Gymnodraco acuticeps: 117560836 Help Entry 117560836         CDS       T09661                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gacu  Gymnodraco acuticeps Pathway gacu04020   Calcium signaling pathway gacu04260   Cardiac muscle contraction gacu04261   Adrenergic signaling in cardiomyocytes gacu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gacu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117560836 (ryr2b)    04020 Calcium signaling pathway     117560836 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117560836 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     117560836 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gacu04040]     117560836 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:gacu04990]     117560836 (ryr2b) Ion channels [BR:gacu04040]  Voltage-gated cation channels   Ryanodine receptor    117560836 (ryr2b) Domain-containing proteins not elsewhere classified [BR:gacu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117560836 (ryr2b) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RR_TM4-6 RYDR_ITPR SPRY RIH_assoc Ion_trans EF-hand_6 EF-hand_7 EF-hand_1 EF-hand_8 Motif Other DBs NCBI-GeneID:  117560836 NCBI-ProteinID:  XP_034093799 UniProt:  A0A6P8VSF9 LinkDB All DBs Position Unknown AA seq 4099 aa AA seqDB search MTFTPTPVDISKVVMPPQLEDIREKLAENIHELWTMEKIDLGWTYGPVKDEGKRHDPCVM EFCKLSETERNQNLQMAQDTLGTLLALGFHIGLTADHAEEKVKYMRLANKYEQPSGYRPS PVDPLQVFLSPAHEEVVDLLAENDHNVWARERIKQGWTHSPQQDVKAKRSPYLLPYCLLD ERSWRVGRESVRESVCTLLAYGYSLEPLNQEKTTISNPCPFPTEKSRVFRPDKSFSVTRG KWYFEFEIVTAGNMKVGWARPNCAPDKELGSDDQAYVFDGFEAQWYHQGVEPLGRPWQRG DVVGCLVDMAERTMMVTLNGEVLFNDRGSELAAKDFDIGDGLLPVVSVGVNQVGRLNLGR HTDSLQYFAVCGLQEGYEPFAVNMARAPVLWMSWKQPQFTSIKPEDHNLQVTRVSGSKDS LSSLRVSQRMFAHHGGSSEMGFYRLSMSIQCAAVLTSPAGGVPPAASNSLSPGSGRKEQE EMDSDFEVLMKSAHSFAGSRDELNHKDHSHDKTSRLKQRFMLKRTKPDLVSSNSSARLLE DVVVDKDDHVIQSSRYYYSVRVLPGQEAFNVWAGWVTSDFHQHDVTFDTDNALTVTVTLG DDSGKVQESVKRCNCYMVCAGEATGLSQSRRSTGLEIGCSVDTATGLLTFTCSGVEMATF YQVEASTKLFPAVFVKPTTSNMFQFELGSTKNVMPLSAGLLRSQRRNATPQCPPRVQVQH LDPVSWTRVPDRALQVMVDRPDERHGWRVQCHEPLQVMTLHIPDENRSVDILELSELDDL LTFHHHTLLLYCSLCNIGNTRVCHALCSHVDQSQLLHAIQDPNLPGQLRSAFYQLLMQVH LSSHTTECHMMNHEYIVPMTDQTREITLYPSPAYGVNAGNSPPPEGIFSTGLSTSLKPQM RFSTPCFVRSGGLEADGTGEITCTDSPEIPLDILKDLTVEMLTAGVWAVGQNVRHPVGGS FELLLVPLIKLFYNLLVLGVFGDEDLGKVLKLIEPAVFSINAETLSKEEEEDAADDDDEQ CTGGNIKENVTPHQGLLQMMLPEAVKLELCHLLSYLCDCQVRHRVEAVVAFSDNFVGQLQ ENQRFRYNQVMQALNMSAALTARKTKEFRSPPQEQINILLNFREEEQQENCPCPEEIQQL LQDFHHLLNTHSGIELDSDTEDEEDAEMSLKDRLLSLVARVTGLRKTPIEAEGSRPQSAK SLKTLISETMGRWAQETEMEDPELVRAVFTLLHRQYQGLGGQMAEHLRRAYTISQASVED