KEGG   Felis catus (domestic cat): 100142682
Entry
100142682         CDS       T02385                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
fca  Felis catus (domestic cat)
Pathway
fca01523  Antifolate resistance
fca04010  MAPK signaling pathway
fca04014  Ras signaling pathway
fca04062  Chemokine signaling pathway
fca04064  NF-kappa B signaling pathway
fca04068  FoxO signaling pathway
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04210  Apoptosis
fca04380  Osteoclast differentiation
fca04620  Toll-like receptor signaling pathway
fca04621  NOD-like receptor signaling pathway
fca04622  RIG-I-like receptor signaling pathway
fca04623  Cytosolic DNA-sensing pathway
fca04625  C-type lectin receptor signaling pathway
fca04657  IL-17 signaling pathway
fca04658  Th1 and Th2 cell differentiation
fca04659  Th17 cell differentiation
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
fca04668  TNF signaling pathway
fca04722  Neurotrophin signaling pathway
fca04910  Insulin signaling pathway
fca04920  Adipocytokine signaling pathway
fca04930  Type II diabetes mellitus
fca04931  Insulin resistance
fca04932  Non-alcoholic fatty liver disease
fca04936  Alcoholic liver disease
fca05010  Alzheimer disease
fca05132  Salmonella infection
fca05135  Yersinia infection
fca05142  Chagas disease
fca05145  Toxoplasmosis
fca05160  Hepatitis C
fca05161  Hepatitis B
fca05162  Measles
fca05163  Human cytomegalovirus infection
fca05164  Influenza A
fca05165  Human papillomavirus infection
fca05166  Human T-cell leukemia virus 1 infection
fca05167  Kaposi sarcoma-associated herpesvirus infection
fca05168  Herpes simplex virus 1 infection
fca05169  Epstein-Barr virus infection
fca05170  Human immunodeficiency virus 1 infection
fca05171  Coronavirus disease - COVID-19
fca05200  Pathways in cancer
fca05206  MicroRNAs in cancer
fca05208  Chemical carcinogenesis - reactive oxygen species
fca05212  Pancreatic cancer
fca05215  Prostate cancer
fca05220  Chronic myeloid leukemia
fca05221  Acute myeloid leukemia
fca05222  Small cell lung cancer
fca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
fca05417  Lipid and atherosclerosis
fca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:fca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100142682 (IKBKB)
   04064 NF-kappa B signaling pathway
    100142682 (IKBKB)
   04668 TNF signaling pathway
    100142682 (IKBKB)
   04068 FoxO signaling pathway
    100142682 (IKBKB)
   04151 PI3K-Akt signaling pathway
    100142682 (IKBKB)
   04150 mTOR signaling pathway
    100142682 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100142682 (IKBKB)
   04660 T cell receptor signaling pathway
    100142682 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    100142682 (IKBKB)
   04659 Th17 cell differentiation
    100142682 (IKBKB)
   04657 IL-17 signaling pathway
    100142682 (IKBKB)
   04662 B cell receptor signaling pathway
    100142682 (IKBKB)
   04062 Chemokine signaling pathway
    100142682 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100142682 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100142682 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100142682 (IKBKB)
   05206 MicroRNAs in cancer
    100142682 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    100142682 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100142682 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100142682 (IKBKB)
   05221 Acute myeloid leukemia
    100142682 (IKBKB)
   05220 Chronic myeloid leukemia
    100142682 (IKBKB)
   05215 Prostate cancer
    100142682 (IKBKB)
   05222 Small cell lung cancer
    100142682 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100142682 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    100142682 (IKBKB)
   05161 Hepatitis B
    100142682 (IKBKB)
   05160 Hepatitis C
    100142682 (IKBKB)
   05171 Coronavirus disease - COVID-19
    100142682 (IKBKB)
   05164 Influenza A
    100142682 (IKBKB)
   05162 Measles
    100142682 (IKBKB)
   05163 Human cytomegalovirus infection
