Felis catus (domestic cat): 101083516 Help Entry 101083516         CDS       T02385                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X4   KO K19326   nesprin-1 Organism fca  Felis catus (domestic cat) Pathway fca04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:fca00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     101083516 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:fca03036]     101083516 (SYNE1) Chromosome and associated proteins [BR:fca03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     101083516 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SYNE3 Motif Other DBs NCBI-GeneID:  101083516 NCBI-ProteinID:  XP_023110281 LinkDB All DBs Position B2:complement(136633329..137108420) Genome browser AA seq 8829 aa AA seqDB search MAASRTASRSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLTKRKPPLVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMYRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLPGSTSSVDSMVSAETASPPSKRKVA TKIQGNAKKALLKWVQYTVAKQTGIDVKDFGRSWRSGVAFHSVIHAIRPELVDLEKVKGR SNRENLEEAFTIAESELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNTGTDGQ ENDEILPGFPSFANSIQNFKREDGLILKETKVWIEQFERDLTRAQMTESNLQDKYQSFKH FRVQYEIKRKQIEHLIQPVHRDGKLSLDQALVKQSWDRVSSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVELLLQNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHW IQQHAAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEY ADCITVLSDFATEAHKKLSEPLEVSFINVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLI TKESSQEEANEMFATMSGLKERLTKVKECCPPLLYESQQLLIPLEELEKQMTFFYDSLAK IHEIMAVLEREAQSSALFKQKHQELSACQESCKKTMTQIEKGSQNVQKFVTLSSVLKHFD QTKLHRQIADAHGAFQNMVKKIGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK GNPEDLLKKHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG EAPYHLLHLKIDVEKNRFLASVEECRTELDRETTLVPQEGSEKIIKEHRIFFSDKGPHHL CEKRLQLIEELCLKLPVRDPVRNTPETCHVTLKELRAAIDATYKKLVEDRDKWKDYTRRI SEFSSWISAKETQLKGFKNEPIDTANHGEIKHAVEEIRNGVTTKGETLNWLKSRLKILIE VSSENEAQKQGDELAKLSSSFKALIALLSEVEKMLSNFGDCVQYKEIVKSSLGELISDSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGMPGQVRDE LRKLESTLDSMEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKTIKEQVKKLEDT LEEDIKTMEMVKNKWDHFGNNFETLSVWITEKEKELNALETSSSAMDMQINQIKVIIQEI ESKIGCITELEEAAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEGTILGHLSQ QQKFEENLRKIQKSVSEFEDKLADPIKICSSATETYKILQEHMDLCQALEALNSAVTTVS ASAQKVANRATSSVQEAAALQQRYEETWSRAKERQAVLENLLARWQRLEKELSTFLTWLE RCEAIASSPEMDISADRVKVESELQSIQALQNELVSQASVYSNLLQLKESLFSVASKDDV KMMKLHLEQLDERWRDLPQIISKRINFLQSVVSEHQQFDELLLSFSVWIKLFLSELQTTS EISITDHQAAFARHKDHEVEAESKMGDLQRLRDHLAKLGALGRAEDLHLLQGKAEDCFQL FEEASQVVGRRQLALSQLAEFLQRHASLSGVLHRLRHTVETTDSMNKKQTDLLKKDLNRA IQDAKTLESTAVSLDGILAKAQYHLKSGSSEQRTSCRSTADHLCFELERIQNLLGTKQSE ADALAALKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE HELCWLKDKAKQIAQKDVAFASEVDREINRLEVTWDDTKKLIHENQGQCCGLIDLMRDYQ NLKSVVSKVLENANNVLATRTTIKDQEDLKWALSKHESVKNEMCNKQKELDNFTSKGKQL LSELKKIHSSDFNLVKTDMESTVDRWLDVSEKIEENMDRLRASLTIWGDVLSSKDEIDGW SNNSVPQLAESISNLNNSVRAEEFLKEFESEVKNKALRLEELHCKVNDLKELTKNPETPP DLQFIEADLRQKLEHAKEITEEAKGTLKEFTTQSTQVEKFINDITSWLTKVEEALMNCAQ TETWEGLKKVKEIQKELQSQQSNISSTQDNLNSLCRKYHSIELESLGSAMTGLIKNHEAV SQLCSKTQASLQDFLEKHFNESMQEFQEWFSGIKAAAKKSSDRTGDSKVLEAKLHDLQNI LDSISDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD CALELGSFEDQHRKLNLWIHEMDERLSTENFGESKQHIPEKKNEVHKVEMFLGELLAVRE