Felis catus (domestic cat): 101101194
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Entry
101101194 CDS
T02385
Symbol
DOT1L
Name
(RefSeq) LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
fca
Felis catus (domestic cat)
Pathway
fca00310
Lysine degradation
fca01100
Metabolic pathways
fca05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
fca00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
101101194 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
101101194 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
fca03036
]
101101194 (DOT1L)
Enzymes [BR:
fca01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
101101194 (DOT1L)
Chromosome and associated proteins [BR:
fca03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
101101194 (DOT1L)
HMT complexes
Dot1-containing complex
101101194 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
101101194
NCBI-ProteinID:
XP_023099117
LinkDB
All DBs
Position
A2:1382325..1445970
Genome browser
AA seq
1693 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVAADTPVDSGAEEEKAGTTAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKPRKSQTALDLLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRPLLAAT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSAHLRGKGALGREPEADPGRLHLDLDCSRFSLPHFSSASPELSMNGHAAGY
ELCGALSRPPSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLSPAKLV
LRRHLSQDHAAGGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQM
TGERGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQTRESLSTLEKQMGANAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADPGTFDE
VPSAGGLFASVGSCGSTPQHPPLLPQPRGSGAASPAHPLCASPRLGGAAQGPLPDANKGD
LPPEAGFSDPEGEAKRRIVFTVSAGGGSTKQSPPSKPSPLPTGGRGDGSQGHGQDSRKRG
RRKRAAAGTPGLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPE
SLKSSPVPYQDSDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERKIATIS
LESRSPPKTLENGGGLAGRKPTPAGEPANSSKWKSTFSPISDLGLAKCADSPLQAGSALS
QNSLFAFRPPLEEPGSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLS
LHSFSDGASLSHKVPEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDGAGGPKGREAGE
PGXPACGPPDKASLAHGKPGKGRDREPDLKNGHNLFIAAASVPPGGLLSGPGLATAASSV
VSAAPSAQAHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATR
LTNSHAMGSFPSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSXNPLQAVAG
APPPPPPGQPALPXRPPPPNAALPPAPALLPANSEPALLQNLASLPANQAFLPASSAASL
QPANASLSIKLASLPHKAPRPSFTVHHQPLPXLALAQAAPVIPQASSTGPSAVWVSLGMP
PPYAARLAGVKPR
NT seq
5082 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtaggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgcgaagagatcccggacctcaagctcgctatggagaactacgtttta
atcgactacgacaccaaaagcttcgagagcatgcagaggctctgtgataagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccactcagcccatgaaactgaacacc
cggccgtccaacgggctcctgcgccacatcctgcagcaggtgtataaccactcggtgacg
gaccccgagaagctcaacaactacgagcccttctccccagaggtgtacggggagacctcc
tttgacctggtcgcgcagatgatcgacgagatcaagatgaccgaggacgacctgtttgtg
gacctgggcagcggagtgggccaggtcgtgctccaggtggccgcggccaccaactgcaaa
catcactacggcgtggagaaagccgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcggaggagtggagagagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggcggcagaattgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agcagaaacttgagcgacatcggcaccatcatgcgcgtcgtggagctctcgcccctgaag
ggctctgtgtcctggacggggaagccggtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggagcaggaggcg
gctcggcgccggcagcagcgagagaacaagagcaacacgaccactcccaccaaggtgccc
gagagcaaggccgccgtggccgcggacacccccgtggattccggtgccgaggaagagaag
gctgggacgaccgccatcaaaaagccgtccccctccaaagcccggaagaagaagctgaac
aagaaggggcggaaaatggccggcaggaagcgcgggcgccccaagaagatgagcgctgcc
aaccccgagcgcaagccccggaagagccaaactgcactggacctcctgcacgccccggcc
tcgtcgcagacggcggcgccctcgccacaggatgcgtacaggtcacctcacagtcccttc
tatcagctacctccctgcgtgcagcggcacgcccccgaccggccgctgctggcagccacc
