KEGG   Eucyclogobius newberryi (tidewater goby): 140351213
Entry
140351213         CDS       T10929                                 
Symbol
ryr2b
Name
(RefSeq) ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
eny  Eucyclogobius newberryi (tidewater goby)
Pathway
eny04020  Calcium signaling pathway
eny04260  Cardiac muscle contraction
eny04261  Adrenergic signaling in cardiomyocytes
eny04371  Apelin signaling pathway
Brite
Ion channels [BR:eny04040]
 Voltage-gated cation channels
  Ryanodine receptor
   140351213 (ryr2b)
Domain-containing proteins not elsewhere classified [BR:eny04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   140351213 (ryr2b)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 DUF7801
Other DBs
NCBI-GeneID: 140351213
NCBI-ProteinID: XP_072293061
LinkDB
Position
Unknown
AA seq 4881 aa
MTDTGDTDEEFQFLRLGDEVVLQSTFTCNSEPVKLCLSAEGFGSRRCCLEPTSNSKNVPP
DLSLCGFVLAQCLSVRALQEMLAHSEQISKKMGADGSHRTLLYGQALLFLHSYSGMYLSC
MFSSQSSTDKLAFDVGLQDNKTDETCWWIVHPASRQRSDGEKVRVGDDVILVNISSERYL
HLSTGAVSDNKYDNIVVSVAFQQSLWRLAPICSGGGVAQGFLRGGDTLRLLHSHSDACLT
VSSGELGQDFQRELHYETGPASNRACSLWRLEILQVVWSGSHTHWAQPFRLCHLTTGQYL
GFTGENGLHLVNRDNADIRTTAFCFRSTKEKLEPCPNTNVTGMGTAEIKYGDSTCFIQHV
YSGLWLTYSSDAKSTGSLSGHRKAILHSEGHMDDGLKLSRSQNEDSHTARLIRSAALLFN
FFFRKLDGQQELPSSSDIPLIKTVMCSVLDLIEFFKPPPDELDTEAKQKIVGELRKRQKM
FQEEGIINVVVECIDHLHQYSEVSCDAEAVQSEEIIKHFYKILAALIRGNCANCAQFSVS
LEWLVSKLEHHEASSGILEVLHFILLESPEAVHIIKEEHIQSIVSFLDRNGYNHKVLEVL
CCLCVCHGTAVRSNQNLISDSLLPYRDLLLQTRLVNQVISIRPNIFLSMEDSSAQHGKWY
YELVVDHVEHFVTPEPTHLRVGWASTQSYKPRPSGGDGWGGNGVGDDLSSFGFDGLHLWS
GSVGRRVNSPFPHLLKDNDVVSCCLDLSPPCISFRVNGLPVQGMLENFHTDGFLFPVVSL
SAGVRVRFLFGGKHGEFKFLPPPGFTQCCEALLPKTKLRVEQCQTYIFDHEDGTQLIGPT
AFSKPVVFIPNPTDISKTTLPLQLENIRRNMAEHFHELWVLDQIELGWTCGIVKDEEKKI
DPCLVEFSNLTDLERNQNIEMAETTLKTILALGFHILLSDEQAEERLKYITLSSKFELPN
GYKPAPLDLSGVSLSPTLEKLVDFLSENDHNVWAKEHIKQGWAYGAQQDVRAKRSPYLVP
FLQLDVGRRRVQRERVRDTVCILLLYGYSIQSFKKEWASSSTPCLVSAESYRVFRTDKSY
AVTDGKWYFEFEILTAGSMRVGWARPGCAPDRELGSDDQAFVFSGDEAQWYHQGGVPLGT
LPWHRGDVVGCMLDMTERTIKVALNGELLFNEKGSELVAKDFLIDDGLLPVVGLGVNQMG
KLNLGSEPDSLRYFSVCGLQEGYKPFAVDMSSDPSLWLTWWQPQFTSIKPDDTNLHITRM
SNLKDSVPSLRVSQRSFSHQNGRKETCFYRLNMSVECALVLSSPVRTIPPVAPSSLSPAR
KELEEMDSDFEVLMKSAHNFTGSRDELNHHKDHSQDKTSKLKQKFMLKRTKPGLVNSNSS
ARLLEDVLADIADKDNMSHLIQTSKYYYSVRVLPGQAPSCVWVGWVTADFHQSSTTFDID
KVNTVTVTLGDDSGKVQESARRCNCYMVCAGEANGLSQSRRSTGLEISCLVDTATGLLTF
TSSGIETTTFYQVEPSTKLFPAVFVKPTTNSMFQFELGNSKNVMPLSAGLFRSLRWDTTP
QCPERLQVQQLCQVSWTRVPDNALKVLVEQTENCHGWVVQCTESNQMMSLQIPDENRCID
ILELSEHDDLLMFHYHTLLLYSSLCALGNTRICHALCSQVDQSQMFYVLQNSRLPGLLRS
AFYQFLIQVHLSCHSSACLLTNREYILPMMDPACAIFLNPNTVNGSYIPRTLATTLKPQM
