Escherichia coli O104 H4 2011C-3493 (EAEC): O3K_21530
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Entry
O3K_21530 CDS
T02257
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
esl
Escherichia coli O104:H4 2011C-3493 (EAEC)
Pathway
esl00260
Glycine, serine and threonine metabolism
esl00261
Monobactam biosynthesis
esl00270
Cysteine and methionine metabolism
esl00300
Lysine biosynthesis
esl01100
Metabolic pathways
esl01110
Biosynthesis of secondary metabolites
esl01120
Microbial metabolism in diverse environments
esl01230
Biosynthesis of amino acids
Module
esl_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
esl_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
esl_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
esl00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
O3K_21530 (thrA)
00270 Cysteine and methionine metabolism
O3K_21530 (thrA)
00300 Lysine biosynthesis
O3K_21530 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
O3K_21530 (thrA)
Enzymes [BR:
esl01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
O3K_21530 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
O3K_21530 (thrA)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
AFS76169
UniProt:
A0A0E0Y5I3
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All DBs
Position
complement(4447736..4450198)
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHLLRHAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGACRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccacctggtggcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttttgacgggactcgccgcc
gcccagccggggttcccgctggcgcaattgaaaactttcgtcgatcaggaatttgcccaa
ataaaacatgtcctgcatggcattagtttgttggggcagtgcccggatagcatcaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtgttagaagcg
cgtggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtggggcattac
ctcgaatctaccgtcgatattgctgagtccacccgccgtattgcggcaagccgcattccg
gctgatcacatggtgttgatggcaggtttcaccgccggtaatgaaaaaggcgaactggtg
gtacttggacgcaacggttccgactactccgcggcggtgctggctgcctgtttacgcgcc
gattgttgcgagatttggacggacgttgacggggtctatacctgcgacccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctaccaggaagcgatggagctttcctacttc
ggcgctaaagttcttcacccccgcaccattacccccatcgcccagttccagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagtcgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaaggaatggtcggcatggcggcgcgcgtctttgccgcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccacaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggcttactggagccgctggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttgcgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgccattgctcagggatcttctgaacgctcaatctct
gtcgtggtaaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcaacaaagctggctgaagaataaacatatcgacttacgtgtc
tgcggtgttgccaactcgaaggcactgctcaccaatgtgcatggcctaaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgcacctccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgtcacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatctgttgcgtcatgcggcggaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttattgagaacctgcaa
aatctgctcaatgctggtgatgaattgatgaagttctccggcattctttcaggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgactactctggcg
cgggaaatgggttataccgaaccggatccgcgagatgatctttctggtatggatgtagcg
cgtaagctattgattctcgctcgtgaaacgggacgtgaactggagctggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgctgagggtgatgttgccgcttttatggcg
aatctgtcacagctcgacgatctctttgccgcgcgcgtggcgaaggcccgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggtgcctgccgcgtgaagattgcc
gaagtggatggtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttt
tatagccactattatcagccgctgccgttggtgctgcgcggatatggtgcgggcaatgac
gttacagctgccggtgtctttgccgatctgctacgtaccctctcatggaagttaggagtc
tga
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