Gambusia affinis (western mosquitofish): 122822921 Help Entry 122822921         CDS       T07758                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gaf  Gambusia affinis (western mosquitofish) Pathway gaf04020   Calcium signaling pathway gaf04260   Cardiac muscle contraction gaf04261   Adrenergic signaling in cardiomyocytes gaf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gaf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122822921 (ryr2a)    04020 Calcium signaling pathway     122822921 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     122822921 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     122822921 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gaf04040]     122822921 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:gaf04990]     122822921 (ryr2a) Ion channels [BR:gaf04040]  Voltage-gated cation channels   Ryanodine receptor    122822921 (ryr2a) Domain-containing proteins not elsewhere classified [BR:gaf04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122822921 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  122822921 NCBI-ProteinID:  XP_043957955 LinkDB All DBs Position LG20:complement(1243259..1375811) Genome browser AA seq 4962 aa AA seqDB search MADLGEGEDEIQFLRTDDEVVLQCSATIQKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLASTEEKAEGAQGGGHRTLLYGHAVLLRHSYSGMFLCCL STSRSSTDKLAFDVGLQEETTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYGNGSLQVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVMRLLHGHMDECLTVPSGEHG EEQRRSVHYEGGAVSSHARSLWRLETLRVMWSGSHIRWGQPFRLRHVTTGKYLSLTEDKS LLLMDKEKADVRSTAFCFRLSKEKLDPGVRKEVDGMGTPDIKYGDSVCYIQHVNTSLWLT YQTIDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNIFIRGL DTVRKKGKSSTLDLPIDSVSLSLQDLIGYFKPPEDHLDHEDKQNRLRALKNRQNLFQEEG MISLVLECIDRLHVYSSAAHFAEVVGREAAEAWSSILNSLYQLLAALIRGNRKNCAQFSG SLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDV LCSLCVCNGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSDGSAQYRKW YYELIVDQTVPFVTSEPTHLRVGWANTNGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHLW SGCIARTVTSPNQHLLRSEDVVSCCLDLSIPSISFRINGQPVQGMFENFNSEGLFFPVAS FSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLKLEASQDQTVARDLLGPTVTL SQAAFTPTPVDTSQIVLPSHLERIREKLAENIHELWVMNKIELGWTYGVVRDDNKRQHPC LVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKIKSMKLSPTYELSSGYK PAPLDLGHIKLTPTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYML LDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDVSNMSAERFRIFRAEKTYCVN TGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAWQ TGDVVGCMVDLNEHTMMFTMNGEVLLDDSGSELAFKDFEVAEGFIPVCSLGMCQIGRMDF GKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIEVTRMDGTV ELCPCLKVTQRSFGSQNSYNDITFYRLSMPIECAESRSPSYGSLFSPKRELEDFETVSDF