Eublepharis macularius (Leopard gecko): 129345637 Help Entry 129345637         CDS       T09084                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism emc  Eublepharis macularius (Leopard gecko) Pathway emc04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:emc00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     129345637 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:emc03036]     129345637 (SYNE1) Chromosome and associated proteins [BR:emc03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     129345637 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH P53_C Motif Other DBs NCBI-GeneID:  129345637 NCBI-ProteinID:  XP_054858870 UniProt:  A0AA97KMW7 LinkDB All DBs Position 1:complement(130073752..130545572) Genome browser AA seq 8736 aa AA seqDB search MIVNDLFEDIKDGVVLIALLEVLSGQKLPCEQGRKMKRIHGVANIGVALKFLEGRRIKLV NINSTDIADGRPSIVLGLLWTIILYFQIEELTSNLPQLQSLSNSTSSVDSVVSSEATSPP SKRKVVSKVKGNAKKALLKWVQYTAAKQAGVEVKDFGQSWRSGVAFHSVIHAIRPELVDL EKLKTRSNRENLEEAFTIAESELGIPRLLDPEDVDVDKPDEKSVMTYVAQFLKLYPDLHN AASESQETDKEDRLIFRDLKIWVEQFERDLTRAQMMEVSLQEKYQSFKHFRVQYEMKKKH IEPAIQSVRKDGKLSLDQALVKQAWDRVSSRLLEWHLQLDKSLPAPLGSIGAWLYRAETA LREEILVQQAHEETANMIHRKLEQHKDVLKNVDGCKKTFQEIHRAQSVNGVPVPPEQLDD MAERFNFVASSSELHLLKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQNYM TVIENNKFFEQYEVTYQILKKAAEMYAKANGSVEEIESVVKFMNETTTQWRHLSVEVRSV RSMLEEVITNWDRYSSTVASLQAWLEDAEKMLNQPEHAKKDFFRHLPHWIQQHTAMNDAG NFLIETCDETISRDLKQQLLLLNGRWRELFMQVKQYARADELDRMQKEYLDGVAVLSAFT DEANRKLCFPLEVSFLNMKMFIQEMEDIKQKVPVMEAQYKMVTRTAQLITKEIPQEDINE MLSTMSGIKVHLSKINETCPILLYESQKMVPSLEELEKQITNFYESLEKVNEIISVLDPQ VQPADVFKQQHQDLVAYQENCKKALSLIERNSQSIVKFVASSKALQHLNLSVIRKKVTEI QAAFQNMVKKTNDWKKNVEANSRLLKKFEESRSELENVLQIAYCCLKESGNPEELLRKHT EFFSQLDQRVLNAFLKACDELTDILPEQEQHSLQEAVRKLHKQWKDLQSEAPYHLLRLKI EVEKNKFLGTVQECYGELARQQELVAKESSEKIIREHKLSFGDKGPLQLCEKRLLLIEEF CLKLPEWDPLKATFESCKNSLGELKSQVANAYMKLIDHPDKWKDYKNRFSELESWISSRE TQLRKIKYSATDAAKYKHYKTSAQEIRQEACKQEEIITWLKSRLSALSEISSEDAVKKQG DELSKLSSDFKRLLSLLTETEKTLVAVSDCVQYTEEVKDNLEELITNSKEVQEEAEKILD TGSLLQTQQLLQHHLQKTKRLQTKRQDVQQQIARGKQLQIEGGLSPTVQEDLWMLESTLE NMQQSMDKRGNQLQTTVNTWEQFERDKETVVKYLSQASSALERILHFSSLESLSSELEKT KELSRQTVAMAMEAENLVKKSFAIQLGAKSKQSLQQQAKSIQEQVKNVEATLEEDIKTME MVKNKWDHFGKKFEALSIWITEKEKELDTLETSSSSLDMQINQIKVIFKELDGKKNEIPS LEEDTPSFSQYLTSGESAHIKAKLTQIRRYWEELRDRAQHLEETIAGKALIQQKYEEKFT KIQQDLCIYESKLAEPDIICSSSAETHKALQLHMDLSQALEKMKQTLASLSSSGRKITNK ENAVQDVLILQQRHENIMSQVKDKQASLETHLAQWQKQEKDLSTFLAWLERCEAAAKPSE QYVSADRVKLESELQLLRDLQTDIASHVSLYNSLLLLSESLFKSSSKERAEIMKEDLGKL DRRWKVLPQEVGKRISLLQAAVAEHRQFDDLLLSFSDWIKQFLGKLHATSEINTADQQPA ICHNKDHEAEVKNKYKDLKRLRSHVEKLCSFSWPEDHSLFQNKAEDCLQLYQEASQVISR RQELLPHLKVFLELRAAASKVLSRLRQMVETTRNIDKSKSKMLKKELSEVIQDVSKLEST ASTLDASLTKAQYHLKHDGSEQRTSCRNIADNLSIELESVQSLLGTKQNEAEALAALHKS VMEHKEQLLKSIEGIEERADKEGLKEPSLQEIQQRLRVFNQLDDELNSHQHELKWLMSKA KQIVQKDINLAPEVDKEINCLELTWEDTKKLILEKQEQCCILIDLMREYQSLKSIVTKAI EVSSNVTMIKTILKDQEDVKWSLSKHEAARNELNDRQKELDTFTSKGKHLLAELKKIPNC