CFSTPSFVKTREDKSAQSEARTVFIDSPEIPLDQLKCVTVEMLSAAVSVVAHGLRDPAGG
SVELLLVPLVQLFYTQLVMGVFEDADLRRVLTLFLPQAFSDEEQLAKQKDNEEQILENDQ
NFGLLHMKLPEAVQFELCQVLSFLCDCQVRHRVEAIVAFSCNFVGQLQENQRFRYDEVMQ
ALHMSVALTARKTKEFRSPPQEQINMLISFKDKDTKCEDCPCPEEVQQLLKEFHHLLKQH
CGPELDRGSEDDEDAEISIKDQLCSLIFQACGARKSSTDETSSVQNPASFADLISKTTML
WASEAKIDDPDLVKAIFSLLHRQYQGVCGQMGEALSKTYTISQASAEDTTALLTSLCQIR
SLLRVRMGKQEEKLMTDKLGDIINNKVFYQHPNLMRALGMHETVMEVMVNVLGEGKTNEI
MFPKMVAGCCRFLCYFCRISRQNQGALFDHLSYLLEHSQVGLASPSMRGATPLDVAAASV
MDNYELALSLQECELQKVVNYLAHCGVQSCPMLVANGYPDIAWNPVEGERYLDFLRFTVF
CNGESVEENAYVVLKLLIHQPECFGPALRGEGGQGLLSAMEEAIRVSQDVSMDGPHAENH
FNQKNDIQDLDDDFVHMGHAIMTFYSSLIDLLGRCAPEMHLIQAGKGEAIRIRAILRSLI
PVQDLEGVISLPFQMPSISKDGEVDEPDLSAVFSPDHKASMVLFMARVYGIESQLFLLHL
LEFGFLPDLQAAVSLDTNDFGSSDMALSLNRYITTAMLPMLTKCSALLCDLEEHAPLLNS
FILALYSFSKAASLTKAQGDTTEQCLLALCSKLNPVLMQPLLQQLIFDIAHLSEHSKLEL
KLLTRHYEQQWKYYLQTGVGKDVFSEEEGHMSRKLFWTVFNVLEKMSYEPQLYKLGAQCL
TTVARSLPPDDMNPGFLTDRKATIDTDENFDPQPLDTSNVSVPERLESVLNKYAEHSHEK
WSLEMFTAGWVHGEQLCENAKVHPRLKPYRTLAEKDKEAYRCSIKETLKVMLAFGWTIDR
TKGGDVFGKRTCTRRISQSQLSFEGASTFSPKPMDMSSITLSWDQCAMLEQLAENHYNVW
AKKKKVHFQDKGGCHSPLVPYSSLSTKEKIRFREKAQDVLKFLLLNGFTVWREKRTDPHF
PATSNCFGFSLLQHFVYLIDVAQENILELEVMHVRGHTAKGDKASHLQTIRFFPKVVLPL
LEEYLKDHHLYFISSSFCSGTSIYASTKEKEIIVSIFCKLAALIRHRITLFGNEALTFTS
CLQVLAQSLDARTLLHGAKDFFFGSLHMFLDAAAADLEMTVENLHVTLAPLAQSRSQSAR
GVVGILSHTTLVLLPALTSLFKHLGNTKIGSDILVGSIQVSCYRILNSLYSLGTNSSIQK
EGPQSSAGACLAALSQTFPVSFLEPELNQNNPCSVYTTMSVTEIEELGLPEQVAEACPHL
PSLLQGLAEVEKVVMAGAAARQAHYMHITKVLLPMLCSYMSHWSQPSMSDFSSVTPALIS
DLLGHILCIIQNNVGDSRGGWTKQLAVFSQPIICQSSSKLLKMNFVPLMDKLRKKAEAIL
LEEEKMKSKDIGVSEDQLQIQEKFSVLVQDLYAFYPILIPYVDSHRASWLTEMDPDAEQL
FSMVAEVFIFWAKSHNLKWEEQNYVVQNEINNLGFLVQNIPKFDQENKRSKRKGDRYCTQ
TSLIVASVKRLLPVGLNVCFLSDHDLINLARKDFLLKNTKDEIHKRIFQCLSGQKRKTPE
LPVVKPLYSDCPKTQGSTLDLLQTTHRIVRVAQVLYHLDQVENPQRTKKSTWINVLSKQR
KRAVVACLRMTPLYNLPRHKVINLFLQGYNKTWVLTEYNSSEEKLVEDLASAVVVQESGG
DRKEKYFGHRATPADPLQQLITLFSQSALTERNGDLCESYFALMAKSCRTAQDDDEEQSV
QSFEEKEMEKQKLRFQQAELHNRGASEMVLKTISTSKGQGGSLIGLTLKLGIALLNGGNA
NVQQRMLEYLKAKQDVDFFQSLARLMCTCSVLDLNAFERQNKAEGLGMAMDERSVGIAIP
DNDVTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNMTVNIIISTVDYLLRLQESISDFYWY
YSGKAAIDVQGQLNFSNAIKVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVF
AHMQMKLSQDSRQIELLKEFMDLQKDMIVFLLSMLEGNVVNGTTGKQMVDMLVESSANVE
MILTFFAMFLKLKDFTTSVGFREYDPDSSGCISRKDFQKAMETCNRFSHEETHFLVSCIE
TDENEILNYEIFVERFHKPAEDIGFSVSVLLTNLSEHMPHDARLGTFLELAECVLGYFQP
YLGRIEIVGSGKRVERVYFEISESSRSQWDKPQVKESKRQFIFDVVNESRDKEKMEMFVN
FCEDTIFEMQLASNISSEAEERNSEKNVTESENESLDSDKTLFAFQWVFLLLSLLSVKNL
RMLMKMTPRDILKSVLNILHHIFSALLQCVYASVHSAMYVLYVVFISGGLIEAAKNTSVA
