Falco peregrinus (peregrine falcon): 101913442 Help Entry 101913442         CDS       T02856                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism fpg  Falco peregrinus (peregrine falcon) Pathway fpg04020   Calcium signaling pathway fpg04260   Cardiac muscle contraction fpg04261   Adrenergic signaling in cardiomyocytes fpg04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:fpg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101913442 (RYR2)    04020 Calcium signaling pathway     101913442 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     101913442 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     101913442 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:fpg04040]     101913442 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:fpg04990]     101913442 (RYR2) Ion channels [BR:fpg04040]  Voltage-gated cation channels   Ryanodine receptor    101913442 (RYR2) Domain-containing proteins not elsewhere classified [BR:fpg04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101913442 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  101913442 NCBI-ProteinID:  XP_005239218 LinkDB All DBs Position Un AA seq 4942 aa AA seqDB search MHRDDEVVLQCTATVYKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSL SVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAILLRHSYSGMYLCCL STSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHG EEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLSLLDDKS LLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQHVDTGLWLT YQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFNRFIRGL DALSKKAKSSTVDLPIESVNLSLQDLIGYFHPPDEHLEHENKQNRLRALKNRQNLFQEEG MINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFSG SLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLDV LCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKW YYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLW SGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVS FSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRDLLGP TISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKR QHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLL SGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLV PYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAMRLDVCSGIMEKFRIFRTEKT YAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGNEHFG RSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGPSQVG RMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIEVMRI DGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGLFGPKND LEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLKQRFMLRRT KPDYSMSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQY DTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCLVDA ASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKS EHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQFMALHIP EENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAIENKY MPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIGL STSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVRDPVGGS TEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSQEDEIDFSEKELSSDEL KSEEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVA KLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCPEEIRD QLLDFHEDLMTHCGIELDEDGTLDGNSDLTIRGRLLYLMEKVTYLKKKQAEKPVDDDAKT SSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINSVSVE DTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEV MVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSM RGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVE GERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIQIA EDPTRDGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKG EAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDR VYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPL FAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVF DVPLLNEHAKMPLKLLTNHFERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ KKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTSNITIP EKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEIYRWP IKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMSNVTLS RDLHAMAEMMAENYHNIWAKKKKMELEAKGGGNHPLLVPYDTLTAKEKAKDREKAQDILK FLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHF PYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGVL VRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKIALRAFLDNAAEDLEKTMEN LKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRIL ASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNARDRAV LNLPNSVEDVCPNIPSLMKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHWWEHGP ENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQL LKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLLI RFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLISD TKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKN RFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVGRVLDI ANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYDK SWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKCKVEEDF LYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISA SKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLN AFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNT TVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQG PCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSML EGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKR DFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLS EHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVK ESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEENEKDKP EEQDPRMGLFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDMIMALFSS YWSILMGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEG EEGERKPAEAALPAEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLL STPSLSPVPEVQEKIQEQVKEEEKEEKEETKSEPEKAEGEDGEKEEKVKEDKGKQKLRQL HTHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTS AVTEEKEVPVVSVGESTKMNSLEIDNQRVIAVHYVLEESSGYMEPTLRILAILHTVISFF CIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYW DKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKY QMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGK QLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGG GIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDME TKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQ ERCWEFFPAGDCFRKQYEDQLN NT seq 14829 nt NT seq  +upstreamnt  +downstreamnt atgcacagggatgacgaagtggttctgcagtgcactgcaactgtttacaaggagcaacag aaattgtgtcttgctgcagaaggatttggcaacaggctttgctttttggaatccacatcg aattctaagaatgttccacctgatttgtccatctgcacctttgtgctggagcagtctctg tcagtgcgggccctccaggaaatgctggcgaacacagaagaaaaggcagaagggctagtt gatgtggaaaaatggaaatttatgatgaagtctgcacaaggtggcggtcatcgaacgcta ctctatgggcatgcaatcttgctgcgccattcctacagcggcatgtatctatgctgtctc tctacgtctcgatcttcaatggataagctggcatttgatgtaggattgcaagaggacaca acaggtgaggcatgctggtggaccatccatcctgcttccaagcaacgatcagaaggagaa aaagtgcgtgttggagatgatcttattttagtcagtgtctcttcagagagatatttgcat ctctcttatggcaatggtagcttgcacgttgatgcagccttccagcaaacgctctggagt gtagcacccatcagttcgggaagtgaagctgcccaaggatatctgataggaggggatgtt ctgaggttattgcatggtcacatggatgaatgtttgacagtcccttctggtgaacacgga gaagaacaaagaagaactgtccattatgaaggtggcgctgtgtcaattcatgctcgttcc ctttggcgactagagactctaagagttgcgtggagtggcagccacattagatggggacag