Eublepharis macularius (Leopard gecko): 129329935
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Entry
129329935 CDS
T09084
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
emc
Eublepharis macularius (Leopard gecko)
Pathway
emc00270
Cysteine and methionine metabolism
emc00480
Glutathione metabolism
emc01100
Metabolic pathways
emc01240
Biosynthesis of cofactors
emc04216
Ferroptosis
Module
emc_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
emc00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
129329935 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
129329935 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
129329935 (GCLC)
Enzymes [BR:
emc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
129329935 (GCLC)
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Motif
Pfam:
GCS
Motif
Other DBs
NCBI-GeneID:
129329935
NCBI-ProteinID:
XP_054835668
UniProt:
A0AA97KZ44
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Position
1:complement(63103348..63133457)
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETQRHAEHVRKHGILQFLHIYRAVRERHKDVLKWGDEVEYMLVAFDH
EKKRAQLSLIGEEVLHTLQEKGERVNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
QDNMRKRRQEAASVLKENAALCTVTSFPRLGCPGFTIPESPPTPIEAGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPNDDGEAARAVKPDHVYMD
AMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAAAPFYRGYVTDIDCRWGV
ISASVDDRTREERGLEPLKNNRYRIDKSRYDSIDSYLSEGGEKYNDIDLTIDKEIYDHLV
SEGIDHLLAQHIAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSD
IGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAV
RQGMFYFRKDISKGGNAVVDGCGPAQNGTETDAEEYALMSIDTIINGKEGVFPGLIPILN
SYLENMEVDVDTRCSILNYLKLIKKRASGELMTAARWMREFIASHPDYKRDSVITDEINY
NLIWKCHQIAQEQVECPELLGVGFNKAKYTGTKTDAF
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctcctgtcgcagggctccccgctgagctgggaggagacgcagcggcacgcggag
cacgtgcgcaaacacggcatcctccagttcttgcacatctaccgggccgtgagggagagg
cacaaggatgtgctcaaatggggagacgaggtggaatacatgttggtagcttttgaccat
gagaagaagagagctcagttgtctctaattggagaagaagttcttcatactttgcaagaa
aagggtgaaagagtaaatcctaaccatccaactctgtggaggccagaatatggaagctat
atgattgaagggacacctggacagccttatggaggaaccatgtccgaatttaacactgtg
caagacaacatgagaaaacggcgccaggaagctgcttctgttctgaaagaaaatgcagct
ctttgcactgtcacatcttttccaagattaggatgtccaggatttacgataccagagagc
cccccaacacctattgaggcaggtgcatctaagtctctctttttcccagatgaagccatt
aacaaacaccccagatttagtaccttaacaagaaatattcggcacagaagaggagaaaaa
gtagtgataaatgtaccaatatttaaggacaagaatactccatcgccattcatagaaaca
ttccctaatgatgatggtgaagcagcaagagccgtcaagcctgaccatgtatatatggat
gctatggggtttggaatgggcaattgctgtcttcaggttacattccaggcatgcagcatt
tctgaagcaagatacctttatgatcaactagctaccatctgtcccattgtaatggcttta
agtgctgcggctccattctacagaggctatgtgaccgatattgattgccgttggggagta
atatctgcatcagtagatgacaggacacgagaagagaggggattagagccactgaagaac
aaccgttacagaattgataaatccagatacgattccatagatagttacctctctgagggt
ggcgaaaagtacaatgatattgatttgacaatagataaagaaatctacgaccacctagtc
agtgaaggcatagaccatcttttggcacaacatattgctcacttatttattcgagatcca
ttgactttatttgaagagaaaattcatctggatgatgcaaatgaatctgatcattttgag
aatattcaatcaacaaactggcagacaatgagatttaagccaccgcctccaaattcagat
attggatggagagttgagttcagaccaatggaggttcaattaacagactttgaaaattct
gcctatgttgtatttgtggtgctgctgaccagagtcattctttcatacaaactggatttt
ctgattcctttgtccaaggtggatgaaaacatgaaagtagctcagaaacgggatgctgtc
cggcagggcatgttttatttcaggaaagatattagtaaaggcggcaatgctgtagtggat
ggatgtggcccagctcagaatggaacagaaacagatgcagaagagtatgctctaatgagt
atcgatacaataatcaacgggaaggagggtgtgtttcctggtttaattccaattttaaat
tcttaccttgaaaacatggaagtggatgtggatacaagatgcagcattctaaactactta
aaactgataaagaagagagcgtcaggagaattgatgacagctgctcgatggatgagagag
ttcattgcaagccacccagactacaaacgtgatagtgtgatcacggatgaaataaactac
aacctgatttggaaatgccatcagattgcgcaagaacaagtagagtgtcctgaactgctt
ggggtgggctttaacaaagcaaaatacactgggactaaaaccgatgccttttga
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