Frieseomelitta varia: 122528765 Help Entry 122528765         CDS       T09482                                  Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism fvi  Frieseomelitta varia Brite KEGG Orthology (KO) [BR:fvi00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:fvi04121]     122528765 Enzymes [BR:fvi01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      122528765 Ubiquitin system [BR:fvi04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     122528765 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N zf-UBR DUF765 CTU2 Motif Other DBs NCBI-GeneID:  122528765 NCBI-ProteinID:  XP_043510178 LinkDB All DBs Position Unknown AA seq 4921 aa AA seqDB search MATKIRGSYTWSAVTKPLLAISQGSFDKNDILELAKSIVIREYDFLSKGELYETFYTSVA VLAADYFCSCISTFSKSQISIVCQACRILLLRLMDKLSQHQEQLGNGTSTVLSTKQLLLP ILALCTGQSLLSSTEEAALIAMIKSSNIPHDIKSQLSPEAEKDTSQSCKDSERIQCDLSG SILEQLTMPLQGSTMPMPVVENSNEAKTMNDSVVSEIHSDIKTTFVTNNINILRNMDVGD TLLDMCLNLPHLSCYTRKYQSYLHKKSFTLPVNASDAHAIRHNLHSVSNDINMVHNVISL PFLEPLTPGKLEKLSLLTMSCLYCSIVYATASSIVGITNAVSPKCSTNTSAGTQTASGIK TAEEEYDTLAITVVEKSLEIFGLVSNVIKNSTRAGGHILQNHLLIGVWLLVAGLQAQLTV SGLSAADKGKEEKGKSPSKARDGTIRVNLTKIQQGFGVLSVALASHTLTLMSALLEDVSI EAIADSSTPPEPAPLDILSTATALQRAFTFLQAVPLNHLLFYLATISYRRACTLKRIQKH PFEGDALSQSDSTTYYEDLLSCSDNSTDEEEDSEPILGLWFEETIAPSDGSPANGTKESN NETNAERTVTTIVPDNREPHGYISLATKIFQFMNQHLIGNRSLYVREYVVNGLVEQQMVI LAAIIRDLDHETARTETGTISVFYGATLGTMYSEFSQALSLYTHNLLVQNTLSESLQNTL LQHLGVNPWSGTESTTPCTWPLQVYPRTLSVLAQVLLLKPRAEKEAACISIWHRLITTIV ENVCNPPSTFEAENEDLNVEHAQLVLILFHSLNFMQKKSVLLVTGSGAVRCSEAVKTPMK DSQLLHLSRLLLLLEYMMKHLYDAPPALLEQVRWNLFSATSLVCDVKDGNKQTARIFTPW TVIEDNYRKIDNQDEFSMKPRFYNLSTTDFNNQDTPKLDGVACNFILGAPDKMKYPLLVD ALIDILNVLNQADMQKRIGADSKDKTPTFVGLCAIRYCFSICWRLLLMLPPSTLYMDKLA LGEEIPAGPMLLYSLIWGPRAACKTFTSWMNDCLIRQGMYAQYARNLLKTVSSTVNSLKY DVTVAKNCITALKPETNFNNKIIPKNALPKLSSLCILAAVIGKLQILFYESLSKSQSETI ESSKSSQSAESGTTNANKMMINILPHVLSLTESILFSYRSNILHEMLESFELDGKYGSRD YCILDDIIAMAGANWATEASLITFLPNSVKSVIDKWKSISVVHIPWNTYTNDVIPAESYI LATVCQHISSLSEYPTFSINPSLKKLLHNLVTFIVEYVTPTTAPENTDVHNQALDILIAL SMDARTDYLQDMTNKALTKLLGDSDSEARQLREHLFVLHRTYNLIIEYTSDVQEPVSITV DEKILKRCIKYWEQLLEKPVGCKALDLFFAPSTNRSLVSILLCVTSSRSSQQFATHVLRF FNVLFKTAEKGSDGSLERLCGSVSNLAHVEPEKLQVWLKQIILGATNISPNTSLTNAQTP TIVTANTLVAVAGTTEDAQKSDEVSNVPNNEQDRWLISLSNDSASNNQSTSITDDQQQQQ QQLQQQHSMHENSRLLRALTNYIVKEKSSVDQGVPVTILRALIPLAYQILSPTVEGNGFS DLMNVMSTLADAGSEKGHTLLFKAGIEWIELCKEQLINKDLQSLDKPLPFVEAGCCILNY VADVVSAICPQSIQSQDRATSPPWEGATPVNDVNDSDWIDDIPHEDEDSAADDSDDDSLC NKLCTFTITLKEFMNQHWYHCHTCNMVNGVGVCTVCARVCHRGHDVTYAKYGNFFCDCGA KNDGFCQALTKRSPQSSEQHQTNTTAVGSGNTAASTSSSAGIANTSYGNTLGTSVENRDL