ccattcagactaaggcatataacaacaggaaaatatttaagtctcctggatgacaagagt cttcttcttacagacaaagagaaagcagatgtaaaatctacggcattctgttttcggtct tccaaggaaaagttagacatagggacaagaaaagaggtggatggaatgggagcacctgaa ataaaatacggggattcaatatgcttcatacaacacgtagatacaggcttatggctcaca taccagtctgctgatgcaaagtctgtaagaatggggtctgtgcagcggaaggcaataatg caccatgaaggtcacatggatgatggtttaacattgtccaggtctcagaatgaagaatcc cgtacagcacgtgtcatccgtagtacagtcttccttttcaacaggtttataaggggcctt gatgctctcagcaagaaagcgaagtcttccaccgtcgatttgcctattgagtcagtcaat ctgagccttcaggacttgataggctactttcacccccctgatgaacatttggagcatgaa aacaaacaaaacaggctccgagcactgaagaatcgacagaacctcttccaggaagagggt atgatcaaccttgtgcttgaatgtattgatcgcttgaatgtatacagcagtgcagctcat tttgcagatgtagctgggaaggaagctggagaagcatggaaatctattttgaattctttg tatgaattactagcggctctgattcgagggaatcgtaaaaactgtgctcaattttctgga tctcttgattggctgatcagcagattagaaagactggaagcctcttctggaattctagag gttttacactgtgtgttggtggaaagcccagaagctctaaacattattaaggaagggcat attaaatcaatcatctgtcttttggacaaacatggaagaaaccataaggttttagatgtt ttgtgttctctctgtgtttgtcatggagtagctgtgcggtctaatcaacatctaatctgt gataatctcctgccaggaagagatctgctcttacagacacgccttgtcaaccatgtgagc agcatgcggcccaacatcttcttggggattagtgaaggctctgcccaatacagaaaatgg tactatgaacttatggtggaccatctagagccctttgtgactgcagaatcaactcatctg cgagtgggctgggcttcaacagagggctactcaccatatccagggggaggagcagaatgg ggaggaaatggtgttggtgatgacttgtattcctatggcttcgatggtctgcatctgtgg tcaggttgtgtagcacgaacagtaaattctcccaaccaacatctgttaagaactgacgat gttattagctgctgtttggacctgagtgcccccagcatctctttccggataaatggtcag ccagttcaaggaatgtttgaaaatttcaacatagatggcctcttcttcccagttgtcagc ttctctgcaggaataaaggtacgttttttgcttggaggtcgccatggagagttcaagttc cttcctccccctgggtacgccccttgctttgaagctgtcttaccaaaagagaagctgaaa gtggagcacagccgagagtacaagcaggatcgtagctatacaagagacctgctgggtccc acgatctctctgtcacaagcagctttcactccagttcctgtagatactagccagattgtt ttgcctccacacctggaaaggattagagaaaaactagcagagaacatccatgaactttgg gttatgaataagattgaacttggctggcaatatggaccagttagagatgacaacaaaaga caacacccatgcttagtggagttctcaaaattaccggaacaggaaagaaattataacttg caaatgtcacttgaaacactgaaaaccctgctggcattaggctgccatgttggaattgct gatgaacatgctgaagaaaaagtgaaaaaaatgaaacttccaaagaactaccagttgttg agtggatataagcctgctcccatggatctgagttttatcaaactgaccccttctcaagaa gctatggtggataaactagcagaaaatgctcacaatgtgtgggcaagggaccgtataagg caaggctggacgtatggtatccagcaggatgtgaaaaatcgaagaaatcctcgccttgta ccttacgctcttttggatgatcggacaaagaagtcaaacaaagacagtcttcgggaagca gtccgcacccttctaggctatggttacaacctggaagctcctgatcaagatcatgcgatg agactggacgtgtgcagtgggataatggaaaaattcaggatcttccgtacagagaagacc tacgcagtgaaggctgggaagtggtactttgagtttgaggcagttactgcaggagacatg agagtcggttggaccaggccaggttgtctgccagatcaggaacttggctcagatgaagaa gcttttgtttttgatggctttaaggcacagcggtggcatcaaggtaatgagcattttggc cgctcttggttggcaggagatgttgttggatgtatggttgacatgaatgagcacactatg atgttcaccttaaatggtgaaatcctgcttgatgactcaggttcagaacttgcgttcaag gactttgaggttggtgatggatttctacctgtgtgcagcctgggcccatctcaagtggga agaatgaactttggaaaagatgtcagcactctaaaatatttcacgatctgtggcttacag gaagggtatgaaccctttgctgttaacacaaacagagacatcaccatttggctgagtaaa aggctccctcagtttctaccagtgccacaaaatcatgaacatattgaggtgatgagaatt gatggcaccatagacagctgcccctgcctgaaggtcacacagaagtcctttggttcacag aacagtaaaacagacgtcatgttttttcgattaagcatgcccattgagtgtgctgaggtg ttctccagatcagctgcaggagggttaccaggctctggtctttttggcccgaagaatgac ttggaggattatgatgctgattctgattttgaggttctaatgaagactgctcatggtcat ctagttcctgaccggaccgaaagagaaaaagatgccacaaaaccagagttaaacaaccat aaagattatgttcaagaaaagccttcacgtcttaaacaaagatttatgctcaggaggaca aagccagattatagcatgagtcactctgcacggcttactgaggatgtgctagcagatgat agggatgactatgattatttgatgcaaacttccacgtactattattcagtgagaatattt cctggtcaagaacctgctaatgtctgggtgggctggattacgtctgactttcaccagtat gacacaagctttgacttggacagagtgcgtactgtcacagttacactaggagatgaaaaa