Gymnodraco acuticeps: 117545188 Help Entry 117545188         CDS       T09661                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gacu  Gymnodraco acuticeps Pathway gacu04020   Calcium signaling pathway gacu04260   Cardiac muscle contraction gacu04261   Adrenergic signaling in cardiomyocytes gacu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gacu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117545188 (ryr2a)    04020 Calcium signaling pathway     117545188 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117545188 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     117545188 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gacu04040]     117545188 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:gacu04990]     117545188 (ryr2a) Ion channels [BR:gacu04040]  Voltage-gated cation channels   Ryanodine receptor    117545188 (ryr2a) Domain-containing proteins not elsewhere classified [BR:gacu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117545188 (ryr2a) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  117545188 NCBI-ProteinID:  XP_034070774 UniProt:  A0A6P8U205 LinkDB All DBs Position Unknown AA seq 4974 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIYKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEDKADGHVVVEIWTAQGGGHRTLLYGHAVLLRHSY SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECL TVPSGEHGDEQRRTVHYEGGAVSTHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKY LSLIEDKSLLLMDKEKADVKSTAFCLRSSKEKLDPGVKKEVDGMGVPDIKYGDSVCYIQH VDTSLWLTYQTVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRSARVIRSTVFL FNLFIRGLDTLRKKGKGSSLDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNR QNLFQEEGMISLVLECIDRLHVYSSAAHFAEAVGREAGEAWSSILNSLYQLLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNYKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSD GSAQYRKWYYELIVDQALPFVTAEASHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSY GFDGLHLWSGSIARTVSSPNQHLLSAEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSD GLFFPVASFSAGVKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPREKLKLEASQDQTAARD LLGPTITMSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRD DNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKSMKLSQT YELSGGYKPAPLDLSHIKLTSTQEAMVDRLAENAHNVWARDRIRQGWTYGIQQAWDSFQD VKNRRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDPSNMSAE RFRIYRAEKTYCVNAGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQ RWHQGNEHFGRAWQTGDVMGCMVDLNEHTMMFTHNGEVLLDDSGSELAFKDFEVGEGFIP VCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRMPQFVPVPP NHQHIEVTRIDGTGESCPCLKVTQRSFGSQNSYTDITLYRLSMPIECAESFSRSSANDSL FTPKKDLEDFETVSDFEVLMKSSNGHNGPNGPERDEFNNHKDYTQEKPSKLKQRFMLKKN KPEGCPSSARLLEEVMAEDRDEYEFLMHASTHYYSVRIFPGQEPSSVWVGWVTSDFHQHD PGFELHKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTT NGLLTFTANGKDLSTYYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSE RKNPVPQCPPRLHVQFLTPVLWSRVPNHFLKVSASRVNDRHGWLVQCSKPMQFMSLHIPE ENKSVDILELSEQRDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYM PGLLRAGYYDLLIDIHLSSYTTARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLS TSLRPRMHFSSPSFVCGTGPSHCTYGNTGSGDCFQYSPEFPLDILKIKTIEMLTEAVREG SMHVRDPIGGTTEFLFVPLIKLFYTLLIMGVFQSEDLKNILRLIEPAVFSERREGQEDME LEVVKEGEGEDGGRSMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDF VACLQDNQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEYI REQLLDFHEDLMRHCGKELDDETGINAESDFTIRGRLMSLVEKVAYLKKKMANLPEEKKE RKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVS IEDTINLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVM EVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASP SMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCLMLVRNGYPDIGWNP VEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIK ISQDLSRDGPSPTSESSKSLSDMLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIH AGKGEAIRIRAILRSLIPIEDLVGVISIPFSMPNLAKDGHVVEPDMSAGFCPDHKAAMVL FLDRVYGIEDQNFLLHLLEVCFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTK CAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAACGKLRPSMMQHLLR RLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAGGWGSFGAASDEELHLSRKLFWGIFD ALSLKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTTS VTVPEKLDYFITRYAEHNHEKWCIERFSNGWSYAEQICEISKSHPLLKPYKGISDKDKEA YCCSVRESLKTMLSWGWSIDRIREGDPASLHNKSRRISQASQLSFEGAPAFSPRPIDMSN VTLSRDMQAMAELLAENYHNIWARKKKMELEAKGGGNHPLLVPYDTLTAKEKSKDREKAQ DILKFLQINGYTASRGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMDFDVGTRPK GEKIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIRPISSGGHASNKEKEMVTSLFCK LGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRLFFESAAEDLEK TQENLKLGQFTHSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQVSC YRILYSLYLLGTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPHTNKFNSFSIFNSKGAK DRAALGLPGQVGEVCPLIPNLEKCLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSNWW EHGPENNPDKADSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKA KAQLLKTHFLPLMEKLKKKAAVVLMDEEQSKAEGRGEMSETELLILDQFTVLIRDLYAFY PLLIRFVDYNRARWLKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSF LITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELIA LAKNRFTQKDTEDEVREIIKNNLHLQGKLEDPAIRWQMALYRDLPNHYEDTSDPQKTVER VLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQ GYEKSWIEAEEHYFEDKLIEDLAKPGEQELSEEEEGQKHIDPLHQLIQLFSRTALTEKCK LDEDNLYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQ TISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSV LDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQN YLRTQIGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQV FNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQK DMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYD PDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGF NVAVLLTNLSEHMPHDTRLQTFLELADSVLNYFQPYLGRIEIMGSAKRIERVYFEISESS RTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVK EESEREKPDEENSEMGFFSVSTVRMALFALRYNVMLLIKVLSMKSLKKQIKKIKSMTVKD MVTTLVSFYLSVMLGFLHIAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLADMPDPT QDEVRGEGEDREKRASPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNASL TELLNTPVPPPAPPTPTTKPPELRRRNQSKSSSSEEKETTAETECEPEKTPEGGHVEKQE KQQKNEKMKPKVRRHHTSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVA FAINFILLFYKVSTSSSVVEEREVVYTSSQSDSRIQWDPLGGEAMETKQEVMDEGGEPLK PVTVRFVLEESTGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMD KAALDFSDSHKKRKPRRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14925 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggaggagaaggcgaggacgaaatccagttcttgcgaactgatgatgaggtg gtcctacagtgctcagccacaatctacaaggagcaacagaagctgtgtctggctgctgaa ggcttcggaaacagactctgcttccttgaatccatctccaactccaagaatgtgcctcca gatctgtccatctgcacttttgtgttggagcagtcgctgtcggtacgagcccttcaggag atgctggccaacaccgaggacaaggctgacgggcatgtagtggtggaaatatggacggcc caaggcggcggccatcgcaccctactgtacggacacgctgtcctgctgagacactcctac agtgggatgtacctgtgctgtctgtccacctcgcgctcatccaccgataaactggctttt gacgttggactgcaggaagatacaacaggcgaggcatgctggtggaccatccatccagca tcaaagcagcggtcagagggggagaaggtcagagtgggggatgatctcatcctggtcagc gtgtcctctgaaagatatctgcatctgtcctacggtaacggcagcctccatgtagacgca gcgttccagcagacattatggagtgtggctcccatctgttctggcagtgaagtagcacaa ggttttttgataggaggggacgtcctgcgcctccttcacggtcacatggacgagtgtcta actgttccgtctggggaacatggggacgagcagaggaggacagtgcactatgagggggga gcagtgtccactcatgccaggtccctgtggaggctggagacactgcgggtggtgtggagt gggagtcacatccgctggggtcagccgttcagactgagacacgtgaccacagggaagtat ctgagtctgatagaagacaaatccctgctgctgatggacaaagagaaagctgatgtcaag tctacagccttctgtttaaggtcctctaaggaaaagctggatccaggagtgaagaaggag gtggatgggatgggtgttcctgacattaaatatggtgactctgtgtgttacatccaacat gttgacaccagcctgtggcttacataccagactgttgatgccaagtgtgcacgcatgggg ggtgtacagagaaaggccatcatgcaccatgagggtcacatggacgacgggctgacgctg tctcggtctcaacacgaggagagtcgctctgccagagtcatccgcagcactgtgttcctg ttcaacctcttcatcaggggtctggacacattaaggaaaaaggggaagggctccagtctc gatcttccaatagactcggtcagtctgagtctgcaggatctgattggctatttccaaccg cctggagatcatctggaacatgaagacaagcagaaccgcctgagagctctgaagaaccgg cagaacctctttcaggaagagggcatgatcagcctggtgctggagtgcatcgaccgtctc cacgtgtacagcagtgcagctcattttgctgaggcagtaggaagagaggctggagaggcc tggagctccatcctcaactccctctaccagctactggctgcactgatccgagggaacagg aagaactgtgctcagttctctggctctttggactggctcatcagcagactggagagactg gaggcctcttctggtatactagaggtgcttcactgtgtgctggtggagagtcctgaggca ctgaacataatcaaagagggacacatcaaatccattatatctctgctggacaagcatggg cgtaactacaaggttctggatgtgttgtgttctctgtgtgtgtgtcacggtgtggcagtg cgctccaaccagcacctgatctgtgacaacctgctgccagggagagacctgctgctgcag acacgcctgatcaaccacgtaagcagcatgcgtcccaacatcttcctgggtgtcagtgac ggctccgctcagtacaggaagtggtactacgagctgatcgtggatcaggcgctgccgttt gtcacagcggaggcttctcacctcagagtgggctgggccaacaccagcggctacgctccc taccccagtgggggcgaggggtgggggggcaacggggtgggcgatgacctttactcctat ggctttgatggtctccatctctggtcaggcagcattgcacggactgtcagctcacccaat cagcacctcctgagtgccgaggacgtggtgagctgctgcctggacctcagtgtgcccagc atctccttcaggatcaacggccagccggttcaaggcatgttcgagaacttcaactctgac ggcctcttcttccctgtggccagcttctctgcaggagtcaaggtgcgtttcctcctgggg ggtcgtcatggggagtttaagttcctccctcctccgggttatgccccctgctttgaggca gtgctgcccagggagaagctcaagctggaggccagtcaggaccagactgcagccagagac ctgctgggtcccaccatcaccatgagccaggcagcgttcacccccacccctgtggacacc agccagattgtgctgccccctcacttggagcggatcagagagaagcttgcagagaacatc catgaactgtgggtgatgaacaagatagagctgggctggacgtacggtgcagtacgagac gataacaagcggcaacacccctgtctggttgagttctcaaagcttcctgaacaagaacgc agctacaacttacagatgtctctggagactctcaaaactctcctggccttgggttgccat