EFLGDVVEPTLDEVMELSENVHKQSHSDRRSLQEELRETGHLTCSRPLHAVSDVFGLQMK
KDGGLYRLMTQERSASVTDLFTSTTQGPGTGAFVRKHQQQKHECTDVTESLEFESVKDVA
QKDLNITSQRCSNKTEEGVRQPSVLWETINTYNKSVLNYFARNYYNIRLLALFITFAINF
ILLFYKVTPLPQTHENVDDKELNSSADNEGLVYFVLEESSGYMEPSLHFLAVAHTFISFC
CIIGYYCLKVPLVIFKREKEVARRLEFDGLYVTVQPPDEDIKGQWDRLVINTPSYPSNYW
DKFVKRKVVEKYGALYGSEKISELLGLDKASLDFNSQRKEKKLKRAALGSLFSSFDIKYQ
MWKLGVILTDRSFLYLAWYMVVSVLGHYNNFFFAVHLLDIAMGFKTLRTILTSVTHNGKQ
LVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEERMDMKCNDMLNCYMFHMYVGVRAGGG
IGDEIEDPAGDEFEVERIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMET
KCFICGIGSEYFDSIPHGFETHTLQDHNLANYLFFLMYLINKDETEYTGQESYVWKMYQE
RSWEFFPVGDCFRKQYEDQLG
NT seq 14646 nt   +upstreamnt  +downstreamnt
atgactgacactggggacactgatgaagaatttcagtttctacgactgggagatgaagtg
gttttgcagagcaccttcacctgtaactcagaacctgtgaagctgtgtctttcagctgaa
ggcttcggtagcagacgctgttgtcttgagccaacctccaactcgaagaatgttcctccg
gacctgtccctgtgtggctttgtgctggctcagtgtctttctgtccgggctctgcaggag
atgttggcccacagtgaacaaatatcaaagaagatgggagctgatggcagccatcgcaca
cttctgtatgggcaggcgctgttattccttcattcatacagtggcatgtatctgagctgc
atgttctcgtctcaatcttcaactgataagctggcgtttgatgtgggtctccaagataat
aaaacagatgaaacatgttggtggatagtgcatcctgcatctagacagagatcagatggt
gagaaggttcgtgttggagatgatgttatattagttaacatttcatcagaaaggtatttg
catctctccactggtgccgtctctgacaataaatatgacaacatcgtggtgtctgtagct
ttccagcagagtctctggcgtcttgctccaatctgttcaggtggaggagtcgctcaagga
tttttaagagggggagacacactccgcctgctgcacagccacagtgatgcatgtttgact
gtttcctctggagagctcgggcaggactttcagagggaattgcattatgagaccggccca
gcctctaatcgcgcttgctctctttggagactagagattcttcaagttgtatggagtggt
agtcacacacactgggcacaacctttccgactctgccacttgaccactgggcagtacctg
ggttttacaggggagaatgggcttcatcttgtcaatcgagacaatgctgacatcagaaca
acagctttttgcttcagatctacaaaggagaagcttgagccttgtccaaacacaaatgtc
actggaatgggaacagcggagataaagtatggggactcgacatgttttattcagcatgtg
tattctggactgtggctaacgtatagctctgatgctaaatcaactgggtccctgagtggt
catcgtaaggccatcttacatagcgagggccacatggacgatgggctaaaactgtcccga
tctcagaatgaggactctcacactgcaagactcatacgtagtgccgctctgctctttaac
tttttcttcaggaaactggatggtcaacaggaacttccctcatcttctgatattcctctg
ataaagacagtgatgtgcagtgttctggatctaattgagttctttaagccaccacctgac
gagttagacactgaggccaaacagaaaatcgtgggcgagttaagaaaacgtcagaaaatg
tttcaagaagaggggataataaacgtagtggttgaatgtattgaccatctgcatcagtac
agtgaagtgtcctgcgacgctgaggctgtgcagagtgaggagatcatcaagcacttttat
aaaatacttgctgcattgatcagaggaaattgtgccaactgcgcacaattctccgtctct
cttgaatggctcgtgagcaaattagaacaccatgaagcctcctctgggatcttggaggtt
cttcactttattcttcttgaaagtcctgaagctgtccacataatcaaagaagaacatatt
cagtccatagtcagttttctggacaggaatggatacaaccacaaggtgttggaggtgctc
tgttgtctgtgcgtgtgccatggtactgcggtccgctccaatcagaacctcatctctgac