gggaaggttcatgagagtataaaacgcagcaactgctatatggtgtgcgcaggagagagc atgagccctggacaaggacgtaataataatggtctggagattggttgcttggttgatgct gccagtggcctgctgaccttcacagctaatggcaaggaattaggcacgtactatcaggtt gaaccaagtacaaagttatttcctgctgtatttgctcaagctacaagccccaatgttttc cagtttgaactgggaagaataaagaatgtaatgccactgtctgctggcttattcaaaagc gaacacaaaaacccagtctctcaatgtccgccacgtctccacgtccagtttctgactcat gtgctttggagcagagtgccaaaccacttcttgaaggttgatgtgtctcggatcagtgaa cgtcaaggctggatgatacagtgcctgaatcctttgcagttcatggcccttcatattcct gaagaaaacagaacaattgatattttagagctgacagaacaagaagaattgctgaaattt cactaccatactctccgattatattcagctgtttgtgctttaggcaataaccgtgtggcc catgctatgtgtagccatgtggatgaatctcagctcctatacgctattgagaataaatat atgccaggattattacgtgcaggatattatgacttactcattgacatccatctcaatacc tatgcaactgccaggttaatgatgaataatgaatttatagttccaatgacagatgagacc aagagtattactttgtttcctgatgaaaacaaaaaacatggcctccctggtataggactt agcacttcattaaggccaagaatgcagttctcctctcccagttttgtaagcattagcagt gaatgctttcagttcagtcctgaattccctctggaaatcttaaaggccaaaaccatagag atgctaactgaagctgttcaggagggcagcctccatgtcagagatccagttggaggttct acagaatttctgtttgtccctctcatcaagctcttttataccctcctaattatgggaatc ttccacaacggagatctaaaacacatcttgcagttgattgagccccgggttttcaaagaa gcaatgagccaggaggatgaaattgacttctctgagaaggagctgagttcagatgagctc aaatcagaagaaggagaggaagaaaccagaggagagcaagtgccaaaggaaggactcctt cagatgaaacttccagaacctgttaaattacagatgtgtcatctgctccagtacctgtgt gactgccaagtacgacaccgaatagaagccattgtagcattttctgatgattttgtggcc aagcttcaagagaatcaacgcttccggtacaatgaagtgatgcaggctttgaacatgtct gctgccctgacagctagaaaaacaaaagaatttcgatccccacctcaggagcagattaac atgctactgaactttaaagatgataaaaatgattgtccttgccctgaagaaattagagat caactcctggatttccatgaagacctaatgacacactgtggaattgaactagatgaagat ggaaccttggatggaaacagtgatttaactattaggggtcgcctcctataccttatggag aaagttacatatctgaagaagaagcaagctgagaagccagttgatgatgatgctaagaca tcctctactcttcagcagttgatttcagacacaatggtacgctgggcccaggaatcagtg atagaagatccggagttagtaagggccatgtttgtattgctacatcgccaatatgacggt attggtggcctggttcgagctctgccaaagacctacaccataaatagcgtgtctgtggaa gacacaatcaaccttctggcatccctcggccaaatccgttccttgcttagtgtcagaatg gggaaggaggaagagaaacttatgattcgtggattaggagacatcatgaataataaagta ttttaccaacatccaaatctcatgagagctttaggcatgcatgaaactgtcatggaagtg atggtaaatgtgcttggtggaggagaatccaaggaaatcacttttccaaagatggtggca aactgctgtcgtttcctgtgttatttttgccgcatcagcaggcagaatcaaaaagctatg tttgatcatcttagctatttattagaaaacagcagtgttggccttgcctctccttctatg cgaggatcaactcctttagatgttgcagcagcttctgtgatggataacaatgaacttgca ttagctttaagggagcctgatctggagaaggtggttcgctacttggctggatgtggattg cagagttgtcctttgttgatttctaaaggctacccagacattggatggaatccagttgaa ggagagcgatatttggattttcttcgttttgctgttttttgcaatggagagagtgtggag gaaaatgctaatgttgtagtcagactgcttatccgtcgacctgaatgttttggtcctgct ctaagaggagaaggaggcaatgggttacttgctgccatggaggaagcgatacaaatagca gaagatccaacaagggatgggccttctccaagtaatggatctagtaaaacccttgaaatg gaagaacaagaagatgacactattcacatgggaaatgcaatcatgaccttttatgctgcc ttgattgatctcttaggacgttgtgcccctgaaatgcatctaatccatgctggcaaaggc gaagccattagaatcagatcaattctaaggtctttgattccactggaagatttggtggga gtaattagtattcctttccacatgccaaccatagctaaagatggtactgtggtggaacct gacatgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagg gtctatggaattgaggaccaggattttcttctacaccttcttgaggttggctttctgcca gatcttcgtgctgctgcttctttagatacagctgctttaagtgccacggatatggctttg gctctgaatcgatacctttgcacagcagtcttgcctctgttgaccagatgtgctcctctc tttgctggcacagagcaccacgcttccctcatcgattccttattacatactgtgtacaga ctctcaaagggatgctctcttaccaaagctcagcgggattctattgaagagtgtttgctg tctatctgtgggcagttgcggccttccatgatgcagcatttgctgagaagattagtattt gatgttcctcttttaaatgaacatgcaaagatgcctctcaagttgctgacaaatcatttt gaaagatgctggaagtattattgtttgccaggtggttggggtaactttggtgctgcctca