SLDKLSQRGQLLSEEGHGAGKEGRLCSQLLTNYQNLLRTTKEKLRNCQLALQEHEALEEA VQSMWSWVKDIQDRLACAESTVGSKDTLEKRLLQIQDILLMKGEGEVKLNMAIGKGEQAL RSSNKQGQKVIQTQLQNLKDVWADIMSSSVRAQSTLESVISKWNDYLEWKNQLEQWMEFV DQKVEHPLQPQPGLKEKFSLLDHFQSIVSEAEDHAGTLHHLASKSRELYQKTEDESFKET AQEELKTQFNDIITVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGD SSATQKKLSKIKELMDSRGIGASRLSRVESLAPAVRQNTSASGCELVDAEMQALRADWKQ WEDSVLQTRTSLENLVSQMALSEQEFSGQVVQLEQALEQLGALLTTCAQQLALLESKNTD KEIVECWRKGQEILDALQKAEPKTEDLKSQLNELCRFSRDLSAYSGKVSGLIKEYNCLCL QASKGCQTREQILQQRFQRAFKDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLS ESENGQHKLNVMVSKGELLSTLLPKEKADGIQAKVATAKEDWKKFHSNLHQKESALENLK IQMKDFEVSAEPVQDWLSKTEKLVQESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLNR LREKAQQLWEGQAASKSFMHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKEL QDWMTDAVHMLDSYCHPISDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS PEGWPAIQQQLQSVKDMWASLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEASL NESERQYAELREKTASLGKAKLLSEEVLSYSSLLEAIELKGAGMTEHYVTQLEFQDLQER YRAITERAKEAVTKSEKLVRLHQEYQRDLQAFEVWLGQEQEKLDRYSVLEGDAHTHETTL RDLQELQVHCAEGQVLLNSVLHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQ FNNVVNKLRLMEQKYQQVDEWLKTLEDKVSLRAGRQSNRAAKEIQLHQMKKWHEEVIAYK DEVEDVGARAQEMLDENHVSSSMGCQATQLASRYQALLLQVLEQIQFLEEEIQSLEESEL SLSSYSDWYSSTHKNFKNVATKIDRVDKATMGKKMKTLEGLLKDMDKGHSLLKSAREKGE RALKYLEDGEAEMLRKDIHEHVEQLKELTSTVRKEHMTLEKGLLLAKEFSDKYKALTQWI SEYQEILHTPEEPKMELYEKKAQLSKYKSLQQMVLSHEPSIKSVREKGEALLELVQDVTL KDKMDKLQSDYQDLCGAGKEHVCSLETKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLME TSSLETITQQLAHHKAMMEEIAGFEDRLNNLKSKGDNLISQCADHLQAKLKQNVYAHLQG TKDSYSAVCSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPSQHPPLSRAEA VKQVKHYRALQEQARTYLDLLCSTCDLSSSSVKTTAKDIQETEQMIEQRLVQAQNLTQGW GEIKHMKAELWIYLQDADQQLQNMKKRHSELELNIAQNMVSQVKDFVKKLQCKQASVTAI TERVNKLTKKQESPEHKEISHLNDQWLDLCLQANSLCLQREEDLQRTRDYHDRMNVVEEF LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKQAVEDLKDQKQKMIEHLNLDDKE LVKEQTSHLEQRWFQLEDLVKRKLQASVTNLEELNVVRSRFQELMEWAEEQQPNIAEALK QSPPPDMAQNLLMDHLAICSELETKQMLLKSLIKDADRVMADLGLNERQIIQKALSDAQR HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ VKTCKSAQASLKTYQNEVTGLWAQGRELMKETTEQEKSEVLGKLQELQSVYDTVLQKCSH RLQELEKSLVSRKHFKEDFDKACHWLKQADIITFPEINLMNESAELHAQLAKYQHILEQS PEYENLLLTLQRTGQAILPSLNEVDHSYLNEKLNALPLQFNVIVALAKDKFYKVQETILA RKEYASLIELTTQSLSELEDQFLKMSKVPTDLRVEEAVSLQEGCRALLGEVARLGEAVDE LNQKKESFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVGLLEDTSSAYQEHEKMCHQLEK QLQAVKTEQSKVNEETLPAEEKLKIYHSLAGSLQDSGIVLKRVTVHLEDLVPHLDPSAYE KAKQQIQSWQEELKVLTSAIGATVTECESRMVQSIDFQTELSRSLDWLRSVKAELSGPVC LDLSLQDIQEEIRKTQIHQEEVQSSLRIMNALSNKEKEKFTKAKELLSADFQHTLAELSE LDGDVQEALRTRQAALTQIYSQCQRYYQVFQAANDWVEDAHEMLQLAGNGLDVESVEENL KSHVEFFSTEDQFHSNLEELQHLVASLDPLIKPTGKEHLAQKMASLEEKSQRIIQDSHAQ LDLLQRCADQWQNYQKAREEVIELMNEAEKKLSEFSLLKASSSHEAEEKLSEHKALASVV NSFHEKVVALEDKTSQLEKTGNDASKAAISRSMTTVWQRWTRLRAVAQDQEKILEDAVDE WTSFNNKVKKATETTDQLQDKLPGGSAEKASKAELLTLLDHHDALVLELEQQQLALGMLR QQALGMLQDGAPQPPGEEPPTVQEITAMQDRCLNMQEKVKNTGKVVKQELKEREVVETQI NSVKSWVQETKEYLGNPTIEIDAQLEELQLLLTEATNHRQSIEKMAEEQKNKYLGLYSIL PSELSLQLAEVALDLGTIHDQIQDKVREVEQSKAMSQEFSRQIQKIAKDLTTILSKLRAK TDNLQQAKIDQKVLGEELDGCNLKLMELDAAVQKFSEQNGQLGKPLAKKVGKLMELHQQT IRQAENRLSKLSQAASHLEEYTEMLEFILKWIEKAKVLVHGKIAWNSANQLREQYIFHQT MLEESEEIPSNLEAMIEKLQCLASIYSTEKMSQQVADLGRESEELRQTIKIRLQNLQDAA KDMKKFETELKNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQI CQSALRIPDDVVASLPLCHCALHLQAEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQ ELIEGAHREIEDTPAATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKH ATMLLTVTEVEGLAEGTEDLDRELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNS EISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAARIHPSTLPSPEFYELGLEP SATAKLDDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLE HGRGPESQMAEHQALMDEILMLQEEISELQSSLAEELVSQSPESDPAEQLALQSTLTVLA ERMSTIKMMASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDHWLLSTKATLDTALG TAQEPMDMEAQLVDCQNMLVEIEQKVVALSELSVHNDNLLLEGKAHTKEEAEQLAVKLRT LKGSLLELQRALHDKQLLMQGTAQEKEESHADLTASQSPGVQEWLAQARTAWAHQRQSSL QQQKELEQELAEQKSLLRSVASRGEEILTQHSAAETSAGIGEKPDVLSQELGMEGEKSAS EDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDRQTQDRSAV TSLLDGLNQAFEEVSSQGGGTKRQNIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEE TEACLFNQETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSV VNQRCHQMKERLQQILNFQNDLKVLCTSLADSKYIILQKLANVFEQPVAEQIEAIQQAED GLKELDAEIIELKKRGDKLQIEQPSMQELSKLQDMYDELMMTIGSWRSSLNQNLALKSQY ERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI INFAVLQETQFHTELMTQASAVLKRAHKRGVELEYILETWSHLDEDHQALSKQLEVVESS IPSVGLVEESEERLIDRIALYQHLKSSLHEYQPKLYQVLDDGKRLLISISCSDLESQLNQ LGEQWLDNTNKVSKELHRLETVLKHWTRYQSESAELIHWLQSAKDRLEFWTQQSVTVPQE LEMVRDHLNAFLEFSKEVDAKSSLKSSVLSIGNQLLRLKKVDTASLRSELSHIDSQWTDL LTNIPTVQEKLHQLQMDKLPSRHAISELTTWISLMENVIQKDEENIKNSIGYKAIHEYLQ KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT EKIQLLEGLLESWSEYENNVQSLKTWYETQENKLKQQHRIGDQASVQSAMKDCQDLEDLI KAKEKEVEKIEQNGLALIQNKKEEVSGVVMSTLRELNQTWANLDHMVGQFKILLKSVFDQ WNNHKEAFDEINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQEKNLQNFG SITNQLLKECHPPVTETLTTTLKDVNMRWNNLLEEIAKQLCSSKALLQLWRRYKDYSKQC ASTVQQQEDGASELLKAATNKDIADDEAATWIQDCNDLLKGLGTVKDSLFVLRELGEQLK QQVDASAASTIQSDQLSLSQRLCALEQALCKQQTMLQAGVLDYETFTKSLEALEAWIVEA EEILQGQDPGHSSDLSTIQQRMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQ NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA QQRRGIIDSQIRQWRRYREMAEKLRKWLVEVSYLPVSALGSVPIPLQQARTLFDEVQFKE KVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWRSASVRLEEQKKKLAFL LKDWEKCENGIADSLEKLRTFKKKLSPPLPDHHEELHAEQMRCKELENAAGNWTDDLAQL ALLKDTLCAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSEKNKE LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENKIQLQQMGERLARASHESK ASEIEYKLGKVNDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP IVYNSCDSDEIQKKLTEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ ATRNLDRRWRNICAMSMERRLRIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSSSGVL YTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKA FQQEISLNHNKIEQIISQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLI RLPLPDDEHDLSDRELELDDSAALSDLHWRDTSADSVLSPQPSSNPSLSLAQPLRSERSG RDTPASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEEVGDDKDFYLRGAVGLSDVMIPE SPEAYVKLTESAIRNTSGAPSALESQIRQLDKALDESRFQMQQTENIIRSKTPTGPELDS SYRGYMKLLGECSGSIDSVRRLEHKLKEEEENFPGFVNLNSTETQTAGVIDRWELIQAQA LSKELRMKQNLQKWQQFNSDLNNIWTWLGETEEELERLQHLELSTDIQAIELQIKKLKEL QKAVDHRKAIILSINLCSPEFTQTGSEKSQDLQDRLSQMNGRWDRVCSLLDEWRGLLQDA LMQCQDFHEMSHGLLLMLENIDRRKNEIVPIDSNQDAETLQDHHKQLMQIRHELLESQLK VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSSSQQD LSSWSSADELDTSGSVSPTSGRSTPNRQRTPRGKCSLSQPGPSVNSPHSRSIKGGCDSSL SEPRPARSGRAFLLRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPML RYTNGPPPL NT seq 26490 nt NT seq  +upstreamnt  +downstreamnt atggctgcctccaggacggcctcacggtctccccgggacatcgccaacgtgatgcaaagg ttgcaagatgagcaagagatagtacaaaaacgtactttcacgaaatggatcaactcgcat ctgaccaagcggaaacccccactggtggtcgatgatctttttgaagacatgaaagatggc gttaagctgcttgctcttctggaggtcctgtctgggcagaaactgccttgtgaacaagga cgccgtatgaagcgaatccatgctgtggctaatattggcacagccctgaagttccttgaa ggaaggaagtccatgtacagaggatcaccgattaaactagtcaacattaactccaccgat atagcagatggccggccatcaatagttctcggattgatgtggaccattattctgtatttc cagattgaggagctgaccagcaacctgccgcagctgcagtccctgcctggcagcacatcc tctgtggacagcatggtcagcgcggagaccgccagccccccgagtaagcggaaggtggcc accaagatccaaggaaatgctaagaaggctttattaaagtgggttcagtatacagtagcc aagcagacgggaatagacgtaaaggacttcgggcggagttggagaagtggagttgccttt cattcggtcatccatgccattcgaccagaactagtggacttggagaaagtgaaaggcaga tctaaccgggaaaacctggaggaggctttcactattgctgaatcagaactaggaattcca agactactggatcctgaagatgttgatgtggataaaccagatgagaagtctattatgacc tatgtagcccagtttctgaagcattaccctgacatccacaacacaggcactgatgggcaa gagaatgatgaaatacttccaggttttccatcttttgcaaattctatccaaaattttaag agagaagacgggctaattttgaaggaaacaaaagtctggatagaacaatttgaaagagat ttgacaagagcacagatgacggaatcaaatttacaggataaatatcagtcatttaagcac ttcagagttcaatatgaaataaaaaggaagcagatcgaacatttaatacaaccagtacat agagacggtaaattgtcacttgaccaagctttggtaaagcagtcctgggatagagtgtcc tccaggctctttgactggcatatacagcttgataaatctctccctgcacctctgggcacc ataggtgcctggttatacagagcggaggtggccctgagagaggaaataaccattcagcag gtgcatgaggaaacggccaacacaatacagcggaaacgcgagcaacacaaggatctgctt caaaacacagatgcccacaaaagagcattccatgaaatctaccggaccagatctgttaac gggatcccagtaccacctgatcaattagaggacatggccgagaggtttcattttgtttcc tccacatcagagctacacttaatgaaaatggaatttctagaattaaagtaccgtctgctc tcactgctggttcttgcagagtcaaagctgaaatcttggatcatcaagtatgggaggaga gagtccgtggagctccttctacagaactacatctcttttatagaaaatagcaagttcttt gaacaatatgaagtgacataccagatcttgaaacagacagctgagatgtacgtcaaagct gatggttcagtggaagaagccgagaatgtgatgaaattcatgaatgaaaccacagcccag tggaggaacctctcagtagaggtcaggagcgtgcgaagcatgctggaagaagtcatcgcg aactgggatcgatatggcaatactgtggctagtcttcaggcctggctggaggatgctgag aaaatgctaaatcaatcagagcatgccaaaaaggatttttttcgaaacttgccccactgg atacagcagcacgctgccatgaatgatgctggcaattttctaattgaaacatgtgatgaa atggtttcccgagatcttaaacagcaattgctattgctcaatggacggtggagggagttg ttcatggaagtcaagcaatatgctcgggccgatgagatggacagaatgaagaaggagtat gcagactgtattactgtcctgtctgattttgcaactgaagcccataagaaactttctgaa cccttagaagtctcttttattaatgtcaagttattaattcaagacttggaggacattgag cagcgggtgcctgtaatggatgctcagtacaagatgattaccaagaccgcacacctcatt accaaggagagctcccaagaagaagccaatgaaatgtttgcaaccatgtctgggctcaaa gaacggctaaccaaggtcaaagaatgttgccctccactcctttatgagtctcagcagctg ttgatcccattggaagaactggaaaagcagatgacgttcttttatgactcgcttgcgaaa atccacgaaattatggcagttctcgagcgtgaagcccaatccagtgccctttttaaacag aaacatcaggaactgtcagcttgtcaagagagctgtaagaaaaccatgacgcagattgag aaaggcagtcaaaatgttcaaaagttcgtgaccttgagcagtgtgttaaagcattttgat cagacgaagctgcacagacagattgcagatgcccacggtgctttccagaatatggtgaag aaaattggagactggaagaaacatgtggaaaccaatagtcgcttgatgaagaaatttgaa gagtctcgagcagagttggagaaggtgctacggatcgctcaggagggcctggaggaaaag gggaacccagaagacctcctgaagaaacatacagaatttttcagtcagctggatcagaga gtgctcaatgctttcctgaaagcttgcgacgagctcaccgacatcctccctgagcaggaa cagcagggcctgcaggaagctgttagaaagctccataaacagtggaaggaccttcaagga gaagccccatatcatttgcttcatctgaagattgatgtggagaagaatagattcctagct