EPGPLKTDMDNTVDKWLDVSEKLDDNIDKLTVSVSLWEDVLAIGDDIDSWCSNSVSQLND IINNLTSCEGTEAFLEEFQAQIKHKEQNLEQLSPKICELKELVNTVQLPTNLQFLEADLR KKLMHTKEMSEIAKETVKDFSTQKIQLQNFINQMEDWLAKMEESLFGCAHSQDPLGLSTI KKIQKELQQQQSNFDSTQETLNSLCRKYPSMELATLGSAVTSLIKKYDAVNQISLKAQNS MQESLEKHFLSSMGEFQNWYSNLKTAVKDLHITSGDSKSIDIKLHELKKVLDSVDDGRKK LEAASQKGEHLYAYLPKSSVSGIQEQIAKAHQDFEGFLKQCLKDKQVLEECVAELESFKN LCKNQSLWLREMEERISTEALGKTKQHIPDKKNEVRKVEAFLEELLAARESFDKFSQKTQ VLNEKGCSAGRESRLAAQYFAAYQTLVKAVKEKLRASRVAFQEHQAFEEALLNMWTWVKD VQEKLVSAEGTSGNKITLEKRLLQIQDIILMKGEGEVKLNMAFGKGEQALKSSNEEGQKM IRNQLQTLKDEWSSIIRTSLSYQSLLESVINQWNDYLERKDQLDQWLESVEYKVEQPLEL QNGLKEKFLQLDYFQAILSEIEDHSKDLHQLIEKTRELHEKTEDDSFKEAAEEELKTQLS DMTMVVKEKMRKAEDIVKDHLLYLDAVHEFTDWLHSAKEELHRWSDASGDSSAIQKKVTK IKELIDSRQTGESRLSRVQTLAPVVKKSTTVQGRKHIDTEMQALQSDWKQWEESVCQTRN GLEELVSQMALSEQEFTTQAAQLEEALQRFSTLLATWSERLTPLDSKHTDKEIVECWHQE KEMLDALTKAEDMSDNIKIQLNDLCRFSKDLSIYSEKVSQLIKEYNSLCLQASKGCQSKE QALQQRFRTVFRDFQQWLVSSKITTAKCFDVPQSVNEAAANLQKIQEFLGETENGQHKLN MVVSKGELLSSILLKEKAKSIQAKVATAKEDWKKFISTLHQKESVLENLKIQMRDFEASS EPLQDWLTETRKMVQESSNRLHDLPAKKREQQKLQSVLEEIRCHEPQLNRLKEKAQQLWE EQAASKTFIHRVSQLSSQYLALSNITKEKVSRMDRIVAEHQQFSHGLKELQDWMTDAIQM LESYCHPTADKSVLDSRMAKLEGLFSVKQEKEIQMKMVLTRGESVLQNTSQEGMSVIEQQ LTTLKDMWSSLLSACIHCKSQLEGALSKWTSYQDDVRQFTSWMDKVEAVMNSSERQSAEL REKNASLSRAKLLKEEVFSHSVLLDKIEVKGMSMTEHYVTQLELQDLQERYQFLKDRIME AITKAEEFVHLHHEYQRNLKAFETWLEKEQEKLSSLSHLEGDAERHEATLRELQELQVHC AEGQALLNTALHFRDEVIPCGIPQLDDRLLESVRQDWTIYQQKLSEVRTQLNTTLSKLRL MEDKFLKVDNWLRTLEEKVNFRTSRQSDRATKEMQLQQMKKWHEEIIVYKDEVEEVGLLA QQILEESRTSSRMGRQATHLTSRYQALILHVLEQIKLIEEEIRSMEESELAFSAYQNWFG ATLRNFRKVATKSDVVDKAAMEKKMQKLEDLMNDMDVGKNLLKSAREKGERAIKYIDGDE AEQLKKEISDCVEKLEEITSSIRKEHTTLAKCLHLTKEFLDKYKAQTQWLSECQIMFHTP VDSKMELYEKKAQLSKYKSFQQMVLSHEPSIKSVTEKGECLLELVHDVNLAENIQKLQTE YQELCNTTKARVASLEVKVKQHEVYNSNLQDVEKWLLQMSTRLVTPDLMENSNLEVITQQ LANHKAVMEEIAGFEDRLNGLKRKGDLLINECADHLQAKFKQNIETQQQGTRDSYSAICS TAQRVYQSLEHELQKHVNHQDTLQQCQAWFSAVQPELKPSPRPPFSLADAIKQVKHFRGL QEQANTYLDLLCSMCDLSDSTVKNTVTDIQLTKQTIEDRIMNSQYLAQGWEEVKQMKAEL WIYLQDAEQQLQNMKKRGAELELNIAQNMVLQVKEFSQKLQFKQAALTAVTEKVSKLTQG QESPEHKEVGHLSTNWLELCLETNNVLLQREEDLQRTRSYHDRINVVEVFLEKFTQEWDN LARSDAESTVTHLEALKKLAQTLQERQFALEELKDHKQKVMEHLNLDDRELVKEQSGHFE MRWVQLEDLIKRKIQLSVTTLEELGVMQAKLQELMEWAEEQQPSICEALKHSPPPDLAQN FLMDHLTICSEVEAKQLVLKALIKDVDRLMTNLGLDERQMLKKCLSDAQSHVDCLSNLVG QRRKHLNKALSERTQFFLATFQAINHLQQHEKKVMFHEFICLLPEDVSKQIRTCKSIQAS LKSFQSEFTGLWSQGRDLMKDTTEQEKSEVLNKLQELQNTYEGVLQKCSQRLVELEKHIV SRKYFKEDLDKVCHWLKQADIVSFPEISLMNSNAELYSQLAKYQQILDQFPEYENLLLTL QKDGQEILPSLNEMDRSYLDEKLSILPQQFNTVIIMAKDKFCKVQEAIFARKEYVSLIEL TTKALSELEDQLINMRKTPSTLLPQEAISLQQDYRAILSEVMNLGAAVDELNHKREVFRS TGQPWQPEEMLLLTTLHHKLKRQIDQKVNQLEDMIEAYQEHEVMCNQFEMQLNSVKEEQA KVNEETLPVEEKLKIYHALAGSLQDSGILLKRIAEHLETLCSQLDSSVHDRANQQVRDWQ EMLETLHTDIGNTVAECENRLVQSIDFQTEICRSLDWLRHIKVELSDPSSFNLKLHNIQE EIRKVQIQQEEVQSRLRIMTALSNNEKEKYIKAKELIPADLEHSLAELSELDGEVQEAIH KKQDKLNKLYSLCQRFYQVAQTTSDWLEDAQELLQLAENGLDMENSEENLRNHIEFFDTE EQFQSHLEELRVLVFKMESFVQATGIEELIQSIEALEEKGMGAKEEGQSQKELLERCAFQ WQEYQTVRQEVIELMNDAEQKLSGFSTAKATSSLEAEEKLESHKSLVSTVNSFHETITSL EEKACQLEKICNDASKATISRSMTTVWQRWTRLRSVAQEQERILEESMQKWNVFNDKMQK ATNIVDQLQDRLPESSIEKASKSELVDLLDYHSNFIQELEQQLSSLGLLKQYACSMLQDI EMASGSEEQMSIMQEIKAMQDRCHNMQQKVKRSGKVVKEELKEREEVEREINKVKFWIQD AKEYLLNPATEVDAQLKDLQGLLTEATVHRQAVEKMAEQQQNKYLGLYTILPSELSLQLA EAGLALVNIHEQIQAKEKESQHSKKLNQEFGRKIQELAKQLNSILFKLKEKTDNIPQAKT DQRVLGEELDRCNIELVELDAAIQDFSEQNLHLAKQLVGQINKLTGLHQQTVRQAEYRAS KLSQASSHLDEYNEMLEFILKWIEKAKILVHGNITWNTATQLHDQFVSHQAMLEESGEIH GDIEAMNERIEYLASVYTTEKMCQQVSELGRQTDELQQVIKARLQNVQDAAKDMKKFETE VKALQIALEQAQISLTSTETGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVCQSALRIPE EVVTSLPICHTALRLQENTSHLQHTAIQQCNIMQEAVVQYEQYEKEMKHLEQLIETAHRE IQDKPIATSNIEELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE VEGLSEGMEELDSEELLPTHSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSAEQLQTEASKIQPSTSSTQESYEPGLESVTSAKLDD LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMETTEVKLNESLETGKSPESQ MAEHQALMDEILMLQDEISELQTSLAEELVSEPLDTNAADQLALQSTLTVLAERMATIKM KASGKRQLLEEKLNEQLEEQRQVQALQRYRCEADELDDWLLNIRATLDSTLATAQDPMDM DSQLIDCQNMLVEIEQKVVALSELSVHNENLLMEGKAHTKDEAEQLAIKLRTLKGSLLEL QRVLHDKQSNIQQGTLQEKEECESDSITSQSPSVQEWLAQARTTRSQQQQNSQQRQKELE KELAEQKNLLRSVASHGEEILIQHSSLDNICPSKKPDMLTQELSLEGEKPSAEDQMKMKW ESLYQEFSIKQKLLQNALEQEQEQPLYSRPNRLVSGMMLFKGGKQEQDKPSAVSLWVGLN EAFEDVSCQAGGAAKESLQIEQKLYSGVSAASSWLDSVEEHLFVATGAVSEVTEACLCNQ ENLAKDIKEMAEKMDENKHLFSQMFPENADNKNVIEDILDCLLQRLILLENVINQRCQQL KGRFKKILNFQNDLKLMFTSLMDNKYIVLQKLAKAIEQPETEQMQAIQQAEDGLKELDAA ISELRKRGDKLQIDQLSMQELSKLQDMYDELIKIIGSRRSGLNQNLALKGQYKQALQDLA DLIETGKEKMAVDQKMIVSSREEVQTLLDKHKEYFQGLESHMIVTETLFRKISSFALVKE TQSHVELMAQASAVLKQAHKRGVEMEYILETWIHLDKDFQELTRQLETVETSIPTVGLVE ESEEGLADRIALYQHLKSSLTEYQPKLYQVLDDGKRLLVSVTCSELETQLNQLGEHWLSK TSKVTKELHRLETILKHWTRYQSESAELIHWLQSAMDRLDFWTQQSVTVPQELEMVRDHL NAFLEFSKEVDAKSSQKSAVLSTGNQLLRLKKVDTAALRAGLSQIDNQWTELLTQIPIVQ EKLHQLQMDKLPSRHAITEVMSWISLMENIISEDEENIKNVVGHKVIHDYLQKYKGFKID INCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGVMNRRWQVLQALITEKIQLLEG FLESWTEYENNVQCLKTWFETQEKRLKKQQRIGDQASVQNALKDCQELEELIKSKEKEVE KIEQSGLLLIQNKKEIVSAVVMNTLQELNHSWANLDHMVGQLKILLQSVLDLWSIHKAAY EELNSYLMEARYSLSRFHLLTGSLEAVKVQVYNLQKLQDELEKQEHSLQKFGSVTNQLLK ECHSPVTETLNNTLKEVNMRWNNLLEEIVERLHSSKALLQLWQKYKTYYMQCCSTVQQYE DRTNELLKVASSKDIGDDEVTAWVHDCNDLLKGMKTVKDALFVLYELGEQLNQQVDSSAA AAVQSSQRSLSQNLSALEQALSRQQSILQAGAQDYQTFTKSLKGLEDWIKQAEEILKTKD PTHSSDPSTIQNRMEELKRQMLKFSSMASDLDRLNELGYRLPLNDKEIKRMQNLNRHWSM ISSQSTERFSKLQSFMLQQQTFLEKCETWMEFLVQTEQKLATEISGSYQLLLEQQRAHEL FQAEMFSRQQILHSIIVDGQHLLEQGQVDDRVEFNLKLALLSNQWQGVIRRAQQRRGIID SQIHQWQRYRDMAEKLRKWLVEVSSQTVCGLDNFPIPLQQAKVLLDEMQFKEKGLLRQQG SYILTVEGGKQLLLCADGETEAALQTELTEIQERWKLTNLRLEEQKKQLTFLLKDWEKCE KGIADSQEKLKAFKKKLSQPLPDHHDELHTEQIRCKELESAAEGWTDDLAHLSLLKENLS AYISADDILVLNERIELLHRQWEELCHQVSLRQQQVNERLNEWAVFNEKNKELCEWLTQM ESKVSQNGDILIEEMIEKLKKDYQDEIAVAQENKIQLQQMGERLAKASHESKALEIEYKL GKVNDRWQHLLDLIAARMKKLKETLVAVQQLDKNMSILRAWLAHIESELSKPIVYETCDS EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATETECDSIQQATRNLDRR WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSSSGVLYTVAKEEL KKFEAFQRQVHESLTQLELINKQYRRLARENRTDFSCSLKQMVHEGNQRWDNLQKRVTSI LRRLKHFIGQREEFETARDNILVWLTEMDLQLTNIEHFSECDVQAKIKQLRAFQQEISLN SNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLTDDE HDLSDREVDLDESTDLSDIHWQDKSADSILSPHPSSNLSLSLPQPLRSERSGRDTPASVD SIPLEWDHDYDLSRDLETAVSRALQSEEEEEGQSYLRGAASVTGEPSSLEKHIRQLDKAL DTSRFQIQQTENIIRSKTPTGPELDSSYKGYMKLLGECSGSIDSVRRLEHKLKEEEEKLS GFINLNSTETQTAGVIDRWELIQAQALSKELRMKQNLQQWQQFSSDLNNIWIWLGKTEEE LEQLNCLDLSTDIQTIELQIKKLKELQKAVDNRKAIILSINLCSSEFMQSDSEENKKLQE RLSQMNMRWDHVCTMLEEWRCSLQNALMQCQDFHEMSHGLLLWLENIDRRKNEILPISPN LDSDTLQDHHRLLMQIRRELLESQLKVASLQDMSCQLLVNAEGKDCLEAKEKVHVIGNKL KLLLKEVTHHIKDLEKTLDISSSQLDLSSWSSVDELDTSGSLSPVSGRSTPSRQRTPRGK CSVSQPGPSVSSPHSRSARGGSDSSRSESQPPRQQHPCFLLRVLRAALPLQLLLLFLIGL ACLVPMTEEDYSCAMANNFARSFHPMLRYTNGPPPL NT seq 26211 nt NT seq  +upstreamnt  +downstreamnt atgatagtcaatgatctatttgaagatatcaaagatggagtagtattgattgcccttttg gaggttctctcaggacaaaaattgccttgtgaacaggggcgtaaaatgaagagaattcat ggagtagccaacattggtgtagcccttaagttcctggaaggacgacggattaagcttgta aacattaactcaactgacattgcggatggtagaccatctattgtgcttggattgttgtgg actatcattttgtattttcagattgaggaacttacaagcaacctcccacagctgcagtca ttatccaacagtacctcatctgtggacagtgttgtcagttcagaggctaccagtccacca tctaagcgaaaggtggtatccaaagtcaaagggaatgcaaagaaggcattgctaaaatgg gttcaatacacagcagcaaagcaagctggcgttgaagtcaaggattttggacaaagctgg aggagtggtgtcgcgtttcattcagttattcatgctattcgtccagaattagtggatttg gaaaagctgaaaacaagatcaaacagggaaaatctggaagaagcctttacaattgcagag tcagaactgggaatcccaagacttcttgatcctgaagatgtggatgtggataagccagat gaaaaatctgtcatgacctatgtggcacagttcctgaaactctaccctgatcttcataat gcagctagtgaatcacaagagactgacaaagaggacagactaatattccgagacctgaaa atctgggtagaacaatttgaaagggacttgacaagagctcaaatgatggaagtaagcttg caagagaaataccagtcatttaaacattttagagttcaatatgaaatgaagaagaaacac attgaacctgcgatccagtctgtaaggaaggatggcaaactgtcacttgatcaagcattg gtgaagcaggcatgggacagagtttcttcccggttattagaatggcacctgcaacttgat aaatctcttcctgctcctttgggctctattggtgcctggctttatagggcagagactgct cttcgagaagaaatccttgtccagcaagctcatgaggaaacggccaatatgatacatagg aagcttgaacagcataaggatgtgcttaaaaatgtagatggctgcaaaaaaacgttccag gagatccacagagctcaatctgtcaatggagttcctgttccaccagagcagctagatgat atggcagagaggtttaattttgttgcctcttcatctgagcttcatctgctgaaaatggag ttcttggaattgaagtaccgtctgctatcgctcttggttctagcagagtcaaaattaaaa tcatggattattaaatatggaagaagggaatctgttgaacttctgcttcaaaactatatg actgttatagaaaataacaaattttttgagcagtatgaagttacataccaaatcctgaag aaggcagctgagatgtatgccaaagctaatggctcagtggaagaaatagagtctgtggtg aagttcatgaatgagacaaccacacagtggaggcacttgtcagtagaggtgagaagcgtg aggagcatgttagaggaagtcatcaccaactgggatcgctacagcagcacagtggctagt ctgcaggcttggctggaggatgctgaaaaaatgctgaatcaacctgaacatgccaaaaag gatttcttccggcatttacctcattggatacaacagcacactgctatgaatgatgctggg aattttctgattgagacttgtgatgaaaccatttccagagatttaaaacaacagcttcta ctgctcaatggacggtggagggaattatttatgcaagttaagcaatatgctcgagcagat gaattagacagaatgcagaaggaatatttggatggtgttgctgtcttgtctgcttttact gacgaagcaaataggaaactctgtttccctttagaagtgtcctttttaaacatgaagatg tttatccaagaaatggaggatattaaacaaaaagtgcctgtgatggaagctcagtacaag