Euwallacea similis: 136415537 Help Entry 136415537         CDS       T10684                                  Symbol RyR Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism esim  Euwallacea similis Brite KEGG Orthology (KO) [BR:esim00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:esim04040]     136415537 (RyR)    04990 Domain-containing proteins not elsewhere classified [BR:esim04990]     136415537 (RyR) Ion channels [BR:esim04040]  Voltage-gated cation channels   Ryanodine receptor    136415537 (RyR) Domain-containing proteins not elsewhere classified [BR:esim04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    136415537 (RyR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  136415537 NCBI-ProteinID:  XP_066256245 LinkDB All DBs Position 20:3323122..3350647 Genome browser AA seq 5121 aa AA seqDB search MVAETEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGDETGKGTGSGHRTLLYGNAILLRHQNSDMYLACLST SSSNDKLAFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTK ENELSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSSWSTEE GHNIVIYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHITTGRYLAVNENNELY LVNREEATTALTAFCLRYEKDDQKVVLEDKDLEVIGSAIIKYGDSTVIVQHSESGLWLSY KAYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQFINGL ESLQVNRRHSMFFQVVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRLRALRNRQDLFQE EGILNLILEAIDKINVITSQGFLAALAGDQSWEMISMYLYQLLAAIIKGNHTNCAQFANS NRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKV LDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVASVRPNIFVGRVAGSAIY QKWYFEVTVDHLEQTTHMTPHLRIGWANSKGYIPYPGGGEKWGGNGVGDDIYSFGFDGAF LWTGGRSTQIVGNVVEPYIRKNDVIGCALDLTVPQIAFTFNGNPIRGSFRNFNLDGMFFP VISCSSKLSCRFLLGGDHGKLKFCPPDEFSPLVESLLPQQILNLDPCFYFGNMNKNVIAG PLLIEDDTAFVPNPVDTSMVSLPSYIESIKDKLAENIHEMWAMNKIEAGWTWGEYRDDLR HIHPCLVPFDKLPPAENRYDCQLAVQTLKTIIALGYHITMDKPPSRIKTVRLPNEPFMQA NGYKPAPLDLSAIALTPKLEELVDQLAENTHNLWAKERIQQEWTYGLNEDPELLRSPHLV PYNKVDEAIKKANWDTASETVRTLLVYGYIIDPPTGEQQETLLAEATRLRQQAFRTYRAE KNYAVGSGKWYFEFEILTAGPMRVGWAKADCAPGCMLGSDENTWAFDGYNEEKVYSNSAE SFGKQWQVGDVVGVFLDLIDHTISFSLNGELLMDALGGETTFADVQGDNFVPAFTLGVGQ KARLCFGQDVNQLKYFTMCGLQEGYEPFCVNMNRAVTYWYTKDQPIFENTDDMPDTKIDV TRILAGSDSPPCLKISHNTFETMEKANWEFLRLSLPVICHPEFITEEEKMRRWNEIKVRQ HRLKIEADQQMTGPNPNPAHIENIMKSGFSMTDIKGLHRNYSEDAVEADEVLKQQHLSRT AGHGKAMPARPPRKGSLSRNTNVNGFEDGYIHVNGAKSGVPRSTSELDMNRYYDTARQNT DKSEEKKKRGRSPFRFFSKKRGDASSAERTKNKKSRTPEPHTVRMSTMSPTARSVGLSNT MLSRSPTMKQQPQGDGLQAPSAVPQQKQLSVPQTSDVEAVGNEIYDAECLKLINEYFYGV RIFPGQDPAHTYVGWVTTQYHFFSKEFNQEHVLKSSVVITDDYDRIVDFIERQSCYMVRA DELYNQVTQDASGKGASQGMFIGCFLDAATGYISFTCDGKPTSHKFKMEPETKLFPAIFV EATSKEVMQIELGRTSTSLPLSAAVLQNSAKHVIPQFPPRLKVQCLKPHQWARVPNHNLQ VHALKLSDIRGWSMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYSALC YQSNYKAAHVLCHHVDQKQLLYAIKSEYMSGPLRQGFYDLLISLHLEAAATTMEVCKNEY