Gambusia affinis (western mosquitofish): 122824885 Help Entry 122824885         CDS       T07758                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism gaf  Gambusia affinis (western mosquitofish) Pathway gaf04020   Calcium signaling pathway gaf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gaf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122824885 (ryr3)    04020 Calcium signaling pathway     122824885 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gaf04040]     122824885 (ryr3) Ion channels [BR:gaf04040]  Voltage-gated cation channels   Ryanodine receptor    122824885 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  122824885 NCBI-ProteinID:  XP_043961667 LinkDB All DBs Position LG22:5450148..5581393 Genome browser AA seq 4854 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLEPTSEAKYVPP DMCICNFVLEQSLSVRALQEMLANTGASSEAKADHEKWAGQGGGHRTLLYGHAILLRHSF SDMYLTCLKTSRSLTDKLSFDVGLQEDSVGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSNCNGNIQVDASFMQTLWNVQPTCSSGSMAVGYLIGGHVMRLCHGHDESLT IPGADKSEEEQRIVNYEAGKGASRARSLWRLEPLRISWSGSHIRWGQSFRLRHLSTGHYL ALTEDRGLVLEDREKCHTKATAFCFKPSKEKGDSGMKRDIDGMGVPEIKYGDSVCFVMHV ATGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTFLF KNFIKALDSAAAGETNTVAGYVEEVLQTLNDLIEYFKQPDVDLEHEEKQARLRSLIKQQD LFKEEGMLALLSKCIDRMNLYDSAAHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRTN CTQFSRNLDWLVSKLERMESSSGILEVLHCVLVESPEALNIIQKAHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRTNQNLICDNLLPKRDLLLQTRLVNDVQSIRPNIFLGIAEGS AQYKKWYYELVIDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNIDGF FFPVVSFSAGVKARFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKDYKRDHDGV RDLLGTTQFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFGKLPETEKNYNVQMSSETLKTLLALGCHVAQVNVHAEEDLKKIKLP KDYMMSNGYKPAPLELSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKSR RNPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEVVHAIDDQSIETIRFFR VEQTYAVKTGKWYFEFEVLSGGDMRVGWARPGCRPDVELGTDDQAYVFDGYRGRRMHAGS RYFGHPWKKGDVVGCMINMEDKSMIFTLNGELLITSKGSELGFADFETEDGFIPVCSLGM SQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREITMWFSKRLPTFFNVPHDHMHIE VTRIDGTVDSPPCLKVTHKTFGTQNSNSDMVYCRLSMPVEFYSADRLLDESLKLSQTPKE DGSIDYGSITTYYHSVRVFAGQDPATVWMGWVTPDYHYYSKNFSLSKTQTVTVTLGDERG RVHESIQRSNCYMVCAADALGPSSSSRSNTDLEIGCLVDLATGLVSFTANGKELPTAYQV EPNTKLFPAVFCCPTSSNLFQFEFVKIKDAMPLSSAMFRSEQRNPVPQCPPRLDVQTIVA VLWSRMPNTFLNVETARVSERHGWVVQCLEPLQMIAVHIPEENRCLDIMELSEHEDLRKF HYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYDVLISIHLET AKEARLMMNNEFIIPVTDETRSIKLFPDESKRHSLPGVGLSTSLKPRVNFAPVGIISTKR HQFLYSPQIPLGVLKEKAISMLTEAVQGGGSHIRDPVGGSLEYQFVPILKLIGTLLIMGV