Falco cherrug (Saker falcon): 102053979 Help Entry 102053979         CDS       T02911                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism fch  Falco cherrug (Saker falcon) Pathway fch04020   Calcium signaling pathway fch04260   Cardiac muscle contraction fch04261   Adrenergic signaling in cardiomyocytes fch04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:fch00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102053979 (RYR2)    04020 Calcium signaling pathway     102053979 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     102053979 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102053979 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:fch04040]     102053979 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:fch04990]     102053979 (RYR2) Ion channels [BR:fch04040]  Voltage-gated cation channels   Ryanodine receptor    102053979 (RYR2) Domain-containing proteins not elsewhere classified [BR:fch04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102053979 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  102053979 NCBI-ProteinID:  XP_027657311 LinkDB All DBs Position Unknown AA seq 5131 aa AA seqDB search MACAVASPSSAAEPRRRRGRAVGREGAGLLPAVVLLFAAPTPQQLGPFTSVTLGAGQVDD EVVLQCTATVYKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRAL QEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRS SMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGN GSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRR TVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLSLLDDKSLLLTD KEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTYQSAD AKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFNRFIRGLDALSK KAKSSTVDLPIESVNLSLQDLIGYFHPPDEHLEHENKQNRLRALKNRQNLFQEEGMINLV LECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWL ISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLC VCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELM VDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWSGCVA RTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGI KVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPTISLS QAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCL VEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLLSGYKP APMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALL DDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAMRLDVCSGIMEKFRIFRTEKTYAVKA GKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGNEHFGRSWLA GDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGPSQVGRMNFG KDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIEVMRIDGTID SCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGLFGPKNDLEDYD ADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLKQRFMLRRTKPDYS MSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFD LDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCLVDAASGLL TFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNP VSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQFMALHIPEENRT IDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAIENKYMPGLL RAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLR PRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLF VPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSQEDEIDFSEKELSSDELKSEEG EEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQEN QRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQLLDF HEDLMTHCGIELDEDGTLDGNSDLTIRGRLLYLMEKVTYLKKKQAEKPVDDDAKTSSTLQ QLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINSVSVEDTINL LASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVL GGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTP LDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEGERYL DFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIQIAEDPTR DGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRI RSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIE DQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTE HHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPLL NEHAKMPLKLLTNHFERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQ ELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTSNITIPEKLEY FINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEIYRWPIKESL KTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMSNVTLSRDLHA MAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQI NGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQ EIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHR ISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKIALRAFLDNAAEDLEKTMENLKQG QFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILASLY ALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNARDRAVLNLP NSVEDVCPNIPSLMKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNP DKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTH FLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVD YNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLISDTKSK MSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSM KDTEDEVRDIIRSNLHLQGKYRAFYFKKLMTKLAFILTWMKLKSPKSSSSHANSHLEMST THTLRKLPIEKSCTLIECEESSDQKTSPPVIKKSFVDYPFMMIQSNAHTKTVDVTVVKKW KSRKVEEMPASCGFLGCNKLLLSNCLEDPAIRWQMALYKDLPNRTEDSSDPEKTVGRVLD IANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYD KSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKCKVEED FLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAA EMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLM QSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKD MVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDP DGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFN VAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSAN KEENEKDKPEEQDPRMGLFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMK DMIMALFSSYWSILMGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDP TQDEVRGEGEEGERKPAEAALPAEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHN PNAGLSDLLSTPSLSPVPEVQEKIQEQVKEEEKEEKEETKSEPEKAEGEDGEKEEKVKED KGKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSAVTEEKEVPVVSVGESTKMNSLENDNQRVIAVHYVLEESSGYMEPTLRILA ILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVIN TQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSA VLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTI LSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFH MYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ QEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQ ESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15396 