TMALLSSLSQIRSLLSVRMGKEEERLMIRRLGDIMNNKVFYQHPDLMRALGIHETVMEVM VNVLGEGESKEITFPKMVASCCRFLCYFCRISRHNQGALFDHLSYLLENSSVGLASPSMR GATPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLRSCPMLVAKGYPDIGWNPVEG ERYLDFLRFAVFCNGESVEENAYLVLRLLIRRPECFGPALRGDGGNGLLSAMEEAIRISE DPSMDGACTTYQSNRALDVVQDNNDDLIHMGHAIMTFYSALIDLLGRCAPEMHLIQGGKG EAIRIRAILRSLIPIQDLEGVISIAFQFPSVSKDGLVVDPDLSTVFCPDHKAAMVLFLDR VYGIENQHFLLHLLEVGFLPDLQAAVCLDTADLGSTDMALALNRYLCTTVLPLLTKCSAL FCPLEDHALLVDSLIQAIYGLSRALSLTKAQRDTIEQCLLAVCSELQPSMMQPLLRRLVF DVPHLTDDSNMPLKLLASHYEQRWKYYSLAAGQGEQALASEEELHLSRKLFWGVFKALAK KPYEPQLFGLCVQCLAAVSMALPPDHMDSCCVSDTERKTSMDTEGHFDPQPVDTSSVSVP ERLEFVVNKYAEHTHEKWSLDKFANGWVHGEQQCENTKVHPRLKPYRALAEKEKEAYRWA IKETIKSMLAFGWTIERTKEGEAFGTHTVTRRVSQSGQLSFEGASTFSPKPMDMSSITLS WDQCAMALQLAENYHNAWAKKKKLELESKGGGNHPMLVPYDTLTAKEKTKFRERAQDALK FLQLNGYNVWRDRKTAEMDFPAIANCFGFTLLQQLLAHTEEAQEHVLELEVMQARGQMSK GERAAHQQPIHFFPKVILPFLEQYVKSHRPYFLPTSHCSSGNKSHASKKEKEMIASLFCK LAALVRHRISLFGNEASSVARCLHVLAQTLDARALMKSAPEFIQASLHSFFEAAAADLEM TVENLSVTLVCLPQSRSQQARGVAKVLSFTTSVLLPTLTSLFQHLGNQHFGVLLLVGSIQ VYCYRILNSLHSLGTSSSIYMEGQRAAAGACLAALTGTFPVCFLEPSLNQNNPYTIYNTM SASEREDFGLADQVEDMCPYLPSLNQALEEVEDLAAAGAGARQAQYIHVTEVTLPMLCSY MSRWWDWGPEGLPDSPICTAVIPQHASDLLGHILRVIHNHVGCSQGDWMKQLAVFSQPII CKAHTGLLKSHFLPLMEKLRKRAECVLLEEEQMKAEWCDTSEAELQIQEKFTVLVRDLYA FYPLLIPFVDSNRASWLKEPNPDAEQLFCMVAEVFIFWAKSHNFKWEEQNFVVQNEINNL AFLVNNDKMSKFDHEQRRVKRKGDRYSTHTSLIVASMKRLLPVGLRVCFPSDHSLIMLAK SGFSQKNTEDEIRERVFNGLQRQVLNGLRQESLYTDPPGQLGAITDGQRTVDRILEIARV LYYLDQVEHPQRNKKPAWHRVLSKQRKRAVVACLRMAPLYNLPRHRAVNLFLQGYNKSWI SAEDHSFEEKLVEDLARGGVMDLCGGDREEGKDVGEGARAIDPLLQLITLFSRSALTETR SVKLGNDGLYKSYAAIMAKSCHREDDDEEEQEVESFEEKEMEKQKLLYQQARLHRRGASE MLLQTISASKGEMGSMIAPTLKLGIAVLNGGNAAVQQKMLDYLRDKQDVGFFQSMAGLMR SCSVLDLNAFERQNKAEGLGMAMDESSGDKVMPDKDLTCDLFRFLQLLCEGHNSDFQNYL RTQTGNNTTVNIIITTVDYLLRVQESISDFYWYYSGKDVIDVHGQQNFSKAIEVAKQVFN TLTEYIQGPCAGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIELLKELMDLQKDM VVFLLSMLEGTVVNGTIGKQMVDMLVESAGNVEMILKFFDMFLKLKDLTSSDTFKEFDPE CKGCISRKDFQKAMENCKRFSQAEIPFLLSCMKTDDSEIVDYEAFVDRFHEPAKDIGFSL AVLLTNLSEHMPNDSRLVTFMGLAECVLSYFQPYLGRIEILGSGKRIERVYFEISEASRT QWEKPQVKESKRQFIFDVVNEGGEKEKMEMFVNFCEDTIFEMQLAAQISGSDSGERHADK GEDEKSDNLDDKGRFFVYQWLFLLISILSVKNLKTLMRMTLKDMLMSAVFLLRFIVMAQA RCMCVLVQGILYVLYIAFVSGGLIEGAKRMRISDLLGGIIEPTLDEVMELPSGVDRQRKY SASFSSQRELREMGHVAAVTSPMEVDVLSDIFGLKMKKDGGQYRLITQDLSASGTTSKTI TTADTQRKAQTATEETTEDQTTPGLVNTGGEVTEKKTVKQKADWKAKRCSDKFEEPESQH SALWETISTHNKSLQNYFARNFYNMRLLALFVAFAINFILLFYKVASLPASQKEEGVVTS DSSEGLDSADDDDIEGTYYFVLEESSGYMEPSLLFLAVAHTIISFCCIIGYNCLKSAHCG AFGWQVPLVIFKREKEVARKLEFDGLYVTVQPPEEDIKGQWDRLVINSPSFPSNYWDKFV KRKVMDKYGDFYGCEKISELLGLDQAAFDFSSESKESRRLKREASWSALLKSIDMKYQVW KLGVVFTDNSFLYLAWYMAMSVLGHYNNFFFAAHLLDIAMGFKTLRTILTSVTHNGKQLA LTVGLLAVVVYLYTVVAFNFFRKFYDKSDDKNTQDMKCNDMLTCYMFHMYVGVRAGGGIG DEIEDPAGDDFEVERIFFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKC FICGIGNEYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERC WEFFPVGDCFRKQYEDQLG NT seq 12300 nt NT seq  +upstreamnt  +downstreamnt atgacctttactcccacaccagtagacatcagcaaggtggtaatgcccccacaacttgag gatatccgagaaaaactggctgagaatatccatgaactctggacaatggaaaagattgat cttggatggacatatggacctgtgaaagatgaaggtaagaggcatgatccgtgtgtgatg gagttctgcaagctgtcggagacggagaggaaccagaaccttcagatggcccaggacaca ctcgggactctcctggctctgggctttcacattggtttgactgctgaccatgctgaggag aaagttaaatacatgagactagccaacaagtacgagcagcccagcggctacagaccctct ccagtagaccctctccaggtgtttctgagcccagcccacgaggaggtggtcgacttgctg gcagagaacgatcacaacgtgtgggccagagaacgtatcaagcaaggatggacccattca ccccaacaggatgtgaaagccaagcggagcccgtacctgttgccctactgcctgcttgat gaaaggagctggagagtgggccgggagagtgtcagagagagtgtgtgcaccctgctggcc tacggttacagtttggagcctctcaaccaggaaaagaccacgatatccaatccatgtccc tttcccactgagaaaagcagagtgttcagaccagataaatctttctctgtgactcggggg aagtggtactttgaatttgaaatagtgactgctgggaatatgaaagtgggctgggctcga ccgaactgtgctccagataaagagctcggctcagatgaccaggcgtacgtctttgatgga tttgaggctcagtggtaccatcagggtgtggagcccctggggcggccctggcagagaggc gatgtggtgggctgcctggtggacatggctgaacgcaccatgatggtcacactgaatgga gaggtgctgtttaatgacagaggatcggagctggctgccaaggactttgatatcggagac ggcctgttgccagtggtcagtgttggagtgaaccaggtggggaggctgaacctgggtcgc cacactgactctctgcagtactttgctgtgtgtggcctgcaggagggctacgaaccgttt gctgtcaacatggccagagccccagtcctatggatgagttggaaacagcctcagtttacc tccataaagcctgaggatcacaacctacaggtcaccagagtcagtggctcaaaggattct ttatccagcctgagggtttcccagcggatgtttgcacaccacggtggaagcagtgagatg ggcttttaccggctcagcatgtccatccaatgtgctgccgtcctcacaagcccagcgggg ggggtgcctccagccgcctccaactctctctctccaggttcaggaaggaaagagcaggag gagatggactccgactttgaagtgctgatgaagtcagcccacagctttgctggctcaaga gatgagctcaaccataaggatcatagtcacgacaaaacatcaagattgaaacagcggttc atgctgaagaggaccaaaccagacctcgtcagcagcaactcatctgctcggcttctagaa gatgtggtagttgacaaagatgatcatgttatccagagctccagatattactattccgtg agggttcttccgggccaggaggcgttcaatgtgtgggcaggctgggtgacctctgacttt catcaacacgacgtgacgtttgacaccgacaatgccctcactgtaaccgtcaccctcgga gatgacagtggcaaagtccaggaaagcgtgaagcggtgcaactgttacatggtgtgtgct ggggaggcaacaggcctgtcccagagtcgcagaagtacggggttggaaatcggatgttca gtcgacacggccaccgggctgctcacctttacctgcagcggagtggagatggccaccttc taccaagtggaagccagtacaaagctgtttcctgctgttttcgtcaagcccaccaccagc aacatgttccagtttgaactggggagcaccaagaatgtgatgccactgtcagccggtttg cttcgcagccaaagaaggaatgccacccctcagtgtcctccgagggttcaggtgcagcat