LTSDEVRLILLLIEPNVFGEAKEGEEGSGGEVVVAGEKEEVSKNEEKAVEAGEEETKESK PAAKGLLEKSLPESVKHQMCELLHYFCDCELQHRIEAIVSFSDRFVSKLQYNQKFRYNEL MQAFNMSAAVTAKKTKEFRSPPHEQINILLNFSAGEDCPCPEEVQDELSSFHEELRLHCG IPMEEEEAEQDTSIKGRLLALLYKIKGPPQKTEEEPTETEQAAPTNLKELISQTITSWAQ ESHIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLVSLGQIRSLLS VRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPK MVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNN GLALALEEPDLEKVVMYLAGCGLQSCAILVAKGYPDLGWNPIEGERYLSFLRFVVFCNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKSPAGATAG SGEEEGEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLV GIISIPLKMPVINKDGSVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFL PDLKASASLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFGNTEHYAHLVDSTLETIY RLSKGRSLTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPLLTEYCKMPLRLLTNH YEQNWKYYCLPSGMGGFGLASEEELLLTKKLFWGIFDSLSQKKYDSELFKMAKLCLCAIA GALPPDFVDTSLGATVEKQESVDAQGNFEPKPINTANISLPEKLDYIANKYAEHSHDKWA SEKMSAGWKHGDSLDEQAKAHPLLKPYKSLSEKERETYRWPVKESLKSMLAMNWNIERTK EGEAMFQQRESEKQRKLSESQSNGFSPAPMDLHNVTLSRELQTMVEVVAENYHNIWAKKK KSELLSKGGGLAHPLLVPYDTLTAKEKYRDKEKAQELFKFLQISGYAITRGLKDMEQDSS SMEKRFAYKFLKRLLKNIDSAQEFIAHLEAMATSGKTDKSPHEQEIKFFAKVLLPMIDQT FKNHCLYFLSTPSKNLSSCGCASNKEKEMVTSLFCKMAALVRHRISLFGSDSAIMVSCLH ILSHSLDTRTVMKSGAELVKVGFKAFFENAAEDLEKLVEMLKLGKFMQSRAQMKSVTQSI NYVTVALLPILTALFEHIRTHEFDVDLLVDDVQLSCYRILMCFYSLGTGKNVFVERHLPA IGESLATLVGAMPVAFLEPHLNSHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKL LKDVDDVSESGARYSDMPQVIEVVLPMLCNYLSYWWEKGPENSAPDTDCCTMVTSEHLSL ILGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTMEKLKKKTVKVVS EEELLKADGKGDNQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSTEL FRMVAEIFILWCKSNNFKREEQNFVIQNEINNLGFLTGEGKSKMSKSGGDQERKHKRRRG EYYSIQTSLIVAALKKLLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEYLRQNLHLQ EKSDDPAVHWQLNLYKDVVVKSEEPSDSEHTVERIQSISAAVFNLEQVEQPLRNKKCIVQ KLLSKQRKRAVVACFRMAPLYNLPRHRAINFFIPAYERLWIEAEEYSFEEKLVQDLAKTP MKIVEEEEEEVAEIKPDPLHQLILHFSHNALTERSHLEVDPLYIAYADMMAKSCAEDEEE EEEEGREKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGTMVTYTLKLGIS ILNGGNVQVQQKMLGYLTDKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEG SIHTQRGSKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLL RLQESISDFYWYYSGKDVIDETGKHNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSR LWDAVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQM VDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFREYDPEFKGIISKKEFQKSMESQKQYN QSEIEFLLSCAEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDARLNTFL DLAESVLSYFEPYLGRIEILGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNE GGESEKMEMFVNFCEDTIFEMQLASQISEPDAVEQPEEEEEEEGHSILEELAGGEDGAPE SASAFTTACRSVKKNLSEIRQIFTIKTARKQYKKIKKLSIKELITGFFSFLWMIFIGFFK GIFSLVFGFFHVIWSSMFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDVGEGDKVEAME SSGSLDKAMAPAGDATEVDVMLELLTPKKEGGKHVEPGLGDVSELSGESSTADSKKKAAA KTAAPSESETEKADTETREKEDKPKEEEAKEPAVEEKPKSRSSQPKEASPAFMSTIFAIL DVYLNKILNYLARNFYNLRFLALFVCFAINFILLFYKVTGEAEEEEEDEEHLWEEEDDEN TLFDMDEFVLQESTGYMLPTLRFLAVFHTVISLVCLVGYYCLKVPLVVFKREKEIARKLE FDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDMYGAERIAELLG LDKSALDFDPTVETVEKEASLLSWLSSIDTKYHIWKLGVVLTDNYFLYLIWYTTMSIFGH FNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14565 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaggatgagatccagttcttgagaactgatgatgaggtg gtgctccagagcgtggccaccatccagaaggagcatcgcaagttctgcctggccgcagag ggactcggaaaccgcctgtgttacttggaacccacctctgaagccaagtatgttcctcca gacatgtgcatttgtaactttgtgctggagcagtcgctgtcggtccgcgccctgcaggag atgctggctaacactggagcgagcagcgaagcgaaagccgaccatgaaaaatgggcgggt cagggaggcggacaccggaccctgctctacggtcacgccatcctcttacgtcactccttc agtgacatgtacttgacctgtttgaagacatcaaggtctctgacagacaagctgtcattt gatgtcggactgcaagaagattcagtaggagaagcctgctggtggacgattcatccggcg tccaagcagagatcggaaggagagaaagtccgcattggagatgatctgattctcgtcagc gtgtccactgagagatatctgcatctctcgaactgtaacggcaacattcaggtagacgcc tccttcatgcagaccctctggaacgtccagcctacgtgttcgtcaggcagcatggctgta gggtatttgattggcgggcatgtgatgcgtctctgtcatggtcacgacgagagcttgacc atccctggagcagataagagtgaagaggagcaaagaatagtgaactacgaggcggggaag ggagcatcaagagcccgctccctgtggagactggagcctctcaggatcagctggagcggc agccacattcgatggggccagtctttccgtctgcgccatctctccactggtcactatctg gccttgactgaagaccgtggtttggtcttggaggacagagagaagtgtcacaccaaagcc actgctttttgctttaagccatccaaggaaaaaggcgactctggcatgaagagggatatt gacgggatgggagtacccgagataaagtatggtgactctgtctgttttgtcatgcacgtg gcaactggactgtggctgtcctacctggcgcctgatgccaaatcgtctcgtcttggtccc ctgaaaagaagggcctgccttcactctgagggccacatggatgatggtctcatcctacag cgctgccagcatgaggaatctcgggctgctcgcatcatccgaaacaccacattcctcttc aaaaacttcataaaggcactggacagcgctgcagctggagagacgaatacggtggccgga tatgttgaagaggtgctgcagacgttgaacgatctgattgaatatttcaagcagcccgat gtagatctagagcacgaggaaaaacaggcgaggcttcgctcactcatcaagcaacaagac ctcttcaaggaggagggtatgctggccctgctctccaaatgcattgaccggatgaacctg tacgacagcgcggcccactttggagagatggccggggaggaagctggtgcagcgtggaag gacatcctcaacctcctctatgaactcctggctgcactgattcgtggaaaccggacaaac tgcacccagttctcccgaaacttggactggctggtcagcaaactggaaagaatggagtca tcatcaggaatcttagaagtcctccactgtgtgttggtggaaagcccagaagccctgaac atcattcagaaagctcacattaaatccatcatctctcttctctacaagcacggacgcaac cacaagattctggatgtgctgtgctctctgtgtgtgtgcaacggggtggcagtgagaacc