tctgtagaagaatgcagaactgagctggatcgagagaccacgctggtgccccaggaaggc agtgaaaagattattaaggagcacaggattttcttcagtgacaaaggtcctcatcatctt tgtgagaaaaggttacagcttattgaagaactgtgtctgaaactccccgtccgggaccca gtaaggaacacacctgaaacctgtcacgtgactctcaaagagctcagagctgccattgac gccacctacaagaagcttgtggaagaccgggacaagtggaaggactacactagaagaatt tctgagttctcatcttggatatctgcaaaggagacacaattgaaagggtttaagaatgag cccatcgataccgccaaccatggagagattaaacatgctgtagaggagatcagaaatggt gttaccacaaagggtgagactctcaactggctgaaatccaggcttaaaattttaattgaa gtttcttctgagaatgaagcccaaaagcaaggagatgagttggcaaaattatctagttct ttcaaggctctcatagctttgttgtcagaggttgaaaagatgttaagcaactttggggac tgtgtccagtacaaagaaatagtcaaaagttcccttggagagttgatttctgactctaaa gaagtccaggagcaagctgagaagatcttggacactgaaaatctgtttgaagcacagcaa ttacttcttcatcaccagcaaaagacaaagaggatttctgcgaagaagagagacgtgcag cagcagatagcacaggctcagcagggagaaggtgggatgcccggccaagtccgggacgag ctgcggaagctggagagcaccctggacagcatggagcatagcagagagaagcaggaacgc cgcatccaggtcacattaagaaagtgggagcgatttgaaacaaacaaagagacagtggtc agatacctttttcaaacaggttccagccatgagcgctttttgagttttagcagtttggaa agtttatcttcagaattggaacagacaaaggagttttctaaacgaacagaaggtattgca gtccaggctgagaatcttgtgaaggaagcttccgagataccacttgggcccaagaataag cagctgcttcaacagcaggccaagacaatcaaagagcaagtcaaaaaattagaagacaca cttgaagaagatattaaaaccatggaaatggtgaaaaacaagtgggatcattttggcaat aattttgagaccctgtccgtctggataactgagaaagaaaaagaactcaatgccttggaa acttcatcatctgccatggacatgcaaatcaaccagattaaggtcataattcaggaaata 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cagagccccccaccggatatggcccagaacctcctcatggaccacctcgccatctgcagt gaactggagaccaaacagatgctcctgaaatcgctcataaaggacgccgacagggtgatg gctgaccttggcctaaatgagcggcagatcatccagaaagccctttctgatgcacagaga catgtgaattgcctcagcgacttagtgggccagagacgaaagtacttaaacaaggccttg tccgagaaaacccagttcctcatggcggtgttccaggcaaccagccaaattcaacaacat gagcgaaagataatgttccgtgaacacatctgcctgttaccggatgatgtgagcaaacaa gtcaaaacatgcaagagtgcgcaagccagcctcaagacgtaccaaaacgaggtcactgga ctttgggctcagggtcgtgaattaatgaaagaaaccacagagcaggaaaagagtgaagta ctgggtaagcttcaggaattacagagtgtctatgacaccgttttacaaaagtgtagccat cggctccaagaactagagaaaagtttggtttctaggaaacattttaaggaagattttgat aaagcctgtcactggctaaaacaagcagatattattacatttcctgaaatcaacctaatg aatgagagcgctgagctgcacgcccaactggccaaataccaacacattcttgaacaatct ccagaatatgaaaatctcctacttacgctgcagagaactgggcaggccatattgccatcg ctgaatgaagtcgatcattcctacctcaatgaaaagctaaatgctcttcccctgcaattt aatgtaatcgttgccttggctaaagacaagttctataaagtccaagaaacaattcttgct cggaaagagtacgcttccttgatcgagttgacaacccagtctctgagtgaacttgaggac cagttcttaaagatgagcaaagtccccactgacctgagagttgaagaggccgtgtctctt caggaaggctgccgagccctgttgggagaggtggcccgcctcggggaagcggtggatgag ctgaaccaaaagaaagaaagttttagaagtacaggacagccttggcagccagacaagatg ctgcacctcgtcaccttgtaccacaggctgaagcgacaaacggaacaaagggttggctta ctggaagacacctccagtgcctatcaagagcatgagaagatgtgccaccagctagaaaaa caactgcaggctgtgaaaacggagcagtccaaagtgaatgaggagacgcttcccgcagag gagaagctcaaaatctatcactcgctggcgggaagccttcaggactcaggaatcgtgcta aaacgagtgaccgtgcatcttgaagatctggttccacaccttgacccctcggcttatgag aaagccaagcagcagatccagtcctggcaagaggagttgaaagtcttgacttctgccatt ggcgcaacggtgaccgagtgtgagagccgcatggtgcagagcatagacttccagacagag ctgagccgctccctggactggctgaggagcgtgaaggcagagctaagtgggccggtgtgc ctggacctgagcctccaggacatccaggaggagatcagaaagacccagattcatcaggaa gaggtccagtccagcctgagaatcatgaatgccctgagtaacaaggagaaggagaaattc acgaaagccaaagagctcctttctgcagattttcagcacactcttgctgagctctcagag