VIPIGQDLKDLYENSEMGHSLRRLQMESVMPQMKTSDISENIENIKSLYSPYFPLDVVRD YIMTALAESVEINQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLSDEDVDKLLIMVCPE TWDPTFEKDGKDEHRKGLLQMKMAEGAKLQMCYLLHHLCDIQLRHRVESIIAFSHDFVGD LQTDQLRRYIEIKQSDLPSAVAAKKTKEFRCPPREQMNAILSKFKMEGFKNMEEEEKENC PLGDDLCERMNNFHDHLMVHVSLLALQAPVEEENPEDKLKPGPLKKLYNFINAVKELEEE PKPEIEPERKTPEEVFRKVLISTIVRWAEEAQIELPNLVKEMFGLLVRQYDSVGELIRAL EKTYIINSKTKSDVAEMWIGLSQIRALLPVQMSQEEEELMRERLWKLVNNHTFFQHPDLI RVLRIHENVMAVMINTLGRRSQAQSDASATAQNPEGETGAAKEKDTSHEMVVACCRFLCY FCRTGRQNQKAMFEHFDFLLDNSNILLSRPSLRGSTPLDVSYSSLMENTELALALREHYL EKIAVYLSRCGLQSNTELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIR LLIRRPECLGPALRGEGEGLLKAIVDANKMSERITDRRKMMEESPEGTVNLQQFSHPLPE GDEDEDYIDTGAAILNFYCTLVDLLGRCAPDAAVIALGKNESLRARAILRSLVPLEDLQG VLSLKFTLHNPAQGEERPKSDMPSGLTPPHKQSVVLFLERVYGIETQELFYRLLEEAFLP DLRCATMLDRHDGSESDMALSMNRYIGNSILPLLIQHSKFYSEAENYASLLDATLHTVYR LSKNRMLTKGQREAVSDFLVALTSQLQPSMLLKLLRKLTVDVSNLSEYTTVALRLLTLHY DRCAKYYGSSGGQGLYGAASDEEKRLTMMLFSNIFDSLSKMDYDPELFGKALPCLTAIGC ALPPDYSLSKNYDDEWYTNKAASGPDGPYNPQPINTSVVQLNNDLNNIVQQFSEHYHDAW ASRKLENGWRHGDSYSGWDGNKTHPRLKPYSMLSDYERERYKEPVRESLKALLALGWTVE HTEVDLPSTNRSSQFSRGESSSAFDYNPHPVDMTNLTLSREMQNMAERLAENSHDIWARK KREELITCGGGIHPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRPNRGGQQETE QSTSGPAIELRFAYSLLEKLIQYLDKATINMKLLKPSQTFSRRNSYVKSSRDIKFFSKVV LPLMEKYFSTHRNYFIAVATATNLTGAASLKEKEMVAALFCKLASLLRSRLAAFGADVRI TVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTIINLQEGKYSHLRGTHL KTSTSLFYVNAVLLPVLTAMFDHLANCEYGSDLLLDEIQVASYKILQGLYHLGTDSTLHH DRKYLKHEMEKYKPALGSCLGAFSSTFPVAFLEPHLNKNNQFSLLNRIADHSLEAQDIMA KMEQFMPTLETILSEVDQFVESNKTYSEDPHIIDVTMPMLCSYLPFWWGQGPDNVSPTGG SHVSMVTSEHMNQLLKNVLNLIRKNIGNENAPWMTRIAAYTQQIIINISEELLKDVFLPL AERVRKRTEAMFHKEESLRGFIKSSTDDTSQIETQIQEDWHLLVRDIYSFYPLLIKYVDL QRNHWLRHNIEEAEHLYNHVAEIFNIWSNSQYFLREEQNFISANEIDNMVLIMPTATRRT VVTDGSQPSVGKMKKKKKNRDKKRDKDKEIQASLMVACLKRLLPVGLNLFAGREQELVQH CKDRFLKKLPEYEIIDFAKTQLTLPNKIDPADEMSWQHYLYSKLGKNKSLTVNVLDSSGK NQLEETIERIVAMSKVLYGLHMIDHPQQQQKGVYRSIVSTQRKRAVLSCFRQASLHSLPR HRAINIFIRTYRDFWLQDENVGQEVMIEDLTQSFEDSELKKKDEEEEEGKPDPLTQLVTT FCRGAMTERSGALQEDPLYMSYAEIIAKSCGEEEEEGDEGGEEGGEGEEGGSSIHEQEME KQKLLFNQARLANRGVAEMVLLHISACKGVPSEMVMKTLELGISVLRGGNFDIQMGMLNH LKDKKDVGFFTSIAGLMNSCGVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALF RFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDP AGKANFFKAIGVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSK HSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMF LKLKDLTSTTSFLEIDINSDGWVYPKDFKEKMEQQKSYTPEEIEFLLACCEINHDGKIDY VGFIDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILG GSKRIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFINFCEDAIFEM QHASGLMAVEESGGGGPTRATTYNYLTDEDEQKGARDPIRRSYQAVKDGIYYGLSALSPS