agcctgctgccatacagagacctgctgctgcaaacgcgtcttgttaatcaggtcatcagt
ataagaccgaacatctttctgtcaatggaagacagctctgcccaacatgggaagtggtac
tatgagcttgtcgttgatcatgttgagcactttgtcacacccgaacccacacacctgaga
gtgggctgggcttccactcagagttacaaaccgcggccttcaggaggggacggctgggga
ggcaacggggtcggagatgaccttagctcctttggttttgatggactgcacttatggtca
ggttcagttgggcgcagagtaaactccccttttcctcatttgctcaaagacaatgatgtc
gtgagctgctgtctggacctcagtcctccatgtatctctttccgagtcaatggtctgcct
gttcaggggatgctggagaacttccacacggatgggttcctttttcctgtggttagtttg
tcagcaggagtcagggttcgttttttgtttgggggaaaacatggagaattcaagttcctg
cctccacccggttttactcaatgttgtgaagctctcctgccaaaaaccaagttgagggta
gaacaatgtcaaacatatatttttgaccatgaagatggaacacagctcattggcccgact
gcatttagcaaaccagttgtttttattccaaatccaactgacatcagtaagactacactg
cctcttcaactcgaaaatatcagaagaaatatggcagaacatttccatgaactttgggtc
ttggatcaaattgaacttggatggacttgtggaattgtaaaagatgaggagaaaaagata
gatccctgtctggttgagttttctaatctcacagatcttgaaagaaaccaaaatattgaa
atggcagagacaactctcaagactatccttgcccttggttttcacattctattgtctgat
gagcaggctgaggaaagactcaaatatattactctctcatccaagtttgaattaccaaat
ggttacaaacctgctcctcttgatctgagtggtgtttcactcagtccaactcttgaaaaa
ctggtggattttttatctgaaaacgaccacaacgtatgggccaaggagcacatcaagcaa
ggatgggcctatggagctcaacaggatgtgagagccaagaggagcccgtaccttgtgccc
ttcctccagctggatgtaggaaggaggagagtgcagagggagcgggtcagagatactgtt
tgtatcctgctgctttatggatacagcatacagtcatttaaaaaggaatgggcttcatcc
tctactccatgtcttgtttctgctgagagttaccgggtgttcagaacagataagtcatat
gctgtgactgacgggaagtggtactttgaatttgaaatactgacagctggaagtatgaga
gtgggctgggccaggccgggctgtgctccagacagagagcttggctcagatgaccaagct
tttgtgttcagtggagatgaggcccagtggtatcaccagggtggagtaccactcgggaca
ttaccgtggcacagaggggatgtggtgggctgcatgttggacatgactgaacgcactata
aaggtcgctcttaatggagagctgctgtttaatgaaaagggttctgaactggttgccaaa
gactttctcatcgatgacggcttgttacctgttgttggtcttggagtgaaccagatggga
aagcttaacttaggctctgagccggattctttgcggtatttttctgtgtgtggcttgcag
gagggctacaaaccatttgctgttgacatgtccagcgatccgtctttatggttgacttgg
tggcagcctcaattcacttccataaaaccagacgacacaaatttacatattacgagaatg
agtaacttgaaggattctgtgcctagtctaagagtctctcagcggtcattttcccatcag
aatggcaggaaggagacatgtttttatcgtctaaacatgtcagttgaatgtgccttagtc
ctcagcagcccagttcgaacaataccccctgtggcccccagctctttgtcaccagcaaga
aaagagctggaggagatggattcggactttgaagtgctgatgaagtcagcccacaacttt
actggttcaagagacgagctcaatcaccacaaggatcacagccaagacaagacatcaaag
ctcaaacaaaagttcatgctgaagaggactaaaccaggcttagtgaacagtaactcatca
gcgaggcttttggaggatgtgttagctgacatagctgacaaagacaacatgagtcatctt
atccagacctctaaatattactattcagtgcgagttcttcccggccaagcgccctcgtgt
gtgtgggttggctgggtgacagccgactttcatcaaagtagcacaacgttcgatattgac
aaggtgaacactgttactgtaactcttggtgatgatagtgggaaggtccaggaaagtgcc
aggcgctgtaactgttacatggtttgtgccggagaggccaatggtctgtctcaaagtcgc