nt NT seq  +upstreamnt  +downstreamnt atggcttgcgcggtggcttctcccagcagtgctgcggagccgcgcagacgtcgcggacgg gcagtgggacgtgagggcgcaggcctgttgccggcggtggtgctgctgtttgcagcaccc acaccccagcagctcggccctttcaccagcgtgacgttaggtgcaggtcaagtggatgac gaagtggttctgcagtgcactgcaactgtttacaaggagcaacagaaattgtgtcttgct gcagaaggatttggcaacaggctttgctttttggaatccacatcgaattctaagaatgtt ccacctgatttgtccatctgcacctttgtgctggagcagtctctgtcagtgcgggccctc caggaaatgctggcgaacacagaagaaaaggcagaagggctagttgatgtggaaaaatgg aaatttatgatgaagtctgcgcaaggtggcggtcatcgaacgctactctatgggcatgca atcttgctgcgccattcctacagcggcatgtatctatgctgtctctctacgtctcgatct tcaatggataagctggcatttgatgtaggattgcaagaggacacaacaggtgaggcatgc tggtggaccatccatcctgcttccaagcaacgatcagaaggagaaaaagtgcgtgttgga gatgatcttattttagtcagtgtctcttcagagagatatttgcatctctcttatggcaat ggtagcttgcacgttgatgcagccttccagcaaacgctctggagtgtagcacccatcagt tcgggaagtgaagctgcccaaggatatctgataggaggggatgttctgaggttattgcat ggtcacatggatgaatgtttgacagtcccttctggtgaacacggagaagaacaaagaaga actgtccattatgaaggtggcgctgtgtcaattcatgctcgttccctttggcgactagag actctaagagttgcgtggagtggcagccacattagatggggacagccattcagactaagg catataacaacaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagac aaagagaaagcagatgtaaaatctacggcattctgttttcggtcttccaaggaaaagtta gacatagggacaagaaaagaggtggatggaatgggagcacctgaaataaaatacggggat tcaatatgcttcatacaacacgtagatacaggcttatggctcacataccagtctgctgat gcaaagtctgtaagaatggggtctgtgcagcggaaggcaataatgcaccatgaaggtcac atggatgatggtttaacattgtccaggtctcagaatgaagaatcccgtacagcacgtgtc atccgtagtacagtcttccttttcaacaggtttataaggggccttgatgctctcagcaag aaagcgaagtcttccaccgtcgatttgcctattgagtcagtcaatctgagccttcaggac ttgataggctactttcacccccctgatgaacatttggagcatgaaaacaaacaaaacagg ctccgagcactgaagaatcgacagaacctcttccaggaagagggtatgatcaaccttgtg cttgaatgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagatgtagct gggaaggaagctggagaagcatggaaatctattttgaattctttgtatgaattactagcg gctctgattcgagggaatcgtaaaaactgtgctcaattttctggatctcttgattggctg atcagcagattagaaagactggaagcctcttctggaattctagaggttttacactgtgtg ttggtggaaagcccagaagctctaaacattattaaggaagggcatattaaatcaatcatc tgtcttttggacaaacatggaagaaaccataaggttttagatgttttgtgttctctctgt gtttgtcatggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgcca ggaagagatctgctcttacagacacgccttgtcaaccatgtgagcagcatgcggcccaac atcttcttggggattagtgaaggctctgcccaatacagaaaatggtactatgaacttatg gtggaccatctagagccctttgtgactgcagaatcaactcatctgcgagtgggctgggct tcaacagagggctactcaccatatccagggggaggagcagaatggggaggaaatggtgtt ggtgatgacttgtattcctatggcttcgatggtctgcatctgtggtcaggttgtgtagca cgaacagtaaattctcccaaccaacatctgttaagaactgacgatgttattagctgctgt ttggacctgagtgcccccagcatctctttccggataaatggtcagccagttcaaggaatg tttgaaaatttcaacatagatggcctcttcttcccagttgtcagcttctctgcaggaata aaggtacgttttttgcttggaggtcgccatggagagttcaagttccttcctccccctggg tacgccccttgctttgaagctgtcttgccaaaagagaagctgaaagtggagcacagccga gagtacaagcaggatcgtagctatacaagagacctgctgggtcccacgatctctctgtca caagcagctttcactccagttcctgtagatactagccagattgttttgcctccacacctg gaaaggattagagaaaaactagcagagaacatccatgaactttgggttatgaataagatt gaacttggctggcaatatggaccagttagagatgacaacaaaagacaacacccatgctta gtggagttctcaaaattaccggaacaggaaagaaattataacttgcaaatgtcacttgaa acactgaaaaccctgctggcattaggctgccatgttggaattgctgatgaacatgctgaa gaaaaagtgaaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcct gctcccatggatctgagttttatcaaactgaccccttctcaagaagctatggtggataaa ctagcagaaaatgctcacaatgtgtgggcaagggaccgtataaggcaaggctggacgtat ggtatccagcaggatgtgaaaaatcgaagaaatcctcgccttgtaccttacgctcttttg gatgatcggacaaagaagtcaaacaaagacagtcttcgggaagcagtccgcacccttcta ggctatggttacaacctggaagctcctgatcaagatcatgcgatgagactggacgtgtgc agtgggataatggaaaaattcaggatcttccgtacagagaagacctacgcagtgaaggct gggaagtggtactttgagtttgaggcagttactgcaggagacatgagagtcggttggacc aggccaggttgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgat ggctttaaggcacagcggtggcatcaaggtaatgagcattttggccgctcttggttggca ggagatgttgttggatgtatggttgacatgaatgagcacactatgatgttcaccttaaat ggtgaaatcctgcttgatgactcaggttcagaacttgcgttcaaggactttgaggttggt gatggatttctacctgtgtgcagcctgggcccatctcaagtgggaagaatgaactttgga aaagatgtcagcactctaaaatatttcacgatctgtggcttacaggaagggtatgaaccc tttgctgttaacacaaacagagacatcaccatttggctgagtaaaaggctccctcagttt ctaccagtgccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagac agctgcccctgcctgaaggtcacacagaagtcctttggttcacagaacagtaaaacagac gtcatgttttttcgattaagcatgcccattgagtgtgctgaggtgttctccagatcagct gcaggagggttaccaggctctggtctttttggcccgaagaatgacttggaggattatgat gctgattctgattttgaggttctaatgaagactgctcatggtcatctagttcctgaccgg accgaaagagaaaaagatgccacaaaaccagagttaaacaaccataaagattatgttcaa gaaaagccttcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatagc atgagtcactctgcacggcttactgaggatgtgctagcagatgatagggatgactatgat tatttgatgcaaacttccacgtactattattcagtgagaatatttcctggtcaagaacct gctaatgtctgggtgggctggattacgtctgactttcaccagtatgacacaagctttgac ttggacagagtgcgtactgtcacagttacactaggagatgaaaaagggaaggttcatgag agtataaaacgcagcaactgctatatggtgtgcgcaggagagagcatgagccctggacaa ggacgtaataataatggtctggagattggttgcttggttgatgctgccagtggcctgctg accttcacagctaatggcaaggaattaggcacgtactatcaggttgaaccaagtacaaag ttatttcctgctgtatttgctcaagctacaagccccaatgttttccagtttgaactggga agaataaagaatgtaatgccactgtctgctggcttattcaaaagcgaacacaaaaaccca gtctctcaatgtccgccacgtctccacgtccagtttctgactcatgtgctttggagcaga gtgccaaaccacttcttgaaggttgatgtgtctcggatcagtgaacgtcaaggctggatg atacagtgcctgaatcctttgcagttcatggcccttcatattcctgaagaaaacagaaca attgatattttagagctgacagaacaagaagaattgctgaaatttcactaccatactctc cgattatattcagctgtttgtgctttaggcaataaccgtgtggcccatgctatgtgtagc catgtggatgaatctcagctcctatacgctattgagaataaatatatgccaggattatta cgtgcaggatattatgacttactcattgacatccatctcaatacctatgcaactgccagg ttaatgatgaataatgaatttatagttccaatgacagatgagaccaagagtattactttg tttcctgatgaaaacaaaaaacatggcctccctggtataggacttagcacttcattaagg ccaagaatgcagttctcctctcccagttttgtaagcattagcagtgaatgctttcagttc agtcctgaattccctctggaaatcttaaaggccaaaaccatagagatgctaactgaagct gttcaggagggcagcctccatgtcagagatccagttggaggttctacagaatttctgttt gtccctctcatcaagctcttttataccctcctaattatgggaatcttccacaatggagat ctaaaacacatcttgcagttgattgagccccgggttttcaaagaagcaatgagccaggag gatgaaattgacttctctgagaaggagctgagttcagatgagctcaaatcagaagaagga gaggaagaaaccagaggagagcaagtgccaaaggaaggactccttcagatgaaacttcca gaacctgttaaattacagatgtgtcatctgctccagtacctgtgtgactgccaagtacga caccgaatagaagccattgtagcattttctgatgattttgtggccaagcttcaagagaat caacgcttccggtacaatgaagtgatgcaggctttgaacatgtctgctgccctgacagct agaaaaacaaaagaatttcgatccccacctcaggagcagattaacatgctactgaacttt aaagatgataaaaatgattgtccttgccctgaagaaattagagatcaactcctggatttc