Felis catus (domestic cat): 101084482 Help Entry 101084482         CDS       T02385                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism fca  Felis catus (domestic cat) Pathway fca04020   Calcium signaling pathway fca04024   cAMP signaling pathway fca04260   Cardiac muscle contraction fca04261   Adrenergic signaling in cardiomyocytes fca04371   Apelin signaling pathway fca04713   Circadian entrainment fca04911   Insulin secretion fca04921   Oxytocin signaling pathway fca04972   Pancreatic secretion fca05020   Prion disease fca05022   Pathways of neurodegeneration - multiple diseases fca05410   Hypertrophic cardiomyopathy fca05412   Arrhythmogenic right ventricular cardiomyopathy fca05414   Dilated cardiomyopathy fca05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:fca00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101084482 (RYR2)    04020 Calcium signaling pathway     101084482 (RYR2)    04024 cAMP signaling pathway     101084482 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     101084482 (RYR2)    04921 Oxytocin signaling pathway     101084482 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     101084482 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     101084482 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     101084482 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     101084482 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     101084482 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     101084482 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101084482 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     101084482 (RYR2)    05414 Dilated cardiomyopathy     101084482 (RYR2)    05415 Diabetic cardiomyopathy     101084482 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:fca04040]     101084482 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:fca04990]     101084482 (RYR2) Ion channels [BR:fca04040]  Voltage-gated cation channels   Ryanodine receptor    101084482 (RYR2) Domain-containing proteins not elsewhere classified [BR:fca04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101084482 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  101084482 NCBI-ProteinID:  XP_023096126 LinkDB All DBs Position D2:complement(11155192..11913133) Genome browser AA seq 4986 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREGGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYRLSMPIECAEVFSKTVTG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAAFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNDCYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEED TEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESGSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNRSRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRTF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTSMHRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSASHFESH RLQTGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRV QESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLW DAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVD MLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQS ETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLEL AESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGG EKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTV KSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASV SRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSE DLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQE QKVKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFW KKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGN AKVSSLDSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFK REKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFY GRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLY LAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEI YRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTV PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQ YEDQLN NT seq 14961 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgaaggcgaggacgagatccagttcctacgaactgacgatgaagtg