KEGG   Felis catus (domestic cat): 101087931
Entry
101087931         CDS       T02385                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
fca  Felis catus (domestic cat)
Pathway
fca01521  EGFR tyrosine kinase inhibitor resistance
fca01522  Endocrine resistance
fca01524  Platinum drug resistance
fca04010  MAPK signaling pathway
fca04012  ErbB signaling pathway
fca04014  Ras signaling pathway
fca04015  Rap1 signaling pathway
fca04022  cGMP-PKG signaling pathway
fca04024  cAMP signaling pathway
fca04062  Chemokine signaling pathway
fca04066  HIF-1 signaling pathway
fca04068  FoxO signaling pathway
fca04071  Sphingolipid signaling pathway
fca04072  Phospholipase D signaling pathway
fca04140  Autophagy - animal
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04152  AMPK signaling pathway
fca04210  Apoptosis
fca04211  Longevity regulating pathway
fca04213  Longevity regulating pathway - multiple species
fca04218  Cellular senescence
fca04261  Adrenergic signaling in cardiomyocytes
fca04370  VEGF signaling pathway
fca04371  Apelin signaling pathway
fca04380  Osteoclast differentiation
fca04510  Focal adhesion
fca04550  Signaling pathways regulating pluripotency of stem cells
fca04611  Platelet activation
fca04613  Neutrophil extracellular trap formation
fca04620  Toll-like receptor signaling pathway
fca04625  C-type lectin receptor signaling pathway
fca04630  JAK-STAT signaling pathway
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
fca04664  Fc epsilon RI signaling pathway
fca04666  Fc gamma R-mediated phagocytosis
fca04668  TNF signaling pathway
fca04722  Neurotrophin signaling pathway
fca04725  Cholinergic synapse
fca04728  Dopaminergic synapse
fca04810  Regulation of actin cytoskeleton
fca04910  Insulin signaling pathway
fca04914  Progesterone-mediated oocyte maturation
fca04915  Estrogen signaling pathway
fca04917  Prolactin signaling pathway
fca04919  Thyroid hormone signaling pathway
fca04920  Adipocytokine signaling pathway
fca04922  Glucagon signaling pathway
fca04923  Regulation of lipolysis in adipocytes
fca04926  Relaxin signaling pathway
fca04929  GnRH secretion
fca04931  Insulin resistance
fca04932  Non-alcoholic fatty liver disease
fca04933  AGE-RAGE signaling pathway in diabetic complications
fca04935  Growth hormone synthesis, secretion and action
fca04936  Alcoholic liver disease
fca04973  Carbohydrate digestion and absorption
fca05010  Alzheimer disease
fca05017  Spinocerebellar ataxia
fca05132  Salmonella infection
fca05135  Yersinia infection
fca05142  Chagas disease
fca05145  Toxoplasmosis
fca05152  Tuberculosis
fca05160  Hepatitis C
fca05161  Hepatitis B
fca05162  Measles
fca05163  Human cytomegalovirus infection
fca05164  Influenza A
fca05165  Human papillomavirus infection
fca05166  Human T-cell leukemia virus 1 infection
fca05167  Kaposi sarcoma-associated herpesvirus infection
fca05168  Herpes simplex virus 1 infection
fca05169  Epstein-Barr virus infection
fca05170  Human immunodeficiency virus 1 infection
fca05200  Pathways in cancer
fca05205  Proteoglycans in cancer
fca05207  Chemical carcinogenesis - receptor activation
fca05208  Chemical carcinogenesis - reactive oxygen species
fca05210  Colorectal cancer
fca05211  Renal cell carcinoma
fca05212  Pancreatic cancer
fca05213  Endometrial cancer
fca05214  Glioma
fca05215  Prostate cancer
fca05218  Melanoma
fca05220  Chronic myeloid leukemia
fca05221  Acute myeloid leukemia
fca05222  Small cell lung cancer
fca05223  Non-small cell lung cancer
fca05224  Breast cancer
fca05225  Hepatocellular carcinoma
fca05226  Gastric cancer
fca05230  Central carbon metabolism in cancer
fca05231  Choline metabolism in cancer
fca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
fca05415  Diabetic cardiomyopathy
fca05417  Lipid and atherosclerosis
fca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:fca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101087931 (AKT1)
   04012 ErbB signaling pathway