gttggccttgcagatgaacacgctgtagagaaagtcaagagcatgaagctgtcacaaacc tatgagttgtccggcgggtataaacctgctcctctggacctgagccacatcaaactgacc tccacccaggaggccatggtggacagactggctgagaacgcacacaacgtctgggcacgg gatcgcatccgccagggctggacctatggcattcaacaggcttgggactctttccaggat gtgaagaaccgtagaaacccccgcctggtgccctacgttctgctggatgagaggaccaag aagtccaacaaagacagtctgagagaggccgtcaggactctgctgggatatggatacaac ctggaagctccagaccaggaccacgcggctcagtctgaccccagcaacatgtctgctgag aggttccgcatttacagagcagaaaaaacctactgtgtcaatgctgggaagtggtacttt gagctggaggtattaacagcaggagagatgagggtgggctgggccaggccagggtgcctc ccggaccaggagctggggtctgatgaccaggcctttgtatttgatggctttaaggtccag cgctggcaccagggtaacgagcactttgggcgcgcctggcagacaggggatgtgatgggc tgcatggtggatctgaacgaacacaccatgatgttcacacacaatggagaagtgctactg gatgactccggatcagagctggccttcaaggactttgaagttggtgaaggttttatccca gtgtgcagtctgggtgtatgtcaggtgggacgaatgaacttcggtaaagacgtcagcact ctgaagtacttcaccatctgcggcctgcaggaaggctacgagccgtttgctgtcaacatg aaccgggacgtcaccatgtggctcagcaagaggatgcctcagtttgtacctgtgcccccc aaccaccaacacatagaggtgacgaggatagatgggacaggggagtcgtgtccttgccta aaggtcacccagaggtcatttggctcacagaacagttacactgacatcaccttgtacaga ttgagcatgcccatagagtgtgcagaatccttttctagatcctcagctaacgacagcctc ttcacaccaaagaaggatctggaagactttgaaactgtgtcagactttgaggtcctgatg aagtcttctaacggtcacaatggacccaatggacctgagagagacgaattcaacaaccac aaagattatacccaggagaagccctccaagctcaagcaacggttcatgttgaagaagaac aagccagagggctgtccatcatctgcccgtctgttagaggaggtgatggctgaggacagg gacgaatatgaattcctaatgcacgcctctactcactactactcggtgcggatcttccct ggccaggagcccagcagtgtgtgggtgggctgggtcacctctgactttcaccagcacgac ccgggctttgagctgcacaaagtccggactgtcactgttaccctaggagatgaaaagggc aaagttcatgagagtataaagcgcagtaactgttacatggtgtgggctggagagagcagc agtcctggtcaggggaggaacaacaacggcttagagatcggctgtctggtagacacaaca aacggactgctgacatttacagccaacggcaaagacctcagcacatactaccaggtggag cccagcactaagctgttcccagcagtctttgccaaggccaccagccccaatgtcttccag tttgaactgggccgtattaagaatgtgatgcctctgtcagctggtctgtttaagagtgag aggaagaacccagttcctcagtgtcctccacgactgcatgtccagtttctcactcctgtg ttatggagtcgagttcccaaccacttcctcaaggtgtcagcatccagagtgaatgacaga cacggctggctggtccagtgtagcaaacctatgcagttcatgtccctgcatatacctgaa gagaacaagtcggtggatatcctggagctgtccgagcagagggatctattaaagtttcac taccataccctcagactgtactcggccatctgtgctctgggaaacaacagggtggcacac gccctctgctcccacgtagatgaggcacagctcctgcaggctatagagaataagtacatg ccaggtttgctccgtgcgggttactatgacctgctcatcgacatccacctgagcagctac accacggcgcgcctcatgatgaacaatgagtacatcgttccaatgacagacgaaaccaag agcatcaccctgtttccagacgagaagaagaagcacggcctgccaggcatcggcctcagc acctccctgagacccagaatgcacttctcctccccaagctttgtgtgtgggaccggacca tcacattgtacctacggaaacaccggatcaggagactgtttccagtatagccctgaattc cctttagacatattgaaaattaaaacgattgagatgctaacagaggccgtgcgggaagga agcatgcacgtacgggatccaatcggaggcaccactgagttcctctttgtcccgctcatc aagctcttctacaccctgctcatcatgggggtttttcaaagtgaagatctgaagaacatc ctcagactgattgaaccagctgtgttctctgaaagacgggaagggcaggaggacatggag ctggaggtggtgaaggagggggaaggagaggatggagggaggagcatgccaaaagaagga ctgctacagatgaagctaccagagcctgtaaaactccagatgtgccatgtgctgcagtac ctgtgtgactgccaggtgcgtcatcgtatcgaggcggtggtggctttctctgatgacttt gtggcctgtctccaagacaaccagaggttccgctacaatgaggtgatgctggcactcaac atgtctgcagccctcactgccaagaagaccaaagagttcagatctcctcctcaggaacag