ctggacggagacgttcaggaagctttacgcaccagacaggctgccttgacccaaatatat agtcaatgtcagaggtactatcaagtatttcaagcagctaacgactgggttgaggatgct 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cagacaaccctgacttccccagaagtcggacgtcttagtctcaaggaacaactttcgcat cgacagcatctgctctctgagatggagtcactcaagccaaaggtccacgccgtgcagatc tgccagagtgccctccggatccccgacgatgtggtcgccagcctgccgctctgccattgt gccttgcacctgcaggcagaggccagccgattgcagcacacggctatccagcagtgcaac atcatgcaggaggccgtggtacaatatgaacaatatgagcaagaaatgcagcacctccag gagcttatagaaggagctcacagagagattgaagacacacccgcggccaccagcaacatc caggagctgcaagcccagatttctcggcatgaggagctggctcagaaaatcaagggctac caggagcagatcgcctctttgaactccaagtgcaagatgctgacgatgaaagccaagcat gccaccatgctgctgacggtgacggaggtggaggggctggcggaggggacggaggacctg gaccgggagctcctccccgcgacctcggcccacccctctgtggtcatgatgactgcgggt cgctgtcacactttgctgtcacctgtcacagaggagtctggggaggagggaaccaacagt gaaatttcctctccacctgcctgtcgctccccttcacctgtggctaatacagatgcttct gttaaccaggacattgcttattaccaggccttatctgctgagaggttgcagacagatgct gccaggatccaccccagcacgttgccatcgccggagttctatgaactaggactggagcca tctgctaccgctaagctggatgatttgcagcgttcttgggaaaccctaaagaatgtgatc agtgaaaagcagcgcactctctatgaagctttggaaaggcagcagaagtaccaggactcc ctccagtccatctccacaaaaatggaggccatcgagatgaaactcagtgagagtctggag cacggcaggggtccagagagccagatggcggagcatcaggcactgatggatgagattctc atgcttcaagaggagatcagtgagctccagtcgtctctggcggaggagctggtgtcccag tctcccgagtccgaccccgcggaacagctggccttgcagtccacactcaccgtcttagcc gagcggatgtccaccatcaagatgatggcgtcagggaagcgacagcttttggaggagaag ttaaatgatcagcttgaggaacagagacaggagcaggccctgcagaggtaccgctgtgaa gccgacgagctggaccactggctcctgagcaccaaggccactctggacaccgcactgggt acagcccaggagcctatggacatggaagcccagctggtggattgccagaacatgctagtg gaaatcgagcagaaggtggtggccttatcggagctgtcggtccacaatgacaacctgctg ctggagggcaaggcccacaccaaggaggaggcagagcagctggccgtgaagctgagaacc ctcaagggcagcctcctggagctgcagagagccctacatgacaaacagctcctcatgcag ggaacagcccaagagaaggaggagagccatgccgacctcaccgccagtcagagccccggt gtccaggaatggctggcccaagcacggactgcatgggcccaccagcgacagagcagtctc cagcaacaaaaagagttggaacaggaattagcagagcagaagagcctcctgcggtcagta gccagtcgtggagaggaaattctcacccaacactcagctgcagagacttctgctggtatt ggcgaaaaacctgatgtgttatcccaggagttggggatggaaggggagaaatcagcctct gaagaccagatgagaatgaaatgggaaagcctacatcaagaatttagtaccaagcagaaa ctactacagaatgttctggaacaggaacaagagcaagtgctctacagcaggccaaatcgg ctcctgtctggcgtgccactgtacaaaggggataggcagacccaagacagatctgcagtg acgtctttactggatggattgaaccaggcgtttgaggaggtttcgtcccagggcgggggg acaaagaggcagaacattcacttggaacagaagttatatgatggggtctcagctacctct acatggttggatgatgttgaggaacgcttatttgttgccacagcacttttaccagaagaa accgaagcttgcctcttcaaccaagagactcttgccaaagatattaaggaaatgtctgaa gaaatggataagaacaagaacttgttttcccaagcatttccagagaatggtgataaccga gatgttattgaagacactttgggttgtcttttgggccggttatccttgttagactcagta gtgaatcagcgatgtcatcagatgaaggaaagacttcagcaaatactaaatttccagaat gatctgaaggtgctgtgtacatcactggccgacagcaaatacatcattctgcagaaactg gcaaatgtgtttgaacagcccgtggcagagcaaattgaggcaatacaacaggctgaagat gggctaaaggaattggatgcagaaatcattgaattaaaaaagcgtggtgacaagttgcag attgagcagccttccatgcaggaactgtccaaacttcaggacatgtatgatgaactgatg atgaccattggctcctggcggagtagtctgaaccagaatcttgccctcaagagtcagtac gaaagggccctgcaagatctggctgacctgctggagactggacaggagaagatggcgggt gaccagaaaatcattgtgtcttccaaggaggaaattcaacaactgcttgacaaacataag gaatactttcaaggcctggaatctcatatgatcctgacggagacactcttcagaaagata atcaactttgcggtcctacaagaaacacagttccacacagaactgatgacacaggcttca