ctcgacccggtgtcgtggaccagagtaccggaccgtgctttacaggtgatggtggatcgg ccagatgagcgccatggctggagggtccaatgccatgagcccctgcaggtcatgaccctt cacatccccgatgaaaacaggtctgttgacattttggagctgtcagaactggatgacctc ttgacctttcaccaccacactctcctgctctactgctctttatgcaacattggaaacact cgagtttgccacgccctctgcagtcatgttgaccaatcccagctccttcatgccattcag gatcccaacctccctggtcaactccgctctgcgttttaccagcttctcatgcaggttcac ctgagcagccacaccactgaatgtcacatgatgaaccatgagtacattgtgcctatgact gaccagaccagagaaatcaccctttatcccagccctgcttatggtgttaatgcggggaat agtccacctccagaaggcattttcagcactggtctcagcacatctcttaaaccacagatg cgtttctccactccttgttttgtcaggagtggtggattagaggcggatggtacaggtgag ataacctgcacagacagcccagaaatccctttggacatactgaaggacctgactgtggag atgctgactgctggagtgtgggctgtggggcagaatgtgagacatcctgtaggaggcagc tttgagctcctgctagttccccttatcaagctgttctacaacttactggtgttgggtgta tttggggatgaggatctggggaaagttctgaagctaatagaacctgcagtcttctccata aatgccgaaaccctcagcaaggaagaggaagaagacgctgctgatgatgacgacgaacaa tgcacaggaggcaacataaaagaaaatgtcactcctcatcaaggacttcttcaaatgatg cttccagaagctgtcaaacttgagctctgccacctgctctcctacctgtgtgattgccag gtgcgccacagggtggaagctgtggttgccttctctgacaactttgtgggtcagctgcag gagaaccaacgatttcgttacaaccaggtcatgcaagcgctcaacatgtcagctgccctc actgcccgcaagaccaaggagttccgctcacctccacaggagcagatcaacattctgctg aacttcagagaggaagagcagcaggagaactgtccgtgtccggaggaaatccagcagctc ctgcaagacttccatcacctcctcaacacacactctggcattgagttggacagcgacaca gaggatgaagaggatgctgagatgtctcttaaagatcggcttctcagtctagtggcgaga gtcactggactgagaaagacaccaatagaagcggaggggagcagaccgcagagtgccaag tccctgaaaacgctgatctctgagacgatggggcgttgggctcaggagacggagatggag gaccctgagctggtgagggccgtcttcacgttgctgcaccgccagtatcagggcctcggg ggccaaatggcagagcacctccgcagagcctacaccatcagccaggcctcggtagaagac accatggctctgctgtcctctctgagccagatccgctccctcctcagcgtccgcatgggg aaggaagaggagcggctgatgatcagaagattaggagacataatgaataacaaggtcttc tatcagcaccctgacctaatgagggcgctggggattcatgagaccgtgatggaggtgatg gttaatgttcttggagaaggggaatcaaaggagattacctttcccaagatggtggccagc tgctgtcgattcctgtgttatttttgccgcatcagccgtcacaatcagggggccctgttc gaccatctcagctacctgctggaaaacagcagtgttggactagcttccccatccatgcgt ggagccactcctctggatgtggcagcagcttcggttatggataataacgaactggcttta gcgctgagggaacctgacctagagaaggtggtccagtaccttgctggctgtggtctccgg agctgtccgatgctagtggctaaaggctaccctgacattgggtggaaccctgtggagggc gagcgttacctggactttctgcgttttgcagtcttctgcaatggtgagagtgtagaggag aatgcttacctggtgttgaggctgctgattcgtcggccagagtgttttggccccgctctg cgaggggacgggggaaacggcctcctatcagcaatggaggaagccatcaggatctcggag gacccttccatggacggagcttgcaccacctaccagtccaacagagcactagatgttgtc caggacaataatgatgacctcattcacatggggcacgccatcatgaccttctactctgcc cttatcgacttgctgggccgctgtgctccagagatgcatttgattcaaggaggcaaagga