EVLLKSSHGPNGPSGHDRDEFNNHKDYTQEKPSKLKQRFTLKKNKPDNSCLTSARLSEEV AVDDREGYEVLMQASTYYYSVRIFPGQEPSSVWVGWVTSDFHQYDPSFELNKVRTVTVTL GDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLSFTANGKELSM YYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSERKNPAPQCPPRLHVQ FLTPVLWSRVPNHFLKVSASRVNDRHGWQVQCSDPLQFMSLHIPEENRFVDILELSEQND LLKFHYHTLRLYSAICALGNNRVAHALCSHIDEAQLLQAIENKYMPGLLRAGYYDLLIDI HLRSYATARLMMNNEYIVPMTHETKSITLFPDDLKKHGLPGIGLSTSLRPRMHFSCPSFI RVTESSCHDNGNSGPGSCFQYSPEFPLDILKVKTIEMLTEAVREGSMHVRDPVGGSTELL FVPLIKLVYTMLIMGIFQNGDLKNILQLIEPSVFSEPRDGQEKLPRELEMLKNVETAGRG EDGGRNMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQDNQR FRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDDKQECPCPEYIREQLLDFHE DLMRHCELDEERGIDGDSDFTIRGRLMSLVEKVSYLKKKMGSLPKEKKDRKPSTLQQLIS NTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKAYTINSVSIEDTINLLAAL GQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGD SKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVA AASVMDNNELALALREPELEKVVQYLAGCGLQSCVMLVHKGYPDIGWNPVEGERYLDFLR FAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIRISQDPSRDGPS PVSESSRTFSDMLDEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEALRIRA ILRSLIPIEDLVGVISIAFSMPNLAKDGIVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQ NFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPF ASLIDSLLHTVYRLSKGCCLTKAQRDSIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNE HTKMPLKLLTNHYERCWKYYCLSGGWGSFGVASDEELHLSRKLFWGIFDALSCKRYDQEL FKLALPCLSAVAGALPPDYMESNYMAQMEKQSSMDSEGNFNPQPADTTNVTVPEKLDYFI TRYAEHNHERWCIEKFSHGWTYEEHLCESSKTHPLLKPYKALPEKDKEAYCWSVRESLKT MLSWGWSIDRNREGDTATLHNKSRRISTASQLSFEGAPAFSPRPVDMSNVTLSRDMQSMA ELLAENYHNIWARQKKMELEAKGGGRHPLLVPYDTLTAKEKSKDREKAQDILKFLQINGY IVSRGKKSPELDTPAIEKRFAYTFLQKLITYVDQAHQHMMEFDVGAKLKGGKIPHEQQIK FFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRHRISL FGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDSVAEDLEKTQENLKLGQFT HSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNVFGEDLMLDEVQVSCYRILNSLYFLG TNKSIYVERQRPALGKCLAAFSAAFPVAFLEPQLNKFNGFSIYNNKASKDRTALGLPGPV GDVCPLVPNLEKSLEEIMELAESGMKYTQMPHVMEVVLPMLCSYMSHWWEHGPESNPDKD DSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKAQLLQTHFLP LMDKLKKKAAVVLMDEEQSRAEGRGEMSETELLIMDQFTILVRDLYAFYPLLIRFVDYNR GRWLKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLISDTKCKMSK GIVSDQERKKMKRKGDRYSTQTSLIVATLKRLLPVGLNICAPGEQELIALAKNRFTQKDT EDEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPYHYEDTSDPEKTVKRVLDIAHVLFHL DQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEE HYFEDKLIEDLAKAGEREPSEEEEGIKHIDPLHQLIQLFSRTALTEKCKLDEDNLYMAYA DIMAKSCHDEEDEEGEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGVMGPM VASTLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKA EGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTV NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPC TGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDGFKEYDPDGKGVISKRDF HKAMESHKHYTQSETDFLLSCAETDENELLDYEEFVMRFHEPAKDIGFNVAVLLTNLSEH MPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEESEREKCDEEN PDMGFFSVSTVRLALIALRYNVMLLIKVLSMKSLKKQMKKIKNMTLKDLVTTLVSFYWSV LLGLLHVTFSVARGFCRIFYNTFMGGNLVEGARAVKVSELLATMPDPTQDEVRGEGDERE KRLSERSSPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNATLTELLNSPV PPSAAPPAPQPELRQRHQSKSGPSEKKEEIPEAEPEKLSEEEHVVKQEKQVKNEKMKSKV RKHHNSKSDEPDLQESAVLKKILAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKV STSSSLVEKKEAVHTSSHADSSVQWDPLLRERLESNDRLSDETGEPLKPVSVRFVLEESS GYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDD IKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGLDKAALDFSDAHKK RKPRKDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLD IAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGELPDMK CDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGL IIDAFGELRDQQEQVKEDMETKCFICGIGNEYFDTVPHGFETHTLQEHNLANYLFFLMYL INKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14889 nt NT seq  +upstreamnt  +downstreamnt atggctgacctgggagagggagaggatgagatccagttcctgcgaacagatgatgaagtg gttctacaatgttcagctacaattcaaaaagagcagcagaagctctgcctggcagctgaa ggctttggaaacagactctgcttcctggagtccatctccaactccaagaatgttcctcca gacctttccatctgtacctttgtgttggagcagtccctatctgtccgagcccttcaggag atgctggccagcacagaggagaaggctgaaggggcccagggtggtggacatcgcactctg ctctatggacacgctgttttactacgacactcatacagcggaatgttcttgtgctgtctg tccacctcacggtcgtctacagacaaactggcttttgacgtaggactgcaggaggaaacg acaggtgaggcatgctggtggaccatccatccagcatcaaagcagcgttcagagggagag aaggttagagtgggagatgatctcatcctggtcagcgtctcctctgaacgatatctgcat ctgtcctatgggaatggcagcctgcaggtagatgcagccttccagcagacactttggagt gtggctcccatctgttctggcagcgaagtagcacaaggtttcctaataggaggggatgtt atgcgcctcctccatggacatatggatgaatgtctgactgttccatctggggaacatgga gaggaacaaagaaggtcagtgcactatgaaggaggagcagtttcgagtcatgctagatcc ctgtggagactggagacgctgcgcgtcatgtggagtgggagtcatatccgttggggtcaa cctttcagactcagacatgtgaccacagggaaatatctgagtctgactgaagataagtct cttcttctgatggacaaagagaaagctgatgtgaggtccactgccttctgcttcaggttg tccaaggaaaagctggaccctggtgtgaggaaggaggtggatgggatgggtacaccagac attaagtatggtgactctgtgtgctatattcaacatgtcaacacctcgctgtggcttaca taccaaactattgatgcaaagtgtgcccgtatgggtggagtacagagaaaggccatcatg caccatgaaggtcacatggacgatgggctcactctgtctcggtcacaacatgaggagagc cggactgccagggtcatccgcagtaccgtctttctcttcaacattttcatcagaggtctg gacacagtgagaaagaaaggaaaaagttctactttagatcttccaatagactcagtcagt ctgagtctgcaagatctgattggctacttcaaaccacctgaagatcacctggaccatgaa gacaagcagaaccgactgagagctctaaaaaacagacagaacctcttccaagaggagggg atgatcagcctggtgctggagtgtattgatcgtctccatgtgtacagcagcgcagctcac tttgctgaggtggttggaagggaggctgcagaggcctggagctccatcctgaactcattg