LLTSSLRRRTSSPLYLSDKQERQGRDKQRHTYLAKQLETSKDWIQGYLWKSGLVSSLVDL TRALVPAVDASCRKNSVIGCHTRAQMALKQLHTVDKKFEYTDQLMLPTLGSQEGAFENVR MNYSGDQGQTIRQLLSAHMIRRVAMCCLSSPHGKRQHLAVSHEKGKITVLQLGALLKQPD SSKRKLTLTRLASAPVPFTVLSVTGNQWNEDFLAVCGFKDCHVLTFNTSGTVSDHLVLYP QLETGNFIIKAIWLPGSQTQLALVTADFVKIYDLAKDALCPQYYFLVPTGKIRDCTFMHA EDGVFYLLIISSAGYIYGQAMDEVSSAKYGPFYVTNTLDVYHPEIRDNGQVGGGGVSIYY SHALQLLFFSYACGKSFIAPLKYMETDITTVFQINLTGNKSSNGNKSNNNQPQPLCQWSE VPNHPGLICSILETSNNPVILMIKPDTIMIQEIKAIPAKAKIMDMVVIRHSSSNAEHRTT LILLCEDGSLRIYMAGMEQTGYWMSPAVQPVGIMATIKPARKKKTIKAGKPTGSVTFPID FFEHCQVMNDVEFGGNDLLQIYNVAQIKHRLNTTGMYVVSTKTMGFTVEVTNNDAVLVIT GIRVLLGNQDVQRAPVYIEVFGRSIRTTVSRSRWFDIPLTREESLQADKKLTITFGPSQD PEGVIMVDCIKIYGKTKDAFGWPEEIEDVPTGQSTSAPLTTINSETDSALSAPASLSSVD STTKDNSLDIDRMIAGMLEVLELSFNVPSNDENKLSLKATAIEVASQLLILPTPPPVQVH TTALLAALHPSKQAYHLHKDYVLLSHVLDSLKSMRELEDARDIDAENFYRLVLIVRSISI SRPQNFAKFTEQYTNKPIDETNVPIFEKDRQNVSQPRKSTDENQQHLVVQLMEMLWSLHM AYPKNMALAPVVVPGLTHAEGTIHAIVEIIHSFTTCDVERNIPLAAKLYLQLLLSSDTTI SFTVKQAIIRVLRPRYKRRRVYIPSPPNCSTPGTAVDAEEKPTTSSVSQSHRELPTATST VSTGIDRDTEHLDAEAIGSSVIDPLAVMLATDGNQSSTAPTTSAVSASISRNSAGGSASG AGGTSSSSSSSGPIARGAVNPLETLLGSGSFPQMLDVPPDTDDETMVELAIALSLQDHES GNADLQVLRQGFQQSLSNLQGLENLQNLNGPALQSLQALAAQGLVQVQNTNQGQEGGGHY SDTTASAGGSDDEGSTAATDGSTLRTSPAEQGGSGGSKGSESGGSESGGSAVDSMTGEHN VSGRSSAYGDNGPDSIPPIGGIGVNQAQRSETNSVGVPAAFTVTEQEEGTEQEHVAEQEN DTSCETTAKLHTIRLLLLDKLMRFVPNLTNVPGVLTVPFMQVLLMLTADLDGQEEKDKVC VERLLRILVTELEMDKPDTSNIWQRSNKREVHLVIMRLLSVLMSRSKHTAKTQAENSNFI SQMAAAILNKAGVIDYCSTLLKALLEYWKTTSTEEADTILGGQLLKEHLTTSLPDMSPLF LRQHVKGHAGDIFEPYPQLLTEMVLRLPYQVYKYAESSSTQSAFEQPWYFYLCEYMMSYQ TPLVRRQVRKLLLFICGNKEKYRQLRDLHALISHVQSVQQCCTAGGFDPLQTRPHSINLP YDSLVDLIEHLKCCVEIATSRTGNWQRFCLKQNTVLSYLFTISTLLDEGVSPTVLQLLQC AICSSNKSKETTATTTATTTTTTSSNTNGNDESLANAQVPQSTATMAHQQQPAVGYVNPQ TVGRCYGCATAATEHCLTLLRALATNQVAKEVLCKQGLIQELVEHNLRKGTVQMQEEVRQ LLCLVTRDNAQSTKELCALLTGRITLTLRGRVVTSDLSLAVRHEMALLAALIQKEDTCWE QKLRCVMQLFLMACKESKSPVVMESIILPCLKILQGLVKPEQQPAVSAKKSKDRGAGVES LASIQPAESITIDVNKWLNGDAKHSYSEWIRRVPAAKRMEQQQSSGRPSLKKEEVRALYL MEKYGHRWYNRCLRGVQGVQPLKLADGAWLKEVLFNPSSRLARQVACNMIESLCQGTERK KEVLVLLTCYLEELRTAGESSTEFLTLYQSLIRQPPWKQFLAVRGVMTLLADLLTREIEE LHRLEETTLTSDLAQGYSLKMLTELMATFLEQENIKQQYKSRLVGAVLNGYLSLRRLVVQ RTRLIDDTQKKLLELLEEMTTGTEEETKAFMAICVETVQKYSVEDVRTPVFIFERLCSII YPEENDVGEFYLTLEKDSQQEDFLQGRMLGNPYSSLEPGLGPLMRDVKNKICLDCELIAL LEDDNGMELLVNNKIISLDLPVKEVYKKIWVPEGGECDAMRVVYRMRGLLGDATEEFVES LNANSEQEINNEEVYKMANVLADCGGLQVMVNRLAAIQNVNRARPLLQVLLKLFRLSVKV KKNQEVLSKLGAVTVFLDVLQRCLATESENWQAKIIEQLLEIMETILTHASLSTLEAFSR TSSGPEHIKALLSCAQSTAVRQSNVLPQLARVLAALTYGNREKMSLLCDYFKPVLDFYEF DHEHTPEDEQKLELFCILTQAIERNAIGNTLKDYIISMGIVKDAFEYITVRAPCLKPTLL