atggttacaagaacagcacaacttataactaaggaaattcctcaagaagacatcaatgaa atgctttcaaccatgtcaggaattaaagtacatctcagcaagattaatgagacctgccct attctgctgtatgaatctcaaaaaatggttccttcccttgaagaattggagaagcaaatc acaaacttttatgaatctcttgaaaaagtcaatgaaattatttccgtcttagatcctcaa gtacagcctgcagatgtttttaaacagcaacatcaggatctagtagcttatcaagaaaat tgcaaaaaggctttgtcactaattgagagaaatagtcagagcattgtgaagtttgtggcc tcaagtaaggcattacaacacctcaatttgtcagtgattcgaaaaaaagtcacagaaatt caagctgcttttcagaatatggtcaagaagacaaatgactggaagaaaaatgttgaggca aatagccgtttgctgaagaaatttgaagaatctagatcagaattagaaaatgtgctacag attgcatattgttgtctgaaggaaagtggtaatcctgaagaacttctcaggaaacatact gagtttttcagccagttggaccagagggtgctaaatgctttcctgaaagcttgtgatgaa cttactgacatccttcctgagcaagaacaacacagtctccaggaagctgttaggaagcta cataaacaatggaaggatctccagtcagaagcaccataccatttacttcgcttaaagatt gaagtggaaaagaacaaattcctaggaacagtgcaagaatgttatggtgaattagctcga cagcaagagctggtggccaaggagagcagtgagaagataattagagagcacaagttgtcc tttggtgataaaggacccttacagctatgcgagaagagactactcctgattgaagagttt tgcttgaaactaccggaatgggatccccttaaagcaacctttgaaagttgcaagaattcc cttggtgaacttaaatcccaggttgccaatgcctatatgaagctaatagaccacccagat aaatggaaagactacaaaaataggttttctgaattagaaagttggatttcatcaagggaa acccagcttaggaagattaagtacagtgccactgatgctgcaaaatataagcactataaa acatcagcacaggaaatcaggcaagaagcttgcaagcaagaagaaattatcacttggttg aaatctaggctttcagctctgtctgagatttcttctgaggatgcagtaaaaaaacaaggg gatgaactttctaaactttctagtgatttcaagaggctcttaagtttgttgacagagact gagaagacattggttgctgtcagtgattgtgtccagtacacagaagaagtgaaagacaac ttggaagaactaatcacaaactcgaaagaagttcaggaagaggctgagaaaatcttagat acaggaagtttgctacaaactcagcaacttcttcaacatcatttgcaaaagacaaagagg ctccagacaaagaggcaagatgtgcagcaacaaattgcccgaggtaagcagctacagatt gaaggtggtctgtctcccactgtgcaagaagatttatggatgctggaaagcacattagaa aacatgcagcaatctatggataaacgtggcaatcaactgcagaccactgtaaacacgtgg gagcagtttgaaagagataaagaaactgttgtaaagtatcttagtcaagcgagttctgca cttgaacgcatcttacattttagcagcttagagagtttgtcatcagaattggaaaaaaca aaagaactttctaggcagacagtggctatggcaatggaagctgagaatcttgtcaagaaa tcctttgcaatacagcttggtgcaaagagcaagcaaagccttcagcaacaagccaagtca atccaggaacaagttaaaaatgtggaagctacccttgaagaagatattaaaaccatggaa atggtgaaaaacaagtgggatcattttggcaaaaaatttgaagctttgtccatctggatc actgaaaaagaaaaagagctggataccttggaaacatcctcatcttccttggatatgcaa atcaaccaaattaaggttatttttaaggaactagatggcaagaaaaatgaaatcccaagt cttgaagaggatactccctcattttctcaatatcttacctctggagaatcagctcatata aaagccaagctgacacagatcagaaggtactgggaagaactcagagatcgtgcacagcat cttgaagaaacaattgcagggaaagcattgatacagcaaaaatatgaagaaaaattcaca aagattcaacaggacctgtgtatatatgaatccaaactggcagagccagatattatatgc tcttcatcagcagaaactcacaaagctcttcagcttcatatggatctctctcaggccctg gaaaaaatgaaacaaacattggcttctctgtcatctagtgggcgcaaaattacaaacaag gaaaatgcagttcaggatgttttaatactacagcaaagacatgaaaacattatgagccaa gttaaagataaacaagcctcactagagactcacctagcgcagtggcagaaacaggagaag gatctgtctaccttcctggcatggttagaaaggtgtgaggctgcagccaaaccttcagaa caatatgtttctgctgacagagtcaaactggaaagtgaactgcagctactcagagattta caaaccgatattgcatcccatgtatcattgtataacagcctattgctgttaagtgagtca ctgtttaagtcaagttccaaagaacgtgcagaaataatgaaagaagatttgggaaagcta