tatcaactgctggctgcactgatccggggaaacaggaaaaactgtgctcagttttccggc tctctcgactggctgataagcagactggagcgactggaagcttcttcaggtatcttggag gtgcttcattgtgtgctggtggaaagcccagaagccctaaacattatcaaagaaggacac atcaaatctatcatttctcttctggacaagcatggacgcaaccataaggtcctagacgtg ttgtgttcactgtgtgtctgtaatggcgtggcggtgcgctccaaccagcacctgatctgt gataacctgctgccaggaagagatctgctgttgcagacccgcctcatcaaccacgtaagc agtatgcgcccaaacatcttcctgggtgtcagtgatggctctgcccagtacagaaaatgg tactatgaacttattgtggatcagacggtgccatttgtcacttctgaaccaactcacctc agggttggctgggccaacaccaatgggtatgcgccgtaccccagtggaggggagggctgg gggggcaatggggtgggtgatgatctctactcgtacggcttcgatggacttcacctgtgg tcaggctgcattgcacggactgttacatcgcccaatcagcacctgctgcggtcagaagat gtggtgagctgctgcctggacctgagcattcccagcatctccttcaggatcaacggccag cccgttcagggcatgttcgagaacttcaactcagagggccttttctttcctgtggccagt ttttctgcgggggtcaaggtgcgttttctcctcggggggcgtcatggagagttcaaattc cttcccccttctggctacgctccctgctttgaggcagtgttgcccagggagaaactcaaa ctggaggccagccaggaccagactgtagccagagacctgctgggtcccacggtcactctg agccaggccgcattcacacccacccctgtggacaccagccagattgttctgccatctcac ttggagagaatcagggagaaacttgcagaaaacatccatgaactgtgggtgatgaacaag atcgaactgggctggacgtacggtgtggtgcgagatgataacaagcggcagcacccctgc ttagtggagttttccaagcttcctgaacaggaacgaagctacaacctgcaaatgtctctg gagactctgaaaaccttacttgctttgggatgccatgttggattagcagatgaacatgct gttgaaaaaataaagagcatgaaactatcaccaacgtatgagttgtccagtggctacaaa cctgctcctctggacctgggtcacatcaagctgactcccacacaggaagcaatggtggac aagctggctgaaaatgcccacaatgtctgggcaagagaccgaatccgtcagggctggaca tatggaatccaacaggatgtgaagaaccggagaaaccctcgccttgttccatacatgctg cttgatgagagaaccaaaaagtccaataaagacagtctgagagaggctgttaggactcta ttgggctatggatacaacctagaagctccagaccaggatcatgctgctcagtctgatgtc agcaatatgtctgcagagagatttcgcattttcagagcagagaagacctactgcgttaac actgggaagtggtactttgagctggaggtactgacagctggagaaatgagggtgggctgg gcaaggccaggctgtctaccagaccaggagctgggatctgatgaccaggcctttgtcttc gatggttttaaggtccagcgctggcaccagggcaatgagcactttggccgtgcctggcag actggtgatgtagtgggctgcatggtagatctgaacgagcacacaatgatgttcactatg aatggagaagtgctgctggatgattctggatctgagctggccttcaaggattttgaagtt gctgaaggcttcatcccagtctgcagtctgggaatgtgtcagattgggaggatggatttt ggtaaagatgtcagcactctgaagtacttcaccatctgtggcctgcaggaaggctatgag ccgttcgccgtcaatatgaaccgggatgtaaccatgtggctcagcaagagactgcctcag tttgtgcctgttccccccaaccaccaacacattgaggtgaccaggatggatggaacagtg gagttgtgtccctgccttaaggtcacccagaggtcatttggttcccagaacagttacaat gacatcactttctacaggctgagcatgcctatagaatgtgctgaatccagatccccgtct tatggcagcctgttctcaccgaagagggagttggaggattttgaaactgtgtcagacttt gaagtcttgttgaagtcatctcacggtcccaatggtcccagtggacatgacagagatgaa ttcaacaaccacaaagactacacccaggagaagccctccaagctaaaacaacggttcaca ctgaagaaaaacaagccagacaacagctgtctaacatctgctcgcctgtcagaggaagtg gctgtcgacgacagagagggctacgaagtcctaatgcaagcttctacttactactactca