NMKHKINEMQQMSIPELFIGFFKLIFYTFYYSGFGVAVVIQYFLGILMSLMRGPVVEEPS VEIKEEEKTSHLRVLPPLPPAEDPGSQLTPALVDASRGESAGHHKASGHELAAGAQASLS AEGEGLTATEEGVELGDVELSEQPLSLSDLLGGEQAKLAAQEKVEAQAAQQAAMQAIESE TKAKAGTESSVMRQINFSGYTHRAVSFLARNFYNLKYVALVLAFCINFMLLFYKVTTLGG DAEGSGAEPDIIDGSASGSGSGSDEEEDEDLPELVIVDEDFYYMAHVMRLAALLHSMVSL AMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPEDDDLKSHWDKLVISAKSFPVNY WDKFVKKKVRQKYSETYDFDSISNLLGMEKTSFQQQEADEGHKSIIWYIINIDWRYQIWK SGVTFTDNSFLYSLWYFVFSILGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVL TVLLLTIIVYIYTVIAFNFFRKFYVSEEDEEVDRKCHDMLTCFVFHLYKGVRAGGGIGDE IEPPDGDDYEAYRIMFDITFFFFVIIILLAIIQGLIIDAFGELRDQLEKVIEDMDSNCFI CGLDKGYLDKVPHGFDTHVQQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWD FFPMGDCFRKQYEDEIGGGGG NT seq 15366 nt NT seq  +upstreamnt  +downstreamnt atggtggcagaaaccgaagggggatccgaacaggatgatgtctccttcttgcgaacggaa gacatggtctgtctttcctgcaccgctacgggagaacgcgtgtgcttggctgctgaagga ttcggcaacagacactgcttcctggaaaatatagctgacaagaacatcccccccgatctg tcgcaatgcgtttttgtaatagaacaggccttgtcggtgcgtgccctgcaagagctggtc acggcggccggagatgagaccgggaaagggactggttccgggcatcggaccctcctctat ggtaacgcaattcttctgagacatcagaacagcgacatgtacctggcatgtctttctacc agctcgagcaacgataaattggcctttgatgtcggcttacaagagcacagtcaaggagag gcctgctggtggacagtgcaccccgcaagtaaacaaagatctgaaggcgaaaaagtgaga gtgggtgacgatcttatcttggtttctgtcgccactgaacgctacttgcacacgaccaaa gaaaacgagctctcaattgtgaacgccagtttccacgtaacccattggtcagttcaacct tacggtactggtatttcccgcatgaagtacgtgggttatgtatttggaggtgatgtcctg cggttcttccatgggggcgacgaatgtctcacgattccctcgagctggagcaccgaggaa ggccacaatattgtaatttatgaaggtggcagcgtaatgtcccaagccaggtccttgtgg aggctggagctggcacgcactaaatgggcgggtgggtttatcaactggagtcacccgatg agaattagacacatcaccactggacggtatttggccgtgaatgaaaacaacgagttatat ctcgtcaaccgggaggaagccaccacagccctgacggcgttttgcttgaggtacgagaag gacgatcagaaggtggtgctcgaagacaaagatctggaagtgatcggttcggctataatc aaatatggcgactccacagtcatcgtgcagcattcggagtctgggctgtggctctcttac aaagcgtacgaaacaaagaaaaaaggcgtgggcaaagtggaagaaaaacaagcggtcctc cacgaggagggaaaaatggacgacggtctggacttcagtcgcagccaggaagaggagtct cgcaccgctcgtgttataagaaaatgtagctccctcttcactcagttcataaacggcttg gaaagtctccaagtgaacagacgtcactccatgtttttccaagtggtcaatctcaacgaa atggtcatgtgcctcgaggatttgatcaactactttgctcagcccgaagacgacatggaa catgaagagaagcagaaccgattgagggcgttgcggaacagacaagatttgttccaggag gaagggatcttgaacttgattctggaggccatcgacaagatcaacgtgatcacgtcccag gggttcctggccgccttagcgggcgatcagagttgggaaatgatttccatgtacctttat cagctgctcgcggccatcatcaaagggaatcacaccaattgcgcgcagttcgccaactcc aacaggctgaactggttgttttccagactgggatcgcaagcatccagcgagggcacaggg atgctggacgtgctccattgtgtgctgattgactccccggaggccttgaacatgatgcgc gatgaacatatcaaggtcatcatctccctcttggagaaacacgggagagatcccaaagtc ttggacgtcttgtgctcgctctgcgtcggtaacggggttgccgtgcgcagctcgcaaaac aacatctgcgactacctcctgcccggcaaaaatttgcttttacaaacccagctggtcgat