KEGG   Equus przewalskii (Przewalski's horse): 103549630
Entry
103549630         CDS       T04644                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X2
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
epz  Equus przewalskii (Przewalski's horse)
Pathway
epz01521  EGFR tyrosine kinase inhibitor resistance
epz01522  Endocrine resistance
epz04010  MAPK signaling pathway
epz04012  ErbB signaling pathway
epz04014  Ras signaling pathway
epz04015  Rap1 signaling pathway
epz04022  cGMP-PKG signaling pathway
epz04024  cAMP signaling pathway
epz04062  Chemokine signaling pathway
epz04066  HIF-1 signaling pathway
epz04068  FoxO signaling pathway
epz04071  Sphingolipid signaling pathway
epz04072  Phospholipase D signaling pathway
epz04114  Oocyte meiosis
epz04140  Autophagy - animal
epz04148  Efferocytosis
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04210  Apoptosis
epz04218  Cellular senescence
epz04270  Vascular smooth muscle contraction
epz04370  VEGF signaling pathway
epz04371  Apelin signaling pathway
epz04380  Osteoclast differentiation
epz04510  Focal adhesion
epz04540  Gap junction
epz04550  Signaling pathways regulating pluripotency of stem cells
epz04613  Neutrophil extracellular trap formation
epz04620  Toll-like receptor signaling pathway
epz04650  Natural killer cell mediated cytotoxicity
epz04660  T cell receptor signaling pathway
epz04662  B cell receptor signaling pathway
epz04664  Fc epsilon RI signaling pathway
epz04666  Fc gamma R-mediated phagocytosis
epz04668  TNF signaling pathway
epz04720  Long-term potentiation
epz04722  Neurotrophin signaling pathway
epz04725  Cholinergic synapse
epz04726  Serotonergic synapse
epz04730  Long-term depression
epz04810  Regulation of actin cytoskeleton
epz04910  Insulin signaling pathway
epz04912  GnRH signaling pathway
epz04914  Progesterone-mediated oocyte maturation
epz04915  Estrogen signaling pathway
epz04916  Melanogenesis
epz04917  Prolactin signaling pathway
epz04919  Thyroid hormone signaling pathway
epz04921  Oxytocin signaling pathway
epz04926  Relaxin signaling pathway
epz04928  Parathyroid hormone synthesis, secretion and action
epz04929  GnRH secretion
epz04934  Cushing syndrome
epz04935  Growth hormone synthesis, secretion and action
epz05010  Alzheimer disease
epz05022  Pathways of neurodegeneration - multiple diseases
epz05034  Alcoholism
epz05132  Salmonella infection
epz05135  Yersinia infection
epz05160  Hepatitis C
epz05161  Hepatitis B
epz05163  Human cytomegalovirus infection
epz05164  Influenza A
epz05165  Human papillomavirus infection
epz05166  Human T-cell leukemia virus 1 infection
epz05167  Kaposi sarcoma-associated herpesvirus infection
epz05170  Human immunodeficiency virus 1 infection
epz05200  Pathways in cancer
epz05205  Proteoglycans in cancer
epz05206  MicroRNAs in cancer
epz05207  Chemical carcinogenesis - receptor activation
epz05208  Chemical carcinogenesis - reactive oxygen species
epz05210  Colorectal cancer
epz05211  Renal cell carcinoma
epz05212  Pancreatic cancer
epz05213  Endometrial cancer
epz05214  Glioma
epz05215  Prostate cancer
epz05216  Thyroid cancer
epz05218  Melanoma
epz05219  Bladder cancer
epz05220  Chronic myeloid leukemia
epz05221  Acute myeloid leukemia
epz05223  Non-small cell lung cancer
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
epz05226  Gastric cancer
epz05230  Central carbon metabolism in cancer
epz05231  Choline metabolism in cancer
epz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:epz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103549630 (MAP2K1)
   04012 ErbB signaling pathway
    103549630 (MAP2K1)
   04014 Ras signaling pathway
    103549630 (MAP2K1)
   04015 Rap1 signaling pathway
    103549630 (MAP2K1)
   04370 VEGF signaling pathway
    103549630 (MAP2K1)
   04371 Apelin signaling pathway
    103549630 (MAP2K1)
   04668 TNF signaling pathway
    103549630 (MAP2K1)
   04066 HIF-1 signaling pathway
    103549630 (MAP2K1)
   04068 FoxO signaling pathway
    103549630 (MAP2K1)
   04072 Phospholipase D signaling pathway
    103549630 (MAP2K1)
   04071 Sphingolipid signaling pathway
    103549630 (MAP2K1)
   04024 cAMP signaling pathway
    103549630 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    103549630 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    103549630 (MAP2K1)
   04150 mTOR signaling pathway
    103549630 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103549630 (MAP2K1)
   04148 Efferocytosis
    103549630 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    103549630 (MAP2K1)
   04210 Apoptosis
    103549630 (MAP2K1)
   04218 Cellular senescence
    103549630 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103549630 (MAP2K1)
   04540 Gap junction
    103549630 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103549630 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103549630 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103549630 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    103549630 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    103549630 (MAP2K1)
   04660 T cell receptor signaling pathway
    103549630 (MAP2K1)
   04662 B cell receptor signaling pathway
    103549630 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    103549630 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    103549630 (MAP2K1)
