KEGG   Equus przewalskii (Przewalski's horse): 103554541
Entry
103554541         CDS       T04644                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
epz  Equus przewalskii (Przewalski's horse)
Pathway
epz01521  EGFR tyrosine kinase inhibitor resistance
epz01522  Endocrine resistance
epz04010  MAPK signaling pathway
epz04012  ErbB signaling pathway
epz04014  Ras signaling pathway
epz04015  Rap1 signaling pathway
epz04022  cGMP-PKG signaling pathway
epz04024  cAMP signaling pathway
epz04062  Chemokine signaling pathway
epz04068  FoxO signaling pathway
epz04071  Sphingolipid signaling pathway
epz04072  Phospholipase D signaling pathway
epz04140  Autophagy - animal
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04210  Apoptosis
epz04218  Cellular senescence
epz04270  Vascular smooth muscle contraction
epz04360  Axon guidance
epz04370  VEGF signaling pathway
epz04371  Apelin signaling pathway
epz04510  Focal adhesion
epz04540  Gap junction
epz04550  Signaling pathways regulating pluripotency of stem cells
epz04613  Neutrophil extracellular trap formation
epz04625  C-type lectin receptor signaling pathway
epz04630  JAK-STAT signaling pathway
epz04650  Natural killer cell mediated cytotoxicity
epz04660  T cell receptor signaling pathway
epz04662  B cell receptor signaling pathway
epz04664  Fc epsilon RI signaling pathway
epz04666  Fc gamma R-mediated phagocytosis
epz04720  Long-term potentiation
epz04722  Neurotrophin signaling pathway
epz04726  Serotonergic synapse
epz04730  Long-term depression
epz04810  Regulation of actin cytoskeleton
epz04910  Insulin signaling pathway
epz04912  GnRH signaling pathway
epz04914  Progesterone-mediated oocyte maturation
epz04915  Estrogen signaling pathway
epz04916  Melanogenesis
epz04917  Prolactin signaling pathway
epz04919  Thyroid hormone signaling pathway
epz04921  Oxytocin signaling pathway
epz04926  Relaxin signaling pathway
epz04928  Parathyroid hormone synthesis, secretion and action
epz04929  GnRH secretion
epz04935  Growth hormone synthesis, secretion and action
epz05010  Alzheimer disease
epz05022  Pathways of neurodegeneration - multiple diseases
epz05034  Alcoholism
epz05132  Salmonella infection
epz05152  Tuberculosis
epz05160  Hepatitis C
epz05161  Hepatitis B
epz05163  Human cytomegalovirus infection
epz05164  Influenza A
epz05165  Human papillomavirus infection
epz05167  Kaposi sarcoma-associated herpesvirus infection
epz05170  Human immunodeficiency virus 1 infection
epz05200  Pathways in cancer
epz05205  Proteoglycans in cancer
epz05206  MicroRNAs in cancer
epz05207  Chemical carcinogenesis - receptor activation
epz05208  Chemical carcinogenesis - reactive oxygen species
epz05210  Colorectal cancer
epz05211  Renal cell carcinoma
epz05212  Pancreatic cancer
epz05213  Endometrial cancer
epz05214  Glioma
epz05215  Prostate cancer
epz05218  Melanoma
epz05219  Bladder cancer
epz05220  Chronic myeloid leukemia
epz05221  Acute myeloid leukemia
epz05223  Non-small cell lung cancer
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
epz05226  Gastric cancer
epz05230  Central carbon metabolism in cancer
epz05231  Choline metabolism in cancer
epz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:epz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103554541 (RAF1)
   04012 ErbB signaling pathway
    103554541 (RAF1)
   04014 Ras signaling pathway
    103554541 (RAF1)
   04015 Rap1 signaling pathway
    103554541 (RAF1)
   04370 VEGF signaling pathway
    103554541 (RAF1)
   04371 Apelin signaling pathway
    103554541 (RAF1)
   04630 JAK-STAT signaling pathway
    103554541 (RAF1)
   04068 FoxO signaling pathway
    103554541 (RAF1)
   04072 Phospholipase D signaling pathway
    103554541 (RAF1)
   04071 Sphingolipid signaling pathway
    103554541 (RAF1)
   04024 cAMP signaling pathway
    103554541 (RAF1)
   04022 cGMP-PKG signaling pathway
    103554541 (RAF1)
   04151 PI3K-Akt signaling pathway
    103554541 (RAF1)
   04150 mTOR signaling pathway
    103554541 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103554541 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    103554541 (RAF1)
   04218 Cellular senescence
    103554541 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103554541 (RAF1)
   04540 Gap junction
    103554541 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103554541 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103554541 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103554541 (RAF1)
   04625 C-type lectin receptor signaling pathway
    103554541 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    103554541 (RAF1)
   04660 T cell receptor signaling pathway
    103554541 (RAF1)
   04662 B cell receptor signaling pathway
    103554541 (RAF1)
   04664 Fc epsilon RI signaling pathway
    103554541 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    103554541 (RAF1)
   04062 Chemokine signaling pathway
    103554541 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103554541 (RAF1)
   04929 GnRH secretion
    103554541 (RAF1)
   04912 GnRH signaling pathway
    103554541 (RAF1)
   04915 Estrogen signaling pathway