cacgtggccagcgttaggcccaacatattcgtgggaagagtcgcgggaagtgccatttat caaaagtggtactttgaggtgaccgtcgatcacttggagcagactacccatatgactccg cacttgaggatcggatgggccaattcgaaagggtatataccatatccgggtgggggggag aagtggggaggcaacggagtgggagacgatatctattcttttggattcgatggggcattt ctgtggactggaggcagatccacccagatcgtcggcaacgtagtcgagccatacattagg aagaatgatgtgattgggtgcgcattggatttgacggtgccccaaatcgcgttcaccttc aatgggaatccgattcgaggcagttttaggaacttcaacttagacggcatgttctttcca gttataagctgctcctcgaaattaagctgtcgattcttactcggtggcgaccacggcaaa ttgaagttttgccctcccgatgaattctcccccctggtggaaagccttctgccccagcaa attctcaacctggatccatgcttctattttggaaacatgaacaaaaacgttatagccggc ccccttcttatcgaggacgatacggcctttgttccgaatccagtggatacttcgatggtc agtctgcctagctacatcgaatcgatcaaagacaaattggcggaaaacatccacgaaatg tgggccatgaacaagatagaggccggttggacttggggggagtaccgcgacgacttaaga cacattcatccatgcctggtgccctttgacaagttgccgccggcggagaacagatacgac tgccagttagctgttcagaccctcaagaccatcatcgctctgggctatcacatcacaatg gacaaaccgccgtccagaattaagacagtcagacttcccaacgagcctttcatgcaggcg aacggctacaagccagcccctctggacctgagcgcgatcgctctcacccctaaactggaa gagttggtggatcagcttgccgaaaacacgcacaatttgtgggcgaaggagcggatccag caggagtggacgtacggcctgaatgaggatccggaattgttacgcagtccccatttagtg ccgtacaataaagtggacgaggccattaagaaggctaattgggacaccgcttctgagacc gtaaggacgctgttggtgtacggttacatcatcgacccccccaccggggaacagcaggag actctgctggctgaggcaacgagattgagacagcaagctttcaggacttatagagctgag aagaactatgcggtcggctctggcaagtggtatttcgaattcgagattttaaccgcaggg cccatgcgcgtcggatgggccaaggccgattgcgcgccgggatgcatgctcggctctgac gaaaacacgtgggcctttgatggttacaatgaagaaaaggtttatagcaattcggcagag tctttcggcaagcagtggcaagtgggcgatgtggtcggagtctttctcgatttaatcgat cacactataagtttctccctcaacggggaattgttgatggacgccttggggggcgaaacc acattcgcagacgttcaaggggataacttcgtccccgccttcacattgggggtgggccaa aaagcccgactgtgcttcggacaggacgtcaatcagctcaaatacttcaccatgtgcggt ttgcaggagggctacgaacccttttgcgttaacatgaatcgggcggtgacctactggtac accaaggaccagccgattttcgagaatacagatgacatgcccgataccaagatcgacgtg acccgtattttggcgggttccgacagccccccctgtttgaaaatcagccacaacacgttc gagaccatggaaaaggccaattgggagtttcttaggcttagtctgcccgtcatatgccat cccgagttcatcacggaggaagaaaaaatgcgtcgctggaacgagatcaaggtccggcag catcggctgaaaatcgaggccgaccaacagatgactggaccgaacccgaatcccgcgcat atcgagaacataatgaaaagcggcttttccatgactgatattaaaggcttacatcggaac tactcggaagatgctgtggaggccgacgaggtcttgaagcagcaacacttgtccaggacg gcaggtcatgggaaggcgatgcccgccagaccgcccagaaaggggtcgctatccagaaat acgaacgttaatggattcgaagatggctacattcacgtaaatggtgctaaaagtggagtg ccgcgttcgaccagcgaactcgacatgaacagatactacgacacagcccgtcaaaacacc gacaaaagtgaggaaaagaagaaaagagggcggtcacctttcaggtttttctccaaaaag cggggggacgcctccagcgccgagcgcaccaaaaataagaagtccaggacgccggaaccg catacagtgcgcatgagcacaatgagccccaccgctcgttcagtggggttgtccaacacc atgctctctcgaagccccactatgaagcaacagccccaaggcgacggtcttcaggccccc tcggcggtgccccaacaaaaacaactgtcggtgcctcagacctccgatgtcgaagccgta