agaagcacaggtttggaaattagctgtttagttgatacagcgactgggcttctcacattt
acctccagtggaattgaaacgacaaccttctatcaggtagagccaagtacaaagcttttc
cctgctgtatttgtcaagccaacaacaaacagcatgtttcagtttgaactgggcaatagt
aagaacgttatgcccctgtcagctggtttgtttcgcagcctcaggtgggacacgactcct
cagtgccctgaaaggctacaagtccaacaactgtgtcaagtttcctggacacgtgttcca
gataatgcactgaaagtgttggtagagcagacagaaaactgccatggttgggtagtgcaa
tgcacagagtccaaccaaatgatgtcacttcagatcccagatgaaaacaggtgtattgac
attttggagctctcggaacacgatgacctgctgatgtttcactaccacaccctgctcctc
tactcctctctgtgtgccctggggaacaccagaatttgccatgccctttgtagtcaagtg
gaccagtcccagatgttttatgtcctacagaattcccgcctcccaggattgctacgctct
gcattttaccagtttcttattcaggttcatctcagttgccacagctcagcatgtctgctg
acgaaccgagaatacattcttcctatgatggacccggcctgtgccatctttcttaatccc
aacactgtgaacggcagctatattccaagaacactggccacaacccttaaaccacagatg
tgcttttctactccttcctttgtgaagactcgtgaggacaaaagtgctcaaagtgaagca
agaacagtttttattgactctcctgaaattcctttagatcaactaaagtgtgtaactgtg
gagatgctctctgcagctgtgagtgttgtggctcacggcctgagagatcctgcagggggc
agcgtggagcttctgctggttccactggttcaattgttttacactcagcttgtgatggga
gtatttgaggatgccgacttgaggcgagttctcactctgtttttaccacaagctttttct
gatgaagagcaactcgcaaagcaaaaagacaatgaagaacaaatattggagaatgatcaa
aattttgggttgcttcatatgaaactcccagaagctgtgcaatttgagctttgtcaggtg
ctatctttcctctgtgattgtcaagtgcgccaccgggttgaagctattgttgcattttct
tgcaattttgtcgggcagcttcaagaaaaccagagatttcgatatgatgaagttatgcag
gcccttcacatgtcggttgcactcactgctcgtaaaacaaaggagttccgatcccctcca
caagaacagataaacatgctgataagctttaaagacaaagatacgaaatgtgaggactgt
ccatgcccagaggaagttcagcagcttctgaaagaattccaccatcttttaaaacagcac
tgtggcccagaattagacagaggctcagaggatgatgaagatgcagagatatctataaaa
gatcaactttgtagtttgatatttcaagcatgtggagcgagaaagtcatccacggatgag
acttcctcagtccaaaaccctgcatcctttgctgatcttatctccaagacaacgatgctt
tgggcgtcagaagctaaaatagatgaccctgacttggtgaaggccattttctccttgtta
catcgacagtatcaaggtgtctgtggccaaatgggagaagctctttctaaaacgtacaca
ataagccaggcatctgctgaggacaccacagctctcctcacctctctgtgtcaaatacgg
tctctcctcagagtgcgcatgggcaagcaggaggagaaactgatgactgataaactgggg
gacatcataaacaacaaagtattctatcaacatccaaatttaatgagggctctgggtatg
catgaaactgtaatggaagtgatggtaaatgttttgggagaagggaaaacaaatgagatc
atgtttccaaaaatggtggcaggctgttgtcgtttcctctgctatttctgccgcatcagc
cgccaaaatcaaggagcattgtttgaccacctgagctatctgcttgaacacagtcaggtg
ggactagcttcaccctcaatgcgaggtgccactcctttggatgtagcagccgcctctgtc
atggacaactatgaactggcattatcattacaagaatgtgaactacaaaaggtggttaat
tatcttgcacattgtggcgtccagagctgtcccatgcttgttgctaatggatatcctgac
attgcgtggaaccctgtggagggagagcgttacttggatttcctccgttttaccgtattt
tgtaacggtgaaagtgtggaggaaaatgcgtatgttgtgctgaagctgctcattcaccag
cctgagtgttttgggcctgctctgcgtggagaaggaggtcagggcctcctctcagccatg
gaggaagccatcagggtgtcccaggacgtgtctatggacgggcctcatgcagaaaaccac