gacagaagatggaaagttctacctcaggaagttggcaaaagaatcagtttgctccaagct gcagttgctgaacacaggcagtttgatgatctcctcctaagtttttctgactggattaag caattccttggtaaactccatgctacgtctgagataaatacagctgatcaacagccagct atatgtcacaacaaggatcatgaagcggaagtgaaaaataagtataaagacctaaagaga ctgaggagtcatgttgaaaagctgtgctctttcagttggccggaggaccatagtctgttc cagaataaggctgaagactgtctccagctttaccaagaggccagtcaagtaattagtcga aggcaagagcttctgccccatctcaaggtcttcctagagcttcgtgctgctgcatcaaag gtactctcccgcttgagacagatggtagaaaccactagaaatatagacaagtctaaatct 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aaagcttcagggaaacgccagctgctagaggagaagctaaatgagcaattagaagaacag cggcaagtacaagctctacaaagatatcgttgtgaagcagatgagcttgatgactggctc ctcaatataagagccacactagacagcaccttggctactgctcaagatcctatggacatg gattctcagctgattgattgccagaacatgcttgtggaaattgaacagaaggtggtggct ttgtctgaactgtcggttcacaacgaaaaccttctcatggaaggaaaagctcataccaag gatgaggctgagcagctggcaataaagctgagaaccctaaagggaagtcttttggagttg cagagagtcctccatgacaagcagagcaacatccaacagggaactctgcaggaaaaggaa gagtgtgaatccgattcaatcacctcccaaagtcctagtgtccaagaatggttggcacag gcacggacaacccgttcacagcaacagcaaaacagccagcagagacagaaggagctggag aaagagctggcagagcaaaagaacctacttcgatcggtggcaagtcatggagaagaaatc cttatccagcattcttctcttgataacatttgtcccagcaagaagccagatatgttaaca caagagctgagcttagaaggagagaaaccatcagctgaagatcaaatgaaaatgaagtgg gaaagtctttatcaagaattcagtattaagcaaaaattgctgcaaaatgctctggaacaa gagcaggagcagccgctttacagtagaccaaacagacttgtttctggcatgatgctgttc aaaggaggaaaacaagagcaagataagccatcagctgtatctttatgggttggtttgaat gaagcttttgaagatgtatcatgccaggctggaggagcagcaaaagagagcctgcagatt gaacagaagctgtacagtggtgtttcagctgcctcttcctggctagatagtgttgaagaa catttatttgttgccacaggtgcagtttctgaagtgactgaagcttgcctctgtaatcag gagaaccttgctaaagatatcaaggaaatggcagaaaaaatggatgaaaacaagcattta ttttctcaaatgtttcctgagaatgctgataacaaaaatgttatagaagatatattggat tgcttgctacagagactaatattactggagaatgtgataaaccaaaggtgccagcagttg aaaggaagattcaaaaaaatacttaattttcagaatgacctgaagttgatgtttacatcc ctgatggataacaagtatattgtcctgcagaagctagctaaagccattgaacagcctgaa acagaacaaatgcaggctattcagcaagcagaagatggactaaaagagctagatgcagca atcagtgaattaaggaaacgtggagataagctacagatagatcaactttccatgcaagag ttatcaaaactacaggatatgtatgatgagttgataaagatcataggatcccgacgtagt ggactgaatcagaatctagcccttaagggtcagtataaacaagcgttgcaggacctagct gacctcattgagactggcaaagaaaagatggcagttgaccaaaaaatgattgtttcctct agagaggaagtccaaacacttctcgacaagcataaggaatatttccagggactggagtca cacatgatcgtgacagaaacactttttaggaagataagcagttttgctcttgtaaaggaa actcagtcccatgtagaactgatggcacaagcctctgcggtgttaaaacaggctcataag aggggagtggagatggaatatattttagagacctggatacatcttgataaggacttccaa gaactcacaagacagctggagactgtagaaactagcattcctactgttggattggtagag gagtctgaagaaggacttgctgatcggattgcactttatcagcatttgaaatctagcctt acagagtaccagcccaaactttaccaggtattggatgatgggaaaagactattggtttct gtcacctgttcagaattggaaactcagctaaaccaactaggggagcactggttaagtaaa accagcaaagtcaccaaggaactacatagattggaaactatccttaaacactggacaaga taccaaagtgaatcggctgagctaattcattggctgcaatcagcaatggatcggctagat ttctggacccagcaatcagttacagtccctcaagaactggaaatggtccgagatcatttg aatgcttttttggaattttcaaaagaggttgatgccaagtcatcccagaagtctgctgtt