gaagctatccgcattcgagccatcctgaggtcgctcatccccattcaggatctcgaagga gtcatcagcatcgcctttcagtttccctctgtgtctaaagatggtctggtggttgatcct gacctatccacagtgttctgcccagaccacaaggcagctatggttctgttcctggaccgg gtgtatggcattgagaaccaacattttcttctccacctgctagaagtgggctttcttcct gaccttcaggccgccgtctgccttgacactgctgacttgggatccactgatatggccctg gccctgaacagatacttgtgtacaactgtgctccccctgctcaccaaatgttcagctctc ttctgtccattagaggaccatgctttgctggtggattctctcatccaggcaatctacggc ctctccagggctctcagcctcaccaaggctcagagagacactattgaacagtgtctgttg gccgtgtgcagtgaactccaaccatctatgatgcagcctctccttcgacgccttgtcttc gatgttccccatctcacagacgacagcaacatgccactaaagctcttggccagtcactac gagcagaggtggaagtactactcgctggctgcagggcagggtgagcaggctctggcctct gaagaggagctccacctgtcgagaaagttgttttggggtgtgtttaaggccttggcaaag aagccctatgagcctcagttattcgggctgtgtgtccagtgcctggctgccgtgtccatg gctcttcctcctgaccacatggactcatgctgtgtgtcggatacagagagaaaaacctca atggacacagaaggacactttgacccccagcctgtagatacctcaagcgtgtcagtgcca gaaagactggagtttgttgtgaataagtacgcagagcacactcatgagaagtggtcactg gacaagtttgccaacggctgggttcacggggagcagcaatgtgagaacaccaaggttcac cctcgcctcaagccatacagggctctggctgagaaggaaaaggaggcgtaccgctgggcc attaaagaaaccataaagagtatgctggcctttggatggactatagagagaaccaaagaa ggagaagcattcggcacgcataccgttacacgcagagtatctcagtctggacagctttct tttgaaggagcatcaaccttcagccctaaaccaatggacatgagtagcatcaccttatca tgggaccagtgtgctatggctttacagttagctgaaaactaccacaatgcctgggctaag aagaagaaattagagctggagagcaaaggaggaggaaaccatccaatgcttgtaccctat gatactctaacagccaaggagaagaccaaattcagagaaagagcgcaggatgctctcaag ttccttcagcttaacggctataatgtgtggagggatcggaagacagccgagatggacttt ccagccatagccaactgctttggcttcactctccttcagcagctgctggctcacactgag gaggcccaggagcatgtgttggagctggaggtgatgcaagccagaggacagatgtctaag ggagagagagctgcacaccagcagccaattcattttttccccaaggttatccttcctttc ttggaacaatatgtgaagagccatcgtccatacttcctgcccacttctcactgctcaagt gggaataaaagccatgcatcaaaaaaggaaaaggagatgattgcaagcctcttttgtaag cttgcagctctagtaagacacaggatctccctctttggaaacgaagcgtcgtcagttgca agatgcctccatgttttggctcagactctggatgccagagcattgatgaagtcagcccca gagtttatccaagcatccctgcattcattcttcgaggcagccgcagctgatctggagatg acagtggaaaacctgtctgtgaccttggtctgtttgcctcagagtcggagtcaacaggcc agaggagttgccaaggttctcagcttcacaacctctgttctcctgcccaccctcacctcc ctctttcagcatcttggcaaccaacactttggagtgctcctcctggtggggagtatccag gtgtactgttacaggatcctcaacagcctccactctcttggcaccagcagcagcatctac atggaggggcagagggcagcagcaggggcttgtctggcagctctgactgggacgtttcct gtttgcttcctggagccttctctaaaccaaaacaacccttacaccatctacaacaccatg agtgcctctgagagagaagactttgggctagcagatcaggtggaggacatgtgtccctac ctgccctctctgaatcaggctctggaggaggtggaggatttggctgcagctggtgctggg gctcgccaggcacagtacatccatgtcactgaggtcactctgcctatgctgtgcagctac atgtctcgttggtgggactggggccccgagggcctgccagatagcccgatctgcaccgct