Felis catus (domestic cat): 101096157
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Entry
101096157 CDS
T02385
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
fca
Felis catus (domestic cat)
Pathway
fca05012
Parkinson disease
fca05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
fca00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
101096157 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
101096157 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
fca01001
]
101096157 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
fca04131
]
101096157 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
fca04147
]
101096157 (LRRK2)
Enzymes [BR:
fca01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101096157 (LRRK2)
Protein kinases [BR:
fca01001
]
Serine/threonine kinases: TKL group
LRRK family
101096157 (LRRK2)
Membrane trafficking [BR:
fca04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
101096157 (LRRK2)
Exosome [BR:
fca04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
101096157 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
COR
LRR_4
Ras
LRR_9
Arf
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
Beta-prop_EML_2
LRR_NXF1-5
LRR_13
AAA_22
T2SSE
nSTAND3
Ank_2
ABC_tran
Kdo
PduV-EutP
MMR_HSR1
GTP_EFTU
SRPRB
G-alpha
AAA_7
TsaE
AAA_16
ARM_CUL7_CUL9
Beta-prop_WDR19_1st
TniB
cobW
MobB
WD40_Prp19
WD40_WDHD1_1st
AAA_29
Septin
NACHT
FtsK_SpoIIIE
AAA_23
SRP54
LRR_6
Beta-prop_HPS5
Motif
Other DBs
NCBI-GeneID:
101096157
NCBI-ProteinID:
XP_023112714
UniProt:
M3VXC2
LinkDB
All DBs
Position
B4:67888721..68026054
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYADHASKLFQGKN
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEVLGIHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEETDIFLLIFDAMRTFSANDEVQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLHVVHCLHSLAIPCSNV
EVLMSGNVRCYNIVVEAMKAFPDNEKIQEVSCCLLHRLTLGNFFNILVLNDVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEEKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNASMDTM
VVVAPKIITVMKYHEASLSVQLEALRAILHFIVPGMPEESKEDTEYQHKLHMVKKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSLAHFPDALQVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLGLIGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTMLELSV
SFSNLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVMLEKACDQN
NSIMVECLLLLGADANRTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDRTSNLRKETNIGSTLA
RMVLRYQMKSVVEEGAASGSDGNFPEEVLDKFDEWTFIPDSCVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQRCSPNLQRHSNSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NGLTNFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDISRNDINPSVVLDPAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKISGICSHLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAVPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNDIQYLPSPAHWKSLNLRELLFSFNQISVLDLSEKAHVWSRVEKLHLAHNKLKEI
PPEIGCLENLTSFDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKSKKSDPGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILLERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPEQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFIVECMVATNH
NSKSASIWLGCGHTDKGQLSFLDLNMEKHTSEEVTDSRILCLALVHLPAEKESWIVCGTQ
SGMLLVISTEDGKKRHTLKKMTDSVTCLYCNSVPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKISYSGRVKTLCLQKNTALWIGTGGGHVLLLDLSTRRIIRIVHNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKSTEGTQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRNELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggtagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatttgctggtgttcacgtacgcggaccacgcctccaagttatttcaaggcaaaaat
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttctatgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggaccgcaggatattggacgtgattgggaagtacttgggatccaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagttggactaaaggcctta
gatctcctcctaacttcaggtaaaatcactttgctgatattggatgaagagactgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaagtccaaaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctaaatgcattaaaaaattttaaagatgaagag
gaaattgtgcttcatgtagtgcactgtttacactccctagcaattccttgcagtaatgtt
gaagtcctcatgagtggcaacgtgaggtgttacaatattgtggtagaagccatgaaagca
ttccctgacaatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacttta
ggtaatttttttaatattcttgtattaaacgatgtacatgagtttgtggtgaaagctgtg
cggcggtattcagagaacgccacgttacaaattgcagcgctcagctgtttagcactcctc
actgagaccattttcctaaatcaagatttggaggaaaagaatgaaaatcaggagaatgat
gatgaggaagaagaaaagttgttttggttggaagcctgttacaaagcgttgacgtggcat
agaaagaacaagcacgtgcaggaagctgcatgctgggccctaaacaacctcctcatgtac
caaaacagtctccatgagaagatcggagacgaagacggccagttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcgaaagaagtcttccaggcctctgcaaat
gcgttgtccactctgttagaacaaaatgttaatttcagaaaaatcctcttgtcaaaagga
atatacctgaatgtattggagttaatgcagaagcatatacattctcctgaggttgcagaa
agcggctgtaaaatgctaaatcatctttttgaaggaagtaatgcttccatggatacgatg
gtagtagtggcccccaaaataataacagttatgaaatatcatgaggcatcgttatcagtg
cagctggaggcacttcgagctattttacattttatagttccaggcatgccagaagagtcc
aaggaagatacagaatatcaacataagctacatatggttaaaaaacagtgtttcaggaat
gatattcacaaactggtcctagcagcgttgaacaggttcattggaaatcctgggattcag
aaatgtggattgaaagtaatttcttccttagcacattttcctgatgcattacaagtatta
tccctggaaggtgctattgattcggtacttcacacacttcagatgtatccagatgaccaa
gaaattcaatgtctgggtttaggtcttataggatgcttgattacaaagaagaatttatgc
ataggaactggacatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggctgaagtacagattaaaggatttcagacaattttaacaatgctggaattgtcagtg