ggcaacgaaatttacgatgccgaatgcctgaaactcatcaatgagtatttttatggagtg cgcatattcccaggacaagatcctgcccacacttacgtggggtgggtcaccactcagtac catttcttcagtaaagagtttaatcaggaacatgtattgaagtcatccgtagtcatcacg gatgactacgacagaatcgttgattttatcgagaggcagtcctgctacatggtgagagct gacgagttatacaaccaagtgactcaggacgcttcgggcaaaggagcctcccaaggaatg tttattggctgtttcctggatgctgccactgggtacattagttttacctgcgacggcaaa ccaacgtctcacaagtttaaaatggaaccggaaaccaagctctttcctgcgatcttcgtg gaggccaccagcaaagaagtaatgcaaatcgagttgggaaggacatccaccagtttgccc ttatcagcagcagtgctgcagaacagcgccaagcacgtaatccctcaatttcctccgagg ttgaaggtccagtgcttgaagccacaccagtgggctcgtgtgcccaatcacaacctccaa gtacatgctttgaaattatcggacatccgaggctggtccatgctgtgtgaggacgccatc tcaatgctggccctgcacataccggaggaagaccggtgcatcgacattctggaactgatc gaaatggataaattgctgagtttccatgcacacacgcttactttgtattcagctttgtgc taccaaagtaactacaaggcagcccacgtgttgtgccatcacgtggaccagaagcagctc ctctacgccattaaatcagaatacatgagcggaccactgcgacagggcttctacgattta ctgatttctctccacttggaggccgcggccactaccatggaggtttgcaagaacgagtat gtcatccccattgggcaggacctgaaagatttatatgagaactcggaaatggggcacagt ctgcgaaggctccagatggagtcggtcatgcctcaaatgaagacttctgacattagtgaa aacatagagaacataaagagtctctactccccgtattttcctctggatgttgtgcgggac tacatcatgacagctctagcagagtcggtggaaatcaatcaagttcacaatagagaccca attggcggctccaacgaaaacttgttcttacctttgttgaagctcgtggatcgccttcta ctcgtaggaatgttgagcgacgaagacgtggacaagctcctcataatggtttgtccggag acgtgggatcccacctttgaaaaggacggcaaagacgaacaccgcaagggtctcctccaa atgaaaatggcggagggagcaaagctgcaaatgtgctatttgctgcatcacctctgcgac atccagcttcgacatcgcgtagagtccattatcgccttcagccatgatttcgtaggggat ctgcagacggatcagctgcgtcgttatattgaaattaaacaatctgatctgccgtccgcg gtcgcggccaagaagaccaaagagttccggtgtccacccagggagcagatgaatgccatt ttgagtaagttcaagatggaaggtttcaaaaacatggaggaagaagaaaaagaaaactgc cctctgggcgatgatttatgcgagaggatgaacaacttccacgaccacctcatggttcac gtgtcgttgttagccttgcaagctcccgttgaggaagagaaccccgaggacaaactcaaa ccaggccccttaaaaaagctgtataatttcattaatgccgtcaaagaactcgaggaggag cccaaacctgaaatcgagcctgaaaggaagactccggaggaagtgtttagaaaggtttta ataagcaccattgtgaggtgggctgaggaggctcaaatcgagcttccgaacctcgtcaaa gagatgtttggcctcctggtgcgtcaatacgactccgtgggcgaactgattcgagctctc gagaagacgtatatcataaattccaagaccaagagtgacgttgctgaaatgtggatcggt ctcagccagatccgcgccctgttgcccgtgcaaatgtctcaagaggaagaggagctgatg cgtgaacgcctctggaaactggtcaacaaccataccttcttccagcatccagacttgatt cgggtcttgaggattcatgagaacgtgatggccgttatgatcaacactttaggaagaaga tcgcaggctcaatcggatgccagtgccacggctcagaatccagagggggaaacgggagcg gccaaggagaaggacacttcgcacgaaatggtggtcgcatgttgccgtttcctttgctac ttttgccgcacggggcgccaaaaccaaaaagccatgttcgagcactttgacttcctgtta gacaacagcaacatcctcctttccaggcccagtttacggggttccactcccttggacgtg tcttactcctcgctgatggaaaacaccgaactagcattggccttgagggagcattacctg gagaaaattgcagtttatctgtcgcgctgcggccttcaatccaataccgagctggttgaa aagggttatcctgacttgggctgggacccagtggaaggtgaacgatacctggactttttg