RTDSDELKDYISKPALKYILRFLTGLATDHEPTQLAVSQFTISIIHRLEQVSSDEHVGSL AENLLEALCTNKRVAELIEKARQHTRSEKKRLAMAMRERQLGALGMQTNDKGQVVASGAI LQQMEDLGDETGLVCVICREGYKFKPNMVLAIYTFSKRCNVEEFETKQRKTVGYSTVTHF NVVHVDCHMSAVRLARGRDEWESAALQNANTKCNGLLPLWGPQVLESAFASCLARHNTYL QEYTSHRDISYPSTVHDLKLLLLRFAQEKSFHEDSGGGGPQSNMHLIPYLIHTALYVINT TLADARADKTLIGYLETQPNSSWLESCYEAEGPFYQCTMSLLLHTPARWKTYRIVHLNRL IVLAHQRYVSPSGPTKTIVDVTVKHYAVYKSALIFFGLVDCIYANFFKKVNVLSDNQWPS VLAEYIRHNDEAMLKASERVLATYRDELLPCTSFEEFCDVAGLLDEVTEPTYISDVLRRL G NT seq 14766 nt NT seq  +upstreamnt  +downstreamnt atggcgaccaagattcgtggtagctatacatggtcagcagtaacgaaaccattattggca atatcacaaggttcatttgataaaaatgatatcttggaattggcgaagagcattgttata cgtgaatatgacttcctctctaagggagaactttatgaaaccttttatacatctgtggca gtgcttgctgcagattatttctgtagttgcatcagtacgttttctaaaagtcaaatatcc atagtttgtcaagcatgtagaatattgcttcttaggctcatggataagttgtctcagcat caagaacagttaggaaatggaacttctactgttttaagtacgaaacagctgttacttccg atacttgccctttgtactggacaatctttactttcatccaccgaagaagcagccttgatt gctatgataaaaagttccaacataccgcatgacattaaatcgcagctatcccccgaagct gagaaagatacctctcaatcgtgtaaagattctgaacgaatacagtgtgatttatctggt agcattttagaacaactaactatgccgttgcaaggttctacgatgccgatgcccgttgtt gaaaattccaacgaggctaaaacaatgaatgacagtgttgtcagtgaaattcactcagac ataaagacaacatttgttacaaataatataaatattctgcgaaatatggatgtgggagac acgctgttagatatgtgtttgaatcttcctcacttgtcgtgttatactcgcaaatatcag tcatatttgcacaaaaaaagtttcactttgcctgtgaatgcctccgacgcacatgctata cgtcataatttacattctgtgtcaaacgacattaatatggttcacaacgtaatatcattg ccttttttagaacctctaactccaggcaagctagaaaaattatcgctactgacaatgtct tgtttgtattgctccatcgtgtacgccactgcatcgagtatcgttggtataacaaatgct gtgtcaccgaaatgcagcacgaatacctctgctggcacgcaaaccgcttcgggtattaaa actgcggaagaagaatatgacactttggcgattaccgttgttgagaaaagccttgaaata ttcggtctagtttcaaacgtaattaaaaacagcacacgagccggaggtcatattcttcaa aatcatttattgatcggagtatggttgttagtggctggtttacaagctcaactcaccgtg agtggtttaagtgcagcggataaggggaaagaagaaaagggcaaatcgcctagtaaagcg cgtgatggaacaattcgcgtcaaccttacgaaaattcaacaaggttttggagtactttca gttgctttagcctctcatacgctcacgttaatgagtgctctgttggaagatgtttccatt gaagcaattgctgattcctcgactccgccagaaccggctccgttggatatactatccacc gctacagcgcttcaaagagcatttacttttctacaagctgtgccacttaatcacttgttg ttttacttagccactatcagttacagaagggcttgtactttgaagagaatacaaaaacat ccgtttgaaggcgacgctttgagtcagtcagactctacgacttactatgaagatctcttg agttgttcagacaattctaccgacgaagaggaggacagcgaacctattttgggcttgtgg ttcgaggaaacaatcgccccgtccgacggatcgccggcgaacggtactaaagaatctaac aatgaaaccaacgccgaacgaactgtgacaactatcgttcctgataatcgtgaacctcat ggatatatatcactggccactaaaatttttcaatttatgaaccaacatttgattggtaat agaagtttgtacgttcgtgaatatgtagtgaatggtttggtcgaacaacagatggtaata ttagcagcaataatcagagatttggaccatgaaactgctaggacagagaccggtactata