gtcctacagtgcaccgcgaccatccacaaagaacaacagaaactgtgcttggcagcggaa gggtttggcaacagactttgcttcctggagtctacttcgaattccaagaatgttccccca gacctctccatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggag atgctggctaacacagtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtacctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacaacaggtgaggcttgttggtgg actattcatcctgcctccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgttgcacggacac atggatgaatgcctcactgtcccttcgggagaacacggtgaagagcagcggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccggtcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacatataaatacaggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gacggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agcactgtcttccttttcaatagatttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccacagtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagtgcggcgcatttcgcggacgtggcggggaga gaaggaggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaagtccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgc catggagtagcggtccgttccaaccagcatctcatctgtgacaatctgctgccgggaaga gacctacttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtactatgagctgatggtggac catacggagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagttggagat gacctcttttcctacggatttgatggccttcacctgtggtcaggttgtattgcacgcact gtaagctcaccgaatcaacatctcttgagaaccgacgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcgttccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctacttggggggagacatggagaatttaaattccttcctccacctgggtatgct ccttgttatgaagctgttctcccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccctgtggacaccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttgcagatgtcacttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccgtctcaggaagcgatggtggacaagctggcg gagaacgctcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacagaagaaaccctcgcctggttccctacacccttctagatgac cgcaccaagaagtccaacaaggacagcctccgtgaggctgtgcgcacgctgctgggatat ggctaccatctggaggcgccagatcaagatcacgctgcccgagccgaagtgtgtagcggc accggggagaggttccgaatcttccgcgcagagaaaacctatgccgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgctggagacatgagagtcggatggagcaggcca ggttgtcaacctgaccaagagctgggctcagacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgat gttgtgggatgcatggtggacatgacggagcacaccatgatgttcacactgaatggcgaa atccttctggatgactcgggctccgaactggcgttcaaggacttcgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgct gtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccttcaaaccatgagcatatcgaggtgaccagaatagacggcaccatcgacagttct ccgtgtttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatg ttctatcgcctgagcatgccaatcgagtgtgctgaggttttctccaagacggtgacaggc gggctcccaggcgccggcctctttgggcccaagaatgatctggaggattacgatgcagat tctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaag ccctctcgtctgaaacaaaggtttttgcttagaagaacaaagccagattatagcacgagc cattctgcaaggctcacggaagatgtccttgcagatgatcgggatgattatgactacttg atgcaaacgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgatacaggctttgacttggac agagttcgtacagtaaccgttactctaggagatgaaaagggaaaagtacatgaaagcatc aaacgcagcaactgctatatggtgtgcgcgggcgagagcatgagcccagggcaaggacgc aacaataatggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacgttc accgccaacggcaaggagctgagcacctactaccaggtggagccaagtacaaagttattt cctgcagcttttgcccaagctacaagtcccaatgttttccagtttgagctgggaagaatc aagaatgtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgcca cagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctctccatatcccggaggagaacagatctgttgac atactggagctgacagagcaggaagagctgctgaaattccactaccacacgctccggctt tactccgccgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtg gacgaaccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggcc ggctactatgacctgctgattgacatccacctgagctcctacgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccct gatgagaacaaaaagcatggcctcccggggattggcctcagcacctccctcaggccacgg atacagttttcctcccccagttttgtgagcatcaataacgactgctaccaatacagtcca gagttcccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaa gagggcagcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgaggacttaaaa cacatcttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagac actgaggctctggagaaagagccctccatggaagactccaagccagaaggagctggagaa gaagaagccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgag ccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcag cgcttccgttacaatgaagttatgcaagctttaaacatgtcggccgcgctcactgccagg aagacaaaggaatttcggtccccacctcaggaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcac gaagatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaac agtgacttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaaacaagccgaaaaaccagttgagagtggctccaagaagtcctccactcttcagcag ttgatttctgagaccatggtccgatgggcacaagagtctgtcattgaagaccctgaactg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat ctcatgagggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctt tgttacttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctat ttattggagaacagcagtgttgggcttgcctcaccagcaatgagaggttcaacaccactg gatgtggcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagcca gatttggaaaaggtagttcggtatttggctggttgtggactgcagagttgcccgatgctg gtatctaagggttacccagatattgggtggaatccagttgaaggagagagataccttgac tttctccgatttgctgtcttctgtaatggggagagcgtggaagagaatgctaatgttgtg gtgaggttgctcatccggaggcccgagtgtttcggtcctgctttgagaggggaaggtggg aacggtcttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcaccaactagtggatccagtaaaacacttgagacagaagaggaggaggatgac actatccacatggggaatgccatcatgacgttttatgcagctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattctgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggtt caagatttcctcctccaccttctcgaggttggctttctgcctgatctccgggctgctgct tctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctt tgcacagccgtgttgcctttattaacaagatgtgcccctcttttcgcgggcacagaacac cacgcttctctcattgactcgttactgcacactgtgtacagactttcgaagggctgctca cttaccaaagctcagcgggattccatagaagtttgtttgctctctatttgtggccaattg agaccttctatgatgcagcacttgctccgaagattagtgtttgatgtcccattattaaat gaacatgcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatacgctgaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa accatgctggcgtggggttggagggttgagagaacacgggagggagacagcatggccctc tacaaccgttctcgtcgtatttctcagacaagccaggtttctgttgatgctgcccatggt tatagcccccgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaaatggagctg gagtccaaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcttacagatcaatgga tatgctgtatccaggggattcaaggacctggaattggacacaccttccattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatc aagttctttgctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagtagacccctctgttctggaggacatgcgtcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggactgtcatgaagactggcctggagagtgttaaaagtgcgctcagaacgttt ctggacaatgcagcggaggatctggagaagacgatggagaacctcaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcgttaggagaatgtcttgct gcttttgctggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacatc tactctatctacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactaac gtggaggatgtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaa ttagctgagtccggcattcgctacacacagatgccacacgtcatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcacggacctgaaaataatccagaaagg gctgaaatgtgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatata ttgaaaatcatatataataacctgggaattgatgagggagcctggatgaagaggttagca gtattttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggtggtgtcggaggaggaccatctg aaagctgaggccaggggggatatgtccgaggcagagcttctcattctcgatgagttcacc actctggccagagatctctatgccttctacccgctcttgattagatttgtggactataac agggcaaagtggctaaaagaacctaacccagaagcagaggaccttttccgcatggtggcc gaagtgtttatctactggtcaaaatcccacaatttcaaaagagaagagcagaactttgtg gtacagaatgaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtcg aaggccgctgtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactcc acgcagacctctctcattgtggcagctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagac actgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagatttaccgaacaggactgaagat acatcagatccagagaagaccgtagagagagtattagatatagcaaatgtgctttttcat cttgagcagaaatctacatctatgcaccggagatattacagtctggtggagcacccacag agatcgaagaaagctgtatggcacaaacttctgtccaagcagaggaagagggcagtggtg gcctgcttccgaatggctcctttatataatctgccaaggcaccgggccgttaacctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataagctg atagaagatttagcaaaacctggagcagaccctccagaggaagaggaaggcacgaagaga