atcaacatgcttctgaacttcaaggatgagaagcaggagtgtccctgtcctgaatacatc agagaacagctgctggactttcatgaagacctgatgagacactgtggtaaagaattggat gacgagacagggataaatgctgaaagtgacttcaccatccggggtcggctcatgtcgttg gtggagaaagtggcctacctgaagaagaagatggccaacctgccagaggagaaaaaagaa aggaaacccagtacactacagcagctgatctcagacaccatggtccgctgggctcaggag tcggtgatcgaggatccagagctggtcagagccatgtttgtcctgctgcaccggcagtat gatggtatcggaggacaggtgcgggcgctccctaagacctacaccataaactcagtgtcc atcgaggacaccatcaacctgttggcagctctggggcagatcagatctctgctgagtgtc cgtatgggcagagaggaggagaaactgatgatcagagggctgggtgacatcatgaacaac aaggtgttctaccagcaccctaacctgatgagagctctggggatgcacgagaccgtcatg gaggtcatggtcaacgtgctcagcggaggagactccaaggaaatcacctttcctaaaatg gtggccaactgttgtcgtttcctctgttacttctgtcgcatcagccggcagaaccagaag gccatgtttgatcacctcagctacctgctggagaacagcagcgtaggcctcgcctctcct tctatgcgagggtctactcctctggatgtggctgcagcatcagtcatggataataatgaa ctggccctggctttgagagagccagacctggagaaggtggtgcagtacctggccggctgt gggctgcagagctgcttgatgctggtgcgtaacggataccctgacatcggctggaaccct gtggagggggaacgctacctagacttcctccgcttcgctgtcttctgtaacggtgaaagt gtggaggagaatgccaacgttgtggtgaggcttctgattcgccgaccagaatgttttggt cccgcccttcgaggagaaggaggtgatgggttgttggcagcgatggaggaagccatcaag atatctcaggatctctccagagacggtccctctcctacatctgagagcagcaagtcactc agtgacatgctggaggaagaggaagatgatacaatccacatggggaatgccatcatgacc ttctatgctgctctcattgacctgctgggccgctgtgctccagagatgcatttaatccat gctggtaaaggtgaagcaatccgtatcagagccatcctgaggtctctgattcccatcgag gacctggtgggggtcatcagtattccattttcgatgcccaacctggctaaagatgggcat gtggtggagccagacatgtcggctggtttctgtccggaccataaagcagccatggtcctg ttcctggacagagtctacggtatagaggatcaaaacttcctgctgcacctgctggaggtc tgcttcttaccagacctgagagctgctgcctctctggacactgttgctctcagtgccaca gacatggccttggccctcaacaggtatctgtgcacagccgtgttgcccctcctcactaaa tgtgctcctctgtttgcgggaacggagccgttcgcctcgctcatcgactccctcctccac accgtctaccgcctgtccaaaggctgctgcctcaccaaggcccagagggacgccattgag gagtgtctgctggctgcctgcggaaagctgaggccttcgatgatgcagcatctgctgagg aggctggtgtttgacgttcctctgctcaatgaacacaccaagatgcctctgaagctgttg accaatcactacgagcgttgttggaagtattactgcctggcggggggctggggcagcttc ggagcggcatcagatgaagagcttcacctctccaggaaactcttctggggaatttttgat gctctgtctctcaagcggtatgaccaggagctgtttaagctggcgctgccgtgtctcagt gcggtggctggagctctcccccccgactacatggagtctaactacatggccatgatggag aaacagtcgtccatggactcagagggaaacttcaccccacagcctgctgacaccaccagt gtgactgtcccagagaaacttgactattttataaccagatatgcagagcacaaccatgag aagtggtgtatagaaaggttttccaatggctggtcatatgcggaacagatatgtgaaatc tccaagagccaccctttactgaaaccttacaaaggcatttctgataaggataaagaggcg tactgctgttcagtcagagagtctctgaagaccatgctgtcgtggggctggagcatcgac aggatcagagaaggagaccctgccagcctgcacaataagtccaggaggatatcacaggcc agccagctgtcttttgaaggagctccagctttcagccccaggcccatcgatatgagcaat gtgacactgtccagagacatgcaggctatggcagagctgcttgcagagaattatcataat atctgggccaggaaaaagaaaatggagctggaagccaaaggtggaggaaaccatcctctg ctggttccctatgacacactgactgccaaagagaaatccaaagatagagaaaaagcacaa gacatcctcaagttcctgcagatcaatggatacactgcttccagaggggtgaagtcacag gagcttgacactccagcgatagagaagcggttcgcctacaccttcctccagcagctcatc acatacgtagaccaggcacaccaacacatgatggacttcgatgtgggaacaagaccaaag ggagagaagattcctcatgaacaacagataaagttctttggaaaggtcgtcttgccattg