Escherichia coli O26 H11 11368 (EHEC): ECO26_0002
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Entry
ECO26_0002 CDS
T01098
Symbol
thrA
Name
(GenBank) fused aspartokinase I and homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
eoj
Escherichia coli O26:H11 11368 (EHEC)
Pathway
eoj00260
Glycine, serine and threonine metabolism
eoj00261
Monobactam biosynthesis
eoj00270
Cysteine and methionine metabolism
eoj00300
Lysine biosynthesis
eoj01100
Metabolic pathways
eoj01110
Biosynthesis of secondary metabolites
eoj01120
Microbial metabolism in diverse environments
eoj01230
Biosynthesis of amino acids
Module
eoj_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
eoj_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
eoj_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
eoj00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
ECO26_0002 (thrA)
00270 Cysteine and methionine metabolism
ECO26_0002 (thrA)
00300 Lysine biosynthesis
ECO26_0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
ECO26_0002 (thrA)
Enzymes [BR:
eoj01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
ECO26_0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
ECO26_0002 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
BAI23366
LinkDB
All DBs
Position
337..2799
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHLLRHAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDDRFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccacctggtggcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttttgacgggactcgccgcc
gcccagccgggattcccgctggcgcaattgaaaactttcgtcgaccaggaatttgcccaa
ataaaacatgtcctgcatggcattagtttgttagggcagtgcccggatagcattaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtgttagaagcg
cgtggtcacaacgttaccgttatcgatccggtcgaaaaactactggcagtggggcattac
ctcgaatctaccgtcgatattgctgagtccacccgccgtattgcggcaagtcgtattccg
gctgatcacatggtgctgatggcaggcttcaccgccggtaatgaaaaaggcgaactggtg
gtacttggacgcaacggttccgactactccgcggcggtgctggctgcctgtttacgcgcc
gattgttgcgagatttggacggacgttgacggggtctatacctgcgacccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctaccaggaagcgatggagctttcctacttc
ggcgctaaagttcttcacccccgcaccattacccccatcgcccagttccagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagtcgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaaggaatggtcggcatggcggcgcgcgtctttgccgcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccgcaaagcgactgtgtgcgggctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggcttactggagccgctggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgtaccttgcgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgctattgctcagggatcttctgaacgctcaatctct
gtcgtggtaaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcaacaaagctggctgaagaataaacatatcgacttacgtgtc
tgcggtgttgccaactcgaaggcactgctcaccaatgtgcatggcctaaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgcacctccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgtcacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatctgttgcgtcatgcggcggaaaaatcgcgg
cggaaattcctctatgacaccaacgttggggctggattaccggttattgaaaacctgcaa
aatctgctcaatgctggtgatgaattgatgaagttctccggcattctttcaggatcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacgctggca
cgggaaatgggttataccgaaccggatccgcgagatgatctttctggtatggatgtggcg
cgtaaactattgattctcgcccgtgaaacgggacgtgaactggagctggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgccgagggtgatgttgccgcttttatggcg
aatctgtcacagctcgacgatcgctttgccgcgcgcgtggcgaaggcccgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggcgtctgtcgcgtgaagattgcc
gaagtggatggtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttc
tatagccactattatcagccgctgccgttggtgctgcgcggatatggtgcgggcaatgac
gttaccgctgctggtgtctttgccgatctgctgcgtaccctctcatggaagttaggagtc
tga
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