KEGG   Felis catus (domestic cat): 101092346
Entry
101092346         CDS       T02385                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X5
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
fca  Felis catus (domestic cat)
Pathway
fca01521  EGFR tyrosine kinase inhibitor resistance
fca01522  Endocrine resistance
fca04010  MAPK signaling pathway
fca04012  ErbB signaling pathway
fca04015  Rap1 signaling pathway
fca04024  cAMP signaling pathway
fca04062  Chemokine signaling pathway
fca04068  FoxO signaling pathway
fca04150  mTOR signaling pathway
fca04270  Vascular smooth muscle contraction
fca04510  Focal adhesion
fca04650  Natural killer cell mediated cytotoxicity
fca04720  Long-term potentiation
fca04722  Neurotrophin signaling pathway
fca04726  Serotonergic synapse
fca04730  Long-term depression
fca04810  Regulation of actin cytoskeleton
fca04910  Insulin signaling pathway
fca04914  Progesterone-mediated oocyte maturation
fca04928  Parathyroid hormone synthesis, secretion and action
fca04934  Cushing syndrome
fca05010  Alzheimer disease
fca05022  Pathways of neurodegeneration - multiple diseases
fca05034  Alcoholism
fca05160  Hepatitis C
fca05161  Hepatitis B
fca05200  Pathways in cancer
fca05205  Proteoglycans in cancer
fca05208  Chemical carcinogenesis - reactive oxygen species
fca05210  Colorectal cancer
fca05211  Renal cell carcinoma
fca05212  Pancreatic cancer
fca05213  Endometrial cancer
fca05214  Glioma
fca05215  Prostate cancer
fca05216  Thyroid cancer
fca05218  Melanoma
fca05219  Bladder cancer
fca05220  Chronic myeloid leukemia
fca05221  Acute myeloid leukemia
fca05223  Non-small cell lung cancer
fca05224  Breast cancer
fca05225  Hepatocellular carcinoma
fca05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101092346 (BRAF)
   04012 ErbB signaling pathway
    101092346 (BRAF)
   04015 Rap1 signaling pathway
    101092346 (BRAF)
   04068 FoxO signaling pathway
    101092346 (BRAF)
   04024 cAMP signaling pathway
    101092346 (BRAF)
   04150 mTOR signaling pathway
    101092346 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101092346 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101092346 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101092346 (BRAF)
   04062 Chemokine signaling pathway
    101092346 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101092346 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    101092346 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    101092346 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101092346 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    101092346 (BRAF)
   04720 Long-term potentiation
    101092346 (BRAF)
   04730 Long-term depression
    101092346 (BRAF)
   04722 Neurotrophin signaling pathway
    101092346 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101092346 (BRAF)
   05205 Proteoglycans in cancer
    101092346 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    101092346 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101092346 (BRAF)
   05212 Pancreatic cancer
    101092346 (BRAF)
   05225 Hepatocellular carcinoma
    101092346 (BRAF)
   05226 Gastric cancer
    101092346 (BRAF)
   05214 Glioma
    101092346 (BRAF)
   05216 Thyroid cancer
    101092346 (BRAF)
   05221 Acute myeloid leukemia
    101092346 (BRAF)
   05220 Chronic myeloid leukemia
    101092346 (BRAF)
   05218 Melanoma
    101092346 (BRAF)
   05211 Renal cell carcinoma
    101092346 (BRAF)
   05219 Bladder cancer
    101092346 (BRAF)
   05215 Prostate cancer
    101092346 (BRAF)
   05213 Endometrial cancer
    101092346 (BRAF)
   05224 Breast cancer
    101092346 (BRAF)
   05223 Non-small cell lung cancer
    101092346 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101092346 (BRAF)
   05160 Hepatitis C
    101092346 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101092346 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    101092346 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    101092346 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101092346 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101092346 (BRAF)
   01522 Endocrine resistance
    101092346 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:fca01001]
    101092346 (BRAF)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101092346 (BRAF)
Protein kinases [BR:fca01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101092346 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 101092346
NCBI-ProteinID: XP_006929486
UniProt: A0A2I2ULH6
LinkDB
Position
A2:complement(155188171..155347774)
AA seq 764 aa
MAALSGGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEA
LLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSS
SSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKK
ALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFF
TLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQE
EASIAETALTSGSSPSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRS
SSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQ
RERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHI
IETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR
WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK
IHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2295 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggcggcggcggcggcggtggcgcggagcagggccaggctctgttc
aacggggacatggagcccgaagccggcgccgcggcctcttcggctgcggaccctgccatt
cccgaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcc
ctattggacaaatttggtggggagcataatccaccatcaatatatctagaggcctatgaa
gaatacaccagcaagctagatgccctccaacagagagaacaacagttattggaatccctg
gggaatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcc
tcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaaccccacagat
gtgtcacggagcaatcccaagtcaccacagaaacctatcgttagagtcttcctgcctaat
aaacagaggacagtggtacctgcaagatgtggagttacagtccgggacagtctaaagaaa
gctctgatgatgagaggtctaatccctgagtgctgtgctgtttacagaattcaggatgga
gagaagaaaccaattggctgggacactgatatctcctggctcaccggagaggaattgcat
gtagaagtgttggaaaatgttccacttacaactcacaactttgtacggaaaacgtttttc
accttagcattttgtgacttttgtcgaaagctgcttttccaaggttttcgctgtcaaacg
tgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattat
gaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggag
gaggcctccatagcagagactgccctaacgtctggatcgtccccttctgcccccccctcc
gattctactgggccccaaattctcaccagtccgtctccttcaaaatccattccaattcca
cagcctttccgaccagcagatgaagatcatcgaaatcaatttggacagcgagaccggtcc
tcatcagctccaaatgtgcatataaatacaatagaacctgtcaatattgatgacttgatt
agagaccaggggtttcgtagtgatggaggatcaaccacaggcttgtctgccaccccccct
gcctcattgccgggctctctcactaatgtaaaagcattacagaaatctccagggcctcag
cgggaaaggaaatcttcttcatcctcagaagataggaatcgaatgaaaacacttggtaga
agggattcaagtgatgattgggagattcctgatgggcagatcacagtgggacagagaatt
ggatccgggtcatttgggacagtctacaagggaaagtggcatggtgatgtggcagtgaaa
atgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtagga
gtactcaggaaaactcggcatgtgaacatcctgctcttcatgggctattcaacaaagccc
cagctggctattgtcacccagtggtgtgagggctccagcttataccaccatctccacatc
atcgagaccaaattcgagatgatcaagctgatagatattgctcggcagactgcgcagggc
atggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatattttt
cttcacgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcga
tggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaa
gtaattcgaatgcaagataaaaacccatatagctttcagtcagatgtatatgcatttggg
attgttctatatgaattgatgactggacagttaccttattcaaacatcaacaacagggac
cagataatttttatggtgggacgaggatatctttctccagatctcagtaaggtacgaagt
aactgtccgaaagccatgaagagattgatggcagagtgcctaaaaaagaaaagagatgag
aggccactgtttccccaaattcttgcctctattgagctgctggcccgctcattgccaaaa
attcaccgcagtgcatcagaaccctccttgaatcgggctggcttccagacagaggatttt
agtctctatgcttgtgcttctccaaaaacacccatccaggcagggggatatggagaattt
gcagccttcaagtag

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