ttgagcacgggaaaccaactcctccgtctgaagaaagtggatactgcagctctgcgtgca ggactgtctcagattgacaaccaatggactgagcttctgacacagattcctatagtgcaa gaaaaactgcatcagctccagatggacaaacttccttctcgccatgcaatcacagaagtc atgagttggatttcactgatggaaaacatcattagtgaagatgaggaaaatattaaaaat gtagtagggcataaagttattcatgattatcttcagaaatataagggtttcaaaatcgat ataaactgtaaacagttaactgtggactttgttaaccagtcagtactacaaattagcagt caggatgtggaaagtaaacgcagtgacaagactgattttgcggaacaacttggagtgatg aatagacgctggcaggttctgcaggctctgataacagaaaaaatccagctcttagaaggt tttctggaatcctggacagaatatgaaaataatgttcaatgtctaaaaacttggtttgaa actcaggagaagagactgaagaaacagcaaagaattggagatcaggcttcagtccagaat gccttaaaagactgtcaggagctggaagagctaataaagtcaaaggagaaagaagttgaa aaaatagaacagagcggacttttgttgatacaaaataaaaaagaaattgtctcagctgtg gtcatgaacacacttcaagaactcaatcattcctgggcaaatttggaccacatggttggc caactgaagatattgttgcagtcggtccttgatctgtggagcattcacaaagcagcttat gaagaactgaatagctacttgatggaagccagatattctctgtcacgcttccatcttctt acaggttctttggaagcagtgaaagtccaagtatataaccttcagaagttgcaggatgaa ttggaaaaacaagagcatagtctacagaaatttggatctgtgaccaatcagctactgaaa gagtgtcattcacctgttacagaaacacttaacaacactttaaaagaagtaaacatgagg tggaacaaccttctggaagagattgtagagcggctgcattctagtaaagctctgcttcag ctctggcagaagtataaaacctattacatgcagtgctgtagcacagtccagcagtatgag gatcgaacaaatgaacttttgaaagttgcatccagcaaggatattggtgatgatgaagtc actgcttgggttcatgactgcaatgacctacttaaaggcatgaagacagtgaaagacgct ctctttgtcctatatgaactgggagaacagctgaaccaacaggtggactcttctgctgca gcagctgtccagtctagtcagcgctctttgagccagaacctgtctgctttagaacaggct ctcagcaggcagcaatctatattacaggctggagcacaagattatcagacatttactaaa agtttaaaagggctggaggactggataaagcaagctgaagaaatactgaaaacaaaagac ccaactcattcatcagatccatccacaatccagaacaggatggaagaacttaaacgccaa atgttaaagttcagcagtatggcatcagacttggatcgtctaaatgagcttggatatcgg ctacccttgaatgataaagaaattaaaagaatgcaaaatttgaatagacattggtccatg atctcatcacagtccacagaaagattcagtaagctacagtccttcatgctgcagcaacag accttcctagaaaaatgtgaaacctggatggaatttttggttcagactgaacagaaattg gctacagagatttcaggaagctaccagcttcttctggaacagcagagggcacatgagcta ttccaggcagagatgtttagtcgccagcagattttacattccatcattgtggatggtcag catcttctcgagcaaggacaggtggatgacagggttgaatttaatctgaaactggccctt ctcagtaaccaatggcagggagtgattcgcagagctcagcagaggaggggtatcattgac agtcagatccaccaatggcaacgctacagagacatggcagagaaactgcgcaaatggcta gtggaagtatctagtcagactgtgtgtgggctagacaattttcccatcccactgcagcaa gctaaagtgctgttggatgaaatgcagtttaaagaaaaaggtcttcttcgtcaacaaggc agctacattttaaccgtagaaggagggaaacagctattactgtgtgcagatggtgagaca gaagcagccctacagactgaacttacagaaatccaggagcgctggaaattgaccaacctc cgacttgaagaacagaagaaacagcttacattcttgttaaaagattgggaaaaatgtgaa aagggcattgcagattcccaggaaaaactaaaagccttcaagaagaaactctctcaaccc ttgccagaccatcatgatgaacttcatacagaacagattcgttgcaaggagctggagagt gctgccgagggatggacagatgatcttgcccacttgtctttgttaaaggagaacttgtct gcttacatcagcgcagatgatatcttggttctcaacgagcgcattgagcttctgcacaga cagtgggaagagctgtgtcaccaggtttccttgagacagcagcaagtgaacgagagacta aacgagtgggcagtcttcaatgagaagaacaaagagctctgtgagtggttgacacagatg gagagcaaagtgtcccagaatggagatatcctcattgaggaaatgatagaaaaacttaaa aaggattatcaagatgaaattgcagttgcccaagagaataaaatccagctccagcaaatg