    100142682 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100142682 (IKBKB)
   05169 Epstein-Barr virus infection
    100142682 (IKBKB)
   05165 Human papillomavirus infection
    100142682 (IKBKB)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100142682 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100142682 (IKBKB)
   05142 Chagas disease
    100142682 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100142682 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100142682 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    100142682 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100142682 (IKBKB)
   04936 Alcoholic liver disease
    100142682 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    100142682 (IKBKB)
   04931 Insulin resistance
    100142682 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100142682 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:fca01001]
    100142682 (IKBKB)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     100142682 (IKBKB)
Protein kinases [BR:fca01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   100142682 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH Glyco_hydro_65m
Other DBs
NCBI-GeneID: 100142682
NCBI-ProteinID: XP_003984800
LinkDB
Position
B1:complement(40484454..40557736)
AA seq 756 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPYPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLVHILNMVTGIIHTYPVTEDESLQSLKARIQNDTGIPEEDQELLQEAGLA
LIPDKPATQCISEGKLNEGRTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSLEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNAARLSHSGQLMSQPSTAPNSLPESVKKSEELVAEAHTLCTQLE
NAMQDTIKEQDQSLRSLDWSWLQTEEEEQNGLEQAS
NT seq 2271 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttcgctgccaacccagacatgtggggcctgggagatgaaagaacga
cttgggacagggggatttggaaacgtcattcgatggcacaatcaggaaacaggtgagcag
attgctatcaagcagtgccggcaggagctcagcccccggaatcgagagcggtggtgcctg
gagatccagatcatgagaaggctgaaccaccccaatgtggtagctgcccgggatgtcccc
gaggggatgcagaacttggctcccaatgacttgcctctgctggccatggagtactgccaa
ggaggagatctccgaaagtacctgaaccagtttgagaactgctgtggcctgcgggaagga
gccatcctcaccttgctgagtgacattgcctctgcacttagataccttcatgaaaacaga
atcatccatcgggatctgaaaccagaaaacatcgtcctgcagcaaggagaacaaagatta
atacacaaaattattgacctaggatatgccaaggaactggatcagggcagtctctgtact
tcctttgtggggaccctgcaatacctggccccggaactcctggagcagcagaagtacaca
gtgactgtggactactggagcttcggcaccttggcttttgagtgcatcacaggcttccga
cctttcctccctaactggcagcctgtgcagtggcattccaaagtccggcagaagagtgag
atggacattgttgtcagtgaagacttgaatggagcggtgaagttttccagctccttaccc
tatcccaataatctgaacagcgtcctggcacagcgacttgagaagtggctgcagctgatg
ctgatgtggcacccacgacagaggggcaccgatcctgtgtatggtcccaatggctgtttc
aaggccctggatgacatcttaaacctaaagctggttcacatcttgaacatggtcacaggc
atcattcacacgtatccagtgacagaggatgagagtctgcagagcttaaaggccagaatc
cagaatgacacagggatccccgaggaggaccaggagctgctgcaagaagctggtctggca
ttgatccctgacaagccggctactcagtgtatttcagagggcaagctgaatgagggccgc
acattggacatggatctcgtctttctctttgacaacagtaaaatcacgtatgagactcag
atctcgccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaac
ctctccttcttccagctgaggaaagtgtggggccaggtttggcacagcatccagaccctg
aaggaggactgtaaccggctacagcagggacagcgagctgccatgatgaatctcctccgg
aataatagctgcctctccaagatgaagaattctatggcttccatgtctcagcagctcaaa
gccaagttggatttctttaaaaccagcatccagattgacctggagaagtacagtgagcag
acagaatttgggatcacatcagataaactgctgctggcctggagggaaatggaacaggct
gtggagctctgtgggcgggagaatgaagtgaagcacctggtggagcggatgatggcgctg
cagaccgacattgtggacctgcagaggagccccatggggcggaagcaggggggaacgctg
gacgacctagaagagcaagcgagggagctttacaggagacttcgggaaaaacccagagac
caacgaactgatggtgacagtcttgaaatggtccggctgcttcttcaggccatccaaggc
tttgagaagaaagtgcgagtgatttatacgcagctcagtaaaactgtggtttgcaagcag
aaggctctggaactgttgcctaaggtggaagaggtggtgagtttaatgaacgaagacgag
aagactgtcgtccggcttcaggagaagcggcagaaggagctctggaatctcctgaagatc
gcttgtagcaaagttcgtggtcctgtgagtggaagcccagatagcatgaatgctgctcgc
ctcagtcactctggtcagctaatgtctcagccttccactgcccctaacagcttgcctgag
tctgtcaagaaaagtgaagaactggtggctgaagcacacacgctctgcacccagctagaa
aatgcgatgcaagacaccatcaaagagcaggaccagagtttaaggtctctagactggagc
tggttacagacggaagaagaagagcagaatggcctggaacaggcctcttga

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