Escherichia coli O17 K52 H18 UMN026 (ExPEC): ECUMN_0002
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Entry
ECUMN_0002 CDS
T00831
Symbol
thrA
Name
(GenBank) fused aspartokinase I; homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
eum
Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Pathway
eum00260
Glycine, serine and threonine metabolism
eum00261
Monobactam biosynthesis
eum00270
Cysteine and methionine metabolism
eum00300
Lysine biosynthesis
eum01100
Metabolic pathways
eum01110
Biosynthesis of secondary metabolites
eum01120
Microbial metabolism in diverse environments
eum01230
Biosynthesis of amino acids
Module
eum_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
eum_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
eum_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
eum00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
ECUMN_0002 (thrA)
00270 Cysteine and methionine metabolism
ECUMN_0002 (thrA)
00300 Lysine biosynthesis
ECUMN_0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
ECUMN_0002 (thrA)
Enzymes [BR:
eum01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
ECUMN_0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
ECUMN_0002 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF6247
Motif
Other DBs
NCBI-ProteinID:
CAR11227
UniProt:
B7N7M7
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All DBs
Position
295..2757
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHLLRHAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccacctggtggcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttctgacgggactcgccgcc
gcccagccgggattcccgctggcgcaactgaaaactttcgtcgaccaggaatttgcccaa
ataaaacatgtcctgcatggcattagtttgttggggcagtgcccggatagcatcaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtattagaagcg
cgcggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtggggcattac
ctcgaatctaccgtcgatattgctgagtccacccgccgtattgcggcaagtcgtattccg
gctgatcacatggtgctgatggcaggtttcaccgccggtaatgaaaaaggcgaactggtg
gtgcttggacgcaacggttccgactactctgctgcggtgctggctgcctgtttacgcgcc
gattgttgcgagatttggacagacgttgacggggtctatacctgcgacccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctaccaggaagcgatggagctttcctacttc
ggcgctaaagttcttcacccccgcaccattacccccatcgcccagttccagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagccgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaaggaatggttggcatggcggcgcgcgtctttgcagcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccacaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggcttactggagccgctggcagtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttgcgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgccattgctcagggatcttctgaacgctcaatctct
gtcgtggtaaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcagcaaagctggctgaagaataaacatatcgacttacgtgtc
tgtggtgttgccaactcgaaggctctgctcaccaatgtacatggccttaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgcacctccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgttacgccgaacaaaaag
gctaacacctcgtcgatggattactaccatctgttgcgtcatgcggcggaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttattgagaacctgcaa
aatctactcaatgcaggtgatgaattgatgaagttctccggcattctttctggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacgctggcg
cgggaaatgggttataccgaaccggacccgcgagatgatctttctggtatggatgtggcg
cgtaaactattgattctcgctcgtgaaacgggacgtgaactggagctggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgccgagggtgatgttgccgcttttatggcg
aatctgtcacagctcgacgatctctttgccgcgcgcgtggcgaaggcccgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggcgtctgccgcgtgaagattgct
gaagtggatggcaacgatccgctgttcaaagtgaaaaacggcgaaaacgccctggccttc
tatagccactattatcagccgctgccgttggtgctgcgcggatatggtgcgggcaatgac
gttacagctgccggtgtttttgccgatctgctacgtaccctctcatggaagttaggagtc
tga
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