tcggtgttctacggtgccacactgggcaccatgtattccgaattttctcaagctttgagt ctttacacgcataatctacttgttcaaaacacattgagcgaaagtttgcaaaacaccctt cttcagcatttaggtgtgaatccatggtctggaacggaaagtacaactccatgtacttgg cctcttcaagtatatccacgaacattaagtgtgttggcacaggttctcctattaaagcct cgagcggagaaagaagcggcctgtataagcatatggcatcgtttgatcacgactatagtt gaaaacgtgtgcaatccaccttccacgtttgaggcagaaaacgaagatttgaacgtggag cacgctcaactggttttgattctatttcactctcttaatttcatgcaaaagaaatcggtg ctgcttgtaactggcagcggcgctgtacgttgcagcgaggcagttaaaactccaatgaaa gattctcagttactgcatttatcgcgattattgttgttgctcgaatatatgatgaaacat ctttatgacgccccacctgcgttacttgaacaagttcgatggaatttgttttctgcgacg agtttggtttgtgatgtcaaagatggtaataaacaaacggctcgaatttttacgccatgg acagtaatcgaagacaattatcgtaaaattgataatcaagatgaattttcaatgaaacct cggttttataatctttccaccacagatttcaataatcaggacactcccaaattggacgga gtggcttgcaatttcattctgggtgcgccagataaaatgaagtatccactcttggtcgat gcgttaatagatattttaaatgttctgaatcaagctgatatgcaaaagaggattggcgct gatagcaaagacaaaacgcccactttcgtaggattatgcgcaattcgttattgtttctcc atatgttggcgattattgctaatgttaccaccgtctactctgtatatggataaattggct cttggtgaggaaatccctgctgggccaatgttgttgtattctttgatttggggacccaga gccgcgtgcaaaactttcaccagttggatgaacgactgtttaatcaggcaaggaatgtac gcgcaatatgcaagaaatctgttgaaaacggtatcatcgacggtaaactctctcaaatac gatgtcacagttgcaaaaaactgcattacggcgttgaaaccggaaactaactttaacaat aaaataataccgaaaaacgcgttgcccaaactcagttcgttgtgtattttggctgcagtt atcggaaaattacaaattcttttctacgaaagtctgtcgaagagtcaaagtgaaactatc gagagttcgaagagcagccaaagtgcggaatccggaactacgaatgcaaataaaatgatg atcaatattctaccacacgtcctttcattgacagaatcgattttattctcgtatcgatca aatatattgcacgagatgctcgaatctttcgaattagacggtaaatacggttctagagat tattgtatacttgatgatatcatcgcaatggcaggcgcaaattgggcgaccgaagcgtct ttgatcacgtttctaccgaattcggtaaaatcagtcatagataagtggaagtctatcagc gttgttcacattccatggaatacttacacaaatgacgttataccggcagagagttacatt ctggctaccgtgtgtcagcatatcagttcactttctgaatatccaacgttttctattaat ccgtcattgaaaaaattgttgcacaatttagttacatttatagtggagtacgtcacccct acgacagcaccagaaaatacggatgttcataatcaagcgctggatattcttattgcattg tctatggatgctcgcacagattatcttcaagatatgactaacaaggcattgacaaaactg ctaggtgatagcgatagcgaggcacgtcagctacgagaacatcttttcgtattgcatcgc acctacaatttgataattgaatatacgagcgatgtccaagaacctgtcagtattaccgtt gatgaaaaaatcttgaaacgatgtattaaatattgggaacaactattggaaaaaccagtc ggatgcaaggcgttggatctgttttttgcaccgagcaccaatcgatctctcgtttctata ttgttgtgtgtaacatcttcgcgatcctcgcaacaatttgccacccatgtgttaagattt ttcaacgtgttatttaaaacagctgagaaaggaagcgacgggtcgttggaacgtctttgt ggatccgtatcgaatttggctcacgtagagccggaaaagttgcaagtatggctgaaacaa attattttaggagcaacgaatatctctccaaatacatctttgacaaatgcacaaacccca acgatagtgacagcaaatacactggttgccgttgctggtacaactgaagatgcccagaag