gtgcggatcttccctggtcaggagcccagcagtgtgtgggtcggctgggttacctctgac ttccatcagtatgacccaagctttgagctcaacaaagtccgaactgtcaccgttaccctg ggagacgagaaaggaaaggttcatgagagcataaagcgcagtaactgctacatggtgtgg gctggagagagcagcagcccaggacagggcaggaacaataacggcctggagatcggctgc ctggtggacacaacaaacggtctgctgtccttcacagccaatggaaaagagctcagcatg tactaccaggtggagcccagtacaaaactgtttccagctgttttcgccaaggccaccagt cccaacgtcttccagtttgaacttggccggattaagaatgtgatgcctctgtcagccggt ttgtttaaaagtgagaggaagaacccagctccccagtgccccccgcgtctccatgtccag tttctcactccagtgttatggagccgtgttcccaaccacttcctcaaggtttcagcttcc agagtgaatgatcgacacggctggcaggtccagtgtagcgatcccctgcagttcatgtct ctccacatacctgaagagaacaggttcgtggatatcctggagctgtcagagcagaatgac ttattaaagtttcactaccacactctcagactgtactctgcaatctgcgccttggggaac aatagagtggctcatgctctgtgctctcacattgatgaggcccagctcctacaggctata gagaacaagtacatgccaggtttgcttcgtgcgggctactatgacctcctcatcgacatc cacctgaggagctatgcaacagctcggctgatgatgaataatgagtacattgtacccatg acacatgaaacaaaaagcatcacactgtttccagatgacctgaagaagcatggcctgcca ggcatcggactcagcacatccctgagacccagaatgcacttctcttgtccaagctttata cgtgtgactgagtcctcatgccatgacaacggaaatagtggaccaggaagttgtttccag tacagccccgagttccctttagatattttaaaagtgaaaactatcgagatgctgacagag gcagtgcgggagggaagtatgcatgttcgggatccagtagggggaagcacagagttgcta ttcgtccctcttatcaagctggtgtacaccatgctcatcatgggaattttccaaaatgga gatctgaagaacattctccaactcatagaaccatctgtgttctctgaaccaagagacggg caggaaaagcttcccagagagctggagatgttgaagaacgtggaaacagcgggaagagga gaggatggagggaggaacatgccgaaggaagggctgctgcagatgaagctgccagagccg gttaaactgcagatgtgccatgttttgcagtacctgtgtgactgccaggtgcgccatcgt atcgaggcggtggtggccttctccgatgactttgttgcttgtctccaagacaaccagcgc tttcgctacaatgaagtgatgctggctctgaacatgtctgctgcactcactgccaagaaa accaaagagttcagatctcccccacaggaacagatcaacatgctgctgaacttcaaggat gacaagcaggaatgtccctgtccagaatatatccgggagcagctactggacttccatgaa gatctgatgagacactgtgagctggatgaggagagaggaatagatggggatagtgacttc accattcgaggtcgtctcatgtcgctggtggagaaggtgtcctacctgaagaagaagatg gggagcctgcccaaggaaaaaaaggacaggaagcccagtaccttacagcagcttatctct aatacgatggtccgctgggctcaggagtcggttatagaggatccagagctagtgagagcc atgtttgtccttctgcaccgccagtatgatggcattggaggacaggttcgagctcttcct aaagcctacactatcaactccgtatccatagaggacaccatcaacctgctggctgccctg ggtcagatccgctctctgctgagtgtccggatgggcagagaggaggagaagctgatgatc agagggcttggtgatatcatgaacaacaaggtgttctaccagcatcccaacctgatgaga gctctgggcatgcatgagacggtcatggaggtcatggttaacgttctcagtggaggagac tccaaggaaatcaccttccctaaaatggtggccaactgttgtcggtttctgtgctacttc tgccgaatcagccgccagaatcagaaggccatgtttgaccatctgagctacctgctggag aacagcagtgtaggccttgcctctccctccatgcgtggatccactcctctggacgtggct gcagcatcagtcatggataacaatgaactggctctggctctaagagaaccagagctggaa aaggtggtgcagtatctggctggctgtgggctgcagagctgtgtaatgctggtgcataag ggatacccagacattggctggaaccctgtggagggggagcgctacctggactttctgcgt tttgctgtcttctgcaatggggagagcgtggaagagaacgccaatgttgtggtgagactt