aaccagaatctgatctgtgacaacctgctgccaaaaagggacctgctgctccagacccga ctagtcaacgatgttcaaagtatcaggcccaacatcttcctgggcatcgctgaaggttcg gctcagtataagaagtggtactacgagttggtcatcgaccaggtggaccactttgtgacc ggagagccgacccacctgagggtgggctgggccaacaccaaaggctacgctccgtatccc ggcggaggagagggctggggtggaaacggcgttggggatgacctttactcctacagcttt gatggacttcatctgtggtcaggtcggatccccagagccgtggcctccattaaccagcac ctgctgaactcggatgatgtggtcagttgctgcttggatttgggcgctcccagcatgtcc ttcaggatcaacgggcagccggtgcagggcatgtttgaggactttaacatcgacggattc ttcttccctgtcgtcagcttctctgctggagtgaaagcccgtttcctgcttggtgggcgt cacggagactttaagttcttgccgccagccggttactctccgtgctacgaagcgctcctg cccaaggagaagatgcatgtggagcctgtgaaggattacaagcgggaccatgacggggtc cgtgacctgctgggaaccacccagttcctgtctcaggcctccttcattcccacaccggtt gacaccagccagattgttctgccccctcatctggagaacatccgcgacaagttggcagaa aacatccacgaactttggggaatgaataagatcgaactgggctggacgtatggcaaggtt cgtgacgacaacaagaggcagcacccttgtcttgtggatttcggcaagctgcctgaaact gaaaagaactacaacgtgcagatgtcaagcgaaacactcaaaacgctgttggcactcggc tgccatgttgcccaggttaatgttcacgctgaagaagacctgaagaaaatcaaattacca aaagactacatgatgtctaatggatacaagcctgcgccactggaactttctgacgtgaaa ctgactccaggtcaagaggttctggttgataaactggccgaaaacgcacacaatgtttgg gccaaagacagaatcaaacaaggatggacctatggcatccagcaggatgtgaagagcaga cgtaatcctcgcttggtgccatatgctttattggatgaacgcacaaagaagtctaacaga gacagtctgagagaggccattcggacgatggttggatacggatatgatatcgaccctcca gaccaggaggttgtgcatgcaatagatgatcagagcatcgagacaatccgctttttccgc gtggagcaaacgtacgccgtgaagaccgggaagtggtactttgagtttgaggtcctgagt ggaggcgacatgagggtcggctgggccagaccgggctgcaggcccgacgtggagctggga acggatgaccaggcctacgtctttgatggatacaggggtcgacggatgcatgctggtagc cgttactttgggcatccttggaagaagggcgacgtggttggttgcatgatcaacatggag gacaaatccatgattttcactctgaatggagagctcctgatcaccagcaagggctctgag ctcggctttgctgactttgaaacagaggatggttttattccggtgtgcagtctcgggatg tctcagatcggccgcatgaacctcggcaaggatgccagcacgtttaagtactacaccatg tgtggtctccaggagggttttgagccttttgctgtcaacatgaacagggagataaccatg tggttcagcaagcgcttgcccacctttttcaacgttccccacgaccacatgcacatcgag gttaccaggattgacgggacagtggacagtcccccgtgtcttaaggtcacacacaagacg tttggcacccagaacagcaacagcgacatggtttactgcagactgagcatgccggtggag ttctactctgcagacaggctgctggacgagtcactgaaactcagccaaactcccaaagaa gatggaagtattgactatggaagcatcacaacctattaccattcggtgagagtgtttgcc ggacaggaccccgccaccgtatggatgggctgggtcaccccagactatcactactacagc aagaacttcagtctcagcaagacgcaaaccgtcaccgtcaccctgggagacgagcggggc cgggtccacgagagtattcagaggagcaactgctacatggtgtgtgcagcagatgcactg ggcccgtcttcctccagccgctcaaacaccgacctggaaatcggctgtctggtcgacttg gccaccggcctcgtctccttcaccgccaacggcaaagaactgcctacagcgtatcaggtg gagccaaacaccaagctgttcccggctgtgttttgctgccccaccagttccaacctcttc cagtttgaatttgtcaaaataaaggatgccatgccgctgtcgtcagccatgttcagaagc