ccgcccgcactgcagaagctgctagaatccttcaagattcagtacttgcagttcttggcc
tacaccaagaccgcccagtacaaggccagccttcagcagctgctggaccaggagaaggag
aagaacgcccggctgctgggggccgcacagcagctgttcggccactgccaggcccagaaa
gaggagatcaagaggctcttccagcagaaactggatgagctgggggtgaaggcgctgacc
tacaacgacctgattcaggcgcagaaggagatctcggcccataaccagcagctgagggag
cagacggagcagctgcaggaggacaacagggagctgaggagccagagcctgcagctgctc
aaggctcggtgtgaggagttgaagctggactggtccacgctgtcgctggagaacctgctg
aaggagaagcaggccctgaggagccagatctccgagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaag
tcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgcgggaaaggcgccctgggc
cgggagccggaggcggaccccggccggctgcacctcgacctggactgctctcggttctcc
ctgccgcacttcagcagcgccagcccggaactctccatgaacggccacgcggccggctac
gagctctgcggtgcgctgagccggcccccgtccaagcagaacaccccccagtacctggcc
tccccgctggaccaggaggtggtgccctgcacccccagccacggcagccggccaaggctc
gagaaggtgtctggcctggccttgccggactacaccaggctttccccggccaagctggtg
ctgaggcggcacctcagccaggaccacgcggccggcggcaagacggcggccggggagctg
cacccgcgagccgagcacgccaaggagaacggccttccgtaccagagcccgggcatcgcc
aacggcatcaagctgagccctcaggacccccggccctcatcccccgtggccttacagatg
acaggggagaggggcagcgagaagggtttgaaggagcgtgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcccagcaagctgccc
gtcagcatccctctggccagcgtggtgctgcccagccgtgccgagaaagtgagaagcacc
cccagccccgtgccgcagacccgagagtccttgtccacacttgaaaagcagatgggcgct
aacgcacacagcgccggaagcaaaagtctcgccccagcccctgcaggcttctacgcgggc
tcggtggccgtcagcccagcccccctcgcttccggagcagatcccggcacctttgacgag
gtccccagcgcaggcggtctgtttgccagcgtggggtcctgtggctccaccccgcagcac
ccgcccctgctgccgcagccccgcggctctggcgcagcctcgcccgcccacccgctctgc
gccagcccccgcctgggcggcgccgcccagggtccgctccctgacgccaacaaaggggac
cttcctcccgaggccggcttctcggaccccgagggcgaagccaagcggaggatcgtcttc
accgtctcggccggcgggggcagcaccaagcagtcgcctcccagcaagcccagccctctg
cccacgggcggccgcggggacggcagccagggccacgggcaggacagccgcaagcggggc
agaaggaagcgggcggcggcagggacccccggcctgagctcaggcgtgtcgcccaagcgc
cgggccctgccgtccgtggccggcctcttcacgcagtcttcagggtcccccctgaacctc
aactccatggttagcaacattaaccagcctttggaaatcacggccatttcgtcccctgag
agcctgaagagctcccctgtcccctaccaggacagcgaccagccacccgtcctcaagaag
gagaagcccctgagccagaccaacggggcccactactccccactgacctcggacgaggag
cagggctccgaggatgagccgggcagcaccagaattgagagaaaaattgcgacaatctcc
ttagaaagcagatctcccccgaaaaccttggaaaacggtggtggcctggcggggaggaag
ccgacccctgccggcgagcccgccaacagcagcaagtggaagtctaccttttcgcccatc
tccgacctcggcctggccaagtgcgccgacagcccgctgcaggccggctccgccctgagc
cagaactccctgttcgctttccggccccccctggaggagcccggctcggccgacgccaag
ctggccgcccaccccaggaaaagttttcccggtgccctgtcgggggcaggcgggctgagc
ccaagcagcaaccctcccaacggcttcgccttcagcgggggcctggccgccgacctcagt
ttacacagcttcagtgatggtgcttctctctcccacaaggtccccgaggcggcaggcctg
ggcgcccccctgagctttcccgccccccggggcaaggacagcgctgcggagcccgggccc
tttgtgaacaagaggcagctggacggcgcgggcggccccaagggcagggaggcaggcgag
ccgggcnccccggcgtgcggccccccggacaaggcctcgctggcgcacggcaagccgggc
aagggccgggaccgtgagcccgacctgaagaacggccacaacctcttcattgcggccgcc
agcgtgccccccgggggcctcctcagtggcccaggcctcgccacggcggcgtcctcggtg
gtcagcgcggccccctccgcccaggcgcaccgccccttcctgggcacgtttgcccccggc
ccgcagttcgccctgggccccatgtcgctgcaggccaacctgggctcgtctgtgctgcag
tccctgtttggctccgtgccggccgccggcctggtgcacgtctcgtccgccgcaaccaga
ctgaccaactcgcacgccatgggcagctttccctccggggtggcaggcggcgcagttgga
ggtgtctttaaccacgcggtgccttccgcctccgctcatccgtttggagccagtttcggc
agcggggctgcgtgtcgcagcgccacgctgagcnttaacccgctgcaggcggtggccggc
gccccgcccccgcccccaccggggcagcctgccctccccnngcgcccccctccccctaac
gccgccttgcctcccgcccccgcgctgctcccggctaactctgagcccgcgcttctgcag
aacctcgcgtccctcccggctaaccaggctttcttacccgcctcctctgccgcctctctg
cagcctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggccccccgc
ccctccttcacggtgcaccaccagcccctgcccnggctggccctggcccaggccgcgccc
gtgatcccacaggccagctccacggggccgtccgccgtgtgggtttcccttggcatgccg
cctccgtatgccgcgcgccttgcgggggttaagccaagataa
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