    101087931 (AKT1)
   04014 Ras signaling pathway
    101087931 (AKT1)
   04015 Rap1 signaling pathway
    101087931 (AKT1)
   04370 VEGF signaling pathway
    101087931 (AKT1)
   04371 Apelin signaling pathway
    101087931 (AKT1)
   04630 JAK-STAT signaling pathway
    101087931 (AKT1)
   04668 TNF signaling pathway
    101087931 (AKT1)
   04066 HIF-1 signaling pathway
    101087931 (AKT1)
   04068 FoxO signaling pathway
    101087931 (AKT1)
   04072 Phospholipase D signaling pathway
    101087931 (AKT1)
   04071 Sphingolipid signaling pathway
    101087931 (AKT1)
   04024 cAMP signaling pathway
    101087931 (AKT1)
   04022 cGMP-PKG signaling pathway
    101087931 (AKT1)
   04151 PI3K-Akt signaling pathway
    101087931 (AKT1)
   04152 AMPK signaling pathway
    101087931 (AKT1)
   04150 mTOR signaling pathway
    101087931 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101087931 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    101087931 (AKT1)
   04218 Cellular senescence
    101087931 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101087931 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101087931 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101087931 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101087931 (AKT1)
   04613 Neutrophil extracellular trap formation
    101087931 (AKT1)
   04620 Toll-like receptor signaling pathway
    101087931 (AKT1)
   04625 C-type lectin receptor signaling pathway
    101087931 (AKT1)
   04660 T cell receptor signaling pathway
    101087931 (AKT1)
   04662 B cell receptor signaling pathway
    101087931 (AKT1)
   04664 Fc epsilon RI signaling pathway
    101087931 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    101087931 (AKT1)
   04062 Chemokine signaling pathway
    101087931 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101087931 (AKT1)
   04922 Glucagon signaling pathway
    101087931 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    101087931 (AKT1)
   04920 Adipocytokine signaling pathway
    101087931 (AKT1)
   04929 GnRH secretion
    101087931 (AKT1)
   04915 Estrogen signaling pathway
    101087931 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    101087931 (AKT1)
   04917 Prolactin signaling pathway
    101087931 (AKT1)
   04926 Relaxin signaling pathway
    101087931 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    101087931 (AKT1)
   04919 Thyroid hormone signaling pathway
    101087931 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101087931 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101087931 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    101087931 (AKT1)
   04728 Dopaminergic synapse
    101087931 (AKT1)
   04722 Neurotrophin signaling pathway
    101087931 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101087931 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    101087931 (AKT1)
   04213 Longevity regulating pathway - multiple species
    101087931 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101087931 (AKT1)
   05205 Proteoglycans in cancer
    101087931 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    101087931 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101087931 (AKT1)
   05230 Central carbon metabolism in cancer
    101087931 (AKT1)
   05231 Choline metabolism in cancer
    101087931 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101087931 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101087931 (AKT1)
   05212 Pancreatic cancer
    101087931 (AKT1)
   05225 Hepatocellular carcinoma
    101087931 (AKT1)
   05226 Gastric cancer
    101087931 (AKT1)
   05214 Glioma
    101087931 (AKT1)
   05221 Acute myeloid leukemia
    101087931 (AKT1)
   05220 Chronic myeloid leukemia
    101087931 (AKT1)
   05218 Melanoma
    101087931 (AKT1)
   05211 Renal cell carcinoma
    101087931 (AKT1)
   05215 Prostate cancer
    101087931 (AKT1)
   05213 Endometrial cancer
    101087931 (AKT1)
