KEGG   Felis catus (domestic cat): 101081485
Entry
101081485         CDS       T02385                                 
Symbol
ATIC
Name
(RefSeq) bifunctional purine biosynthesis protein ATIC
  KO
K00602  phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
Organism
fca  Felis catus (domestic cat)
Pathway
fca00230  Purine metabolism
fca00670  One carbon pool by folate
fca01100  Metabolic pathways
fca01523  Antifolate resistance
Module
fca_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:fca00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    101081485 (ATIC)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    101081485 (ATIC)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101081485 (ATIC)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:fca04147]
    101081485 (ATIC)
Enzymes [BR:fca01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.3  phosphoribosylaminoimidazolecarboxamide formyltransferase
     101081485 (ATIC)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.10  IMP cyclohydrolase
     101081485 (ATIC)
Exosome [BR:fca04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   101081485 (ATIC)
SSDB
Motif
Pfam: AICARFT_IMPCHas MGS
Other DBs
NCBI-GeneID: 101081485
NCBI-ProteinID: XP_003991166
UniProt: M3WB05
LinkDB
Position
C1:199730291..199758591
AA seq 592 aa
MAPGQLALFSVSDKTGLVEFARNLTSVGLNLIASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFDLIRVVVCNLYPFVKTVASPDVTVEQA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVAVCTEMQNSDSKDTSLETRRQLALKAFT
HTAQYDEAISDYFRQQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINL
CDALNAWQLVKELREALDLPAAASFKHVSPAGAAVGIPLSEDEARVCMVYDLYEALTPIS
TAYARARGADRMSSFGDFIALSDICDVPTAKIISREVSDGIVAPGYEDEALKILSKKKNG
SYCVLQMDPSYSPDENEVRTLFGLRLSQKRNNGVIDKSLFSNVVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEDEDLVKWKALFEEVPELLTEAEKKEWVDKLNEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADRVVIEACDELGIILAHTNLRLFHH
NT seq 1779 nt   +upstreamnt  +downstreamnt
atggcacccggccagctcgccttatttagtgtctctgacaaaacgggcctcgtggaattt
gccagaaacctaacttctgttggtttgaatttgatcgcttctggagggactgcaaaagct
ctcagggatgcaggtctggcagtcagagatgtctccgagctgacaggatttcctgaaatg
ttaggggggcgtgtgaaaaccttgcatcctgcagtccatgctggaatcttggctcgtaat
atcccagaagataatgctgacatggctagacttgatttcgatcttatcagggttgtcgtc
tgtaatctgtatccctttgtgaagacagtggcttctccagatgtaactgttgaacaggct
gttgagcagattgatattggtggagtaaccctcctgagagcagcagccaaaaaccacgct
cgagtaacagtagtatgtgaacctgaggactatgtggccgtttgcacagagatgcagaac
tccgacagtaaagacacctccttggagactagacgccagttagccttgaaggctttcact
catacagcacaatatgatgaagcgatttcagattacttcaggcaacagtatagtaaagga
atatctcagatgcccttgaggtatggaatgaatcctcaccaaactcctgcccagttatac
acgctgaagcccaagcttcccatcacagttctaaatggagcccctggatttataaacttg
tgtgatgctttgaatgcctggcagctggtgaaggaactcagagaagctttagaccttcct
gctgctgcctctttcaaacatgtcagcccagcaggtgctgctgttggaattccactaagt
gaagatgaagccagagtctgcatggtctatgatctgtatgaagcacttacacccatatca
actgcgtatgcaagagcaagaggggctgataggatgtcttcatttggtgactttatcgca
ttatctgatatttgtgatgtccctactgccaaaattatctccagagaggtatctgatggt
atcgtcgccccaggatatgaagatgaagctttgaaaatactctctaaaaagaaaaacggg
agctactgtgttcttcagatggacccgtcttacagtccagatgaaaacgaagttcgaact
ctctttggtcttcgtttaagtcagaagagaaataatggtgttattgacaagtcattgttt
agcaatgttgtgaccaagaataaagatttgccagagtctgcgctcagagacctcattgta
gccaccattgctgtgaagtacacgcagtctaactccgtgtgctatgccaagaatggtcag
gttattggcattggagcaggacagcagtctcgaatacactgcacacgccttgcaggggat
aaggcgaactactggtggcttagacatcatccacaagtgctttcaatgaagtttaaaact
ggagtgaagagagcagaaatctccaatgccattgatcagtatgttactggaaccattggc
gaggatgaagatttggtaaagtggaaggcattgtttgaggaagtccctgaactgctaact
gaagcagagaagaaagaatgggttgacaaacttaatgaagtttctatcagctctgatgcc
ttctttcctttcagagataacgtagacagagctaaaaggagcggcgtggcatacatcgct
gctccttctggttctgctgccgacagagttgtgatagaggcttgtgatgaactgggaata
attctcgctcatacgaatcttcggctctttcatcactga

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