ggagaacgacttgctaaagcaagccatgaaagcaaagctttggagattgagtataaactt ggcaaggtcaatgacagatggcagcatcttctagatctcattgcagccaggatgaagaaa ctaaaggaaaccctggttgcagtccaacagttggataagaacatgagcatcctgagagct tggcttgcccacattgagtcagagctgtccaaacccattgtctatgaaacctgtgactcc gaggagattcaaaggaaactaaatgaacagcaggaactacaaagagacatagagaagcat agcactggagttgcatctgtcctcaacctttgtgaagtcctcctccatgactgcgatgct tgtgctacagaaacagaatgtgactccatccagcaggccacacggaatctggaccgaagg tggcgaaatatctgtgctatgtcaatggaaaggcgactcaagattgaagagacatggcga ctgtggcagaagttcttggatgactattctcgttttgaagattggctgaaaatttctgaa aggacagctgctttccctagttcttctggtgtcctgtacacagttgctaaggaagaacta aaaaaatttgaggcttttcagcgacaagtacatgaaagtctgactcagctagaactgatt aacaaacagtatcgccgtttggctcgagagaaccgtactgacttttcttgtagtctcaag cagatggtccatgaaggaaaccagagatgggacaacttacaaaagcgagtcacctcgatc ctccgcagacttaaacatttcattggccagcgtgaagagtttgagacagcacgtgacaac attctggtctggctaacagagatggacctacagttgaccaacattgaacatttctcagag tgtgatgttcaagcaaaaataaagcaactcagggcttttcaacaggagatctcactgaac agcaacaaaattgagcagatcattgcccagggtgagcagctgatagaaaaaagtgaaccc ctggatgcagcggtcatcgaagaagagcttgatgagcttcgacgatactgccaggaagtc tttggccgagtggaacgctatcataaaaaactaattcgtctccctcttacagatgatgaa catgacctctctgatcgtgaagtggatctggatgaatccacagatctctctgacatccac tggcaggacaaatctgcagatagcattctctccccacatccctcctccaacctctccttg tcccttccccagcccctccgaagtgaaaggtcaggacgggatactcctgctagtgtggac tccatccccttggaatgggatcatgactatgacctgagccgtgatttggagactgcagtg tcaagggcattacaatctgaagaagaagaggagggacaatcttatcttagaggagcagca agtgtcacaggagaaccaagttccttggaaaaacatatccggcagcttgacaaggcctta gacaccagtcgtttccaaatacagcaaactgaaaacattatacgcagtaaaacaccaaca ggaccagagctagattccagttataaaggatacatgaaacttcttggtgagtgcagtggg agtatagactcagtaagaaggcttgagcacaaattgaaagaagaagaggaaaaactgtct ggatttattaacctaaacagcacagagacacaaacagcaggtgtgattgatcgatgggag ttaatccaggcccaggccttaagtaaggaactaaggatgaagcagaatcttcagcagtgg cagcaattcagttctgatctaaacaacatctggatttggctaggaaaaactgaagaggag cttgaacagctgaattgccttgatctcagcacagatatacagacaattgagctccagatt aaaaaactaaaagagctacaaaaggctgttgataaccgcaaagccatcattttgtcaatc aacttgtgcagctcggaatttatgcagtctgatagtgaagaaaataagaagctacaggaa cggctatctcagatgaacatgcgctgggatcatgtatgcactatgttagaagagtggcgc tgttcactacagaatgctctgatgcaatgtcaggatttccatgagatgagccatggattg ctgctatggctggaaaatattgacaggaggaaaaatgagatcctgcctatcagtccaaac ttggattctgataccctgcaggatcatcacagactgctgatgcaaatccgacgtgagctg ttagaatcccagctgaaagtggcatctcttcaagatatgtcctgccaactcctagtcaat gctgaaggcaaggattgtctggaagccaaagagaaggtccatgtcattggaaacaaactt aaacttctcctgaaagaggtcacacatcacattaaggacttagagaaaacccttgatatt tcaagcagtcagctggacttgtcctcctggtcatcagtggatgagctggacacttcagga tctctcagtccagtatctggaaggagtactccaagcagacagagaacgccacgaggcaaa tgtagtgtatcacagcctggaccctctgtcagcagtccacatagcaggtcagcaagaggt ggctcagattcctcccgttctgagagccagccacctcggcagcagcacccgtgcttcctt ctcagagtcctcagagcagctctcccacttcagcttctcttgctattcttgattggtctt gcctgccttgtgccaatgacagaagaagactacagctgtgccatggccaataactttgca cgttcctttcaccccatgctaagatatactaatggtccaccacctttgtga

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