ttcaaccaaaagaatgatattcaggacttagatgatgacttcgttcacatgggacatgct
ataatgaccttctactcatctcttatcgaccttctgggccggtgtgctcctgagatgcat
ctcattcaagctggaaaaggagaagccattcgcatccgggcaatattaagatccctcatt
cctgttcaggaccttgagggtgtcattagtttgccctttcaaatgccttcaatatctaaa
gatggtgaagtggatgagcctgacttgtctgcagtattttctccagatcacaaggcctcc
atggttctgttcatggcccgagtttatggcattgagagtcaactttttctcttgcactta
ttagagtttggatttctgcccgatctgcaagctgcagtttcacttgacactaatgacttt
ggatcatctgacatggccctgtccctaaacagatacataactactgcgatgcttccaatg
cttaccaaatgctcagctctcctttgtgatttagaggaacatgccccgctcttaaattct
tttattctagctctatacagcttttccaaggctgcgagcttgaccaaagcccagggagac
acaactgaacaatgtctgttggctttatgcagtaaactcaatccagttttaatgcagccg
cttctgcagcagctcatattcgacatcgctcatctttcagaacacagcaaactggagcta
aagctgctgaccagacactacgagcagcagtggaagtattatttacagacaggagtgggg
aaagatgtgttttctgaagaagaaggtcacatgtccagaaagttgttctggaccgttttc
aatgtcttggagaaaatgtcttatgaaccacagttatataagctgggtgctcagtgcctc
acaactgttgctaggagcttgcctccagacgatatgaatcccggcttcctgacagacaga
aaagccacaattgacactgatgaaaactttgaccctcagcctctggacacctcaaatgtg
tcagtgcccgagcgcctggagtctgttctcaacaagtatgcagaacattctcatgagaag
tggtcactggagatgtttacagccggctgggtgcacggggagcagctgtgtgaaaatgcc
aaagtccatcctcgcctgaaaccgtacagaactcttgctgaaaaggataaagaagcatat
cgttgctctataaaggaaacgctaaaggtgatgctggcgtttggctggacgatagacaga
actaaaggaggagatgtgtttggaaaacggacatgcactcgtaggatttctcaatctcag
ctgtcgtttgaaggtgcatccacattcagcccaaagccaatggatatgagcagcatcacc
ttgtcctgggatcagtgtgcaatgttagaacagctggcagaaaaccactacaatgtctgg
gccaagaaaaagaaagttcactttcaagacaaaggaggatgccattctccacttgtccct
tacagtagcttgtctacaaaagagaagattagatttagagaaaaggctcaggatgttctg
aagttcttgctgttgaatggtttcacagtgtggagagagaaaaggacagacccacatttt
ccagccacatccaactgctttggcttctctcttcttcaacactttgtttatctcatagat
gttgctcaagagaatattttggagctagaggtgatgcacgtcagaggacacacggctaag
ggagacaaagcctcacatctacaaacaatacgtttcttccccaaggttgtcctccctctt
ttggaagaatatctgaaggatcatcatttgtatttcatctcaagttctttctgctctggc
actagtatttatgcatcaacaaaagaaaaagagataattgtgagcattttctgtaagctt
gctgcactaataaggcacagaataacactttttggaaatgaagctctgacatttaccagc
tgcctccaagttttagcccagtctctagatgcaaggacactgctgcatggagccaaagac
tttttctttggatctctgcacatgtttttggatgcagctgcagcggacctggagatgaca
gtggaaaacctgcatgtgactttggctcctctggctcagagcaggagtcagtcggccaga
ggagtggtggggattctcagccacacgaccttagtgctgcttcctgctctcacctccctc
tttaagcatcttggcaacactaaaattggctccgatattttagtgggaagtatccaggtt
tcctgttacaggatcctcaactctctttactctctcggtacaaacagcagcattcagaaa
gaggggccacaatcatcagccggtgcgtgtctggccgccctctcccaaaccttccctgtt
tcctttcttgagcctgaattaaaccaaaacaacccatgttctgtctacaccaccatgagt
gtaactgaaatagaagagctggggctgcctgagcaggtggcagaggcgtgtcctcatcta
ccctctctgctgcaggggctggcagaggtggagaaggtggtgatggcgggagcagctgcc