tcggacgaggtcagtaatgtgccgaataacgaacaggatcgatggttgatttcgttatca aacgattcagctagcaataatcagtcaacgagtatcaccgacgaccaacaacagcaacaa caacagcttcaacagcaacactcgatgcatgaaaatagtcgactcttgcgagcgcttaca aattacatagttaaagagaaaagcagcgtcgatcaaggtgtacctgttacgattcttcga gcccttataccattagcttatcagattctttctccgacggttgagggcaatggattctcg gatttaatgaatgttatgtcgacgttagccgatgctggttccgagaaagggcatactcta ctgtttaaagccggaatcgaatggatcgaactttgcaaggaacaattgatcaacaaagat ctccaaagtttggataaaccgttgccgttcgttgaagctggctgttgtatactaaactac gtggcagacgtagtaagtgcgatttgtcctcagtcgatacaatcgcaagatcgagcaact agtccaccgtgggaaggtgctactccggtcaacgacgtgaacgatagcgattggatcgat gacattccacacgaagacgaagacagtgctgctgacgattctgacgatgatagcctttgt aacaaattatgcacgttcactatcacgctaaaggaatttatgaatcaacattggtatcat tgtcatacctgcaacatggtaaacggagttggagtttgcacagtgtgtgctcgcgtttgt catcgtggacacgacgtcacgtatgcgaaatatggaaatttcttttgcgactgcggtgcc aagaacgacggtttttgtcaagcattgacgaaacggagccctcaatcgtcggaacaacac caaacaaacacaactgccgttggctccggaaatacagctgcatcgactagcagttcggct ggcattgccaatacaagttatggaaatacgcttggtacgtcggtcgagaatcgagacctt cttctcacgagcagtttacgacgaagaacttcgagccctttgtacttgtctgacaaacaa gagagacaagggcgtgacaaacagaggcatacgtacttggccaaacagctggaaacgtca aaggattggatacaaggttatctttggaagagcggcttggtatcgtcgttggtagatttg actcgtgcattagtaccggcagtagatgcatcgtgtagaaaaaactcggtaattggttgt cacacgcgcgctcagatggcacttaagcagttacacacggtggacaaaaagtttgaatat acagatcaattgatgcttcccactctgggatcgcaggaaggagcatttgaaaatgttcga atgaattactcgggagatcaaggacaaactattagacagttgctgtctgcgcatatgata cgtcgcgttgcaatgtgttgtttatcctcgccccatggtaaaaggcaacatctggcggtt tcgcacgaaaagggaaaaataacggtgttacagttaggcgcattattgaaacaacctgat tcgtcgaagagaaaattaacattaacgaggcttgcttctgcaccggtacccttcaccgta ctgtctgtaactgggaatcaatggaacgaagatttcctagcagtttgtggtttcaaggat tgtcacgtattgactttcaatacatctggtaccgtgtcggatcatttggttctgtatcct caattagaaaccggcaactttattataaaagcaatatggctgcctggatcacaaactcag ctagctctggtcactgcggattttgtaaagatttacgatcttgcgaaggatgccctttgc ccccaatattatttcctagtacctaccgggaagataagagattgtacgtttatgcatgca gaggatggcgtgttttatttgttgataatatcctcggccggttacatatacggccaagca atggacgaggtaagctcggcgaaatacggacctttctatgtaacgaataccctcgacgtg tatcatccagaaataagggataatggtcaagttggtggtggaggcgtgtcgatttattat tcgcatgctttgcaattactcttcttcagttatgcgtgtggcaaaagtttcattgcgcca cttaaatacatggaaactgacataactactgtgtttcaaattaatctcactggtaacaaa agttcgaacggaaataaatcaaacaacaatcagccccaaccattgtgtcaatggagcgaa gtgcccaatcatcctggactgatctgttcaattttggagacgagtaacaatcctgtaata ttgatgatcaagcctgatacgataatgattcaagaaatcaaagctatccctgccaaagct aagataatggatatggttgtcataaggcattcaagttcaaatgccgagcatcgaacgacg ttgattttattatgcgaagatggaagtttgagaatttatatggctgggatggaacaaact ggctattggatgtctcctgctgttcaaccggtaggcataatggcgacgattaaaccggcg