gtcattcctcaacatgctagtgaccttcttggccacatcctccgtgtcatccacaaccat gtcggctgtagccagggcgactggatgaaacagctggcagttttttcccagccgattata tgcaaagcccacactgggctgttaaagagccacttcctgccactgatggagaaattgaga aagagggccgaatgtgtgctgcttgaggaggagcagatgaaagcagaatggtgtgatacc tctgaagcagagttacagatacaggagaagttcactgtgctggtgcgagacctctacgcc ttttatccactcctcatcccatttgtggattctaatcgtgccagctggctgaaagagcca aaccctgacgctgagcagctgttctgcatggtggcagaggtctttatattctgggccaaa tctcataatttcaaatgggaggaacagaactttgtggtccaaaatgaaataaacaacttg gctttccttgtcaacaacgacaaaatgtccaagtttgaccatgagcagaggagggtgaag aggaagggggatcggtattccacacatacctctctgattgtggcgtccatgaagagactg ctccctgtgggactcagggtttgctttccgagtgaccacagcctcatcatgttggctaag agcggcttctctcagaagaacactgaagatgagattcgagaacgtgttttcaatggcctt cagcgtcaggtgttaaacggcttgaggcaggagtccctttatacagatcctccaggccag ctcggagccattactgacggccaaaggactgtcgacaggattctggaaatagctcgagtt ctttattaccttgaccaggtggagcacccgcagagaaataaaaaacctgcgtggcacaga gtgttatccaagcagaggaaacgagcagtggtggcctgcctgcggatggctcccctttac aacttacccaggcacagagccgtcaacctgttccttcaaggctacaataaatcctggata tcagcagaggaccacagctttgaggagaagcttgtggaggatttagctaggggaggagtg atggatctgtgtggaggtgaccgagaggaagggaaggatgtgggagaaggtgccagagct atcgatcccctcctgcaactcattacactcttcagtcgaagcgccctgacggaaacgagg tctgttaagctcggaaatgacggcctctataagtcctacgctgctattatggccaagagc tgccacagagaggacgatgatgaggaagaacaggaagtggaaagctttgaagagaaggag atggagaagcagaagttgctgtaccagcaggcccggctgcaccgccgtggagcttctgag atgctcctgcaaaccatcagtgccagcaaaggggagatgggctccatgattgctcctaca ttgaagctgggtattgctgttctcaatggagggaatgctgctgttcaacagaaaatgctg gattatctgagagacaagcaagacgttggattcttccagagcatggctggactcatgcgg tcatgtagcgttctggatctaaatgcatttgagaggcagaacaaagcagaaggattaggc atggccatggacgagagctcaggagacaaggtgatgcctgacaaagatttaacctgtgat ctgttccgatttctgcagctgctctgtgaaggacacaactcagatttccagaattacttg agaactcaaaccggcaacaacaccactgtcaacatcataataacaactgtggactattta ctgagggttcaggagtctatcagtgacttctactggtactactcggggaaagatgttatt gatgtacacggacaacagaatttctccaaggccattgaagtggccaaacaggtcttcaac acactcacagagtacatacagggcccgtgtgctgggaaccaacagagcctggctcacagc cgcctgtgggacgctgtcgtaggtttcctccacgtctttgcccacatgcagatgaagctc tctcaggattcgaggcaaattgagctcctgaaagaactcatggatttacaaaaggacatg gttgtgttcttgctttctatgttagaaggtaccgtcgttaatggcactattggaaagcag atggtggatatgttggttgaatctgcaggcaatgtggagatgatcctaaagttttttgac atgttcctcaaacttaaagacctcacctcctccgataccttcaaagagttcgaccctgag tgtaagggctgcatctccagaaaggacttccagaaagccatggagaattgcaagcgtttc tcccaggccgagattcccttcctcctctcatgcatgaagactgacgatagtgaaatcgtg gattatgaggcctttgtggatcgcttccacgagccagccaaagatatcggctttagcctc gctgttcttctcaccaatttgtccgaacacatgcccaacgactcaaggcttgtgacattc