Gambusia affinis (western mosquitofish): 122842118 Help Entry 122842118         CDS       T07758                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gaf  Gambusia affinis (western mosquitofish) Pathway gaf04020   Calcium signaling pathway gaf04260   Cardiac muscle contraction gaf04261   Adrenergic signaling in cardiomyocytes gaf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gaf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122842118 (ryr2b)    04020 Calcium signaling pathway     122842118 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     122842118 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     122842118 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gaf04040]     122842118 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:gaf04990]     122842118 (ryr2b) Ion channels [BR:gaf04040]  Voltage-gated cation channels   Ryanodine receptor    122842118 (ryr2b) Domain-containing proteins not elsewhere classified [BR:gaf04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122842118 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 Motif Other DBs NCBI-GeneID:  122842118 NCBI-ProteinID:  XP_043991636 LinkDB All DBs Position LG13:9646255..9718828 Genome browser AA seq 4962 aa AA seqDB search MLTSSLLRCDLFQFQKMTATGEGEDEGQFLRTGDEVVLQSTFTSHNKHLKLCLAAEGFGS RLCRLEPTSNCKNVPPDLSVCGFVLAQCLSVRALQEMLAHSEQLAAEAKAGVAHRTLLYG QAVMFTHSFSGMYLSCLSSSQTSPDKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVR VGDDLILVSVSSERYLHLSFGTVSDNKSLSDGLIVSASFQQTLWRVAPICSGGAIAQGYL KGGETLRLLHSHSDACLTIPCSEQGEELQRVMHYEIGSVSGHGRSLWRLEILRVAWSGRH TCWGEPFRLCHVTTGRYLGLMEEKGLHLVDRDKADVKTTSFCFRSSKEKLDAGKNTNTDC MGIPEIKYGDSICYLQHLYSGLWLTYQATDAKCRLGGNLRKAILHSEGHMDDGLTLSRSQ REESHTAGLIRNTVSLFTHIIRKLDGFSHEGSLSSLCLPMKTVTCSLQDLIKYFQSPLDG QSHEDKQKNMAALRKRQNMFKEEGVIDLVLDCIDRLHHYSSDSCITDATQWEAVVYLFYE LLADLIRGNRVNCAHFSSSVDWLIGRLDHLEASSGVLEVLHCVLVESPEAINVIKDGHIQ SIISFLEKYGHNNKVLEVLCSLCVCHGVAVRSNQNLICDSLLPDRDLLLQTRLTNQVASM RANIFLAMGESSAQHRRWYYELVVDHTDPFLTAEPTHLRVGWAFTKGYLPMPTGGEGWGG NGVGDDLYSFGFDGLHLWSGCVGRKVSSPFSHLLKDNDVVSCCLDLTVPCISFRVNGLPV QGMLENFNANGLLYPVVSFSAGVRVRFLFGGGHGEFRFLPPPGYASCSEALLPKVKLRVE PCQKYISDCEEGKKELIGPSVPVTPVTFTPTPVDISKIALPPQLEDLREKMAENFHELWV KDRIDLGWTNGPVKDEGKQHDPCLVEFSKLPEQERNQNLQMAEDILKTVLALGFHIVLAD GHAEERIKYMRLHTKYELPCGYRPAPIDLRQIALSSADKDVVTLLAENHHNIWAREYIKQ GWTYGPEQDIKRKRSPHLVPYSLVDERMRKAGMESVREAVRLLLAFGYSLESLSQEQTPL SKPCLFSVEKSRVFRPDKSYAVTMGKWYFEFEVLTAGNMRVGWARPGCTPDKELGSDDQA