KEGG   Equus przewalskii (Przewalski's horse): 103556123
Entry
103556123         CDS       T04644                                 
Symbol
SOS2
Name
(RefSeq) son of sevenless homolog 2 isoform X1
  KO
K03099  son of sevenless
Organism
epz  Equus przewalskii (Przewalski's horse)
Pathway
epz01521  EGFR tyrosine kinase inhibitor resistance
epz01522  Endocrine resistance
epz04010  MAPK signaling pathway
epz04012  ErbB signaling pathway
epz04014  Ras signaling pathway
epz04062  Chemokine signaling pathway
epz04068  FoxO signaling pathway
epz04072  Phospholipase D signaling pathway
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04510  Focal adhesion
epz04540  Gap junction
epz04630  JAK-STAT signaling pathway
epz04650  Natural killer cell mediated cytotoxicity
epz04660  T cell receptor signaling pathway
epz04662  B cell receptor signaling pathway
epz04664  Fc epsilon RI signaling pathway
epz04714  Thermogenesis
epz04722  Neurotrophin signaling pathway
epz04810  Regulation of actin cytoskeleton
epz04910  Insulin signaling pathway
epz04912  GnRH signaling pathway
epz04915  Estrogen signaling pathway
epz04917  Prolactin signaling pathway
epz04926  Relaxin signaling pathway
epz04935  Growth hormone synthesis, secretion and action
epz05034  Alcoholism
epz05160  Hepatitis C
epz05161  Hepatitis B
epz05163  Human cytomegalovirus infection
epz05165  Human papillomavirus infection
epz05200  Pathways in cancer
epz05205  Proteoglycans in cancer
epz05206  MicroRNAs in cancer
epz05207  Chemical carcinogenesis - receptor activation
epz05208  Chemical carcinogenesis - reactive oxygen species
epz05210  Colorectal cancer
epz05211  Renal cell carcinoma
epz05213  Endometrial cancer
epz05214  Glioma
epz05215  Prostate cancer
epz05220  Chronic myeloid leukemia
epz05221  Acute myeloid leukemia
epz05223  Non-small cell lung cancer
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
epz05226  Gastric cancer
epz05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:epz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103556123 (SOS2)
   04012 ErbB signaling pathway
    103556123 (SOS2)
   04014 Ras signaling pathway
    103556123 (SOS2)
   04630 JAK-STAT signaling pathway
    103556123 (SOS2)
   04068 FoxO signaling pathway
    103556123 (SOS2)
   04072 Phospholipase D signaling pathway
    103556123 (SOS2)
   04151 PI3K-Akt signaling pathway
    103556123 (SOS2)
   04150 mTOR signaling pathway
    103556123 (SOS2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103556123 (SOS2)
   04540 Gap junction
    103556123 (SOS2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103556123 (SOS2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103556123 (SOS2)
   04660 T cell receptor signaling pathway
    103556123 (SOS2)
   04662 B cell receptor signaling pathway
    103556123 (SOS2)
   04664 Fc epsilon RI signaling pathway
    103556123 (SOS2)
   04062 Chemokine signaling pathway
    103556123 (SOS2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103556123 (SOS2)
   04912 GnRH signaling pathway
    103556123 (SOS2)
   04915 Estrogen signaling pathway
    103556123 (SOS2)
   04917 Prolactin signaling pathway
    103556123 (SOS2)
   04926 Relaxin signaling pathway
    103556123 (SOS2)
   04935 Growth hormone synthesis, secretion and action
    103556123 (SOS2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103556123 (SOS2)
  09159 Environmental adaptation
   04714 Thermogenesis
    103556123 (SOS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103556123 (SOS2)
   05206 MicroRNAs in cancer
    103556123 (SOS2)
