KEGG   Equus przewalskii (Przewalski's horse): 103552150
Entry
103552150         CDS       T04644                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
epz  Equus przewalskii (Przewalski's horse)
Pathway
epz00562  Inositol phosphate metabolism
epz01100  Metabolic pathways
epz01521  EGFR tyrosine kinase inhibitor resistance
epz01522  Endocrine resistance
epz01524  Platinum drug resistance
epz04012  ErbB signaling pathway
epz04014  Ras signaling pathway
epz04015  Rap1 signaling pathway
epz04024  cAMP signaling pathway
epz04062  Chemokine signaling pathway
epz04066  HIF-1 signaling pathway
epz04068  FoxO signaling pathway
epz04070  Phosphatidylinositol signaling system
epz04071  Sphingolipid signaling pathway
epz04072  Phospholipase D signaling pathway
epz04081  Hormone signaling
epz04140  Autophagy - animal
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04152  AMPK signaling pathway
epz04210  Apoptosis
epz04211  Longevity regulating pathway
epz04213  Longevity regulating pathway - multiple species
epz04218  Cellular senescence
epz04360  Axon guidance
epz04370  VEGF signaling pathway
epz04380  Osteoclast differentiation
epz04510  Focal adhesion
epz04517  IgSF CAM signaling
epz04518  Integrin signaling
epz04550  Signaling pathways regulating pluripotency of stem cells
epz04611  Platelet activation
epz04613  Neutrophil extracellular trap formation
epz04620  Toll-like receptor signaling pathway
epz04625  C-type lectin receptor signaling pathway
epz04630  JAK-STAT signaling pathway
epz04650  Natural killer cell mediated cytotoxicity
epz04660  T cell receptor signaling pathway
epz04662  B cell receptor signaling pathway
epz04664  Fc epsilon RI signaling pathway
epz04666  Fc gamma R-mediated phagocytosis
epz04668  TNF signaling pathway
epz04670  Leukocyte transendothelial migration
epz04722  Neurotrophin signaling pathway
epz04725  Cholinergic synapse
epz04750  Inflammatory mediator regulation of TRP channels
epz04810  Regulation of actin cytoskeleton
epz04910  Insulin signaling pathway
epz04914  Progesterone-mediated oocyte maturation
epz04915  Estrogen signaling pathway
epz04917  Prolactin signaling pathway
epz04919  Thyroid hormone signaling pathway
epz04923  Regulation of lipolysis in adipocytes
epz04926  Relaxin signaling pathway
epz04929  GnRH secretion
epz04930  Type II diabetes mellitus
epz04931  Insulin resistance
epz04932  Non-alcoholic fatty liver disease
epz04933  AGE-RAGE signaling pathway in diabetic complications
epz04935  Growth hormone synthesis, secretion and action
epz04960  Aldosterone-regulated sodium reabsorption
epz04973  Carbohydrate digestion and absorption
epz05010  Alzheimer disease
epz05017  Spinocerebellar ataxia
epz05020  Prion disease
epz05100  Bacterial invasion of epithelial cells
epz05132  Salmonella infection
epz05135  Yersinia infection
epz05142  Chagas disease
epz05146  Amoebiasis
epz05160  Hepatitis C
epz05161  Hepatitis B
epz05162  Measles
epz05163  Human cytomegalovirus infection
epz05164  Influenza A
epz05165  Human papillomavirus infection
epz05166  Human T-cell leukemia virus 1 infection
epz05167  Kaposi sarcoma-associated herpesvirus infection
epz05168  Herpes simplex virus 1 infection
epz05169  Epstein-Barr virus infection
epz05170  Human immunodeficiency virus 1 infection
epz05171  Coronavirus disease - COVID-19
epz05200  Pathways in cancer
epz05203  Viral carcinogenesis
epz05205  Proteoglycans in cancer
epz05206  MicroRNAs in cancer
epz05207  Chemical carcinogenesis - receptor activation
epz05208  Chemical carcinogenesis - reactive oxygen species
epz05210  Colorectal cancer
epz05211  Renal cell carcinoma
epz05212  Pancreatic cancer
epz05213  Endometrial cancer
epz05214  Glioma
epz05215  Prostate cancer
epz05218  Melanoma
epz05220  Chronic myeloid leukemia
epz05221  Acute myeloid leukemia
epz05222  Small cell lung cancer
epz05223  Non-small cell lung cancer
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
epz05226  Gastric cancer
epz05230  Central carbon metabolism in cancer
epz05231  Choline metabolism in cancer
epz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
epz05415  Diabetic cardiomyopathy
epz05417  Lipid and atherosclerosis
epz05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:epz00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103552150 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103552150 (PIK3CA)
   04014 Ras signaling pathway
    103552150 (PIK3CA)
   04015 Rap1 signaling pathway
    103552150 (PIK3CA)
   04370 VEGF signaling pathway
    103552150 (PIK3CA)
   04630 JAK-STAT signaling pathway
    103552150 (PIK3CA)
   04668 TNF signaling pathway
    103552150 (PIK3CA)
   04066 HIF-1 signaling pathway
    103552150 (PIK3CA)
   04068 FoxO signaling pathway
    103552150 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    103552150 (PIK3CA)
   04072 Phospholipase D signaling pathway
    103552150 (PIK3CA)
   04071 Sphingolipid signaling pathway
    103552150 (PIK3CA)
   04024 cAMP signaling pathway
    103552150 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    103552150 (PIK3CA)
   04152 AMPK signaling pathway
    103552150 (PIK3CA)
   04150 mTOR signaling pathway
    103552150 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103552150 (PIK3CA)
   04517 IgSF CAM signaling
    103552150 (PIK3CA)
   04518 Integrin signaling
    103552150 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103552150 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    103552150 (PIK3CA)
   04218 Cellular senescence
    103552150 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103552150 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    103552150 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103552150 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103552150 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    103552150 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    103552150 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    103552150 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    103552150 (PIK3CA)
   04660 T cell receptor signaling pathway
    103552150 (PIK3CA)
   04662 B cell receptor signaling pathway
    103552150 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    103552150 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    103552150 (PIK3CA)
   04670 Leukocyte transendothelial migration
    103552150 (PIK3CA)
   04062 Chemokine signaling pathway
