcaccctgctgggctacggatacaacctggaggctcccgatcaagaccatgctgccaga gcggacttcagtaacatgtcagctgagcggttccgtatcttccgcgctgagaagacgtac agtgtgaacacagggaaatggtactttgagtttgaggtggtgacggcgggagagatgagg gtcggctgggcgcggccaagctgtctcccggaccaggagctgggctccgatgaacacgcc ttcgttttcgacggcttcaaggcccagctgtggcatcagggcaacgagcactttgggcgg tcgtggagcgcgggcgacgtggtgggctgtatggtggatttgaacgaacacaccatgatg ttcacacacaatggagaggtgctgctggatgactccgggtccgaactggcctttaaggac tttgaggtttgggaaggcttcgtcccagtgtgcagcctgggtgtctgccaggtggggagg atgaactttgggaaggatgtgagcacgctcaagtacttcaccatctgtggcctgcaggag ggttacgagcctttcgccgtcaatatgaaccgggacctcaccatgtggctcagcaagagg ctgccgcagttcatcccagtgccgcagaatcacgaacacatcgaggtcacaaggatcgac ggcaccgtggagagtgctccatgtctaaaggtcacccagaggtcgtttggctcccagaac agtaacccagacatcacgttttatcgcctcagcatgcccatcgagtgtaacgaggtcctg atgaagtcgcctggcgggacactcccggccggcggagggaacttctccttcacctctaag aaggacctgttagactttgagacagtgtccgactttgaggtgttgatgaagtcagcccac ggcacgttgggctccagcgtggacaaggagagagacgagttcaacaaccataaagattac acccaggagaaaccatccaagttaaagcagaggttcatgctgaagaggaccaaaccagag tttaacaccagtagctcttcagcacgcctgtcagaggaggtgcttgctgatgacagggat gactatgactacctcatgcagacatccacttactattactcagtgcggatcttccctggc caggagccaagcagtgtgtgggttggttgggtgacctcagacttccaccaatacgacaca gcctttgacctggacaaggtccgcactgtcaccgtaaccctgggagacgagaagggcaaa gtccacgagagcatcaagcgtagtaactgctacatggtgtgggctggggagagtatgagt cctggacaaggccggaacaacaatggtctggagataggttgtctggtggacacggccaac gggctgttaaccttcaccgccaacggcaaggaactcagcacatactaccaggtggagccc agcaccaagttgttccctgccgtgtttgctcaggccaccagccccagcatctttcagttt gaactgggacgcataaagaatgtcatgcccctgtcggcgggtctgtttaagagtgagcgg aggaacccgaacccccagtgcccccctcgcctgcatgtccagttcctgacctcggtgctg tggagccgtgtgccgaaccacttcctgaaggtcgacgtgtcaagggtcaacgaccgccac ggttggctggtcacctgctccgaacctttgcagttcatgtccctgcatatacccgaggag aacaggtcggttgacatcctggagctaacagagcaggaggaactgctgaaattccactac cacactctgagactgtactcggctgtgtgcgccctcggcaacaaccgtgtagcccacgcg ctctgctcgcacgccgacgaggcgcagctgctctacgccatcgagaacaagtacatggca ggactcctccggactggatactacgacctactcattgacatccacctcagtacatacgcc acggcacgcctcatgatgaacaacgagtacatcgtccccatgacggacgagaccaagtcc atcacgctgttcccggacgagaagaagaagcacggcctgccggggatcggcctcagcacc tccctgcgcccgcgcatgctcttctcctccccgtcgttcatctgcagcggggccgactgc ttccagtacagccccgagttccccctggacctcctcaagaccaagaccatcgagatgctg actgaggcggtgagggagggcagcctgcacgtcagggaccccgtagggggcagcaccgag ttcctgtttgttcccctcatcaagctcttctacacgctactgatcatgggggtgttccac aacggggacctgaagaacatactgcagctgatagaaccgtctgtgttctcggagggagcg