catgaagacctaatgacacactgtggaattgaactagatgaagatggaaccttggatgga aacagtgatttaactattaggggtcgcctcctataccttatggagaaagttacatatctg aagaagaagcaagctgagaagccagttgatgatgatgctaagacatcctctactcttcag cagttgatttcagacacaatggtacgctgggcccaggaatcagtgatagaagatccggag ttagtaagggccatgtttgtattgctacatcgccaatatgatggtattggtggcctggtt cgagctctgccaaagacctacaccataaatagcgtgtctgtggaagacacaatcaacctt ctggcatccctcggccaaatccgttccttgcttagtgtcagaatgggcaaggaggaagag aaacttatgattcgtggattaggagacatcatgaataataaagtattttaccaacatcca aatctcatgagagctttaggcatgcatgaaactgtcatggaagtgatggtaaatgtgctt ggtggaggagaatccaaggaaatcacttttccaaagatggtggcaaactgctgtcgtttc ctgtgttatttttgccgcatcagcaggcagaatcaaaaagctatgtttgatcatcttagc tatttattagaaaacagcagtgttggccttgcctctccttctatgcgaggatcaactcct ttagatgttgcagcagcttctgtgatggataacaatgaacttgcattagctttaagggag cctgatctggagaaggtggttcgctacttggctggatgtggattgcagagttgtcctttg ttgatttctaaaggctacccagacattggatggaatccagttgaaggagagcgatatttg gattttcttcgttttgctgttttttgcaatggagagagtgtggaggaaaatgctaatgtt gtagtcagactgcttatccgtcgacctgaatgttttggtcctgctctaagaggagaagga ggcaatgggttacttgctgccatggaggaagcgatacaaatagcagaagatccaacaagg gatgggccttctccaagtaatggatctagtaaaacccttgaaatggaagaacaagaagat gacactattcacatgggaaatgcaatcatgaccttttatgctgccttgattgatctctta ggacgttgtgcccctgaaatgcatctaatccatgctggcaaaggcgaagccattagaatc agatcaattctaaggtctttgattccactggaagatttggtgggagtaattagtattcct ttccacatgccaaccatagctaaagatggtactgtggtggaacctgacatgtctgcgggg ttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgag gaccaggattttcttctacaccttcttgaggttggctttctgccagatcttcgtgctgct gcttctttagatacagctgctttaagtgccacggatatggctttggctctgaatcgatac ctttgcacagcagtcttgcctctgttgaccagatgcgctcctctctttgctggcacagag caccacgcttccctcatcgattccttattacatactgtgtacagactctcaaagggatgc tctcttaccaaagctcagcgggattctattgaagagtgtttgctgtctatctgtgggcag ttgcggccttccatgatgcagcatttgctgagaagattagtatttgatgttcctctttta aatgaacatgcaaagatgcctctcaagttgctgacaaatcattttgaaagatgctggaag tattattgtttgccaggtggttggggtaactttggtgctgcctcagaagaagagcttcat ttatccagaaagttgttctggggtatttttgatgctttatctcaaaagaaatatgaacaa gaactgttcaaactggctttgccttgtttgagcgcagttgcaggggccttacctccagac tacatggaatcaaattatgtcaatatgatggaaaaacaatcttcaatggattcagatggg aattttaatcctcaacctgttgatacatcaaacattacaatccctgaaaagctagaatat ttcattaacaaatatgcagaacactctcacgacaaatggtcaatggaaaagtttgccaat ggatggacatatggtgaaacgtattctgaatctgcaaaagtgcaaccattaatgaaacaa tataagttgctatctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcacta aaaactatgctggcatggggatggcgaattgaaagaacacgggagggagattccatggca ctgtataatcggacacgtcgcatatctcaaaccagtcaaatctctgtagatacagcccac ggttacactccccgagcaattgacatgagcaatgtcaccctctccagagatttacatgct atggctgagatgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggag cttgaagcaaaagtaggaggaggcaaccatcctcttcttgtcccttatgatacactcaca gccaaagaaaaagccaaggacagagaaaaagcacaggatattctgaaatttctacagatt aatggatatgttgtctccagaggacttaaggacctggaattagacacaccttccattgag aaacgctttgcctacagttttcttcagcagcttataagatatgtggatgaagctcatcag tacattctggagtttgatggtggcagcagaggcaaaggagagcacttcccatatgaacaa gaaatcaagttttttgccaaagttgtgctccctttgatcgatcagtattttaaaaatcat cgcctgtatttcttatctgcagcaagtaggcctctcagcagtggaggccatgcctctaat aaagagaaagaaatggtgacaagcctgttctgcaaacttggagttcttgtcaggcatagg atttcactgtttggaaatgatgcaacgtccatagtcaactgtcttcacatactgggccag