gaagaagagcttcatttatccagaaagttgttctggggtatttttgatgctttatctcaa aagaaatatgaacaagaactgttcaaactggctttgccttgtttgagcgcagttgcaggg gccttacctccagactacatggaatcaaattatgtcaatatgatggaaaaacaatcttca atggattcagatgggaattttaatcctcaacctgttgatacatcaaacattacaatccct gaaaagctagaatatttcattaacaaatatgcagaacactctcacgacaaatggtcaatg gaaaagtttgccaatggatggacatatggtgaaacgtattctgaatctgcaaaagtgcaa ccattaatgaaacaatataagttgctatctgaaaaggagaaagaaatttatcgatggcca atcaaagaatcactaaaaactatgctggcatggggatggcgaattgaaagaacacgggag ggagattccatggcactgtataatcggacacgtcgcatatctcaaaccagtcaaatctct gtagatacagcccacggttacactccccgagcaattgacatgagcaatgtcaccctctcc agagatttacatgctatggctgagatgatggctgaaaactaccataacatatgggcaaag aaaaagaaaatggagcttgaagcaaaaggaggaggcaaccatcctcttcttgtcccttat gatacactcacagccaaagaaaaagccaaggacagagaaaaagcacaggatattctgaaa tttctacagattaatggatatgttgtctccagaggacttaaggacctggaattagacaca ccttccattgagaaacgctttgcctacagttttcttcagcagcttataagatatgtggat gaagctcatcagtacattctggagtttgatggtggcagcagaggcaaaggagagcacttc ccatatgaacaagaaatcaagttttttgccaaagttgtgctccctttgatcgatcagtat tttaaaaatcatcgcctgtatttcttatctgcagcaagtaggcctctcagcagtggaggc catgcctctaataaagagaaagaaatggtgacaagcctgttctgcaaacttggagttctt gtcaggcataggatttcactgtttggaaatgatgcaacgtccatagtcaactgtcttcac atactgggccagaccttggatgcaaggactgtgatgaaaactggtctggaatctgttaag atagcgttgagagcatttttggacaatgctgctgaggatctggagaaaacaatggaaaat cttaagcaaggccagtttacacacagcagaaaccagccaaagggagttacccaaatcatt aattataccacagttgctctcctgccagtgctatcttcgttatttgagcatattggacag caccagtttggggaagatttgatattggaagatgttcaggtctcctgttacagaatattg gccagtttatatgctctaggaaccagcaagagtatctatgtagagcggcaacgatcagca ctgggagaatgcttggctgctttctcgggtgcatttccagtggcttttttggaaactcat ttgaacaaacataatatctactcaatttacaataccaagaatgcgagagacagagcagtt ctcaatttgcctaatagtgtagaagacgtttgtccaaatattccttctttgatgaagcta atggaagaaattgtggaactggcagagtctggtattcgttacacacaaatgccacatatc atggaagtgatactgcctatgctgtgtagttacatgtcacactggtgggagcatgggcca gaaaacaaccccgacaaggctgaaatgtgctgcacagccttgacgtcagagcacatgaac actctgttgggtaacatattgaaaatcatctataacaaccttgggattgatgaaggagcc tggatgaagagattagcagtgttttcccagcccatcataagcaaagcgaagccacagctc ttaaagacacacttcctgccactgatggataaactaaagaaaaaagcagcagtagttgta tcggatgaagaacatctaagagcagaaggcagaggtgacatgtcggaggctgaactgctc atcctagatgagttcaccactttggcacgggacctctatgccttctaccctttgttgatt agatttgtggactataacagggcaaaatggctgaaagagcccaatcctgaagcggaagaa ttgttccgcatggtggctgaggtcttcatttactggtcaaagtcgcataatttcaaaagg gaagagcagaactttgtagtacaaaatgaaatcaacaacatgtctttccttatcagcgac accaaatccaagatgtccaaggcagcagtttctgaccaagagaggaagaagatgaagcga aaaggtgaccggtactctatgcagacctctctcatcgtggcagcactgaagagattactt cccataggtctaaacatttgtgctcctggagaccaagagctgattgcactggccaaaaat cgattcagtatgaaagatactgaagatgaagtacgagacatcatccgcagtaatcttcat ctccagggcaagcttgaggatcccgccattagatggcagatggcactttacaaagattta ccaaacaggaccgaagattcctcagatccagagaagactgtgggaagggtcctcgatata gctaatgtactgtttcacctggaacaggttgagcatcctcagcggtccaaaaaagcagta tggcataagctgctgtctaaacagaggaaaagagcagtagttgcctgcttcagaatggca ccattgtataatctgccaaggcaccgagccgtcaatctctttcttcaaggctatgataag tcttggattgaaacagaagaacactattttgaagacaaactgatagaagacttagcaaaa cctggggaggagccaccagaagaagatgaaagccttaaaagagtcgatcctttacatcaa cttattctgctattcagtcgaacagccttgactgaaaaatgcaaagtggaagaagatttt ctgtatatggcttatgctgacattatggcaaagagctgccatgatgaagaggatgatgat ggggaagaagaagtgaagagttttgaagaaaaagaaatggaaaagcaaaaactcctttat cagcaagccagacttcatgaccggggtgctgctgagatggttctacagactatcagtgct agtaaaggtgagatggggccaatggttgcagctaccctaaagctagggattgccatctta aatggaggaaattctacggttcaacagaaaatgcttgactacctcaaagataaaaaggat gtgggattctttcagagccttgctggtcttatgcagtcctgtagtgttcttgacctaaat gcatttgaacgtcagaacaaagcagaaggccttggcatggtgactgaagagggatcagga