ggcccgcccgccgacacgcccgagagtgatgtcactaagggagggggaggggcggagggg gcaggaggagaggagagggctgggaaggtccctaaaggactgctccagatgaaactacct gagcctgtcaaactacagatgtgccacctgctgcagtacttgtgtgactgtcaggtgcgc caccgtatcgaggcggtggtggggttcagcgatgactttgtggctcatctccaagacaac cagcggttccgctacaatgaggtcatgcaagccctcaacatgtcggccgcgctgactgcc aggaagaccaaagagttcagatcaccgccacaggagcagatcaacatgctgctgaacttc aaggatgacaagcaggactgtccttgtcccgaggagatcagagaacaactgctggacttc cacgaagacctaatgacccactgtggcatagagatggatgaggacaagctgaacgaggca gacagtgacttcaccatccgaggacgactcatgtccctggtggagaaggtggtctaccta aagaagaagatgaccttcatgccgaagaacaagaagaaagctaagaaagccagcactctg cagcagctgatcagcgagaccatggtgcgttgggcccaggagagcgtcattgaggaccca gagctggtcagagccatgtttgtgctgctccaccgtcagtacgacggcatcggcggtcag gtccgggccttgcccaaggcctacaccatcaactctgtctctgtggaggacaccatcaag ctgctggcgtcgctgggccagatcagatctctgctgtccgtccgcatgggccgagaggaa gagaaactgatgatcagagggctgggggacatcatgaacaacaaagtgttctatcagcac cccaacctgatgcgggctctgggaatgcacgagaccgtgatggaggtgatggttaacgtc ctgagtggtggggaatccaaggagatcacctttcccaagatggtggccaactgctgtcgt ttcctgtgttatttctgtcgtatcagtagacagaaccagaaagccatgtttgatcacctc agctacctgttggagaacagcagtgtcggccttgcgtctccctccatgcgtggctccacc ccgctagacgtggctgctgcttctgtgatggataataacgagcttgctctggccctcaga gaaccggacttggaaaaagtggtccagtacctggcgggttgtggcctccagagctgttcc atgctggtgtctaaaggttatcctgatattggctggaaccctgtagaaggagaacggtac ctggatttcctccgcttcgctgtgttctgcaatggtgagagtgtggaagagaacgccaat gtggtggtgaggcttctgattcgtcggccggagtgctttggccccgcccttcgtggagag ggagggaatggtctattggcagcaatgattgaagccatcaagatatcagaggaccccagt agggatgggccctcccccacatcagaggccaggaggacgctcagtgacgttttactagaa gaggaggaagaggatgataccatccacatgggcaatgccatcatgaccttctatgctgcc ctcatcgacctgctggggcgctgtgcccctgagatgcacctgattcatgctgggaaaggc gaggcgatccggataagagccatcctccgttccctgatccccatcgaagacctggaaggg gttataagcatcccgtttcccatgcccactctggccaaagatgggtctgttttggagcct gacatgtctgcagggttctgtccggaccacaaggcagccatggtgcttttcctggaccgc gtctatggcatagaggaccagaacttcctgctccacctgctggaggtgggcttcctgccg gacctccgggcagcggcctcccttgacacggctgctctcagtgctacagacatggccctg gccctcaacaggtatctgtgcacggctgtcctgcctctgctcactaagtgtgcccccctg tttgccgggactgagccgtacgcctcgctcatagactctcttctccacaccgtctaccgt ctgtctaaaggatgctgcctcaccaaggcccagcgagacgccatcgaggagtgtctcctg gccacctgcagtaaactgaggccgtctatgatgcagcatctgcttagaagactggtgttt gacgttcctctgctcaatgaacacaccaagatgcccctcaagctcttgaccaatcactat gagcgttgttggaagtactactgtttgacgggtggctggggaagctttggtgcatcgtct gacgaggagctgcatctctcaaggaagctgttctctggcatctttgatgctttgtctcgc aagaggtatgaccaggagctgtttaagctggccctgccgtgcctcagtgccgtagcaggg