accttggatgcaaggactgtgatgaaaactggtctggaatctgttaagatagcattgaga gcatttttggacaatgctgctgaggatctggagaaaacaatggaaaatcttaagcaaggc cagtttacacacagcagaaaccagccaaagggagttacccaaatcattaattataccaca gttgctctcctgccagtgctatcttcgttatttgagcatattggacagcaccagtttggg gaagatttgatattggaagatgttcaggtctcctgttacagaatattggccagtttatat gctctaggaaccagcaagagtatctatgtagagcggcaacgatcagcactgggagaatgc ttggctgctttctcgggtgcatttccagtggcttttttggaaactcatttgaacaaacat aatatctactcaatttacaataccaagaatgcgagagacagagcagttctcaatttgcct aatagtgtagaagacgtttgtccaaatattccttctttgatgaagctaatggaagaaatt gtggaactggcagagtctggtattcgttacacacaaatgccacatatcatggaagtgata ctgcctatgctgtgtagttacatgtcacactggtgggagcatgggccagaaaacaacccc gacaaggctgaaatgtgctgcacagccttgacgtcagagcacatgaacactctgttgggt aacatattgaaaatcatctataacaaccttgggattgatgaaggagcctggatgaagaga ttagcagtgttttcccagcccatcataagcaaagcgaagccacagctcttaaagacacac ttcctgccactgatggataaactaaagaaaaaagcagcagtagttgtatcggatgaagaa catctaagagcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgag ttcaccactttggcacgggacctctatgccttctaccctttgttgattagatttgtggac tataacagggcaaaatggctgaaagagcccaatcctgaagcggaagaattgttccgcatg gtggctgaggtcttcatttactggtcaaagtcgcataatttcaaaagggaagagcagaac tttgtagtacaaaatgaaatcaacaacatgtctttccttatcagcgacaccaaatccaag atgtccaaggcagcagtttctgaccaagagaggaagaagatgaagcgaaaaggtgaccgg tactctatgcagacctctctcatcgtggcagcactgaagagattacttcccataggtcta aacatttgtgctcctggagaccaagagctgattgcactggccaaaaatcgattcagtatg aaagatactgaagatgaagtacgagacatcatccgcagtaatcttcatctccagggcaag taccgagccttttatttcaagaaattgatgacgaaacttgcattcattttgacatggatg aagctcaagtcaccaaaatcttcttccagccatgctaattcacaccttgaaatgtcaact actcatacccttagaaaactacctatagaaaaaagctgtaccttgatagaatgtgaggag tcctcagatcaaaagacatctccacctgtgattaaaaagtcttttgtggactatccattc atgatgatccagtcaaatgctcacacaaagactgtggatgtgacagttgttaagaaatgg aaaagccgaaaggtggaagaaatgcctgccagttgtggctttctaggttgtaataaacta ttattgagcaactgtcttgaggatcccgccattagatggcagatggcactttacaaagat ttaccaaacaggaccgaagattcctcagatccagagaagactgtgggaagggtcctcgat atagctaatgtactgtttcacctggaacaggttgagcatcctcagcggtccaaaaaagca gtatggcataagctgctgtctaaacagaggaaaagagcagtagttgcctgcttcagaatg gcaccattgtataatctgccaaggcaccgagccgtcaatctctttcttcaaggctatgat aagtcttggattgaaacagaagaacactattttgaagacaaactgatagaagacttagca aaacctggggaggagccaccagaagaagatgaaagccttaaaagagtcgatcctttacat caacttattctgctattcagtcgaacagccttgactgaaaaatgcaaagtggaagaagat tttctgtatatggcttatgctgacattatggcaaagagctgccatgatgaagaggatgat gatggggaagaagaagtgaagagttttgaagtgacaggatcacaacgcagcaaggaaaaa gaaatggaaaagcaaaaactcctttatcagcaagccagacttcatgaccggggtgctgct gagatggttctacagactatcagtgctagtaaaggtgagatggggccaatggttgcagct accctaaagctagggattgccatcttaaatggaggaaattctacggttcaacagaaaatg cttgactacctcaaagataaaaaggatgtgggattctttcagagccttgctggtcttatg cagtcctgtagtgttcttgacctaaatgcatttgaacgtcagaacaaagcagaaggcctt ggcatggtgactgaagagggatcaggagaaaaagtgatgcaggatgatgagttcacctgt gacctcttccgcttccttcagttgctttgtgaaggacataattcagattttcagaattac ctgagaactcaaactggtaacaacacaactgttaacattatcatttccactgtggattac ttactaagagttcaggaatccattagtgatttctattggtattattctgggaaagatgtt attgatgaacaaggacaacgaaatttttccaaagctatccaggttgcaaaacaagttttc aatactcttacggaatatatccaggggccgtgtactgggaatcagcaaagtctggcacac agcaggctatgggatgctgtagttggttttcttcatgtgtttgcccacatgcagatgaag