gaaaaagtgatgcaggatgatgagttcacctgtgacctcttccgcttccttcagttgctt tgtgaaggacataattcagattttcagaattacctgagaactcaaactggtaacaacaca actgttaacattatcatttccactgtggattacttactaagagttcaggaatccattagt gatttctattggtattattctgggaaagatgttattgatgaacaaggacaacgaaatttt tccaaagctatccaggttgcaaaacaagttttcaatactcttacggaatatatccagggg ccgtgtactgggaatcagcaaagtctggcacacagcaggctatgggatgctgtagttggt tttcttcatgtgtttgcccacatgcagatgaagctgtctcaggattccagccaaattgaa ttgctgaaggaattaatggatcttcagaaggatatggttgtcatgttgctgtctatgctg gaaggtaatgttgtgaatggaactattggcaagcagatggtcgatatgcttgtggaatcg tccaataatgtcgagatgattctgaagttttttgatatgttcttaaaattgaaggatttg acttcctctgatgcattcaaagaatatgaccctgatggtaaagggataatttcaaagagg gattttcacaaagcaatggaaagccataagcattacactcagtccgaaacggaatttctt ctatcatgtgctgaaacagatgaaaatgagactctggactatgaggagtttgtgaaacga ttccatgaacctgccaaagacattggtttcaatgtcgctgttctcctgaccaacctgtca gaacacatgccccatgatacccgcctgcaaacttttctggaactgtcagagagtgtgctg aattactttcagcctttccttggacgcatagaaatcatgggcagcgcgaagcgcattgaa cgggtttattttgaaataagtgagtcgagtcggactcagtgggagaaacctcaggtaaaa gagtcaaagagacaatttatatttgatgttgtaaatgaaggcggggagaaagaaaagatg gagcttttcgttaatttctgcgaggataccatctttgaaatgcaactggctgcccagatc tctgagtcagacctgaatgaaaggtcagcaaataaagaggagaatgagaaagataagcct gaggaacaggatcctcgaatggggctcttctctctcgtgaccatgaagtcagcattagta gctctcaagtataatttaatgactcttatgaaaatgctcagcatgaaaagcctaaagaaa cagatgaaaaaagtgaagaaaatgaccatgaaggacatgatcatggctttattttcttcc tattggagcattttgatgggcttactacattttgcttgtagtgtcgtccggggcttcttt cgcatcatatgcagtttgctacttggaggaagcctagtagaaggagcaaagaaaatcaag gtggctgaactgttagctaatatgccagatcccactcaagatgaggtgcgtggggaagga gaagaaggggagaggaagccagcagaagctgcactgcctgcagaagacttgacagatctg agaactttatcagatgagagtgatctactttcagatatatttggcttggatttgaaacga gaagggggacagtataaactgatccctcacaatccaaatgctggtttgagtgatttactg agcactccctccttatctccagtgcctgaggtgcaggaaaaaatccaggagcaggtgaaa gaagaggaaaaggaagagaaggaggaaacaaaatctgaacctgaaaaagccgagggagaa gatggagaaaaagaagagaaagtcaaggaggacaaaggaaaacagaaattaagacaactt catactcacagatatggagaaccagaagttcaggaatcagctttctggaagaaaatcatt gcataccaacagaaacttcttaattattttgcacgaaacttttacaatatgaggatgttg gcattgtttgttgcttttgccatcaacttcatcctgcttttctataaggtgtccacatct gctgtgacagaagaaaaggaagttcctgtggtatctgttggggaaagtaccaagatgaac agcctggagattgacaaccagagggtcattgcagtgcattacgtcctggaagaaagcagt ggctacatggagcccacactgcggattttggccatcttacacacagtcatctcattcttc tgcatcatagggtattactgtttgaaagttccactggttatttttaagagagaaaaggaa gtggcaagaaaattggaatttgatgggctgtatataactgaacagccatcagaagatgat attaagggacagtgggatagactcgtaatcaacacacagtcttttccaaataactattgg gacaaatttgtgaagagaaaggtcatggataaatatggtgaattctatggccgtgacagg atcagtgagttactaggaatggacaaagctgctcttgattttagtgatgctcgagaaaag aagaaaccaaagaaggatagctccttatctgctgtgctaaattccattgatgttaagtat cagatgtggaaactaggagttgttttcactgataattctttcctttacctagcgtggtac atgaccatgtcagtccttggccattacaacaattttttctttgctgctcatctccttgac attgcaatgggattcaagacattacgaactatcctgtcatcagtgacccacaatggcaaa cagcttgtcctaacagtgggattactggcagtagtagtatacttgtatacagtagtggcg ttcaattttttccgcaagttctacaacaagagtgaagacggtgatatgccagacatgaaa tgtgatgatatgctaacatgctacatgtttcacatgtatgttggagtccgtgctggtgga ggcattggtgatgaaatagaggatccagcaggagacgaatatgaaatctatcgaattatc tttgatatcactttcttcttctttgtgattgtcatcctccttgcaattattcaaggttta attattgatgcttttggtgagttaagagatcagcaagagcaagttaaggaagacatggag acgaagtgctttatctgtggaataggaaacgactactttgatacagtgccccatggcttt gaaacacacacgctacaggagcacaacttggccaattatttgtttttcctgatgtatctt attaacaaagatgaaacagagcatacaggacaggaatcctatgtatggaaaatgtaccaa gaacggtgctgggagtttttccctgctggtgattgcttccgaaaacagtatgaagaccaa ctcaactaa

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