Felis catus (domestic cat): 101092966
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Entry
101092966 CDS
T02385
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X2
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
fca
Felis catus (domestic cat)
Pathway
fca00790
Folate biosynthesis
fca01100
Metabolic pathways
fca01240
Biosynthesis of cofactors
fca01523
Antifolate resistance
fca04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
fca00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
101092966 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
101092966 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
101092966 (FPGS)
Enzymes [BR:
fca01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
101092966 (FPGS)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
101092966
NCBI-ProteinID:
XP_003995952
UniProt:
A0ABI8ALV8
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Position
D4:86248779..86266177
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AA seq
580 aa
AA seq
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MSQARRHLRPALFLAAVSARVATTGVAARRGLSAWPAPQEPGMEYQDAVRALNTLQTNAG
YLEQVKRQRGDPQAQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWPLYHRLEETKDSSSYVSMPAYFR
FLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPAVCGISSLGIDHTSILGDTVEEI
AWQKGGIFKRGVPAFTVLQPDGPLAVLRDRAQQISCPLYLCPPLEALEEGGPPLTLGLEG
EHQRSNAALALQLARCWLQQKDYRGIGELKVSRPSLLRQMPLAPVFQPTTHMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTASSMQACVRWFRQALHRRPRPSRGSEVLVLLFNSTGDR
DPAALLKMLQPCQFDYAVFCPNLTEVSTVGNADQQNFMVTLDQVLLRCLAHQQHWSRLDE
EQAGPEPGEPTSSLLAPHPPEPRSTSSLVFSCISHALLWISQGRDPVFQPPSPPQGLFAH
PVAGSGAGVLREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1743 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgccgccacctgcgacccgctcttttcctggcggcggtttctgcgcgc
gttgcaactaccggggtagcggctcggcgagggttgagcgcgtggcccgcgccgcaggag
cccggcatggagtatcaggacgctgtgcgcgcactgaacaccctgcagaccaatgctggc
tatctggagcaggtaaagcgccagcggggtgaccctcaggcacagctggaagccatgaag
ctgtacttggcacggagtgggctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggttccacttgtgcctttactgaacgtattctccgaagc
tatggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaacgggcagcccataagccctgagctcttcaccaagcacttctggcccctctac
caccggctggaggagaccaaggacagcagcagctatgtctccatgcccgcctacttccgc
ttcctcacgctcatggccttccacgtcttcctccaagagaaggtggacctggcagtggtg
gaggtgggcattggtggcgcttacgactgcaccaacatcatcaggaagcctgcggtgtgt
ggcatctcctctcttggcatcgaccacaccagcattctgggggacacagtggaggagatc
gcgtggcagaaagggggcatcttcaagcgtggcgtccccgccttcaccgtgctccagcct
gacggtcccctggccgtgctgagggaccgggcccagcagatctcatgtcctctctacctg
tgcccaccactggaagccctggaggaaggggggccgccgctgaccctgggcctggaggga
gagcaccagcggtccaatgccgccttggccttgcaactggctcgctgctggctacagcag
aaggactaccggggcatcggggagctgaaggtgtccaggcccagtctcttgcggcagatg
cccctggcgcccgtgttccagcccacgacccacatgcggcatgggcttcgggacacggag
tggctgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggatggcgcg
cacaccgccagcagcatgcaggcctgcgtgcgctggttccgccaggcgctgcaccgccgc
ccgaggccaagccgcggctctgaggtgcttgtcctgcttttcaactccaccggagaccgg
gatcctgcagcgctgctgaagatgctgcagccctgtcagtttgactatgctgttttctgc
cctaacctgacagaggtctcaactgttggcaatgcagaccagcagaacttcatggtgacc
ctggaccaggtgttgctccgctgccttgcacaccaacagcactggagccgcctggacgag
gagcaggcgggcccggagcctggtgagcccacatcctcgctgctggctccccacccgccc
gagccccgtagcaccagctccctggtcttcagctgcatctcccacgccttgctgtggatc
agtcaaggccgggaccctgtcttccagccacccagtcccccgcagggcctcttcgcccac
cctgtggcaggcagcggggccggcgtgctccgtgaggctgccgccatccacgtgctggtc
accggcagcctgcacctggtgggcggcgtcctgaagctgctggagccggccctgtcccag
tag
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