agattctgcgtgtgggtgaatggggaaagtgtcgaagagaatgcaaatttggtcatcagg ctgctgatacgtagacccgaatgtctcggacctgctctgaggggcgaaggcgagggacta ttgaaagctattgtggatgccaataagatgtcggaaaggataacagacagacgaaagatg atggaggaatcccccgagggcacagtgaacttgcagcagttctcgcatcccctacctgag ggcgacgaggatgaggactacatcgacaccggagccgcaattttgaatttctactgcacc ttggtagacttgctgggcagatgcgcccctgatgccgccgtcatcgctttgggtaaaaat gagtccttgagagccagagccatcctgcgatctttggttcccttggaggaccttcaaggc gttttgagtctgaaatttaccctgcataatccggctcaaggcgaagaacgaccgaagtcg gacatgccctccggattaacgccgcctcataagcaatcggtggtactgttcctggagagg gtttacggtatcgaaacgcaggagctgttctatcggctgctggaagaggctttcttgccc gatctgaggtgtgccaccatgctggacaggcatgatggcagcgagtcggacatggccctc agcatgaaccgctacattggcaactccattttgcctctgctgattcaacacagtaaattt tatagcgaggctgagaactacgcctcccttctcgacgctactctccacacagtctacaga ctttctaagaatcggatgttaaccaaaggccagagggaggcggtgtccgatttcctggtc gccttgactagccagttgcagccgtccatgctgttgaaactgctgagaaagctcactgtg gatgtatccaatttgtcggagtacaccactgttgccttaaggttgctgactttgcattat gatagatgcgcgaagtattatgggtccagtggtgggcaaggactttacggagccgccagc gacgaggagaagcgcctcacaatgatgctattttcaaacatttttgattccctaagtaag atggattacgaccctgaacttttcggcaaagccctaccctgtctgaccgccattggttgc gccctgcctccggattattctttatcgaaaaattacgatgatgaatggtacacgaacaag gcagcgtcaggcccagacgggccctacaacccacagcctataaatacctctgtggtacag ttgaacaacgatttgaacaacatagttcagcaattctccgagcactaccacgacgcttgg gcctccaggaagctggaaaatggctggagacacggggacagttattctggttgggatgga aataaaacccatcccaggttgaagccttattccatgcttagcgactatgagagggagaga tataaagaaccggttagagagtcgcttaaggccttactggcccttggttggaccgtggaa cacacagaagtggacttgccatccaccaatagaagctcccaattttccagaggggagagc agtagcgcttttgattacaatcctcatcctgtggatatgaccaatttgaccttatcgagg gagatgcaaaacatggccgaaagactggcggagaattcacatgatatttgggccagaaag aagagggaggaattaatcacttgtggaggcggtatccacccgcaactagttccctacgat ctcctcaccgacaaagaaaagaaaaaggatcgcgagcgttcccaagaattcctgaaatac ctgcaatatcagggctataaactgcatagacctaatcggggtggtcagcaagaaaccgaa caatccacctccggaccggccatcgaactcagattcgcttatagccttctagagaagctc atccagtacctggataaggcgaccatcaacatgaaactgctcaaaccatcccaaactttc agccgcaggaattcctatgtcaaatcctcgagggacatcaaattcttctccaaagtggtg ctaccgttaatggagaagtacttctccactcatcggaactacttcatcgcagtagccacc gctacgaatttgaccggagctgccagtttaaaggaaaaagagatggtggctgccctcttt tgcaaattagccagtttgttgagatccagattagccgcctttggagcggatgtgaggatt accgtccgatgcctgcaagtattggttaagggcatcgacgccaagtctttggtgaagaat tgtccggagtttatcagaacgtcgatgctgacgtttttcaataatactgctgacgatttg ggacacaccattataaatttgcaggagggtaaatacagtcacttgcggggcactcatctc aagacttcgacgtctttattttatgtaaatgccgtgctattgcccgtgctgaccgctatg tttgaccacttggcaaattgcgaatacgggagtgacttgctgctggacgagatccaggtg gcttcctataagatccttcaaggcctttaccatctgggtaccgactccacgttacaccac gaccgcaaatacctgaaacatgagatggagaagtacaagcccgccttgggctcttgtttg ggggctttcagctccactttccctgtggccttcttagaaccgcatctcaacaaaaacaac