cttattcgccggcctgaatgttttggccccgctcttcgaggtgaaggcggtgatggcttg cttgcagcaatggaggaagctatcagaatctctcaggatccttccagagacgggccgtct ccggtgtctgagagcagcagaacattcagcgacatgctggatgaagaggaggatgatacc atccacatgggcaatgccattatgaccttctactctgcacttattgatctgctgggtcgc tgtgctccagagatgcatctgatccatgctgggaaaggtgaagccctccgcatcagagcc attttaaggtccctgattcccattgaagacctggtgggagtcatcagcatcgccttctcc atgcccaatctggctaaagatgggatagttgtggagccagacatgtcagcaggtttctgt ccagaccataaagcggccatggtccttttcctggaccgggtctatggtatagaagaccag aatttcctcctccaccttcttgaggttggatttctgccagatctcagagctgctgcctct ctggacactgctgccctcagtgccacagatatggccctggccctcaacaggtacctgtgt acagcggtgctgcccctcctgaccaaatgtgctcctctgtttgcggggaccgagccgttc gcctctctgatcgactccctcctccacacggtgtaccgcctgtccaaaggctgctgcctt accaaagctcagagggactctatagaggagtgtctgctggctgtttgtggtaagctgagg ccttcaatgatgcagcacctgctgaggaggctggtgttcgacgttcccctgctgaatgaa cacaccaagatgcctctgaagctgctgaccaatcactatgagcgctgctggaagtattac tgcctgtctggaggctggggcagctttggagtggcttcagatgaagagcttcacctctcc aggaaactgttctggggaatatttgatgctctgtcctgcaagcgttatgaccaggagctc tttaagctggcactgccatgtctgagcgcggtggctggcgctcttcctccagactacatg gagtccaactacatggcccagatggagaaacagtcctccatggattcagagggaaacttc aacccacaacctgcagacaccactaatgtaactgttcctgaaaagctggactattttata accagatatgccgagcataatcatgagaggtggtgcatagagaagttttcgcatggctgg acatatgaagaacacctgtgtgagagcagtaagacccatcccctgctgaagccatacaaa gctctgcctgagaaggacaaggaggcgtactgctggtctgtcagagagtctctgaagacg atgctgtcatggggctggagcatcgacagaaacagagagggagacacggccaccctccac aacaaatccagacggatatcaacggccagccagctgtcttttgaaggagctccagctttc agcccaagacctgttgacatgagcaatgttacactgtccagagatatgcagtctatggct gagctgcttgctgaaaattatcataatatctgggcaagacagaagaaaatggagctagaa gctaaaggtggaggaagacatcctcttctagttccctatgacacgctgactgccaaagag aaatccaaggatcgagaaaaagctcaagacattctcaagtttctccagatcaacggttac atcgtatccagaggaaagaagtctccagagctggacactccagcaatcgagaagaggttt gcctacacattcctccagaagctcatcacatatgtagaccaggctcaccagcatatgatg gagtttgatgtgggagcaaagctgaaaggaggaaagattcctcatgaacagcaaataaag ttctttggaaaggttgttttgccgttggtggatcagtacttcaaaaaccacaggctgtac ttcctgtccacagccattcatccaatcagcagtggaggccatgcctcaaataaggagaag gagatggtgaccagtcttttttgcaaacttggagttcttgtcagacataggatatccttg ttcgggaacaatgcaacatcaatcgtcaactgcctgcagatactaggacagagcctagat gcgaggacagtaatgaagactggactggagtcagtgaaggcagctctgcggtcctacttt gatagtgtggcagaagatttggagaaaactcaggagaacctgaagctgggccagttcacc cactccagagagcaaccacgcggagtgactcagatcatcaactacaccaccttcgccctg ctgccagtgctgtcctccctgtttgagcacattgggcagaatgtgtttggagaggacctc atgttggatgaagtccaggtgtcctgctacagaatactgaatagtctctactttctggga accaacaaaagtatctatgtggagagacagcggccagctttaggaaagtgtttagctgcc ttctcagcagccttccctgtcgccttcctggagccacagctcaacaagtttaacggcttc tccatttacaacaacaaagcaagcaaagacagaacagctttgggtctgccagggccagtt ggagatgtgtgtcctttggttccaaacctcgaaaagtctctggaagagatcatggagctg