ctgtctcaggattccagccaaattgaattgctgaaggaattaatggatcttcagaaggat atggttgtcatgttgctgtctatgctggaaggtaatgttgtgaacggaactattggcaag cagatggtcgatatgcttgtggaatcgtccaataatgtcgagatgattctgaagtttttt gatatgttcttaaaattgaaggatttgacttcctctgatgcattcaaagaatatgaccct gatggtaaagggataatttcaaagagggattttcacaaagcaatggaaagccataagcat tacactcagtccgaaacggaatttcttctatcatgtgctgaaacagatgaaaatgagact ctggactatgaggagtttgtgaaacgattccatgaacctgccaaagacattggtttcaat gtcgctgttctcctgaccaacctgtcagaacacatgccccatgatacccgcctgcaaact tttctggaactgtcagagagtgtgctgaattactttcagcctttccttggacgcatagaa atcatgggcagcgcgaagcgcattgaacgggtttattttgaaataagtgagtcgagtcgg actcagtgggagaaacctcaggtaaaagagtcaaagagacaatttatatttgatgttgta aatgaaggcggggagaaagaaaagatggagctttttgttaatttctgcgaggataccatc tttgaaatgcaactggctgcccagatctctgagtcagacctgaatgaaaggtcagcaaat aaagaggagaatgagaaagataagcctgaggaacaggatcctcgaatggggctcttctct ctcgtgaccatgaagtcagcattagtagctctcaagtataatttaatgactcttatgaaa atgctcagcatgaaaagcctaaagaaacagatgaaaaaagtgaagaaaatgaccatgaag gacatgatcatggctttattttcttcctattggagcattttgatgggcttactacatttt gcttgtagtgtcgtccggggcttctttcgcatcatatgcagtttgctacttggaggaagc ctagtagaaggagcaaagaaaatcaaggtggctgaactgttagctaatatgccagatccc actcaagatgaggtgcgtggggaaggagaagaaggggagaggaagccagcagaagctgca ctgcctgcagaagacttgacagatctgagaactttatcagatgagagtgatctactttca gatatatttggcttggatttgaaacgagaagggggacagtataaactgatccctcacaat ccaaatgctggtttgagtgatttactgagcactccctccttatctccagtgcctgaggtg caggaaaaaatccaggagcaggtgaaagaagaggaaaaggaagagaaggaggaaacaaaa tctgaacctgaaaaagccgagggagaagatggagaaaaagaagagaaagtcaaggaggac aaaggaaaacagaaattaagacaacttcatactcacagatatggagaaccagaagttcag gaatcagctttctggaagaaaatcattgcataccaacagaaacttcttaattattttgca cgaaacttttacaatatgaggatgttggcattgtttgttgcttttgccatcaacttcatc ctgcttttctataaggtgtccacatctgctgtgacagaagaaaaggaagttcctgtggta tctgttggggaaagtaccaagatgaacagcctggagaatgacaaccagagggtcattgca gtgcattacgtcctggaagaaagcagtggctacatggagcccacactgcggattttggcc atcttacacacagtcatctcattcttctgcatcatagggtattactgtttgaaagttcca ctggttatttttaagagagaaaaggaagtggcaagaaaattggaatttgatgggctgtat ataactgaacagccatcagaagatgatattaagggacagtgggatagactcgtaatcaac acacagtcttttccaaataactattgggacaaatttgtgaagagaaaggtcatggataaa tatggtgaattctatggccgtgacaggatcagtgagttactaggaatggacaaagctgct cttgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctccttatctgct gtgctaaattccattgatgttaagtatcagatgtggaaactaggagttgttttcactgat aattctttcctttacctagcgtggtacatgaccatgtcagtccttggccattacaacaat tttttctttgctgctcatctccttgacattgcaatgggattcaagacattacgaactatc ctgtcatcagtgacccacaatggcaaacagcttgtcctaacagtgggattactggcagta gtagtatacttgtatacagtagtggcgttcaattttttccgcaagttctacaacaagagt gaagacggtgatatgccagacatgaaatgtgatgatatgctaacatgctacatgtttcac atgtatgttggagtccgtgctggtggaggcattggtgatgaaatagaggatccagcagga gacgaatatgaaatctatcgaattatctttgatatcactttcttcttctttgtgattgtc atcctccttgcaattattcaaggtttaattattgatgcttttggtgagttaagagatcag caagagcaagttaaggaagacatggagacgaagtgctttatctgtggaataggaaacgac tactttgatacagtgccccatggctttgaaacacacacgctacaggagcacaacttggcc aattatttgttttttctgatgtatcttattaacaaagatgaaacagagcatacaggacag gaatcctatgtatggaaaatgtaccaagaacggtgctgggagtttttccctgctggtgat tgcttccgaaaacagtacgaagaccaactcaactaa

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