gagcagcggaacccggttccacagtgtccgccgcgtctagatgtgcaaaccatcgtggcc gtcctctggagccggatgccaaacaccttcctgaacgtggagacggctcgggtcagcgag cggcacggctgggtggtgcagtgtctggaacctctgcagatgattgccgtgcacatacct gaagagaacaggtgtttggacatcatggagttgtcagagcatgaagacctgaggaagttt cactaccacactctgaagttgtactgtgccctctgtgctctgggaaacacgcgtgtggct cacgccctctgcagccacttagaccaatcacagcttctctacaccatcgacaaccagtac ctgtcgggcatgctcagagaaggcttctacgacgtcctcatcagcattcatcttgagacg gcaaaagaggcacggctaatgatgaacaacgaattcattatccctgtgacggatgagacc cggtccatcaagctgttcccggatgaatccaagcggcattctcttcccggagtcggcctg agcacttccctcaaacctcgggtcaacttcgccccggtcggcatcatcagcaccaaacgc caccagttcctctacagcccccagatccccctgggagtcctgaaggagaaagccatcagc atgctgacggaggccgtgcagggaggaggctcccacatccgagacccggtaggcgggagc ctagagtaccagttcgttcccatcctgaagctcatcggaacgctgctcatcatgggagtc ctgaccagcgacgaggtgaggctgattctcctcctcatcgagcccaacgtgtttggggag gccaaggagggagaagaggggagtgggggcgaggtggtggtggcgggagagaaagaggag gtgagcaagaacgaggagaaggctgtggaggcgggagaggaggagaccaaggagagcaaa ccggccgccaaaggtctgctggagaagtccctgccggagtctgtcaaacaccagatgtgc gagctgctgcactacttctgcgactgcgagctgcagcaccgcatcgaggccatcgtctcc ttctccgaccgcttcgtttccaaactgcagtacaaccagaagtttcgctacaacgagctg atgcaggctttcaacatgtccgccgccgtcacggccaagaagaccaaggagttccgctcg ccgccacacgaacagatcaatattctgctgaacttcagtgcaggggaggactgcccttgt cccgaggaggtccaggatgaactctcgtctttccatgaagaattacggctgcattgtgga attcccatggaggaggaggaggcagagcaggacacatcgattaaaggtcggctcctggct ctgctctacaagatcaagggcccccctcagaagacagaagaggagcccacagagacggag caggccgccccgaccaacctgaaggagctgatttctcagactatcaccagctgggcccag gagtcccacatccaggacccggagctggtgagagtcatgttcagcctgttgaggaggcag tatgacggcatcggcgaactgctgcgggccatgaagaagtcgtacaccatcagcgccgcc tcggtgcaggacgccatcaacctgctggtttctctgggtcaaatcaggtcactgctttct gtgcgcatgggcaaggaggaggaaaagctcatgatcgatgggctcggggacatcatgaac aacaaggttttctaccagcatcccaatctgatgagagttttgggaatgcacgagacagtc atggaggtcatggtaaatgtcctgggtggagacaagtcccaggagattgcctttcccaag atggtggccagctgctgtcgatttctgtgctatttctgccgcatcagccgccagaaccag aaggccatgtttgaccacctgagctacctgctggagaacagcagcgttggattggcgtct gaagcgatgcgaggctccactcctctggatgttgcagcatcttcagtgatggacaacaac ggtctggctttggctctggaggaacctgacctggaaaaggtggtgatgtacctggcagga tgcggcctgcagagctgtgccatactggttgccaagggttacccagacctgggctggaac cccatagagggagagcgttacctctcttttctgagatttgtcgtcttctgcaatggtgag agcgtggaggaaaatgctaacgtggtggtgaagctgctgatccgacgtccagagtgcttc ggccccgccctgagaggagaggggggacagggtctgctggctgcgatgaaggaggccatc aagatctctgaggatcccgctctggacctgcccaagagcccggctggagccaccgcgggg tctggtgaagaagaaggagaagttatccacatgggcaacgccatcatgtccttctactcc gccctcatcgacctgctgggacgctgcgctccagagatgcatcttatcaatgcagggaaa