gctgtactgaaacgggctcacaagaggggggtggagttggagtacattctagagacatgg tctcatctggatgaagaccaccaggcgctcagcaaacagctggaggtggtggaaagtagc atcccaagtgtgggattggtggaggagagcgaggagaggctcatcgaccggatagcactc taccagcatttgaaatccagccttcatgaataccagcccaaattatatcaggtgttagat gatgggaaacgactgctcatatccattagctgctcagatttagaaagccagctcaatcaa ctgggagaacagtggttggataataccaacaaagtgtcgaaggaacttcacagattggaa acagtactgaaacactggaccagatatcaaagcgaatctgcagaacttattcactggtta cagtctgcaaaagacaggctagaattttggactcaacagtctgtgacagtcccgcaagaa ctggaaatggtccgtgatcatctaaatgctttcctggagttttccaaagaagtggatgcg aaatcttccctgaaatcatctgttctgagcatcggaaatcagcttcttcgattaaagaaa gtggacacggcttccctacgttcagaactgtcacacattgacagccagtggactgatctg ctgacaaatattccgactgtacaggaaaagctccaccagctccagatggataagctgccg tcccgccatgccatttctgaactgacgacctggatttctctaatggaaaatgttattcaa aaggatgaagagaacataaaaaattcgataggttacaaggcaattcatgaataccttcag aaatacaagggttttaagatagatattaactgtaaacagttgacagttgattttgtgaat cagtccgtgctacagatcagcagtcaggatgtggaaagtaaacgcagtgacaagactgat tttgctgagcaacttggagccatgaataaaagttggcaaatcctgcagggcctagtgact gagaagatccagctgttggaaggcttattggaatcttggtcagaatatgaaaataatgtg caaagtctgaaaacttggtatgaaacccaggaaaacaaactaaaacaacagcatcgaatt ggagatcaggcttcagttcaaagcgcaatgaaagactgtcaggatctagaagatttgatt aaagcaaaagaaaaagaagtagagaaaattgagcagaatggacttgctttgattcagaac aagaaagaagaagtctctggtgttgtcatgagcacgctgcgggagctcaaccaaacctgg gcaaatttagaccacatggttgggcagttcaagatactgttgaagtccgtgtttgaccaa tggaacaatcacaaggaggcctttgatgagataaacagttacctcatggaggccagatat tctctttcccgcttccgcctgctgactggttctttagaagctgtacaagttcaggtagac aatcttcagaatcttcaagatgatctggaaaaacaggaaaagaacttacagaattttggt tccatcaccaaccaactgttaaaagaatgtcacccacctgtgacagaaactcttaccacc acattaaaagatgtcaatatgagatggaataacttgctggaagagattgctaagcagctg tgctccagcaaggcactccttcaactttggcgaagatacaaggactactccaaacagtgt gcttctacggttcagcagcaggaggatggagccagtgagctcctgaaggcagccactaac aaggacattgctgatgacgaagctgcgacgtggattcaggattgcaacgatctcctcaaa ggcttggggacagtgaaggattccctttttgttctccgtgagctgggagagcagctcaag caacaagtggatgcttcagcagcatcaaccattcaatccgatcagctgtccttgagtcaa cgcttatgtgccctagaacaggctctctgcaagcagcagaccatgttacaggctggagtt cttgactatgaaacctttaccaagagtttagaagctttggaggcctggatagtagaagcg gaagaaatattgcaagggcaggaccctggccactcttctgacctctcgaccatccagcaa aggatggaagaacttaagggacagatgttaaaattcagcagcatggccccagatttagac cgtctaaatgagcttggatataggctacccctgaatgataaagaaatcaaaaggatgcaa aatctgaaccggcactggtctctgatctcctctcagacaacagagagattcagtaagttg cagtcgtttttgctacaacatcagactttcttggaaaaatgtgaaacatggatggaattc ctggttcaaacggaacaaaagttagcagtagagatttctggcaattatcagcatcttttg gagcagcagagagcacacgagttgtttcaagcagagatgttcagtcgtcagcagattttg cactcgatcattattgatgggcagcgtcttctagaacaaggtcaagttgatgacagggat gaattcaacctgaaactgacccttctcagcaatcagtggcagggagtgattcgcagggcc cagcaaaggaggggcatcatcgacagccaaattcgccagtggagacggtacagggagatg gcagaaaagcttcgtaaatggttggttgaagtgtcctatcttcccgtgagtgctctcgga agtgtcccaataccactgcagcaggcaaggaccctctttgatgaagtgcagttcaaagaa aaagtgttcctgcgacaacaaggcagctacatcctaacagtggaggctggcaagcagctt ctgctctcggccgacagtggagctgaggctgccttgcaggcggaactcgctgaaatccaa gagaaatggagatcggccagtgtgcgtctggaggaacagaagaaaaagctggccttcttg ctgaaagactgggaaaaatgtgagaatggtatagctgattctctggagaagctacgaact ttcaaaaagaagctgtctccacccctgccagatcaccacgaagagctccatgcagagcaa atgcgttgcaaggagttggaaaatgcagctgggaactggacagatgacttggctcagttg gctctgctgaaggacaccctctgtgcctacatcagcgccgatgatatctccatcctgaac