gtggatcagtactttaaaaaccacaggctgtacttcctctccacagccatccgtccaatc agcagcggaggccacgcctccaacaaggagaaggagatggtgaccagtcttttctgcaaa ctaggagttcttgtcagacataggatatccttatttggaaacaatgccacctccatagtc aactgcctgcagatactgggacaaagcctggacgccaggacagtgatgaagactggtctt gagtcagtgaaggcagcgctgcggttgttctttgaaagtgcagcagaggatctggagaag actcaggagaacctgaagctgggccagttcacccacagcagggagcagccgcggggggtc actcagatcatcaactacaccaccttcgccctgctgcccgtcctctcctccctgtttgaa cacatcggacagaacatgttcggagaagacctcatattggatgatgtccaggtttcctgc tacagaatcctctacagcctctaccttttaggaaccaacaaaagcatctatgtggagaga cagcgcccagctttggggaagtgtttagctgccttctcagcagcctttcctgtggcattc ctcgagcctcacaccaacaagttcaacagtttctccatcttcaacagcaaaggagctaaa gacagagcagctctaggtcttcccgggcaggtgggggaggtttgtcctctgatcccaaac ttagagaagtgtctggaggagatcatggagttggcagagtctggcatgagatacactcag atgccccatgtcatggaggtggtgttgccgatgttgtgcagctacatgtctaactggtgg gaacatggaccagagaacaacccagacaaagccgacagctgctgcacctctgtgacctct gaacacatgaacactctgctgggaaacattctgaagatcatctacaacaacctgggaata gatgagggggcctggatgaaaagactagctgtcttctctcagccaatcatcagcaaggcc aaagcccagctgctcaagacccacttcctgcctctgatggagaaactcaaaaaaaaagca gcggtggtgctgatggatgaggaacagagcaaggcggaggggaggggggagatgtcagag acagagctcctcatcctggaccagttcaccgtactgatcagagacctgtatgccttttac cctctcctcatacgatttgttgactacaacagggctcggtggctgaaagagtccaaccca gaggctgaggagctgttccgcatggtggcagaggttttcatcttctgggccaagtctcat aacttcaagagagaagagcagaactttgtggtccagaatgaaatcaacaacatgtcgttc ctcatcactgacaccaagtgtaagatgtcaaagggaatagtttcagaccaggagaggaag aagatgaagaggaagggagatcggtactcgatgcagaccagtctcatcgtggccactctg aagcgcctgctgcctgtgggtctgaacatctgcgcgcccggagaacaagagctgatcgct ctggctaagaaccgcttcacacagaaagatacagaggatgaagttcgagagatcatcaag aacaatctgcatttacaaggaaagctggaggacccagctatccgctggcagatggctctg tacagagacctccccaaccactacgaggacacctcagaccctcagaagactgtggagagg gtcctggacatcgctcatgtcctcttccacctagaccaggtggaacatcctcagcgcagt aagaaggccgtgtggcataaactgctgtccaaacagaggaagagagctgtggtggcttgc ttcaggatggcaccactctataacctgcccaggcaccgggctgtcaacctgttcctgcag ggctatgagaagtcctggatcgaggcagaggaacactactttgaagataaactcatagag gacctcgctaaaccaggggagcaggagctatctgaggaagaggaggggcagaaacacatc gatcctctgcatcagctcatccagctgttcagcaggacggccctcacagagaagtgtaaa ctggatgaggataatctctacatggcctatgctgacatcatggcaaagagttgccatgat gaagaagatgaggatggagaggaggtgaagagttttgaagagaaagagatggagaagcag aagctgctgtatcagcaggcgcggctacatgacagaggagccgctgagatggtgctccag accatcagcgccagcaagggtgagatggggcccatggtggcctccactctgaagctgggc atagctattctcaacggaggaaactctactgtacagcagaaaatgttggattacctgaaa gacaaaaaggatgttggtttctttcagagtctggctggtttgatgcagtcatgcagtgtt ctggatctaaatgcatttgagaggcagaacaaagcagaaggactggggatggtgacagag gagggatcagtcatcactcatgagcgtggtgagaaggtcatgcaggatgatgagttcacc tgtgaccttttccgcttcctgcagctgctctgtgaagggcacaactcagacttccagaac tacttgaggacgcaaatagggaacaacacgactgtcaacatcatcatctctactgtggac tacctcctcagagtacaggaatccatcagtgatttctactggtattattctgggaaggat gttattgatgagcagggccagagaaacttctccaaggcaataaatgtggccaagcaggtt ttcaacacgctcactgagtacatccagggtccgtgtacgggcaaccagcagagtttggct catagtcgcctgtgggacgctgtggtcgggtttctgcacgtcttcgctcatatgcagatg aaattgtctcaggactcaagtcagattgagttactgaaagaactgatggatcttcagaaa gatatggtggtcatgctgctgtccatgctggagggtaacgtggtgaatgggaccattggg