   05205 Proteoglycans in cancer
    103556123 (SOS2)
   05207 Chemical carcinogenesis - receptor activation
    103556123 (SOS2)
   05208 Chemical carcinogenesis - reactive oxygen species
    103556123 (SOS2)
   05231 Choline metabolism in cancer
    103556123 (SOS2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103556123 (SOS2)
   05225 Hepatocellular carcinoma
    103556123 (SOS2)
   05226 Gastric cancer
    103556123 (SOS2)
   05214 Glioma
    103556123 (SOS2)
   05221 Acute myeloid leukemia
    103556123 (SOS2)
   05220 Chronic myeloid leukemia
    103556123 (SOS2)
   05211 Renal cell carcinoma
    103556123 (SOS2)
   05215 Prostate cancer
    103556123 (SOS2)
   05213 Endometrial cancer
    103556123 (SOS2)
   05224 Breast cancer
    103556123 (SOS2)
   05223 Non-small cell lung cancer
    103556123 (SOS2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103556123 (SOS2)
   05160 Hepatitis C
    103556123 (SOS2)
   05163 Human cytomegalovirus infection
    103556123 (SOS2)
   05165 Human papillomavirus infection
    103556123 (SOS2)
  09165 Substance dependence
   05034 Alcoholism
    103556123 (SOS2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103556123 (SOS2)
   01522 Endocrine resistance
    103556123 (SOS2)
SSDB
Motif
Pfam: RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH PH_19 PH_13 IQ_SEC7_PH RHG20_PH PH_10
Other DBs
NCBI-GeneID: 103556123
NCBI-ProteinID: XP_070444859
LinkDB
Position
1:complement(183387276..183475838)
AA seq 1316 aa
MRSQSAGDPGELMVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQK
TFPHPIDKWAIADAQSAIEKRKRRHPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEY
ISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGE
LNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVK
LLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPKFNEHFSKLMARP
AVALHFQSIADGFREAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAIT
ALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIG
QCCNEFIMEGPLTKIGAKHERHIFLFDGLMISCKPNHSQSRLPGYSSAEYRLKEKFVMRK
IQICDKEDTCECRHAFELVSKDENSITFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVL
LKEENEQPLRLPSPEMYRFVVKDSEENIVFEDSLQSRSGIPIIKGGTVVKLIERLTYHMY
ADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLAVEKGEQPISADLKRFR
KEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIK
RKKQTQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRK
VQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRVIEI
LQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDEAVELSQDHFKKYLVK
LKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQP
YCLRIEPEMRRFFENLNPMGSSSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSP
GIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAEAELGSAVSAPTSPNTPSTPPASA
ASDLSVFPDVDLSASCGSNSIFAPVLLPHSKSFFSSCGSLHKLSDEPLIPPPLPPRKKFD
HDASNPKGNMKSDDDPPAIPPRQPPPPKVKPRVPAPSGAFEGSLHSPPPPPPREPLPDTP
PPVPLRPPEHFINCPFNLQPPPLGHLHRDPDWFRDVSTRPDSPNTPPSTPSPRVPRRCCV
LSSSHSNLTYPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPMYRLSLLENAETPQ
NT seq 3951 nt   +upstreamnt  +downstreamnt
atgcgcagtcagtcagctggagacccaggagagctgatggttcaggagcaggtacatccc
aatctctcagctaatgaagaatctctctattacattgaagagctgatttttcaactgctt
aataaattatgcatggctcagccaaggactgttcaagatgtggaggaacgagttcaaaag
acctttccgcatccaattgataaatgggctattgctgatgcacaatccgccatagagaaa
cgaaaacgaagacaccctctcttactgcctgtggacaaaatccatccttcattgaaggag
gttttagggtacaaagtggactaccatgtgtccctgtatattgtggctgtactggagtat
atctcagctgatattttaaaattggctggtaattatgtttttaatattcgacattatgaa
atatctcagcaggacattaaagtgtcaatgtgtgcagataaggttttgatggacatgttt
gatcaggatgacataggtttggtttctctctgtgaagatgagccgagttcttcaggtgaa