ggtgaagcattgcgtatcagagccatcctgcgctctctggttcccacatcagacctggtg ggcatcatcagcatccccctcaagatgcctgtgattaataaagacggatccgtgacagaa cctgacatgtcggcctgcttctgcccggaccacaaggcccccatggtgcttttcctggac agagtttacggcattgaggaccagagtttcctgctgcagatgctggaagtcgggttcctg ccggacctcaaagcctcggcgtctctggacacagaagtactgagcaccacggagacggcg ctggccatgaatcgctacatcggttcggctctgcttcctctgctgacccgctgcgccgct ctgttcggcaacacggagcactacgcgcatttggtcgactccacgctggagaccatctat cggctgtccaaaggtcgctcgctcactaaagcccagcgggatgccatcgaggagtgtttg ctggccatctgcaagcatcttcgtccatccatgatgcagcagctgctcaggcgcctcgtc ttcgacgttcctctgctcactgaatactgcaagatgcctctccggctgctgaccaaccac tatgagcagaactggaagtactactgcctgccgtctgggatgggcggctttggcttggcc tctgaggaagaactgcttctcacaaagaaactcttctggggaatttttgactctctttct cagaagaaatatgattctgaactgtttaaaatggccaagttgtgcctgtgcgccatcgct ggagctttgcctccagactttgtggataccagcttaggggcgacggtggagaaacaggag tcagtggatgcacaaggaaactttgagcccaaacccatcaacactgccaacatctccctt cctgaaaaacttgactacattgctaataagtatgcagaacattcccacgacaagtgggct tcagagaagatgtcggctggctggaaacacggagacagtttggacgagcaggccaaagcc catccactgctgaagccttataaatctttaagtgagaaggagagggagacctaccgctgg cctgtgaaagagtccctgaagagcatgctggcgatgaactggaacattgagaggaccaag gaaggagaagccatgttccagcagcgagagagtgaaaaacagagaaagctttcagaatct cagtctaacggattcagtcctgctccgatggacctgcacaatgtcactctgtcccgagag ttacagactatggtggaagtggttgcagaaaattaccacaacatctgggctaagaagaag aagtcagaacttctgagtaaaggaggagggttggctcacccgctgcttgttccctatgat accttgactgctaaagagaagtacagagacaaagaaaaggcccaagagctcttcaagttc ctgcagataagtggctatgctatcacaagaggtctgaaggacatggagcaggactcgtca tccatggaaaaacgttttgcctacaagttcctaaagaggctgttgaagaatatcgactct gctcaggagtttatcgcccatcttgaggccatggctaccagtgggaaaactgacaagtcc ccccatgaacaggagatcaagttctttgcaaaggttttacttccaatgattgatcagaca tttaagaaccactgcctttacttcctgtccacacccagcaagaacctgagcagctgtggc tgcgcctccaacaaggagaaggagatggttaccagcctgttctgtaagatggcagctctt gttagacacaggatttctctctttggaagtgactctgcgatcatggtgagctgtcttcac atcctgtcccactcactcgacacaaggacagtgatgaaatccggcgcagagctggtcaaa gtcgggttcaaggccttctttgagaacgcggcggaggacttggagaagctggtggagatg ctgaagctggggaagttcatgcagtcgcgcgcgcagatgaagagcgtcactcagagcatc aactatgtgactgtggccctgctgcccatcctcactgccctgtttgaacacatcaggacc cacgagtttgacgtggatctgctcgtggatgatgtgcagctgtcctgctaccgaatcctg atgtgtttctacagcctgggaaccggaaagaatgtctttgtggagaggcatcttccagca attggggagagtctggcgaccttggtgggagcgatgccggtggcgttcctggagcctcat cttaactctcacaacccactttcagttttcaacaccaagacgccccgagagcgagccatc ctgagcatgcccgacacggtggaggagatgtgtccggaaatgcctcgcctcgacaagctg ctcaaggacgtcgacgacgtgtcggagtccggcgctcgctacagtgacatgccacaggtc attgaggtcgtcctccccatgctgtgcaactacttgtcctactggtgggagaaaggcccg gagaactcggcgccggacaccgactgctgcaccatggtgacgtctgaacacctgagcctc