gccttgcctccagactacatggagagcagctacgtcaccatgatggagaaacagtcctcc atggactcagagggaaacttcaccccacagcctgccgacaccaaccatgtgaacgtgcct gagaaactggattactttgttaacaaatatgctgagcattcccatgagaaatggtccatg gacaagttggccgacggctgggttcacggcgaccagttctctgagtcttcgaagacacaa cctctgctgaaaccctacaaaagtctgtctgagaaggataaagagatctaccgctggcct attaaagagtctctaaagacaatggtggcatggggctggagcatcgagaggaccagggag ggagacccagctggcctacacaaccgagcccgtaggatatcccaaattagccagcagcac tctctagaaggagctcctgggtttagccccagacccattgacatgagcaacgttacgcta tcccgtgacctgcactctatggcagaactgcttgcggagaactatcacaatatttgggcg aagaagaagaaacttgaactggaagccaaaggcggagggagccaccccctcctggtgccc tatgacaccctcactgccaaagagaagtccaaagacagagaaaaggcacaagacattctc aagttctttcagataaatggctactgtgtatccagggctatgaaggagcaggagttggat acaccatccatagagaagcgttttgcatacactttcctgcagcaactaatcacctatgtt gacgaagcccatgaacacatgctagagtttgatattgggactcgaccaaaaggggaaaag attcctcacgagcaacagatgaagttctttggaaaggtggtgctgccattggttgaccag tacttcaagaatcatcggctctactttctgtccacggccatccgaccaattagcagtggt ggccacgcctccaacaaggagaaggagatggtgaccagtctgttctgcaaacttggagtt cttgtcagacataggatttcactatttggaaacgatgccacctccattgtcaactgtcta cacatactgggacagacactggatgccaggacagtgatgaagacgggtctggagacggtg aaggcggcgttgagagggttttttgacaacgcggcggaggacctggagaagacattggag aacttgaaacagggccaattcacgcacagtcggacccaacctaaaggtgtgacccagatc atcaactacaccaccgtggccctgctgccggtgctttcatccctgtttgagcatattgga cagaacctcttcggagaagacctcatattggatgatgttcaggtgtcgtgttataggatc ctcaacagcctgtatggtttaggcaccaacaagagcatctatgtagaaaggcagcgtccg gccctgggggagtctctggcagcgttctcgggagcatttcccgtggcctttctggagcct gagctcaacaagttcaacagctactctatttacatcaccaagagctcccgggacagagca gctctaggcctgccctcccaggtagggcagatgtgtccactcattccctccttggaaaaa tctctggaagaaattatggatcttgctgagtccggcctccgctacactcagatgccacat gtcatggaggtggtgctgcccatgctgtgcagctacatgtctcactggtgggagcacggc cccgagaacaaccccccggagagagccgatggctgctgtaccaacctcacctctgaccac atgaacaacctactcggaaacattttgaagatcatctacaacaacctggggatcgacgag ggcgcctggatgaaacgactcgcagtgttctctcagccaatcatcagtaaggcgaaggca gggttgttgaaaacacactttctgccgctcatggagaagctgaggaagaaggctgctaca gtgctgctagatgaggaacacatgaaggcggaggggcgaggagagatgtctgaggctgag ctactcatcctggatgagttcaccatcctcgttcgagacctctatgccttttatccactc ctcatccgctttgtcgattataatagggctaaatggctgaaagagcctaaccctgaagct gaggagctatttcgcatggtagcagaggtcttcatattctgggccaagtctcacaatttt aaacgggaggagcagaactttgtggttcagaatgagatcaacaatatgtccttcctcatc acggacaccaagtctaagatgtccaagggggcagtgtcggaccaggagaggaagaagatg aagcggaagggagatcgttactccatgcagactagcctcattgtcgctgccttgaagagg