gtcgatcccctccatcagctcatccttctgtttagtcgaacagctttaacggagaaatgc aaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggaaaaagaaatggagaagcagaagcttctgtaccagcaagccaggctccat gaccgcggggctgctgagatggtgctacagaccatcagtgccagcaaaggtgatactgga ccaatggtagcggcgactttgaaacttggaattgcaatcttaaatggcgggaactccaca gttcagcagaaaatgcttgactatctcaaggagaagaaggacgtgggtttctttcagagc cttgccggcctgatgcagtcgtgcagcgtcctcgacctcaatgcatttgagcggcagaac aaagctgaaggacttggaatggtcaccgaagaaggatcagcctctcactttgaaagtcac agactgcagactggagaaaaggttctccaagatgacgagttcacgtgtgacctcttccgt ttcctccagctgctttgtgagggacacaactcagattttcaaaattatctgagaactcag actggcaataacacaactgtcaacatcatcatctctaccgtagactacctactcagagtc caggaatccattagtgatttctattggtattactctgggaaagatgttattgatgaacaa ggacaacggaatttctccaaagcaattcaagtagcaaaacaagtctttaacacgctcaca gagtatattcagggtccttgcactgggaatcagcagagcttggcccacagcaggctatgg gacgcagttgtgggcttccttcacgtattcgcccacatgcagatgaagctgtctcaggat tccagtcaaatcgagctattaaaagaattaatggatcttcagaaggatatggtggtcatg ttgctgtccatgctagaaggtaatgttgtcaatggaaccattggcaaacagatggtcgat atgcttgtggagtcttccaacaacgtggagatgattctcaagttttttgacatgttctta aaactaaaggatttgacctcttctgacacatttaaagaatacgaccctgacggcaaggga gtcatttccaagagggacttccataaagcgatggagagccataaacactacacgcaatca gaaaccgagtttcttctgtcctgtgcagagacggatgaaaacgaaaccctggactatgaa gagtttgtcaaaaggtttcacgagcccgcaaaggacatcggcttcaatgtggctgttctt ctgaccaacctttcggagcacatgcccaatgatacgcgactgcagactttcctggagttg gcagagagcgtgctgaattacttccagccttttctgggacgcatcgagatcatgggaagt gccaaacgcatcgagagggtgtattttgaaatcagtgagtccagccgaacccagtgggag aagccccaggtcaaggagtccaaaaggcagttcatatttgacgtggtcaacgaaggggga gaaaaggagaaaatggaactttttgtcaacttctgtgaggacaccatattcgaaatgcag ctggcagcgcagatctcagagtcggatttgaatgagaggtcagcgaataaagaagagagt gagaaggagaagccggaagagcaggggcccagaatgggtttcttttccatcgtgacggtc aagtcggccctgtttgctctcaggtataatatcttgaccctcatgagaatgctcagcctg aagagcctgaagaaacagatgaaaaaagtgaagaagatgacgatgaaggatatggtcacg gccgccttttcgtcctactggagtattttcatgagcctcctgcactttgtggccagcgtt tccagaggcttcttccgcatcatttgcagcctgctgcttggcgggagcctagtagaagga gcaaaaaagatccgagtggcagagctcttagccaacatgccagaccccactcaggatgag gtgagaggggatggagaagagggggacaggaggcccatggaggccgccctgccctcggaa gatctgacagacctgaaggaactgacagaggaaagcgaccttctttcggacatatttggc ttggatctgaagagagaaggaggacagtacaaacttattcctcataatccaaacgctggc ctcagcgatctaatgagcaacccggtccctatccctgacgtgcaagaaaaatttcaggaa cagaaggtgaaagaggaagaaaaggaggagaaagaagaaagcaaatctgaacctgaaaag gccgagggagaagatggagaaaaagaagaaaaagccaaagaagataagggtaaacagaag ttgaggcagctccacacacacagatacggagagccagaagttcccgagtcggcattctgg aagaaaatcatcgcatatcaacagaaacttctaaactattttgctcgcaacttttacaac atgagaatgttagccttattcgtcgcgtttgcaatcaatttcatcttgctcttttataag gtctccacttcttctgtggttgaaggaaaggagccccccactcgcagttcaagtggaaat gccaaagttagcagcctggacagtggctcgcctagaatcatcgcggttcactacgtcctg gaggagagcagtggctacatggagcccacgctgcggatcttagccattcttcacacggtc atttctttcttctgcatcatcggctactactgcttgaaagtcccactggttatttttaag cgagaaaaggaagtagctcgaaaattggaatttgatgggctttatattacagaacagcct tcagaagatgatattaaaggccagtgggatagactcgtaatcaacacacagtcatttccc aacaactactgggacaaatttgttaaaagaaaggttatggataaatatggggagttctat ggccgggacagaatcagtgagctccttggtatggacaaagccgccctagatttcagcgat gcccgggaaaagaagaagccaaagaaagacagctccctgtcagccgtactgaactctatt gatgtgaagtatcagatgtggaaactaggagtcgtcttcacggacaactctttcctctac ctggcctggtatatgactatgtccgttctgggacactataacaactttttttttgctgct catcttcttgacattgctatgggattcaagacactgagaaccatcttgtcatcggtaact cacaatggcaagcagcttgtattaactgttggcttgttagctgttgttgtatacctatat actgttgtggcattcaactttttccgaaaattctacaataaaagtgaagatggtgacaca ccggatatgaaatgtgatgatatgctaacgtgctacatgttccacatgtatgtcggggta cgtgccggagggggtatcggcgatgaaatcgaagacccagcaggtgacgaatatgagatc tatcgaatcatctttgacatcaccttcttcttcttcgtgattgtcattctcttggccata attcaaggtttaattattgatgcttttggagagctaagagaccaacaggagcaagtcaaa gaagacatggagaccaaatgtttcatctgtgggataggcaacgattacttcgacacagtg ccacatggcttcgaaacccacactttacaggaacacaacctggccaattacctgtttttt ctgatgtatctcataaacaaagatgaaacagagcacacgggacaggaatcttatgtctgg aagatgtatcaagaaaggtgctgggaattcttcccagcaggggattgtttccggaaacag tatgaagaccagctaaattaa

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