atggggctggcagagtgtgtcttgtcgtacttccagccctacctaggtcgtattgagatc ctcggcagtgggaagcgcattgaacgcgtgtactttgagattagcgaagccagccgcaca caatgggagaagccccaagtcaaagaatccaagagacagttcatttttgatgtggtcaat gagggtggagagaaggagaaaatggagatgtttgtcaatttctgtgaggacaccatcttt gagatgcagctcgcagcccagatatctggctctgactctggagagaggcacgcagacaaa ggagaagacgaaaagagtgacaatctggacgataaaggaaggtttttcgtgtatcaatgg ttgtttttgctgatatctatactttctgttaaaaacttgaagacattgatgaggatgaca ctgaaggatatgctcatgtcggctgtgttcctcctcagattcattgtcatggctcaggcc cggtgtatgtgtgttttagttcagggcatcttatatgtgctgtacatagcttttgtcagt ggtgggctcatagagggagccaaaaggatgaggatatccgatttgctcggtggtatcatc gagccaactcttgatgaggtcatggagctcccaagtggtgtggatcggcagaggaagtac tctgccagtttctcttcccagagagaattgagggagatggggcatgtggcagctgtgacc tctcccatggaggtggatgtactctcagacatatttggcctcaaaatgaagaaggacggg ggtcaatacagacttataacacaagacctctctgccagtgggacaacctccaaaacaatt accactgccgatacgcaacgtaaggctcagactgccacagaggaaacaactgaagatcag acaacgcctggattagtgaacacaggaggggaggtaactgagaagaaaactgtgaaacag aaagcagactggaaagcaaagcgatgctccgataagttcgaggaaccagagagccaacac tctgccctctgggagacgataagtactcataacaagagcctgcagaattactttgcaagg aatttttataatatgcgcttactggctctctttgtcgcctttgcaatcaacttcatcctc ctgttctacaaggtagcctctttgcctgcatcacaaaaagaggaaggagtggtcacgtct gatagcagtgagggattggactctgctgatgatgatgacatcgagggcacatattatttt gtgctggaggagagcagtgggtacatggagccatcactacttttcctggcagtcgctcac acaatcatctccttctgttgtatcatcgggtacaactgcctcaagagtgcacactgtggt gcttttggttggcaggtaccgttggtgatcttcaaacgtgagaaggaggtggcgcggaag ctggagtttgacgggctgtatgtgacggtgcagcctcctgaggaagacatcaaagggcaa tgggaccgactggtcataaactcaccatcatttccaagtaattactgggataaatttgtt aagaggaaggtgatggataagtatggggacttctatggctgtgagaagataagtgaactg ctaggtctggaccaagctgcgtttgacttcagttctgagagtaaagaaagcaggaggctc aagagagaagcttcctggagtgctctactcaagtccattgacatgaagtaccaggtctgg aaactgggcgttgtgttcactgataattccttcttgtacctggcctggtacatggccatg tccgttctgggtcattataacaacttcttctttgctgcccatcttctggacatcgccatg ggctttaagactctccgcaccattctaacttctgtcacacacaatgggaaacagttggcc ctcactgttggcctgttggctgttgtggtgtatctctacaccgttgtggccttcaacttc ttcaggaagttttacgacaagagtgacgacaagaacacccaagatatgaagtgcaatgac atgcttacttgttacatgttccacatgtatgttggagtgcgtgctggcgggggaatcggt gatgagatcgaggatccggctggagacgactttgaggtggagcgcattttctttgacatc accttcttcttcttcgtcatcgtcatcctcttggccatcatccagggcctgataattgat gcctttggggagcttcgtgaccagcaggagcaggtgaaagaggatatggagaccaagtgt tttatatgtggaataggaaatgaatactttgatacggtccctcatggctttgagactcac actctgcaggagcacaacttggcaaactatctattttttctgatgtaccttattaacaag gatgaaactgaacacactgggcaggaatcctttgtgtggaagatgtaccaggagcgttgc tgggaattcttccctgtgggagactgtttccgtaagcaatatgaggatcaactgggatga

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