gaacgcatggagcttctgcagagacagtgggaagaactgtgccaccagctctccttaagg cggcagcaagtgagtgagagattgaatgaatgggccgtcttcagtgaaaagaacaaggag ctttgcgaatggctgacccagatggaaagcaaagtttctcaaaatggagacattctcatt gaagaaatgatagagaaactcaagaaggattatcaagaggaaattgctgttgcccaagag aacaaaatacagctccagcaaatgggagaacgacttgctcgagccagccatgaaagcaaa gcctctgagattgaatacaagcttggaaaggtcaacgaccggtggcagcatctcctggat ctcatggcagccagggtaaagaagctgaaggagaccctggtggccgtacagcagctggat aagaacatgagcagcctgaggacgtggctggctcacatcgagtcagagctggccaagccc atagtctacaattcctgtgactcggatgaaatacagaaaaagcttactgagcagcaggag cttcagagagacatcgagaaacacagcacgggtgtggcgtctgtcctcaacctgtgtgag gtcctgctgcatgactgtgatgcctgtgccacagatgcggagtgtgactccatccagcag gctacgcgaaacctggaccggcggtggaggaatatctgtgccatgtccatggagaggagg ctcagaattgaagagacgtggcgattgtggcagaagtttctggacgattattctcgtttt gaagattggctcaagatttcagaaaggacagctgccttccccagctcttccggggtgctc tatacagttgccaaggaagaactaaagaaatttgaggctttccagcgacaggtgcacgag agcctgacccagctggagctgatcaacaagcagtaccgtcgcctggccagagagaaccgc accgattctgcctgtagcctaaagcagatggttcacgaaggcaaccagagatgggacaac ctgcagaagcgggtcacctccatcttgcgcagactcaagcatttcatcggccagcgtgag gagtttgagactgcgcgggacagcattctggtgtggctgacagaaatggatctgcagctc actaatattgagcatttttctgagtgtgatgttcaagctaaaataaagcaactcaaggcc ttccagcaggaaatctcactgaaccacaataagattgagcagataatttcccaaggagaa cagcttatagagaagagtgagcccttggatgcagcggtcattgaggaggaactggatgaa ctccgacgttactgtcaggaggttttcgggcgcgtggaaagataccataagaaactgatt cgcctgcctctcccagatgatgagcatgacctctctgaccgggagctggagctggatgac tctgcagctctctcggacctccactggcgggacacctcagcagacagcgtgctttccccc cagccttcttccaacccctccctctcactcgcccagcccctgcggagcgagcggtcggga cgagacacccctgccagtgtggactcaattcccctggagtgggaccatgattatgacctc agtcgggacctggagtctgctgtgtccagaactctgccctctgaggatgaagaggttgga gacgataaagatttctacctcaggggagctgttggcttatcagatgtaatgatccccgaa agtcctgaggcctatgtaaaactcacagaaagtgcaatcagaaatacctctggagccccc agtgccttagagtcacagatccgacaactagacaaagccttggatgagagccgttttcag atgcagcaaactgaaaacatcatccgcagcaaaacccccaccggaccagagctagactcc agctacagaggctatatgaaactactgggtgagtgcagcggcagcatagactccgtgagg agactggaacacaaactgaaggaggaagaagagaactttccaggctttgttaacctgaac agtacggaaacccaaacagctggtgtgatcgaccgatgggaactcatccaggcgcaggcc ctgagcaaggagctgaggatgaagcagaacctccagaagtggcagcagttcaactctgac ctgaacaacatctggacgtggctgggggagacggaggaggagctggagcggctgcagcac ctggagctcagcaccgacatccaggcgatcgagctccaaatcaaaaagctcaaggagctc cagaaggctgtggaccaccgcaaagccatcatcctctccatcaacctgtgcagccccgag ttcacccagactggcagtgagaaaagccaggatctgcaagatcgcctgtcccagatgaac ggacgctgggaccgcgtgtgctcattgctggacgagtggcggggcctgctccaggatgca ctgatgcagtgtcaggatttccatgaaatgagtcatggtttgcttcttatgctggagaac atcgacagaaggaaaaatgaaattgtccctattgattctaaccaggatgcagagacactt caggaccatcacaagcagcttatgcaaataaggcatgagctattggaatcccaactcaaa gtggcctcactgcaagacatgtcttgccaactactggtgaatgctgaaggcacagactgt ttagaagccaaagaaaaagtccatgtgattggaaatcggctcaaacttctcttgaaggag gtcagccgacacatcaaggagctggagaagttattagacatgtcaagcagtcagcaggat ttgtcttcctggtcttctgcggatgaactggacacctcgggatctgtgagtcctacatca ggaagaagcaccccgaacagacaaagaacgccacgaggcaaatgtagtctctcacagcct ggaccctctgtcaacagtccacatagcaggtccataaaaggtggctgcgattcctccctt tctgagcctcggccagctcggtccggccgggccttcttactcagagtcctccgcgcggcc cttccactccagcttctcctgttgctcctcatcgggctcgcctgcctcgtaccaatgtca gaggaagactatagttgtgccctctccaacaactttgcccggtcattccaccccatgctc agatacacaaacggccctcctccactctga

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