cggaaaaagaaaaccatcaaggcggggaaaccaacaggatccgttactttccctatcgat tttttcgaacattgtcaagtgatgaacgacgtggaatttggcggtaacgacttgctacaa atttacaatgttgcccaaattaagcataggctgaacacaactggaatgtacgttgtttct acgaaaacaatgggattcactgttgaagttaccaacaatgacgctgttttggtcataacg gggattcgagtattactcgggaatcaggacgttcaaagagcgccggtttacatcgaggta tttggtagaagtattcgaacaactgtaagtagaagtcgttggttcgacatacctttgact cgagaggaaagtctccaagctgacaagaaattaactatcacgttcggaccgtctcaagat cccgaaggtgtcattatggtggattgcattaaaatatatggtaaaacgaaagatgccttt ggttggcctgaagaaatagaggatgtcccgacaggtcagtcaacgtctgcaccactaacc acgataaacagtgagacagatagtgccctatctgcacctgcttctttatcttctgtcgat agcacaacaaaggacaattcccttgatatcgataggatgatcgcgggtatgttggaagtt ttggaattatctttcaatgtaccctccaacgacgagaacaagctatcgttgaaagcaaca gctatcgaggtagcgtcgcaattactcatattaccgactcctcctcccgtacaagtgcat acaaccgcacttctagctgctttacacccgtccaaacaggcgtatcatcttcataaagat tacgtactattgtcacacgtactggactcgttgaagtcgatgagagaactcgaggatgct cgtgacatagatgcagaaaacttttatagactggtacttatagttcggagtatatccata tcacgaccacaaaattttgccaagtttaccgaacaatatacaaacaaaccaatagacgaa accaacgtaccaatttttgaaaaggatcgacaaaatgttagccagcctcgtaagagtaca gatgaaaatcagcaacatttagtggtacaacttatggaaatgttgtggtctttgcacatg gcttatccgaagaatatggctcttgcaccggtcgtagttccaggattaacccacgccgaa ggaacgattcatgcgattgttgaaataatccactcgtttacgacgtgtgatgtggagaga aatattcccttggctgctaaactatatttacagttattactgtcatctgacacgaccatc agctttaccgttaagcaggcaataattcgtgtgcttcgaccgaggtacaaaagaagaaga gtttatataccaagtccccctaattgtagcacaccgggcacggccgtggacgcggaagag aagccaacaacgtcgtccgtgtctcagtcacatcgagaattgccgacagccacgtcaacg gtgtcgaccgggatcgatcgggatacggaacatttggatgcggaagcgattggctcgtca gtgatcgatcctctggcagtgatgctggcaacggatggcaatcaaagttcaactgctcct acaacgagtgcggtatctgctagtataagcagaaactcagctggtggtagcgctagcggt gctggtggcaccagcagcagcagcagcagcagcggaccgatagcaaggggagcggtaaat cctttggaaacgttgctcgggtcaggaagttttccacagatgttggacgtaccgccggat accgacgacgaaacgatggtagaattagcaatcgcgcttagtttacaagaccacgaaagt ggaaacgccgacttgcaagtactgcgacaaggattccaacaaagtctgtcgaacttgcaa ggattggaaaaccttcaaaacttaaacggaccggcattgcaaagcttgcaagcactggca gcgcaaggtttggtccaagttcaaaatacaaatcagggtcaagaaggtggaggtcattat tcagacacgaccgcttctgctggaggctcggacgacgagggatcaactgctgccacagac ggcagtacgctgcggacgtcgccggcagaacaaggtggtagtggtggtagcaagggtagc gagagcggtgggagcgagagcggaggaagtgctgtagacagcatgacaggggagcataat gtatcgggaaggagctccgcgtacggagacaatggtcccgattctatacctccgattgga ggaattggagtcaaccaagcgcaacgttccgaaactaattccgtgggtgttcccgcggct tttaccgttaccgagcaagaagaaggtacggaacaagaacacgtcgcggaacaggaaaat gacacgagctgcgaaactactgcaaaactgcatacgatacgattattattgctggataaa ctcatgcggttcgtaccaaatttgacgaacgtgcctggtgtcttgactgttccatttatg caggtgctactgatgttaactgccgatttagacgggcaagaagagaaagataaagtttgt