Felis catus (domestic cat): 101087772
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Entry
101087772 CDS
T02385
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
fca
Felis catus (domestic cat)
Pathway
fca00230
Purine metabolism
fca00670
One carbon pool by folate
fca01100
Metabolic pathways
fca01523
Antifolate resistance
Module
fca_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
fca00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
101087772 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
101087772 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
101087772 (GART)
Enzymes [BR:
fca01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
101087772 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
101087772 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
101087772 (GART)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_3
ATP-grasp_2
CPSase_L_D2
ATP-grasp_4
Dala_Dala_lig_C
CbiJ
RimK
Motif
Other DBs
NCBI-GeneID:
101087772
NCBI-ProteinID:
XP_003991506
UniProt:
M3WB84
LinkDB
All DBs
Position
C2:11760515..11790087
Genome browser
AA seq
1009 aa
AA seq
DB search
MAARVLVIGGGGREHTLAWKLAQSNRVKHVLVAPGNAGTACLEKISNTATSISDHTALAQ
FCKDENIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTRPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQEKAY
GAAGETIVIEELLEGEEVSCLCFSDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLLLKIKNTVLQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTFDGLLHTSLPVWLENRTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTSGGRVLSVTAIQENLISALEEAKKGLAAIKFEGAIYRKD
IGSRAIAYLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLACGTDGVGTKLKIAQQCNRHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLDTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKFGVDLDAQTWRIPRIFSWLQQEG
QLSEEEMARTFNCGLGAVLVVSKDRTEQILRDIKQHSEEAWVIGKVVACPEGSPRVKVKH
LIETMQANGSVLENGTLKNHFSVQPKKARVAVLISGTGSNLQALIDNTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLEAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVTTLSERVKLAEHRLFPAALQLVASGTVQLGENGKIRWVTE
NT seq
3030 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgcgtacttgtaattggcggtggcggaagggaacatacactggcctggaaa
cttgcacagtctaatcgtgtcaaacatgtgttggttgccccgggcaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccacctcgataagtgatcacactgcccttgctcaa
ttctgcaaagatgagaacattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacctctgcaggagtgcgatgctttggtcccacagcagaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacacggaatcccg
accgcacggtggagagctttcaccagacctgaggaggcctgcagctttattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtgattgtt
gcaaagagcacagaagaagcctgcagggctgtacaggagatcatgcaggagaaagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtttcttgt
ctgtgcttcagtgatggcaggaccgtggcccccatgcccccagcacaagaccataaacga
ttgctggagggcgatcacggccccaacacagggggaatgggagcctactgtccggcacct
caggtttcgaaggatttgctgctgaaaataaaaaatacagttcttcagaggacagtggat
ggtatgcagcaggagggtatgccatacacaggtgttctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgtttcggtgatccagagtgccaagtg
atcctcccgctgcttaaaagtgatctttatgaagtgattcagtctacctttgatggcctg
ctccacacatctctgcctgtctggctggaaaaccgcaccgccctaactgtcgtgatggca
agtaagggctacccaggagattacaccaagggtgtggagataacaggctttcctgaggct
caagctttaggactggaggtgttccacgcaggcactgccctgaaagatggcaaagtggtg
actagtgggggtagagtcctttcggtaacagccatccaggaaaatctcatttcagccctt
gaagaagccaagaaaggactagctgctataaaatttgagggagccatttacaggaaggac
attggctctcgtgccatagcttacctccaacagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctgtggaacagatggtgtggggactaaactg
aagattgcccagcagtgtaatagacatgataccattggccaagatttggttgcaatgtgt
gtaaatgatattctggcccaaggggcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcgatacaactgaagccgttgttgctggaattgccagagcctgtggg
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctcct
ggagagtatgacctggccggttttgccgtcggtgccatggagcgggatcagaaactccct
cacctggaaagaatcaccgaaggggatgttgttattggaatagcttcatctggtcttcac
agcaatggatttagccttgtgaggaaaattgtagcaaaatcttccctccagtactcctct
ccagcacctgatggctgtggtgaccagaccttaggggacttacttctgactccaacgaga
atctacagccattcgctattacctgtcctacgttcaggacatgtcaaggcctttgcccat
attactggtggaggattgctagaaaacatccccagagtccttcctgagaaatttggagtg
gatttagatgcccagacctggaggatccccaggatcttctcatggttacagcaagaagga
caactctctgaggaagagatggccagaacatttaactgtgggcttggggccgtcctcgtg
gtgtcaaaggataggacagagcagattctgagggatatcaagcagcacagcgaagaagcc
tgggtgatcggcaaggtggttgcgtgtcctgaaggttctcctcgtgtgaaagtcaagcat
ctgattgaaaccatgcaagcaaatggatcagtattggagaatggcactctgaaaaatcat
ttctctgtccaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctccaagccctcatagacaataccagggagccaagtagctgtgcacacatcgttgttgtt
atctccaacaaagctgcagtggctggcttagataaagcagaaagagccggaattcccacc
agagtaatcaatcataaattatataaaagtcgtgtagaatttgacactgcaattgaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcagaaaatggaatgggaaaatgctcaacatccatccatccttgctcccg
tcttttaagggttcaaatgcacatgagcaagtcctagaagccggggtcacagtcactggg
tgtactgtgcactttgtagctgaagatgtagatgctggacagattatcttacaagaagct
gttccagtgaagaggggcgacaccgttacaactctgtctgaaagagtgaaattagcagag
cacagactatttcccgcagccctccagctggtagccagtggaactgtacagcttggagaa
aatggcaagattcgttgggtcacagagtag
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