cttcttcctgtgggactgaacatatgtgctccaggagaccacgagctgatcgctctggcc aagaaccgcttcactcagaaagacacagaggatgaggttcgggagattatacggaataac ttgcacctgcagggcaagtaccgggtgtttcacttcaagaagctggtgaagagactgatc atagtgatgaagtggatgaagagccgccaggcttgcaaacccctggccttagacacgccc accgggcacaaacgtctgtccagcacccgcaaacgctctgccactatggagagtagctat gcttacaggcctaccaggaccaccctggcgggcgtcaagagggcatcttctgtggactat gcaaagccacaggggcatgggcagctggaggaccctgctatccgctggcaaatggctctg tataaggagctcccaaacagaagtgaagacacgtctgatccagaaaagactgtggagagg gtcctggacatcgctcatgtcctctttcatctcgaccaggttgaacacccacagaggagt aagaaagctgtgtggcacaagttgttatccaaacagaggaagagggccgtggtggcctgc ttcagaatggcacccctgtataacctgcccaggcaccgggctgtgaacctgtttcttcag ggctatgagaagtcctggattgaggctgaggaacactactttgaggacaaactcatagag gatctggcaaaacctggaggggaggagccccctgaggaagatgagggagccaaacgcatc gatcctcttcatcagctcatacagctgttcagtaggacagccctgaccgagaagtgtaag ctggaggaggacattctctacatggcttatgccgacatcatggccaagagctgtcatgat gaagaggatgaggatggagaggaggtgaagagttttgaagaaaaagagatggagaaacag aagctgttgtaccagcaggccaggttgcatgaccgaggagctgcagagatggtgctgcag accattagtgccagcaaaggtgagatgggccccatggtggcgtctaccctgaagctggga atagctgttctcaacggaggcaattctacggttcaacagaaaatgctggactaccttaaa gacaagaaggatgtgggcttttttcagagtctggcaggtctgatgcagtcgtgcagtgtt ctggatctaaatgcatttgaacgccagaacaaagcagaaggactgggcatggtgacggag gagggatcagtcatcactcatgagcgtggagagaaggtgatgcaggatgatgaatttacc tgtgacctcttccgcttcctccagctgctgtgcgaaggccacaattctgactttcagaac tacctgagaacgcagacgggtaacaacaccaccgtcaacatcatcatctccaccgtggac tatctgctcagggttcaggagtccatcagcgatttctactggtactattctggaaaggat gtcattgacgaacaaggacagcgcaatttctccaaagcaatcaatgtagcgaaacaggtc ttcaatactctgactgagtatatacaggggccgtgcacagggaaccagcagagtctagca cacagtcgcctctgggacgcagtggtcggcttcctccacgtctttgcacatatgcagatg aagctgtcacaggactcaagccagattgagctactgaaggagttgatggacttacagaag gacatggttgtgatgctactgtctatgctggagggcaacgtggtcaacggcaccatcggg aaacagatggtcgacatgttagtcgagtcttccaacaacgtggagatgatcctcaagttc ttcgacatgttccttaaactcaaagacctgacgtcctcagatgcctttaaagagtatgac cctgatggtaaaggagtaatctccaagagggacttccacaaagccatggagagtcacaag cactacacccagtccgagaccgagttcctgctctcctgcgccgaacccgacgagaacgag ttgctggactacgaggagtttgtggagcggttccacgagccggctaaagacatcggcttc aacgtggctgtgctgctgaccaatctgtcggagcacatgcctcacgacacacgtctgcag accttcctggagctggccgagagtgtgttgaattactttcagccgtacctgggccgcatc gagatcatgggcagcgccaaacgcatcgagagggtctacttcgagatcagcgagtccagc cgcactcagtgggagaagccgcaggttaaagagtccaagcggcagtttatttttgacgtg gtcaatgagggcggggagaaggagaagatggagctgtttgtcaacttctgcgaagacacc atctttgagatgcagctggccgcgcagatgtctgacatcggggagcggtcgacggttaag