gtcgaacgactgcttcgaatattggtgacggaattagaaatggacaaaccggacacgagt aacatatggcagcgtagcaacaagcgagaagttcatttggtcattatgcgattgctgagt gttttaatgtctcgttcgaaacacactgcgaaaacgcaagcggaaaattcaaattttatc tctcaaatggcagctgcgatactcaacaaggctggagtaatcgattattgctcgacgttg ttgaaagcgttgttagaatattggaaaacaacgtcgaccgaagaggccgataccatcctt ggtggccaattgcttaaagaacatctcaccacttctctgccggacatgtcgccgcttttt ttgcgacaacatgtcaagggacacgctggagatatattcgaaccttatccacaattgctg acggaaatggtgttgcgattaccctatcaagtatacaaatacgctgaaagcagttcgaca cagtcagctttcgaacaaccttggtacttttatctctgcgagtatatgatgtcttaccaa acgccactcgttagaagacaagtacgcaaattactgctgtttatttgcggtaataaggaa aagtacagacaactgcgggatttgcatgccctgatctcccatgttcaatcggttcaacaa tgctgtaccgctggcggatttgatcctcttcagacacgcccacactccatcaatttaccg tacgattcgttggtagatttgatcgaacacctgaaatgctgtgtagaaattgctacaagt cgcacaggaaattggcagcgattctgtttaaagcagaacacggtgctctcttatttgttt accatatcgacgttgttggacgaaggcgttagtcccacggtgttgcaactcttacagtgc gccatatgctcgagcaacaaatcgaaagaaacgacggccacgacgacggccacgacgacg acgacgacgagcagcaatacgaatggcaatgacgaatctttggcaaacgcccaagttcca cagtcgacggcgacgatggcgcatcagcaacaacctgccgtcggatacgtgaatccgcaa acggtaggtcgttgttacgggtgtgcgaccgcggctacggaacattgcctgaccttgctg cgggctctcgctaccaatcaggtagccaaagaggttctgtgtaaacaaggattgatacag gagctggtcgagcacaatttacgcaagggtaccgtgcagatgcaggaagaggttcggcaa ttgctgtgcctggttaccagggacaacgcgcagtccaccaaagaactttgcgctctgttg accggtcgaatcacactgacgcttcgcggtcgtgtcgtcacgtcggacttgtcgttggcg gtgcgtcacgaaatggcgctgctggcggccttgatacaaaaggaggacacttgttgggag caaaagctgcgctgcgtgatgcagttgttcttaatggcgtgtaaagaatcgaagagcccc gtggtgatggaaagcatcattttaccgtgtttgaagatactgcaaggtctggtgaaaccg gagcagcagccggcggtctcggcaaagaagagcaaggacaggggcgctggcgtcgagtcg ctggcgagcattcagccagccgagagtatcaccatcgacgtgaacaaatggttgaacggt gacgcgaaacactcgtactccgagtggatccgccgcgtgcccgccgcgaagagaatggag cagcaacagtcgtcgggcaggccttccttgaagaaggaagaggtccgagcgctctacctg atggagaagtacggccacagatggtacaaccggtgtctgagaggtgtgcaaggtgtccag ccgttgaaattggccgacggcgcctggttaaaggaggtgttgttcaacccgagttcgcga ctggcgcgacaagttgcttgcaacatgatagagagtctctgtcaggggacggaacggaag aaggaggtactcgtgttgctcacgtgttatctggaggaattgcgaacagctggcgagagt agtacggaatttctgacgctgtaccaaagtttgatcagacagccgccgtggaaacagttt ctggcggtacgaggcgtcatgacattgctcgcggacctcttaacgagagagatcgaggag ctacatcggctggaggaaacgacgttgaccagcgatctggcgcagggctactcgctgaaa atgctcaccgaactgatggccacgttcctcgaacaggagaacatcaagcaacagtacaaa agccgtttggtgggcgctgtgcttaacggttacctctctctgaggagattggtcgtccaa cggacaaggttgatcgacgacacgcagaagaagctgttggaacttctcgaagagatgacc accgggaccgaggaggagacgaaagctttcatggcaatctgcgtggaaactgtgcaaaag tacagcgtcgaggacgtgcgtacgccggtgtttatttttgagaggctctgttccatcatt