gctgagtctggcatgaagtatactcagatgcctcatgtgatggaggtagtgttgcccatg ttgtgcagctatatgtcacactggtgggagcatggaccagaaagcaatcctgacaaggac gacagctgctgcacatctgttacctcagagcacatgaacacactgctgggaaacattctg aaaatcatctacaacaacctgggaattgacgagggggcctggatgaaaagactggctgtc ttttcccagccaatcatcagcaaagctaaagcccaactgttacagacacacttcctgcct cttatggataaactcaaaaagaaagctgcagtggttctgatggatgaggagcagagcagg gctgaagggagaggtgagatgtctgagacagagctcctcatcatggatcagttcaccata ctggtcagagacctgtatgccttctacccgctgctcatacgatttgtggactacaacaga ggaagatggctaaaagagtccaacccagaggcagaagagctgttcagaatggtggctgaa gttttcatattttgggccaagtctcataacttcaaaagagaagagcagaattttgtggtc cagaatgaaatcaacaacatgtcattccttatctccgacaccaagtgcaagatgtcaaag ggtatagtttcagaccaggagaggaagaagatgaagaggaagggtgatcgatactcgact cagaccagtttgatcgtggccacgttgaaacgcctgctgcctgtgggactgaacatctgt gctccaggagaacaggagctcatcgccctggctaagaaccgattcacacagaaggacacg gaggatgaggttcgagagatcatcaggaacaatctccatttacaagggaagctggaggat ccagcaattcgctggcagatggctttgtacagagacctgccctaccactatgaggacacg tctgacccagaaaagactgtgaaaagagtcctggacattgctcatgtcctcttccaccta gaccaggtagagcatcctcagcgcagcaagaaagctgtatggcacaaattgctgtccaag caaaggaagagagccgtggttgcttgtttcaggatggcacccctctataacctgccaagg cacagagctgtgaacttgttcttgcaaggctatgagaagtcctggatcgaggcagaagag cattattttgaagacaaactcatcgaggaccttgctaaagcaggtgaaagagagccatct gaagaagaggagggcataaaacacatcgatcctctccatcaacttatccagctcttcagc agaacagccctcactgagaaatgtaagctggatgaagataacctttacatggcgtatgct gacataatggctaagagttgtcacgatgaagaggatgaagaaggagaagttaaaagcttt gaagagaaggagatggagaagcaaaagctgctgtatcagcaggcccgactgcacgaccgc ggagctgcggagatggtccttcaaaccatcagcgccagcaaaggtgtcatgggccctatg gttgcatccactctgaagctgggtatagccattctcaacggaggaaactcaactgtacag cagaaaatgttggattatttaaaggaaaagaaggatgtgggcttcttccaaagtctggct ggtctaatgcagtcctgcagtgttctggatctgaatgcatttgagaggcagaacaaagca gaggggctgggcatggtgacagaggagggatcagtcatcactcatgagcgtggtgagaag gtcatgcaggatgatgagttcacctgtgaccttttccgcttcctgcagctgctttgcgaa ggacacaactcggatttccagaactacttgaggactcaaactgggaacaatacaaccgtc aacatcatcatctctactgttgactacttactcagagttcaggagtctatcagtgatttt tactggtattattctgggaaggatgttatagacgagcagggccagaggaatttctccaag gcaatcaatgtggccaaacaggtgttcaacacgcttacagagtatatccaggggccgtgc acaggcaaccagcagagcttggcacacagtcgcttgtgggatgctgtggttggcttcctg catgtctttgctcacatgcagatgaaattatctcaggactccagtcagattgagttactg aaagagctgatggatctgcagaaagacatggtggttatgttgctatctatgctagaaggt aatgtagtaaatgggacaattggcaaacaaatggttgatatgttggtggaatcgtccaac aacgtggagatgatcctcaagttctttgacatgttcctgaaactgaaagacctgacctcc tctgatggtttcaaggagtacgaccccgatggaaaaggtgtcatctccaaaagggacttc cataaagccatggagagccacaaacactacacccagtctgaaacggacttcctcctctcc tgtgctgagactgatgagaatgagcttctggactatgaggagtttgtgatgcgtttccat gaaccagccaaggacattggcttcaatgtagcagttttgttgacgaatctgtccgagcac