cgccaggctcactacatgcatatcaccaaggtcctcctgcccatgttatgtagctacatg
tctcactggagccagccaagtatgtcagacttctcctctgtcactcctgcactcatcagt
gatctgctcgggcacatcctttgcattatccaaaataatgtgggggacagtcggggaggc
tggactaaacaactggcagttttttcacagccaatcatatgccaatccagttcaaagcta
ttgaaaatgaattttgttccactaatggacaagttaaggaagaaagcagaagctattctt
cttgaggaggagaaaatgaaatcaaaagacattggtgtttctgaagaccaactccagata
caagagaagtttagtgtgcttgtccaggacctttatgctttctatccgatactcatcccg
tatgtggactctcatcgagccagctggctgacagaaatggatcctgatgcggagcagctg
ttcagcatggtggcagaggtttttatattctgggccaaatctcacaatttaaagtgggaa
gaacaaaactatgtggtccaaaatgaaatcaacaatttgggatttttggtacagaacatt
cccaagtttgaccaagaaaacaagagatcaaagagaaaaggtgatcgttattgcactcaa
acgtccctcattgtggcctctgtgaagagactgctccctgtcggactcaacgtctgtttc
ctaagtgaccatgaccttattaatctggccaggaaggactttttactgaagaacaccaag
gatgagattcacaagcgtatatttcagtgcttgtcaggtcagaagaggaagaccccggag
ctgccagtggtcaagcccctttactcagattgtccaaagactcaagggtcgacattagac
ctactacaaaccacacacagaattgttcgagtagctcaagttctttatcatttggaccag
gtggaaaatcctcagcgaaccaaaaaatcaacatggattaatgtcttgtctaaacaaaga
aagcgagctgtggtggcctgcctaagaatgaccccgctgtacaatctaccgaggcacaaa
gttattaaccttttccttcaaggatacaataagacttgggttttaaccgagtacaacagc
agtgaggagaagcttgtggaagatttggctagtgcggtggtagtgcaggagtctgggggt
gacaggaaggaaaagtactttgggcatcgagccacaccagccgatcctctgcaacaactg
atcactctcttcagtcaaagtgccctgacagagagaaacggtgacctttgcgagtcttat
tttgctctaatggcgaagagttgtcgcacagcacaagacgatgatgaagagcagtcagtg
caaagttttgaggaaaaagaaatggagaagcagaagttacgttttcaacaggcagaactg
cataatcgtggtgcatcagagatggtcttaaaaaccatcagcacaagcaaaggacaaggc
ggctccctgattggcctcacgctgaagctgggaatcgctcttcttaatggaggaaatgct
aatgtgcaacagagaatgcttgaatatttgaaagcaaagcaagacgtagatttcttccaa
agtttggctcgactcatgtgcacatgcagtgttctggatctgaatgcttttgagcggcag
aacaaggcggagggattaggcatggccatggacgaacgctcagttgggattgcgatacct
gacaacgacgtgacctgtgacctcttccgtttcctccagctcttatgtgaaggacataac
tcagattttcagaattacctcagaacacaaaccggaaataacatgacagtcaacataatt
atatccactgtggattatttactgagactacaggagtcaatcagtgacttttactggtac
tactctggaaaggctgcgattgatgtacaaggccagttaaacttctcaaatgccatcaag
gtggctaagcaagtcttcaacactctcactgaatacatacagggcccatgcactggcaac
cagcagagtctggcacacagtcgcctttgggacgctgtcgtcggctttcttcatgttttc
gcacatatgcaaatgaagctatctcaggattcaaggcaaattgaacttttaaaggagttc
atggatttacaaaaggacatgattgtatttttgctctccatgcttgaaggaaatgtggtg
aatggaacaactgggaagcagatggttgatatgttagtggagtcctcagccaatgtggaa
atgatcctcacattcttcgccatgttcctcaaactcaaagactttacaacctcggtcggt
ttcagggagtacgatcccgatagcagcggctgtatctccagaaaagactttcagaaagct
atggaaacctgcaaccgcttctctcatgaggaaacccactttcttgtctcctgcatcgag
acggatgagaacgaaatcctcaattatgagatatttgtggagcgctttcacaaaccggct