    103554541 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    103554541 (RAF1)
   04917 Prolactin signaling pathway
    103554541 (RAF1)
   04921 Oxytocin signaling pathway
    103554541 (RAF1)
   04926 Relaxin signaling pathway
    103554541 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    103554541 (RAF1)
   04919 Thyroid hormone signaling pathway
    103554541 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    103554541 (RAF1)
   04916 Melanogenesis
    103554541 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103554541 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    103554541 (RAF1)
   04720 Long-term potentiation
    103554541 (RAF1)
   04730 Long-term depression
    103554541 (RAF1)
   04722 Neurotrophin signaling pathway
    103554541 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    103554541 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103554541 (RAF1)
   05206 MicroRNAs in cancer
    103554541 (RAF1)
   05205 Proteoglycans in cancer
    103554541 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    103554541 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    103554541 (RAF1)
   05230 Central carbon metabolism in cancer
    103554541 (RAF1)
   05231 Choline metabolism in cancer
    103554541 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103554541 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103554541 (RAF1)
   05212 Pancreatic cancer
    103554541 (RAF1)
   05225 Hepatocellular carcinoma
    103554541 (RAF1)
   05226 Gastric cancer
    103554541 (RAF1)
   05214 Glioma
    103554541 (RAF1)
   05221 Acute myeloid leukemia
    103554541 (RAF1)
   05220 Chronic myeloid leukemia
    103554541 (RAF1)
   05218 Melanoma
    103554541 (RAF1)
   05211 Renal cell carcinoma
    103554541 (RAF1)
   05219 Bladder cancer
    103554541 (RAF1)
   05215 Prostate cancer
    103554541 (RAF1)
   05213 Endometrial cancer
    103554541 (RAF1)
   05224 Breast cancer
    103554541 (RAF1)
   05223 Non-small cell lung cancer
    103554541 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103554541 (RAF1)
   05161 Hepatitis B
    103554541 (RAF1)
   05160 Hepatitis C
    103554541 (RAF1)
   05164 Influenza A
    103554541 (RAF1)
   05163 Human cytomegalovirus infection
    103554541 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103554541 (RAF1)
   05165 Human papillomavirus infection
    103554541 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103554541 (RAF1)
   05152 Tuberculosis
    103554541 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103554541 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    103554541 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    103554541 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103554541 (RAF1)
   01522 Endocrine resistance
    103554541 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:epz01001]
    103554541 (RAF1)
Enzymes [BR:epz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103554541 (RAF1)
Protein kinases [BR:epz01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103554541 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 103554541
NCBI-ProteinID: XP_008523860
LinkDB
Position
15:6070011..6137241
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacgcg
gtgtttgatggccccagctgtatctcccctacaatagttcagcagtttggctatcagcgt
cgggcgtcagatgatggcaaacttacggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaataagcaaagaaccgtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccggagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgtttagattggaatactgatgctgcctca
ttgattggagaagagcttcaagtagatttcctggatcatgttcctctcacaacacacaac
tttgctcggaagacctttctgaagcttgccttttgtgacatctgtcagaagttcttgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgcgtggactggagtaatatcagacaactcttattgtttccgaattccact
attggtgatagtggagtcccagcactgccttccttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacgccccacgccttcacattc
aacacctccagtccctcctctgaaggttccctctcccagaggcagagatcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagccacagtgaatcagcttcaccttcagccttgtccagcagccccaacaatctg
agcccaacgggctggtcacagcctaaaacccctgtgccggcacagagagagcgggcacca
ggatccgggacccaggagaaaaacaaaattagacctcgaggtcagagagattcaagctat
tactgggaaatagaagcgagtgaagtgatgctctccacccggattgggtcaggctccttt
ggaactgtgtataagggcaaatggcacggagacgttgcagtgaaaatcttaaaggttgtt
gaccccacaccagagcagttccaggcgttcaggaacgaggtggctgtcctgcgtaaaaca
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcaattgtg
actcagtggtgtgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttc
cagatgttccagttgattgacatcgcccggcagacggctcagggaatggactatttgcat
gcaaaaaacatcatccacagagatatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagactttggtttggcaacagtcaagtcgcgctggagtggttctcag
caggttgaacaacccactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataataacccgttcagcttccagtctgatgtctactcctatggcattgtactctatgag
ctcatgacaggggaactgccttactcccacatcaacaaccgagatcagatcatcttcatg
gtgggccgagggtatgcctccccagaccttagtaagctatacaagaactgccccaaagca
atgaagaggcttgtggctgactgcgtgaagaaagttaaggaggagaggcctctttttccc
cagatcttgtcttccatcgagttgctccaacactctctaccgaaaatcaaccggagtgct
tctgagccatccctgcatcgggcggcccacaccgaggacatcaatgcctgcacgttgacc
acgtcccctagactgcctgtcttctag

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