attctgggaaacatcctgaagatcctcaacaacaacctgggcattgatgacgctccctgg atgaagaggattgcagtttactcgcagccaatcatctgcaaagctggagctgatttgttg agaacccacttcctgcccacaatggaaaaactaaagaaaaagacggtgaaggttgtgtct gaggaggagctgctgaaggccgacggtaaaggagacaaccaggaagcagagctgctcatc ctggatgagttcgctgtgctctgcagggacctctacgctttctaccccatgctcatccgc tacgtggacaacaacaggtccaggtggctgaaggagccagatgcagactcaactgagctc ttcaggatggtggctgagattttcatcctgtggtgcaaatccaacaacttcaagcgcgag gagcaaaactttgtgattcagaacgagatcaacaatctgggcttcctaaccggggagggc aagtccaagatgtccaagtccggtggggaccaggagcggaaacataaacgccgccgcggt gaatattactccatccagacgtctctgatcgtagctgcactcaagaagctgctgcctatc ggcctgaacatgtgcacaccgggagaccaggagctcatctcattagcaaagatacgctac agcctgaaagacacggacgacgaggtgaaggagtatttgcgtcagaacctccacctgcag gaaaagtctgatgatccagcagttcactggcagctgaacctttataaagacgtagtggtg aaatcggaggagccgtcggattcggagcacacggtggagagaatccagagcatctctgca gcagtcttcaatttggagcaggtggaacagcctctgaggaacaagaagtgcatcgtccag aagctgctgtccaagcagcgtaagcgggccgtcgtcgcttgtttccgcatggctccgctc tacaatttacccaggcatcgcgctatcaacttcttcatcccggcctatgagagactttgg atagaggcagaagagtactcctttgaggaaaagctagttcaggacctggcaaaaaccccg atgaagatcgtggaggaagaggaggaagaggtggctgagatcaagccggacccgctccac cagctcatcctccacttcagccacaacgctctgacagagagaagccacctggaagtagat cctttatacatcgcgtatgcagacatgatggccaagagctgtgcagaggatgaagaggaa gaggaagaagaagggcgggaaaagacattcgaggaaaaggagatggaaaagcagaagatc ctgtaccagcaggcgaggctgcacgctcgtggggctgcagaaatggtgctgcagatgatc agcgccagcaaaggtcgtctgggcaccatggtgacctacaccctcaaactgggcatctcc atcctaaatggaggcaacgtgcaagttcaacagaaaatgcttggttacttgacggacaaa agagacgcaggctttttcaagagtctgtcaggactgatgcagtcttgcagtgtcttggac ctgaatgcatttgagaggcagaacaaggcagaaggacttggcatggtgacggaagaaggc tcaatccacactcagcggggctccaaggtgcttcagaacgacgaattcaccaaagatctg ttccgctttttgcaacttctctgtgagggccacaacggagatttccaaaacttcctgaga acccaaactgggaacacgaccacagtgaacatcatcatcagcactgtggactacctgctc cgcctccaggaatcaatcagtgatttttattggtattattctgggaaagatgtgattgat gaaactgggaagcacaacttctccaaagctttatctgtagccaagcagatatttaactcg ctcactgagtacattcaggggccttgcattggaaaccagcagagtttagctcacagcaga ctgtgggatgcagtcgttggcttcctgcatgtgtttgcaaacatgcaaatgaagctttca caggatgccagtcagattgagttgttgaaggaactgatggatttacagaaggacatggtt gtcatgttgctgtctctccttgagggaaacgtggtgaacgggacaatcgggaagcagatg gtcgacaccctggtggagtcctccagtaacgtggagatgatcctaaaattcttcgacatg ttcctcaaactaaaagacctcacgacgtccgacaactttagggagtacgacccggaattc aaaggaatcatttccaaaaaggagttccagaagtcgatggagagccagaagcagtacaac cagtcagaaatcgaattcctgctgtcgtgcgcggaggccgatgagaacgacatgttcaac tacaaggagtttgtggagcgattccacgagcctgccaaggacatcggcttcaacgtggcc gtgctgctgaccaacctgtccgaacacatgccccacgacgcccggctcaacaccttcctg