gaagacattgggttcagcgtttctgttcttctcaccaacctgtctgaacacatgcctcat
gatgcgagactcgggacatttttggagttggcggaatgcgtcctgggatacttccagcct
tatttaggacgcattgagattgtgggcagtggaaagcgcgttgaacgtgtctactttgag
atcagtgaatccagccgctcacagtgggacaaaccgcaagtcaaagagtccaagaggcag
ttcattttcgacgtggtcaatgaaagcagagataaagagaaaatggagatgtttgtcaat
ttctgcgaggacaccatcttcgaaatgcaactcgcgtcgaatatttcttctgaagccgag
gagaggaattctgaaaaaaatgtaacagaaagtgaaaacgagtccttagacagcgacaag
acattatttgcatttcagtgggtgtttctgctcctgtctttattgtcagtcaagaatctc
aggatgctaatgaagatgacccccagagatatcttaaagtctgtactcaatatattacac
cacatcttctcagctttactgcagtgcgtgtacgcttcagtccatagtgcaatgtacgtg
ctttacgtggtgttcattagtggtggactcatagaagccgccaaaaacacgagtgtggct
gaattcctcggtgatgttgtggagccaactcttgacgaggttatggaactgtcagagaac
gtgcacaaacaatcacattcagacagacgctctcttcaggaggagctgagagaaactgga
cacttgacctgctctagacctctgcatgccgtgtcggacgtatttggattacagatgaag
aaggatggaggtctgtacagacttatgacccaagagcgctccgccagtgtcacagatctg
ttcacgtcaacgacacaaggaccaggcaccggtgcttttgtcaggaaacatcagcaacag
aaacatgaatgtacagatgtcactgaatcacttgagtttgaaagcgtgaaggatgttgca
cagaaagatttgaatataacatctcagcgctgctccaataaaacagaggaaggagtcaga
cagccctctgtgctgtgggagacaataaacacttacaacaagagtgtgctgaattacttt
gcgcggaactattacaatattcgccttcttgctctgttcatcacctttgcgatcaacttc
atccttctcttttataaggtgacgccgctgcctcaaacgcatgaaaacgtagacgacaaa
gagctgaactcctccgctgacaacgagggcttggtttattttgtgctggaggaaagcagt
ggatacatggagccatctctccatttcctggccgtggcacatacattcatttccttctgt
tgcattattggatactactgccttaaggtgcccttggtgatcttcaagcgtgagaaggaa
gtggctcggcggctggagttcgatgggctgtatgtgacagtgcagccgcctgacgaggac
atcaaaggacagtgggaccggctggtcattaatactccatcatatccaagtaactactgg
gataagtttgtcaagaggaaggtagtggaaaaatatggagcgttatatggcagtgagaag
atcagtgaacttctaggtttagacaaggcttctttagacttcaactctcaaaggaaagaa
aagaagctcaaaagagcagctttgggatctttattttcctcctttgacatcaagtatcaa
atgtggaagcttggagtcatactaacagacagatcctttttgtacctggcctggtacatg
gttgtgtccgttctgggtcactacaacaacttcttttttgccgttcaccttctggacatc
gctatgggcttcaagactctccgcactatactgacctctgtcacacacaatggaaagcag
ttggtcctgactgtgggtctgctggcggtggtggtctacctctacaccgtcgtggccttc
aacttctttaggaaattttacaacaagagtgaggacgaggagcgcatggacatgaaatgc
aacgacatgctgaattgctacatgttccacatgtatgtgggagtgcgggcgggaggaggg
attggagacgagattgaggacccggctggagatgaatttgaggtggagcgcatcatcttt
gacatcacctttttcttttttgtcattgttattctcctcgccattatccagggtttaata
attgatgcttttggtgaactccgtgaccaacaggagcaagtcaaagaggatatggagacc
aagtgcttcatatgtggcattggaagtgaatattttgattcaatccctcatggctttgag
acccacacgttacaggatcataacttggccaactatctatttttcctgatgtacctcatt
aataaagatgaaaccgagtacaccggacaggaatcctatgtctggaaaatgtaccaggag
cggagctgggaattctttcctgtgggagactgtttccgtaagcaatatgaggatcagctg
ggatga

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