tacccggaggagaacgacgtcggagaattttacctgaccctggagaaggactcgcagcaa gaagatttcctccaaggtagaatgctgggaaatccttacagcagcttggagccgggctta gggccgctcatgagagacgtgaagaacaaaatctgcctggattgtgagctgatcgcgctt ctagaggatgacaacgggatggagcttttggttaacaacaagataatcagcctggatttg cctgtaaaggaggtgtacaagaaaatctgggtgccggagggtggggagtgcgatgccatg cgcgtggtgtaccgaatgcgcggtttgctcggagacgcgaccgaggagtttgttgaaagt ttaaacgccaacagcgagcaagagataaacaacgaagaggtctataaaatggcgaacgtt ttggcggactgcggtggtcttcaggtaatggtgaatcggttggcggcgatacaaaacgtg aaccgagctcgaccgttgcttcaagtccttctgaaactgttccggctctcggtcaaagtg aaaaagaatcaagaggttttgagcaagttgggagcggtgacggtgttcctggacgttctg caacgctgcctggcaaccgagtcggagaactggcaggcaaaaattatcgagcaactgttg gagatcatggaaaccatcctgacgcatgcctccttatccaccctcgaagccttttcacgg acgtccagcggccctgagcatataaaagcgcttctctcttgcgcccaatcgaccgccgtc agacaaagcaacgtgttacctcagcttgcgcgcgtactcgccgccctcacgtacggaaat cgtgagaaaatgtctctcctttgcgattactttaaaccggtgttggacttttacgaattc gatcacgagcatacgccggaggacgagcaaaagctcgagctgttctgcattctgacacaa gccatcgagcgaaatgcaattggcaacactctcaaagactacatcataagcatgggtatc gtgaaagatgctttcgagtatataaccgtgcgcgccccttgcctcaaacctacgctcttg cgaaccgacagcgacgaactgaaggactatatatcgaaaccggcgctcaaatacatcttg cgatttttgactggcctagccaccgatcacgaaccaacgcagctggcagtctctcaattt actatcagcatcattcacagattggagcaagtgtcttcggacgagcatgtcggatctttg gcagagaatttgctggaagcgttgtgcacgaacaaacgcgttgccgaactgatcgaaaag gcccgacagcacacgcgtagcgagaagaaacgactggcaatggcgatgcgagaacgacag ttgggcgcgttgggtatgcaaaccaacgacaagggccaagtggtcgctagcggagcgatc cttcaacaaatggaagatttaggagacgaaacgggattggtctgtgtaatctgccgtgag ggatataaattcaagccaaacatggttttggccatttacactttttcgaaacgttgcaac gtcgaagagttcgaaacgaaacaaagaaagacggttgggtacagcaccgttacacacttc aatgttgtccatgttgactgtcacatgtctgcggtgagactggcacgtggcagagatgag tgggaaagtgcagcgttgcaaaatgcaaacacaaagtgcaacggacttttgccactgtgg ggtcctcaagtattggaatctgctttcgctagttgtttagcgagacataatacctatttg caagaatacaccagtcatcgggacatatcttatccatcgaccgttcacgatttaaagttg ctgctgctacgattcgctcaagagaaaagtttccacgaagatagtggaggaggcggtcca caatcaaacatgcacttgatcccttatttaattcacacggcactttacgtaatcaacact acgttggcagacgctcgggcggacaaaacgttgattggatatttggaaacgcaaccaaat tctagctggcttgaaagttgttacgaggcagaaggaccattctaccaatgtaccatgtca cttttgcttcacacgccagctcgctggaaaacgtacaggatcgttcatttgaatagacta attgttcttgctcatcaacgatacgtttcaccatcgggtccgacaaaaactatcgtcgat gttaccgtcaagcattatgccgtatataaaagcgccttaatcttctttggtctagtcgat tgtatttatgctaattttttcaagaaagttaacgtattatccgataaccaatggccatcg gttttggccgaatatatcagacataatgacgaagccatgttaaaagcctcggaacgtgta ttagctacataccgcgatgagctgttaccgtgtacgtctttcgaggaattttgtgatgtt gccggcttactggacgaggtaacggaacctacgtacataagcgatgttttgagaagactt ggttaa

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