ttgaattactatgaccttgtcagaactgaaattgcagaagaaagacagtatctccgggaa
ctaaatatgatcataaaagtatttcgagaagcctttctttctgacagaaagctgtttaaa
ccttctgatattgagaagattttcagtaacattttagatatacatgaattgactgtgaaa
cttctaggtttgattgaggacacagttgagatgactgatgaaagcagtcctcatccctta
gctggcagctgtttcgaagatttggcagaagagcaggcttttgatccttatgaaacatta
tcacaggacatcctttcaccaaaattcaatgaacatttcagtaagttgatggccagacct
gcagtggctctacactttcagtccattgctgatgggttcagagaggcggttcgttatgtc
cttccacgcctgatgcttgtgccagtgtatcattgttggcactacttcgaattattaaag
caattgaaagcatgtagtgaagaacaagaagacagagaatgtttgaaccaagctattact
gctctcatgaatctccagggtagtatggaccgaatttataagcagtattcgcctagacgt
cgacctggggatcctgtttgccctttttataatcgtcaattaagaagcaagcacctggct
attaaaaaaatgaatgaaattcagaaaaacatagatggatgggaaggcaaagacatcgga
cagtgttgtaatgaattcattatggaaggtcctttgacaaaaattggtgctaaacatgaa
cggcatatttttctctttgatggcttaatgattagctgcaaacccaatcatagccagtcg
cggcttccagggtacagtagtgcagaatacagactgaaagagaagtttgtcatgaggaaa
atacaaatatgtgataaagaagacacttgcgagtgcagacatgcttttgaattagtctcc
aaagatgaaaacagcatcacatttgctgccaagtctgccgaagagaagaataactggatg
gcagcactcatttctcttcattaccgtagcacactggaccgaatgctggactcagtgtta
ctgaaggaagaaaatgagcagccactgaggttaccaagtcctgagatgtatcgtttcgtg
gtgaaagactctgaggaaaacatagtttttgaagacagcttgcaaagtagaagtggaatc
cccattattaaaggaggaactgtggtgaaattaattgaaaggttgacatatcatatgtat
gcagatcccaattttgttcgtacttttcttactacatatcgttcattttgtaaaccacag
gaattgctaagcttactaattgaacgatttgaaattccagagccagaacctactgaagca
gataaattggcagtagagaaaggcgagcagcccatcagtgcagaccttaaaaggtttcgc
aaggaatacgtccaaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaa
caccatttttatgattttgaaagagatttggagttgcttgaacggctagaatccttcatt
tcaagtgtaagagggaaagctatgaagaaatgggtagagtcaattgctaagatcatcaag
aggaagaaacagactcaggcaaacggaataagccataatatcacctttgaaagcccaccc
cccccgattgaatggcacatcagcagacccgggcagttcgagacctttgatctcatgaca
cttcatccaatagaaattgcacgccagctgacgcttttggaatctgatctctataggaaa
gtccagccttctgaacttgtagggagtgtgtggaccaaagaagataaagaaataaattct
ccaaatttattaaaaatgattcgccacaccacaaatctcaccctctggtttgaaaagtgc
attgtggaagcagaaaactttgaggaacgagtggcagtactaagtagagttatagaaatt
ctgcaagtttttcaagatttgaataatttcaatggcgtactggagatagtcagtgcagtg
aattcagtgtcagtgtacagactagaccataccttcgaggcattgcaggaaagaaaaagg
agaattttggatgaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaa
cttaagtcaatcaatccaccttgtgtgcctttttttggaatatatttaacaaatattctg
aagactgaagaagggaataatgattttttaaaaaagaaagggaaagatttaatcaatttc
agtaagaggaggaaagtagctgaaattactggagaaattcagcagtatcagaatcaacct
tactgtttacggatagaaccagagatgaggcggttctttgaaaaccttaaccccatggga
agttcttctgaaaaagagtttacggattatttgttcaacaaatcactagaaattgaaccc
cgcaactgcaaacagccacctcgatttcctaggaaatcaactttctctttaaaatctcct
ggaataaggcctaacacgggcagacatggctctacctcaggcactttacgaggtcatccc
accccgttagaaagagaaccgtgtaaaatcagctttagtcggattgctgaggctgagctg
ggatcagcagtgtcggcaccaacctctcccaacacgccgtccaccccgccggcgtctgct
gcttcagacctcagtgtgttcccagacgtggacctcagcgcttcctgtggcagcaatagc
atctttgctccagtcctcttgccacactcaaagtccttcttcagttcatgcggtagttta
cataaactaagtgacgagcccctgattcctcctccgcttcctcctcggaagaagtttgat
cacgatgcttcgaatcccaagggaaatatgaaatctgatgatgaccctcctgctattcca
ccaagacaacctcctcctccaaaggtgaaacccagagttcccgctccttctggtgcattt
gaggggtctctgcacagcccacctccaccgccgcccagagagcctcttcctgacacgcct
ccaccggttccccttcggcctccagaacactttataaactgtccgtttaatcttcagcca
cctcccctgggacatcttcacagagatccagactggttcagagacgttagcacacgacca
gattcgcccaacactcctcccagcacaccgtctccacgggtgccacgtcgatgctgtgtg
ctcagttctagtcacagtaatctcacttatcctcaagctccccctgttccaccaaggcag
aattcaagccctcacctaccaaaactgccaccaaagacttacaaacgggagctttcgcac
cccccaatgtacagactgtctttgctagaaaacgcggaaactcctcaatga

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