aagcagatggtggacatgttggtggagtcctccaacaatgtggagatgatcctcaagttt tttgacatgttcctcaagctgaaagacctgacctcctcagacgccttcaaggagtacgac cctgacggaaaaggtgtcatctccaagagggacttccataaggccatggagagccacaaa cactacacccagtcagagacagagttcctcctctcctgtgctgagaccgatgagaatgaa ttgctggactatgaagaatttgtggagcgctttcatgagccagccaaggacatcggcttc aatgtggcagtgctgctgaccaacctgtcggagcacatgcctcatgacacgcggctgcag accttcctggagctggcggacagcgtgctgaactacttccagccctacctgggccgcatc gagatcatgggcagcgccaagcgcattgagagggtctacttcgagatcagcgagtccagt cgcacacagtgggagaaacctcaggtcaaagaatctaagcggcagttcatctttgatgtg gtcaacgaaggaggggagaaggagaagatggagctgtttgtaaatttctgcgaggacacc atctttgaaatgcagctggcggctcagatgtctgacgctggcgagcgctcagcagtgaaa gaggagagtgagcgggagaagccggacgaggagaactctgagatgggcttcttctccgtc agcactgtgcgcatggctctgttcgctctgcgctacaatgtcatgctgctgataaaggtc ctctctatgaagagtttgaagaagcagataaagaagataaagagcatgacagtgaaggac atggtgaccacgctggtctctttctacctgtccgtgatgctgggcttcctccacatagcg ttcagtgtggcccgaggattttgccgaatattttacaacaccttcatgggaggcaatctg gtggagggggccaaaaccataaaggtgtcagagctgctggccgacatgcctgaccccacc caggacgaggtgaggggtgagggggaggacagagagaagagggcctcccctaaagaggac ctggctgacctggcagtgaacaccagtgagacggagctgctttcagacatcttcggcctg gacctgagaagagagggcggccagtacaagatcacccctcataaccccaacgccagcctg acggagctgctcaacaccccggttccccccccggcacccccaaccccaaccaccaaaccc ccagagctcagacggaggaatcagtcgaagagctcttcctcagaggagaaggaaacaaca gcagagacagaatgtgaacctgagaaaacaccagagggtggacatgtagagaaacaagag aaacaacagaagaatgagaagatgaagccaaaagtgagaaggcatcacacctcgaagtct gatgaaccggacctgcaggagtcagctttcctaaagaagatcatcgcctaccagaggaaa cttctgaactactttgccaggaacttctacaacatgaggatgctggcgctgtttgttgcc tttgcaatcaatttcatcctcctcttctataaggtttctacatcctcctctgtggttgag gaaagggaagtggtgtacactagcagccaatctgacagcagaattcagtgggatccactg ggaggagaagcaatggagacgaagcaggaggtgatggatgaggggggggagcccctgaag cccgtcacagtgcgctttgtcttagaggagagcaccgggtacatggagcccatgttacgc atcctggctgtgctccacactgtcatctccttcttctgcatcatcggatactactgtctc aaggtgccattggtgatctttaagcgtgaaaaggaagtggccaggaagctggaatttgat gggctttatatcacagagcaaccctctgaggacgacatcaaaggccagtgggaccgactg gtgatcaacacacaatctttccccaacaactactgggataagtttgtgaagaggaaggtg atggataaatatggagagttctacggccacgaccgcatcagtgagctgctggggatggac aaggctgctctggacttcagcgactcacacaagaagagaaagccccgcagagacagctcc ctggctgctgtgctgaactccattgatgtcaagtaccagatctggaagctgggggttgta ttcacagacaattccttcctgtatctggcctggtatatgaccatgtccatcctgggtcac tataacaacttcttcttcgctgcccatctgctcgacatcgccatgggcttcaagacgcta cgcaccatcctgtcttcagttacacataatggaaaacagctggtgttaacagtggggctg ttggcagtggtggtgtacctctacacagtagtggccttcaacttcttccggaagttctac aacaagagtgaagatggagaactgccagacatgaagtgtgacgacatgttgacatgctac atgttccacatgtatgtaggcgtgagagcagggggtggcatcggagaccagattgaggac ccagcaggagacgagtatgagatctatcgcatcatctttgacatcaccttcttcttcttc gtcatcgtcatcctgctggccatcatccaggggttgatcatcgatgcttttggtgagctg agggaccagcaggaacaagtgaaagaagacatggagaccaaatgttttatctgtgggata ggtaatgactactttgacacagtgccacatggctttgaaacgcacacgctacaggagcac aacctagccaactacctattctttgtgatgtatctcatcaacaaagatgaaacagagcac actggccaggagtcttacgtatggaagatgtaccaggagcgctgctgggagtttttccct gctggagactgtttccggaagcagtacgaggatcagctgaactga

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