   05224 Breast cancer
    101087931 (AKT1)
   05222 Small cell lung cancer
    101087931 (AKT1)
   05223 Non-small cell lung cancer
    101087931 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101087931 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    101087931 (AKT1)
   05161 Hepatitis B
    101087931 (AKT1)
   05160 Hepatitis C
    101087931 (AKT1)
   05164 Influenza A
    101087931 (AKT1)
   05162 Measles
    101087931 (AKT1)
   05168 Herpes simplex virus 1 infection
    101087931 (AKT1)
   05163 Human cytomegalovirus infection
    101087931 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101087931 (AKT1)
   05169 Epstein-Barr virus infection
    101087931 (AKT1)
   05165 Human papillomavirus infection
    101087931 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101087931 (AKT1)
   05135 Yersinia infection
    101087931 (AKT1)
   05152 Tuberculosis
    101087931 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101087931 (AKT1)
   05142 Chagas disease
    101087931 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101087931 (AKT1)
   05017 Spinocerebellar ataxia
    101087931 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101087931 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    101087931 (AKT1)
   05415 Diabetic cardiomyopathy
    101087931 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101087931 (AKT1)
   04932 Non-alcoholic fatty liver disease
    101087931 (AKT1)
   04931 Insulin resistance
    101087931 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101087931 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101087931 (AKT1)
   01524 Platinum drug resistance
    101087931 (AKT1)
   01522 Endocrine resistance
    101087931 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:fca01001]
    101087931 (AKT1)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101087931 (AKT1)
Protein kinases [BR:fca01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   101087931 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7
Other DBs
NCBI-GeneID: 101087931
NCBI-ProteinID: NP_001309364
UniProt: A0A143RHU3
LinkDB
Position
B3:complement(146095795..146116673)
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFPEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMLCGRLPFYNQDHEKLFEL
ILMEELRFPRTLSPEAKSLLSGLLKKDPKQRLGGGAEDAKEIMQHRFFASIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQGDSVEGEDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtggccatcgtgaaggagggttggctgcacaagagaggggaatacatcaag
acctggaggccccggtacttcctcctcaagaacgacggcaccttcatcggctacaaggag
cggccacaggacgtggagcagagagagtccccgctcaacaacttctctgtggcgcagtgt
cagctgatgaagacggagcggcccaggcccaacaccttcatcatccgctgcctgcagtgg
accacggtcatcgagcgcaccttccacgtggagacccccgaggagcgggaggagtggacc
accgccatccagacagtggccgacgggctcaagaggcaggaggaggaaatgatggacttc
cggtcgggctcgcccagcgacaactcgggggccgaggagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctggggaaaggcacg
ttcgggaaggtaatcctggtgaaggagaaggccacgggccgctactacgccatgaagatc
ctcaagaaggaggtcatcgtggccaaggatgaggtggcccacacgctcacagagaaccgc
gttctccagaactctcggcaccctttcctgacggccctgaagtactccttccagacccac
gaccgtctctgcttcgtcatggagtatgccaacgggggcgagctcttcttccacttgtcc
cgggagcgggtcttccccgaggaccgtgcgcgcttctacggcgccgagatcgtgtccgcg
ctggactacctgcactccgagaagaacgtggtctaccgcgacctcaagctggagaacctc
atgctggacaaggacgggcacatcaagatcaccgacttcggcctgtgcaaggagggcatc
aaggacggtgccaccatgaagaccttctgtgggacgcccgagtacctggcccccgaggtg
ctggaggacaacgactacggccgcgcggtcgactggtgggggctgggcgtggtcatgtac
gagatgctgtgcggccgcctgcccttctacaaccaggaccacgagaagctcttcgagctc
atcctcatggaggagctccgcttcccgcgcacgctcagccccgaggccaagtccctgctg
tcggggctgctcaagaaggaccctaagcagaggctgggagggggcgccgaggacgccaag
gagatcatgcagcaccgctttttcgccagcatcgtgtggcaggacgtgtacgagaagaag
ctcagtccgcccttcaagccccaggtcacctcagagacggacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacgccccccgaccaaggcgacagcgtggagggc
gaggacagcgagcggaggccccacttcccacagttctcctactccgccagcggcacggcc
tga

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