    103552150 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103552150 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    103552150 (PIK3CA)
   04929 GnRH secretion
    103552150 (PIK3CA)
   04915 Estrogen signaling pathway
    103552150 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    103552150 (PIK3CA)
   04917 Prolactin signaling pathway
    103552150 (PIK3CA)
   04926 Relaxin signaling pathway
    103552150 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    103552150 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    103552150 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103552150 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103552150 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    103552150 (PIK3CA)
   04722 Neurotrophin signaling pathway
    103552150 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103552150 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    103552150 (PIK3CA)
   04380 Osteoclast differentiation
    103552150 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    103552150 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    103552150 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103552150 (PIK3CA)
   05206 MicroRNAs in cancer
    103552150 (PIK3CA)
   05205 Proteoglycans in cancer
    103552150 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    103552150 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    103552150 (PIK3CA)
   05203 Viral carcinogenesis
    103552150 (PIK3CA)
   05230 Central carbon metabolism in cancer
    103552150 (PIK3CA)
   05231 Choline metabolism in cancer
    103552150 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103552150 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103552150 (PIK3CA)
   05212 Pancreatic cancer
    103552150 (PIK3CA)
   05225 Hepatocellular carcinoma
    103552150 (PIK3CA)
   05226 Gastric cancer
    103552150 (PIK3CA)
   05214 Glioma
    103552150 (PIK3CA)
   05221 Acute myeloid leukemia
    103552150 (PIK3CA)
   05220 Chronic myeloid leukemia
    103552150 (PIK3CA)
   05218 Melanoma
    103552150 (PIK3CA)
   05211 Renal cell carcinoma
    103552150 (PIK3CA)
   05215 Prostate cancer
    103552150 (PIK3CA)
   05213 Endometrial cancer
    103552150 (PIK3CA)
   05224 Breast cancer
    103552150 (PIK3CA)
   05222 Small cell lung cancer
    103552150 (PIK3CA)
   05223 Non-small cell lung cancer
    103552150 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103552150 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    103552150 (PIK3CA)
   05161 Hepatitis B
    103552150 (PIK3CA)
   05160 Hepatitis C
    103552150 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    103552150 (PIK3CA)
   05164 Influenza A
    103552150 (PIK3CA)
   05162 Measles
    103552150 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    103552150 (PIK3CA)
   05163 Human cytomegalovirus infection
    103552150 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103552150 (PIK3CA)
   05169 Epstein-Barr virus infection
    103552150 (PIK3CA)
   05165 Human papillomavirus infection
    103552150 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103552150 (PIK3CA)
   05135 Yersinia infection
    103552150 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    103552150 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103552150 (PIK3CA)
   05142 Chagas disease
    103552150 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103552150 (PIK3CA)
   05017 Spinocerebellar ataxia
    103552150 (PIK3CA)
   05020 Prion disease
    103552150 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103552150 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    103552150 (PIK3CA)
   05415 Diabetic cardiomyopathy
    103552150 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103552150 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    103552150 (PIK3CA)
   04931 Insulin resistance
    103552150 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103552150 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103552150 (PIK3CA)
   01524 Platinum drug resistance
    103552150 (PIK3CA)
   01522 Endocrine resistance
    103552150 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:epz04131]
    103552150 (PIK3CA)
Enzymes [BR:epz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     103552150 (PIK3CA)
Membrane trafficking [BR:epz04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103552150 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 103552150
NCBI-ProteinID: XP_070439270
UniProt: A0ABM4LFQ5
LinkDB
Position
18:20011303..20084139
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccgagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggcc
acattaataactataaagcatgaactatttaaagaagcgagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacgagaagactttgtgaccttcggctttttcaaccctttttaaaa
gttattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
attggtatgccagtgtgtgaatttgatatggttaaagatccagaagtgcaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctaccctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcaaaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacagctaaaa
ctgtgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcttagaaaaatatcctctcagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccagatggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggcagaaagggtgctaaagaggaacattgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacaactacgagcaatttgtacgcgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctgcccaaattgcttctgtccgttaagtggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgcaattacccagaccctatggttcgcggttttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtacttaattcagctagtgcaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaagtctgagatgcacaataaaacagtc
agtcagaggtttggcctgcttttggagtcctattgtcgtgcatgtggaatgtatttaaag
cacctgaatcggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctgcagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgccaagaggccgctgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggtgatgatttacggcaagatatgctaacacttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttacggttgtctgtca
attggtgactgcgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaagggtgcacttcagttcaacagccacacgctacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgatctgtttacacgttcg
tgtgctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagactttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccttagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacaccatggtggatggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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