tctttttccaacctgctggtgcatcattcctttgattcggtgatattccatcagatgtct
tccagtattatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggacgatgagttaaaaagcgtgatgttagagaaagcatgtgatcagaat
aacagtatcatggttgaatgcttgcttctattgggagcagacgccaatcgaacaaaggag
gcaacttctttaatttgtcaggtatgtgagaaagcaagcagtcccaaattggtggaactg
ttactgaatggtggttcccgtgaacaggatgtccggaaagctctgacaataagcattgga
aaaggtgacagccagatcatcagcttactcttacggagactcgccctggatctggccaat
aatagcatttgccttggaggattttgtataggaaaaatcgaaccttcatggcttggtcct
ttgtttccagataggacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtactcagatatcagatgaaaagtgttgtggaagaaggagcagcctcaggcagc
gatgggaattttcctgaagaagttcttgataaatttgatgaatggaccttcattccagac
tcttgtgtagacagtgtgtttggtcaaagtgacgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtgggagaattttaccgagatcgt
gccttacagcgttgctcaccaaatttgcagagacattccaactcattgggacccattttc
gatcatgaagatttactgaggcgaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatattacatcattagacctctcagcaaatgaactaagagacattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatggactcacgaactttccacaacaactgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaattgtatt
gccaaccttgatatctctcgaaacgacatcaacccctcagtagttttggatcctgcagtg
aagtgcccaaccttgaagcagtttaacttgtcatataatcagctgtcttcttttcctgag
aaccttggtgatgtggtagagaaattggaacagctcattttagaaggaaataaaatatca
ggaatatgttcccacttaagcctgaaggaactgaaaattttaaaccttagtaaaaaccac
attacatccctatcagaagatttccttgaggcgtgtcctaaagtggagagtttcagtgcc
cgaatgaattatcttgctgctgtgccttttttgccttcttctctgacaagcctaaaattg
tcccaaaacagatttacatgtgttcctgaagcaattttaaatcttccacacttacggtcc
ttagatatgagcagcaatgatattcaatatctaccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagcgtcttggacttgagcgaaaaa
gcacatgtgtggtcaagagtagagaaactgcatcttgctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaacctgacctcctttgatgtcagttacaatctggaa
ctgagatcctttcctaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactacgtcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcagcagcggttaaaaaaggctgtgccctataaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttactgcagcaactaacgaaaagcaagaaatca
gatcctggggtgcaaagcgccacagttggtatagatgtgaaggactggcctatccaaata
agaggcaaagggaagaaagacctcattctaaatgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcatcctcacttcatgacccagcgggccctctacctggctgtctatgac
ctcagcaaagggcaggctgaagtcgatgccatgaagccttggctcttcaatataaaggcc
cgtgcttcttcttcccctgtgattcttgttggcacacatttggatgtttccgatgaaaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactgctgaacaagcgagggtttcct
gcaataagagattaccactttgtgaatgccacagaggaatctgatgctttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgtcgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttattggaacgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaactcgtaaaagaaaat
cagctacagttggatgaaaatgagcttcctcatgcggttcacttcctaaatgaatcaggg
gtccttcttcattttcaagacccagcactgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatccaaaa
catcctaagggaatcatttcacgcagagatgtggaaaaatttctttcaaagaaaaagagg
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccctg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagctccctcattgtgagaactctgaaattatcattcgactctatgaaatgccttatttt
ccaatgggattttggtcaaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagttttagaccatcacccagag
agtttcttaaaaattacagttccttcgtgtagaaaaggctgtattcttttgggccaagtt
gtggaccacatcgattctctcatggaagaatggtttcctggattactggaaattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gaacatcaaaaaatcttgcttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtcaatccggagcaaccaaggctcaccattcctatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagaattcctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagattttcaataaacatacatcacttagattgttaagacaagag
ctggtggtcctttgccacctgcaccaccccagcttaatatctttgctggcagctgggatt
cgtcctcgcatgttggtgatggagttagcctccaagggttcactggaccgcttgcttcag
caggacaaagccagtctcaccagaaccctacagcacaggattgcactccatgtggctgat
ggcttgagatacctccactcagccatgatcatataccgtgacttgaagccccacaatgtg
ctgctcttcaccctgtaccccaatgctgccatcatcgcaaagattgctgactatgggatt
gctcagtattgctgtagaatggggataaagacatcagagggcacaccagggtttcgtgca
cctgaagttgcaagaggaaatgttatttataaccagcaggctgatgtttattcatttggc
ttactactctatgacatcttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaagggaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggtggagaagttaattaaaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacatatatcgatacctaaaaactttatagttgaatgcatggttgctacaaatcat
aacagcaagagtgcaagcatctggctgggctgtgggcacactgacaaaggacagctctca
tttcttgacctaaatatggaaaaacacacttctgaggaagttactgacagcagaatactg
tgcctagctttggtgcatcttcctgctgaaaaggaaagctggattgtgtgtgggacacag
tctggcatgctcctggtcatcagtaccgaagatgggaaaaagagacatacccttaaaaag
atgactgattctgtaacttgcttatattgcaattccgttcccaagcaaagcaagcaaaaa
aactttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtacgccactg
atgtgtttgagtgaatctatgaattcaactgaaaaaaacattatgtggggaggatgtggc
acaaaacttttctcattttctgatgatttcaccattcagaagctcattgagacaaagaca
aatcagctgttttcttatgcagctttcagtgattccaacatcatagcagtggtggtggac
acggctctctacgttgctaagaaaaatagcccatttgtggaagtatgggataagaagact
gaaaaactctgtgaacttatagactgtgtgcactttttaaaggaggaaatggtaaaagta
aacgcggaatcaaaacacaaaatatcttactctgggagagtgaaaactctctgcctccag
aagaacactgccctctggataggaactggaggaggccatgttttactccttgatctttca
actcgtcgaattatacgtatagttcacaatttttgtgattctgtcagagtcatgatgaca
gcacagttaggaagccttaaaaatgtcatgctggttttggggtatatccggaaaagtact
gaaggcacacaacaccaaaaagagatacagtcttgtttgtctgtttgggatatcaacctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtaagaaatgaattagctgaaaaa
atgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