cagttttccctgctgaatcgaatagctgaccactcattggaggcccaagacataatggcg aaaatggagcagttcatgccgaccctcgagacgattctgtcggaagttgatcagtttgtg gagagcaacaagacctactcggaagatcctcatataatcgatgttaccatgcccatgctg tgctcctatttgcctttttggtggggtcagggacctgacaatgtcagtcctactggagga tctcacgtttcgatggtcacttccgaacacatgaaccaacttctcaagaacgttctcaat ctcatacgaaagaacatcggcaacgagaacgccccttggatgacccgcattgccgcctac acccagcagatcatcatcaacatcagcgaggaactattaaaagatgtcttcctaccgttg gcggaaagggtccgaaagaggaccgaggcaatgttccacaaagaggagagtttgcggggg ttcattaagagcagcaccgatgatacgtctcagatcgagacgcaaatacaagaggactgg cacctactggttagagacatctactccttctatcctcttttgatcaagtacgtggatctt cagaggaaccactggttgaggcacaacattgaagaggcggagcacctttacaatcacgta gctgaaattttcaacatctggtctaattcccagtacttcttgagggaggaacagaacttt atttccgccaacgaaatcgacaatatggtgctaatcatgcccacggcgaccaggagaact gtggttactgatggcagtcagccttccgtaggcaaaatgaaaaagaagaaaaaaaaccga gacaaaaagcgggacaaagacaaggaaattcaagcgtcgctaatggtggcctgcctcaaa cgtcttctgcctgttggtttaaacctctttgcaggtcgtgagcaggagctggtgcagcac tgcaaagatcgcttcttaaagaaactgcccgaatacgaaataatcgattttgcgaaaacc caactgactcttcccaataagatcgatccagctgatgaaatgtcctggcagcactacctt tacagcaaactgggcaaaaacaagagtcttaccgtaaatgtgttggacagcagtggcaag aatcagcttgaggagaccatagagcgaatagttgctatgagcaaagtgttatatggactt cacatgatcgaccatcctcagcaacagcagaagggcgtttatcgatcgatagtttcgact cagcgtaaaagggccgtgttatcttgtttccgtcaagcttctttgcacagtctgcccaga catcgggccattaatatcttcatacgcacctaccgcgacttttggctgcaagatgagaat gtaggacaggaagtgatgatcgaggacctcactcagagcttcgaagattcggagctgaag aagaaagacgaggaggaggaagagggaaagcccgatcctctcactcagctcgttaccaca ttttgcagaggtgcaatgaccgagaggtcgggagcccttcaggaagatcctttatatatg agctatgcggaaattattgctaaatcgtgcggggaagaggaggaggaaggcgatgaaggg ggggaagaaggaggcgaaggcgaagaaggtggctcctctattcacgaacaagaaatggag aaacagaagttgctcttcaaccaggctagattggccaacagaggggtggctgaaatggtg ctgctacacatttcagcatgtaaaggagttccctctgaaatggtgatgaagacgttggag ttgggtatctctgttttgcgggggggtaacttcgacatacagatgggcatgttgaaccat ttgaaggacaagaaagatgtgggcttctttaccagcatcgcggggcttatgaacagctgt ggagtgttggatttggacgcattcgaacggaacaccaaggcggaagggttgggggtgggt tctgagggtgctgccggtgaaaaaaacatgcacgacgcagaatttacttgcgcattgttc aggttcatccagttgacctgcgagggtcacaacttagaatggcaaaactacctgcgcaca caggctggcaacaccactaccgtcaatgtagtcatttgcaccgtcgactatttgcttcgt ctccaagagtccatcatggacttttactggcattactctagcaaggagctgatcgatccc gccggcaaagcgaacttcttcaaagccatcggagtggccagtcaggtgttcaacaccctc actgaagtgattcaaggcccctgcactttgaatcaacaggctttagctcattcccgattg tgggacgctgtgggcggtttcctgttcctgttttcacacatgcaagacaaactgtctaag cactccagccaggtggatttgctcaaagaactgctcaatttgcagaaagatatgatcacc atgatgctgtctatgttggaaggtaatgtggttaacggaactatcggtaaacagatggtg gacacgctggtggaaagcgcctcaaatgtggagttgattctcaagtacttcgacatgttc ctgaaattgaaagatttgacttcgaccaccagttttctggagatcgatattaacagtgat ggctgggtgtaccccaaagatttcaaggaaaagatggaacagcagaagagttacacgccg