gacctggccgaaagcgtcctcagctacttcgagccttacctgggccgcatcgagatctta ggcagcgcaaagcgaatcgaacgcgtttacttcgagatcagcgagtcgagccgcgagcag tgggaaaagccgcaggtgaaggagtcgaagcgccagttcatcttcgacgtggtgaacgag ggaggagagagcgagaagatggagatgtttgtgaacttctgcgaggacaccatctttgag atgcagctggcctcgcagatctctgagccggacgccgtggagcagccagaggaggaggag gaggaagaggggcacagcatcctggaggagctcgctgggggagaagatggcgccccggag tctgcctcggcgttcaccaccgcctgtcgttcggtcaagaagaacctttcagaaatccgg cagattttcaccattaaaaccgcgcgcaagcagtacaagaaaatcaagaagctgagcatc aaggaactgatcaccggcttcttctccttcttgtggatgatctttattggcttctttaag gggattttcagcctcgttttcggtttctttcacgtcatctggtcgtccatgttcggcgga gggcttgttgaaggagccaagaacataaaggtgacggatatcctgggcaacatgccggac ccaacgcagttcggcatccacggggacgtgggagaaggagacaaagtggaagccatggag tcgtcgggcagcttggacaaagccatggctcctgcaggagacgccacagaggtggacgtg atgctggagttgctgacgccgaaaaaggaaggaggaaaacacgtggagcccggcctgggg gacgtgtcagagctgagcggggagtcctccactgcagacagtaaaaagaaagccgctgcc aagacagctgcgccctctgagagcgagacagaaaaggcggacacagagacccgggagaag gaggacaaaccaaaggaggaggaggcgaaggaaccagctgtggaggagaaacccaaatcc agatccagtcagcccaaagaggcgtctccggccttcatgtcaaccatcttcgccattctt gacgtctacctgaataagatactgaactacctggctcgtaacttctacaacctccgtttc ctggctctgtttgtttgcttcgccatcaacttcatcctgctcttctacaaggtcactggt gaagctgaggaagaagaggaagacgaggagcacctttgggaggaggaggatgacgagaac acgctgttcgacatggacgagtttgtgctgcaggagagcaccgggtacatgctgccgacg ctgcgcttcctggccgtgttccacaccgtcatctcgctggtctgcctggtcggctactac tgcctgaaggttcctctggtggtgttcaagagggagaaggagatcgccaggaagctggag ttcgacggtttgtacatcactgagcagccgtccgacgatgacatcaagggccagtgggat cgactcgtcatcaacacgccatctttccccaacaactactgggacaagtttattaaacgc aaggtgatcaacaaatatggcgacatgtatggagctgagcgcatcgctgagcttttgggt ctggataagagcgctctggactttgaccccactgtggagactgtggagaaggaagcgtcc ctgctgtcctggttgagctctattgacacaaagtaccacatctggaaactgggagtggtt ttgactgacaattacttcctgtatctgatctggtataccaccatgtccatctttggacac ttcaacaacttcttcttcgctgctcatctgttggacatcgccatgggcttcaagacgctt cgcaccatcctgtcgtccgtcactcacaatggcaagcagcttgtactgaccgtcggtctg ctggccgtggtcgtctacctctacactgtggtggccttcaacttcttcagaaagttctac aataagagcgaggacgaagacgagcccgacatgaagtgtgacgacatgatgacgtgctac ttgttccacatgtatgtgggcgtgagagccggcgggggcatcggagacgagctggaggac ccggctggagatccctacgaactctaccgcatcttgtttgacatcaccttcttcttcttc gtcatcgtcatcctgctagccatcatccagggtttgatcatcgacgcctttggggagctg agagaccagcaagagcaggttaaggaggacatggagaccaaatgcttcatctgcggcatt gggaacgactactttgatcgaacgcctcacgggtttgaaactcacaccctacaagagcac aacctggccaactacctgttcttcctgatgtacctaatcaacaaggatgagactgaacac acgggtcaggagtcgtacgtgtggaagatgtaccaggagagatgctgggacttcttccct gccggagactgcttccgtaaacaatacgaggaccagctgggttag

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