atgcctcatgacacccgcctgcagaccttcctggagttggccgagagcgtcctcaactac ttccagccatatctgggcaggattgagatcatgggcagtgccaagcgcattgagcgggtt tactttgaaatcagtgagtccagtcggacacaatgggagaaacctcaggttaaagaatca aaacgccagttcatcttcgatgtggtgaatgaaggtggagagaaagagaagatggagctg tttgtgaatttctgtgaggacaccatctttgaaatgcagctagcagctcagatgtccgat gctggcgagcgctcagctgtgaaagaggagagtgagcgagagaaatgtgacgaggaaaac cctgacatgggcttcttctctgtgtctactgtgcgcttggctttaatcgcccttcgttat aacgtcatgttgctcataaaggtgttgtcaatgaagagtctaaagaaacaaatgaagaag atcaagaacatgacactgaaagacctggtgaccactctggtgtctttctactggtcagtg ctgctgggtctcctccatgtgaccttcagtgtggctcgaggattttgcagaatcttctac aataccttcatgggagggaatttagtagagggagccagagctgtcaaggtgtcagaactg ctggccaccatgcctgaccccacccaggatgaagtccgcggtgaaggagatgagagagag aagaggctgtctgagcgcagctccccgaaggaggatctggctgatctagcagttaatacc agtgaaactgagctgttgtcggacatttttggtcttgacttgagaagagaggggggacag tacaaaatcaccccccataaccccaacgctaccctcacagagctcctcaactccccagtg cccccctcagctgcccctcctgctccacagccagaactaagacaaagacaccagtcaaag agtggaccctctgaaaagaaggaagaaataccagaagctgaacctgaaaaactgtcagaa gaggaacatgtggtgaaacaagagaaacaagtgaagaatgagaagatgaaatcaaaagtg agaaagcatcacaactcaaagtctgatgaaccagacctgcaggagtctgccgtcctgaag aaaatcctggcctaccagaggaaactgctgaactactttgccagaaacttctacaacatg aggatgctggccctgtttgttgcatttgcaattaattttatacttctattctataaggtt tctacttcttcatccttggtggaaaagaaggaagctgttcacaccagcagccatgcagac agcagtgtccagtgggatccactgcttcgagaaaggctggaatcgaacgaccggttgtcg gatgagacgggcgagcccctgaagccggtctcagtgcgttttgttctggaggaaagcagc ggatacatggagcccatgttgcggatcctggctgttctccacaccgtcatttctttcttc tgcattatcggatattattgtctgaaggttccactggtaatcttcaaacgtgaaaaggaa gtggccaggaagcttgaatttgatggtctttacatcaccgagcaaccatctgaggacgac attaaaggacagtgggacagacttgtgatcaacacacaatccttccccaacaactactgg gataagtttgtcaagaggaaggtgatggataagtacggggagttttatggccatgaccgc atcagtgagctgctggggttggacaaggctgctctggacttcagtgatgctcacaagaaa agaaaacccaggaaagacagttcactggccgctgtgctcaactccatcgatgtgaagtat cagatctggaagcttggggttgtttttactgataattccttcctgtatctggcctggtac atgaccatgtccatcctgggtcactataacaacttcttctttgctgcccatctgctggac attgctatgggcttcaagaccctgcggaccatcctctcttcagtcacacataatggcaaa cagctcgtgctcactgttggtctgttggcagtggtggtttacctttacacagtggttgcc ttcaacttctttagaaagttttacaacaaaagtgaagatggagaacttccagacatgaag tgtgatgacatgttgacatgttacatgttccacatgtatgtgggcgttcgagcaggcgga gggattggtgaccaaattgaggatcctgccggcgatgagtacgagatctaccggatcatc tttgacatcaccttcttcttctttgttattgtaatcctgctggccatcatacagggcttg atcattgatgcttttggtgaactgagagaccagcaggaacaagtcaaagaagacatggag accaaatgtttcatctgtggaataggaaatgagtattttgacacagtaccacatgggttt gaaactcacacactacaagagcacaacttagccaactacttattttttttgatgtatctg ataaacaaagatgaaactgagcacacaggccaggagtcttatgtatggaagatgtaccag gagcgctgctgggagttttttcctgctggtgactgtttccggaaacagtatgaagatcaa ctcaactga

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