   04062 Chemokine signaling pathway
    103549630 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103549630 (MAP2K1)
   04929 GnRH secretion
    103549630 (MAP2K1)
   04912 GnRH signaling pathway
    103549630 (MAP2K1)
   04915 Estrogen signaling pathway
    103549630 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    103549630 (MAP2K1)
   04917 Prolactin signaling pathway
    103549630 (MAP2K1)
   04921 Oxytocin signaling pathway
    103549630 (MAP2K1)
   04926 Relaxin signaling pathway
    103549630 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    103549630 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    103549630 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    103549630 (MAP2K1)
   04916 Melanogenesis
    103549630 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103549630 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    103549630 (MAP2K1)
   04726 Serotonergic synapse
    103549630 (MAP2K1)
   04720 Long-term potentiation
    103549630 (MAP2K1)
   04730 Long-term depression
    103549630 (MAP2K1)
   04722 Neurotrophin signaling pathway
    103549630 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103549630 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103549630 (MAP2K1)
   05206 MicroRNAs in cancer
    103549630 (MAP2K1)
   05205 Proteoglycans in cancer
    103549630 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    103549630 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    103549630 (MAP2K1)
   05230 Central carbon metabolism in cancer
    103549630 (MAP2K1)
   05231 Choline metabolism in cancer
    103549630 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103549630 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103549630 (MAP2K1)
   05212 Pancreatic cancer
    103549630 (MAP2K1)
   05225 Hepatocellular carcinoma
    103549630 (MAP2K1)
   05226 Gastric cancer
    103549630 (MAP2K1)
   05214 Glioma
    103549630 (MAP2K1)
   05216 Thyroid cancer
    103549630 (MAP2K1)
   05221 Acute myeloid leukemia
    103549630 (MAP2K1)
   05220 Chronic myeloid leukemia
    103549630 (MAP2K1)
   05218 Melanoma
    103549630 (MAP2K1)
   05211 Renal cell carcinoma
    103549630 (MAP2K1)
   05219 Bladder cancer
    103549630 (MAP2K1)
   05215 Prostate cancer
    103549630 (MAP2K1)
   05213 Endometrial cancer
    103549630 (MAP2K1)
   05224 Breast cancer
    103549630 (MAP2K1)
   05223 Non-small cell lung cancer
    103549630 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103549630 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    103549630 (MAP2K1)
   05161 Hepatitis B
    103549630 (MAP2K1)
   05160 Hepatitis C
    103549630 (MAP2K1)
   05164 Influenza A
    103549630 (MAP2K1)
   05163 Human cytomegalovirus infection
    103549630 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103549630 (MAP2K1)
   05165 Human papillomavirus infection
    103549630 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103549630 (MAP2K1)
   05135 Yersinia infection
    103549630 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103549630 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    103549630 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    103549630 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103549630 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103549630 (MAP2K1)
   01522 Endocrine resistance
    103549630 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:epz01001]
    103549630 (MAP2K1)
Enzymes [BR:epz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     103549630 (MAP2K1)
Protein kinases [BR:epz01001]
 Serine/threonine kinases: STE group
  STE7 family
   103549630 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 103549630
NCBI-ProteinID: XP_008516325
LinkDB
Position
1:complement(126345226..126420938)
AA seq 371 aa
MKPERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVAHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP
IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP
PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
QPSTPTHAAGV
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgaagccggagaggaccaacctggaggccttgcagaagaagctggaggagctggagctc
gatgaacagcagcgaaagcgccttgaggcctttcttactcagaagcagaaggttggggaa
ctgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggtgtggta
ttcaaggttgcccacaaaccgtctggtttggtcatggccagaaagctaattcacctggag
atcaagcctgcaatccggaaccagatcataagggagctgcaggttctacatgagtgcaac
tccccatatattgtgggcttctatggcgcattctacagcgatggtgagatcagcatctgc
atggagcacatggatgggggttccttggatcaagtcctaaagaaagctggaagaattcct
gagcaaattttaggaaaagttagcattgctgtaataaaaggcctgacgtatctgagggag
aagcacaagattatgcacagagatgtcaagccctccaacatcctagtgaactcccgtggg
gagatcaagctgtgtgattttggggtcagcgggcagctcatcgactccatggccaactcc
ttcgtgggcacaaggtcttacatgtcgccggaaagactccaggggactcattattcagtg
cagtcggacatctggagcatggggctctctctggttgagatggcggtcgggaggtatccc
atccctcctccagatgccaaggagctggagctgatgtttgggtgccaagtggagggagat
gcggctgagactccgcctaggccaaggacccctggaagacccctcagctcttatggaatg
gacagccgacctcctatggcaatttttgagttactggattacatagtcaacgagcctcct
cccaagctgcccagtggagtattcagtctggaatttcaggattttgtgaataaatgctta
atcaaaaaccctgcagagagagcagatttgaagcaactcatggttcacgcttttatcaag
agatctgatgccgaggaagtggattttgcaggttggctctgctccaccattggccttaac
cagcccagcacaccaacccacgcggctggcgtctaa

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