gaggaaatagagtttttgctggcctgctgcgagatcaatcacgatggcaaaatcgactac gtaggatttatagatcggttccacgagcctgctaaggagattggatttaatttagctgtg ttgctgactaatctatccgagcacatgcctaatgaacctcgattagccagattcttagaa actgctggctctgttttaaattatttcgaacccttcctgggacgaattgaaatattaggt ggcagtaaacgcattgagcgtgtctacttcgaaatcaaagagtccaacatcgaacagtgg gagaagcctcaaatcaaggaatcaaagagggccttcttctactccattgtcactgaagga ggagataaagaaaagctggaggcctttattaacttttgcgaggatgctatttttgaaatg caacacgctagcgggctgatggccgtggaggagtctggaggtggaggccccactagggcc accacttacaattacctgacggatgaggatgaacagaagggtgcaagagacccaattcgt cgttcctaccaggcggttaaagatggcatctattacggattatcggcgctcagtccttcg aacatgaagcacaaaatcaacgaaatgcagcaaatgtccattccagagctattcatagga ttctttaagttaatcttctacacattctactactcgggcttcggggtggccgtagtcatc cagtacttcttgggtattctgatgtcgctcatgcgcggtcctgtcgtcgaggagccttcg gtagaaatcaaagaagaggagaaaacgagccacttaagggtgttgccgccgctgccacct gcagaagatccaggcagtcaactgacaccagctctggtggatgcttcgaggggcgaaagc gcaggacatcataaagcaagtggtcatgaattggcagcaggtgcgcaggcctcgttgtcg gcggaaggtgaaggactcacagctactgaagagggggttgagctaggagacgtcgagttg tccgagcagccgctgtctttgtctgacctcttgggaggtgaacaggccaaactagcagcc caagaaaaggtggaggctcaagccgcccaacaggcagccatgcaggctatcgagtccgaa acgaaagcgaaggctggcactgaatcttccgtcatgaggcagattaatttcagcggctac actcaccgtgcggtctcatttttagctaggaacttctacaacttgaaatatgtagccttg gtgttggccttctgcatcaacttcatgctcctcttttataaggtgacgactttgggcggg gatgctgaaggtagtggcgcagaaccagatataatcgatggttcggccagtggtagcggt tcaggctctgacgaagaagaggacgaagatcttccggagttggtgatagtggatgaggat ttctactacatggcacacgttatgagattggctgcactattgcactccatggtgtcgtta gcaatgctgatcgcatattaccacttgaaggtgcctttggccatattcaaaagagaaaag gaaattgctcggagactcgagtttgaagggttgtttatcgcagaacagcccgaagacgac gacctaaaatcccattgggacaagctagttatttccgcaaagtctttcccagtaaattac tgggacaagttcgtgaagaagaaagtgcgacaaaaatacagcgaaacctacgatttcgat tcgatcagtaatctgttgggaatggagaaaacctcgtttcaacagcaggaagcggacgaa ggccacaagagcattatttggtacataatcaacattgactggcgctatcaaatatggaaa tctggagtcaccttcacggacaattcgtttctttattcgctgtggtacttcgtcttttcc attctgggaaatttcaacaactttttcttcgccgctcatctactggatgtggccgtcggc ttcaagaccctcaggaccattctgcagtccgtaactcacaacggaaaacagttggtttta accgtgttgctactcaccatcatcgtctatatttacacagtgattgcgttcaacttcttt agaaaattctacgtgtcagaggaggatgaggaggtggacagaaagtgtcacgatatgctg acgtgtttcgtgttccatttgtacaaaggcgtgcgcgccggcggaggtatcggagacgag attgagcctcccgatggagacgactatgaagcttaccgcatcatgttcgatatcaccttt ttcttcttcgttatcatcattcttttggctatcattcaaggtttgatcatcgacgcgttc ggagagctgcgtgatcaattagagaaggtcatcgaggacatggactctaattgctttatc tgcggcttggacaagggctatctggataaggtgccgcacggtttcgatacgcacgtgcag caggagcataatttggccaattacatgttcttccttatgcacctgatcaataagccggac accgagtacactggtcaagagacgtatgtgtggaacatgtaccagcagagatgttgggac tttttccccatgggggattgcttccgtaagcagtacgaggatgagatcggcggtgggggc ggttaa

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