gaagagagcgagaaggagaggccggaggaggaaagccctgagatgggcttcttctcggtg accacagtccggacagccctgatggcgctacgctacaatgtcgtgttcctgatgaatgtt ctgtccatgaagagcttgaagaagcagatgaagaggatgaagaagatgaccgtgaaggac atggtgatgacgttagtgaccttctattggtcggtcatcatgggcctgttccacattaca tttaatgtctctcgagggttctgccgtatcatgtacaacacattcctaggaggcagcctt gtggagggagccaaaaccatgaaggtgtcggacctgttggccaacatgccggacccgaca caggacgaggtccgcggggagggagaagacggggagaaggtactggcggcaagagcctct gctgagaaagacctggctgacctagccgtgcccgcggacgggaccgaagtcctctctgac atctttggattggacctgaggagaggcgagggggggcagtacaagatcactgcgcacaac cccaatgccatcctgacggatctgctgaattcccccgttcccgtccccgccccctcgccg gagctgcgaaggcggcgccaggctaagagctccttggaagacctggaggaagggcctgag gagatgaaggaaagcgtgtcggagccagagaaagcagaaggagagaatggagagaagcag gaggaggaaaggagaaaggaggaggacttaaagagaaaggagaaggagaagagaaagcta gagaagaaggaggaaaagcccaaacctaaagtgagacatcaccacacctccaggacggat gagcctgacatgcaggagtctgctttctggaagaagatcatcgcctaccaaaggaagctg ttgaactactttgctcggaacttctacaacatgagaatgctggcgttgtttgtggcattt gcaatcaactttatcctcctcttctacaaggtgtcctcttcctctgcggttgtccatgac aaagcacgcagcccccagtcaggcagcagcttgcggtgggacccactcatggagagcagt gaagcccaggggccccaagatccagagcagggcccggtgtttgtcaactttgtcctggag gagagcacgggatacatggagcccacgctacgcatcctggccatcctgcacacagtcatc tccttctgctgcatcattggctactactgtctcaaggtcccgctggtgatctttaagcgc gagaaggaggtggcgagaaagctggagtttgacggcctctacatcacagagcagccgtct gaggacgacatcaaaggccagtgggataggctggtgatcaacactgggtcatttccaaac aactattgggataagtttgtgaagcggaaggttatggataagtatggtgagttctatggc catgaccgaatcagtgagctgctgggcatggacaaggctgctttggacttcagtgatgcc cacgagaagaagaaacccaagaaagatagctcattagctgcagtgttaaactcaattgat gtcaagtaccagatatggaaactaggagtggttttcacggataattcgtttctgtacttg gcgtggtacatgactatgtccatcctgggtcattataacaacttcttctttgccgctcat ctccttgacatcgccatgggcttcaaaactctccgcacaatcctgtcttctgtcacgcac aacggcaaacagctggtcctgaccgtgggtttactggctgtggtggtgtatctctacact gtggtggcgttcaacttcttcaggaagttctacaataagagcgaagatggagagtcacca gacatgaagtgtgatgacatgctgacatgttacatgttccacatgtatgtgggtgtgcgg gcgggaggaggcatcggtgaccagatcgaggatccggcaggtgatgagtacgagatctac aggatcatctttgatatcaccttcttcttctttgtcatcgtcatcttgctggctatcatc cagggtctgataattgatgcatttggtgaactgagagaccaacaggagcaggtgaaagag gatatggagaccaaatgcttcatctgcggaataggaaatgactactttgacacagtgcct catggctttgaaacacatacccttcaggagcacaacttagccaattatctcttttttgtg atgtacctcattaacaaagacgaaacggagcacacaggccaggagtcgtacgtgtggaag atgtaccaggagcgctgctgggagttcttccctgctggagactgttttcgaaaacaatat gaagaccagctcaactga

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