YVFDGFEAQWCHQGGEPLGRRWLRGDVVGCLVDMFEGTMMVTLNGELLFNDRGSELAAKY LDIRDGLLPVVSVGVNQVGRMNLGRQVESLQYFNVCGQQEGYKPFAFNMTRDPPLWMSWK LPQFTSVLPDDHSLQVTRHRGSMDSLSSLRVSQRVLVQHGGGSEMGFYRLSMPIQCAATL RSPAEGGLQVPSSSLSPSSVRKELEDTDSDFEVLMKSARSFAGSRDELDHKDHSHDKTSK LKQRFMMKRSKPGLVSSNSSARLLEDVIVEKDNYDHLIQSSRYYYAVRILPGQEPFNVWI GWVTSDFHQHGSTFDSDNVGTVTVTLGDDSGKVQESVKRSNCFMVCAGEATGLSQSRRSA GLEIGCLIDTVAGLLTFTSNGIEMSTFFQLEAGTKLFPAVFVKPTTSNMFQFELESIKNA LPLSSALLRSQRRNQSPQCLPRFQVQYLKPVTWTRVPDSGLKVFVDWPDEHHGWRVQCFD PQQVMTLQIPDENKCVDILELSELDDLLAFHQNILLLYCSLCALGNTRVCHALCSHVDQS QILYAIQNPYLPGPLRLAYYQLFIQVYLSSHTTACLTMNHEYIIPLTDQTGEASFYLSPV NGVSDGGDSQTPEGTCRSTCLKPQMRFSSPCFVRGDGTEAEGAVEIACPDSPEIPLDTLR NLTADMLTAGVVAVGQAMRDPAGGSVELLLVPLLRLLYNLLVMGVFEDEDLVRVLRLIEP NVFSKNVKTVEEAKDGKQLGKSINKKDDDAIKQGLLQMELPEPVQLELCHLLSYLCDCQV RHRVEAVTAFSGNFVRQLQENQRFRYTEVMQALNMSAALTARKTKEFRLPPQEQINLLLS FREDEQQENCPCPVELQQLLRDFHHHLNTHCGTETVPDSEEEDDTKMSLKDWLFSRAAKA VGLKKKPTEVEKYKSSSLKSLRRLISEVMVCWAQEREIEDPGLVRAIFTLLYRQYQGLEG RMEGSLSKAYAISQSSVEDTMALLSSLGQIRSLLSVRMGKEEEKLMNRRLGDIMNNKVFY QHPNLMRALGMHETVMEVMVNVLGEGESKEITFPKMVASCCRFLCYFCRISRHNQGALFD HLTYLLENSRVGLASPSMRGSTPLDVAAASVMDNNELALSLKEADLEKVVQYLAGCGLQS CSLLLAKGYTDIGWNPVEGERYVDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALR GDGGDGLLAAMKEAISISQDPSMDGPFPSRTTNAVHSNEDDLIHMGHAIMTFYSALIDLL GRCAPEMHLIQGGKGEAIRIRAILRSLIPVQDLEGVISICFQLPSVSEDGVLVEPDLSTV FCPDHKAAMVLFLDRVYGVESQSFLLHLLEVGFLPDLQAAVSLDTTDLGSTDMALALNRY LCTAVLPLLTKCSALFHDLEDHALLVDSVIQTIYRLSRALSLTRAQRDTTDDCLLALCRK LKPSMMQPLLQRLVFDVLQLSDHSKLPLKMLTSHYEQMWKYYSHTGSQDKQKLASEGELQ LSRKLFWGVFKALTKKSFIPQLLSLCVQCLVAVAKALPPDYVEPGCLSQVDRITSVDTDG YFEPQPVDTSNVSVPETLDFVVNKYAEHTHEKWSLEKFASGWVHGDQLCENTKVHPLLKP YRALAEKEKDSYRWAIKETIKSMLAFGWTIERTKEGDAFGIHACVHTVSQAGQLSFEGAS TFSPKPLDMSSITLSWEQCAMAEQLGENYHNAWAKTKKLELESRGGGHSMLVPYDALTAK EKTKFREKAQEILKFFLLHGYTVWRDRKSVEIDFPPSANCFGHIFLQRMLYYTEETQENM LKLEVIQARGQMPKGERAQNQQPIIFFQKVVLPLLEQYVKRHRLYFLSSSLNSSESRSHS SKREKEMVLCLFCKLADLVRHRISLIGDEASAVTSCLRILAQALDARILTAAASESIQTS LHSFFEAAAADLEMTVGKISETLPHSRGQLSKGVVNTLNYATSILMPTLTSLFHHLANQN YGVDVLVGGIQVSCFKILNSLYSLGTSQSFYMEGQRSAAGACVAALTGAFPVCFLEPTLD HSNPHSIYNVMSPTEIKDQGLPDRMEDTCRPFPSLGEALENVEELAAAGSVAHQMQYIHV AEVTLPMLCSYISHWCRWGPEGHPEGLSSVVPQHASDLIGHILRIIHNHVGASQGDWMKQ LAVFSQPIICKADSELLRSHFLPLMEKLRKRAECVQLEEEVMKAEDCCSSEAELQIQEKY RVLVQDLYAFYPLLIQFVDFNRARWLKETIPEAEQLFSMVAEVFVFWAKSHHFKWEEQSY VVQNRINNLAFLLSGDNMLEFDHIKKGMKMKGDRYSAHTSLIVATIKKLVPVGLRVCFPC DQNLIMLVKNRYSQNNLEDEIREHILRYLKNVFGQASNRVSHGILSADLPAQLEAPADTQ RTVNRVLEIARVLYYLDQVEHPQRSKKPAWNNVLSKQRRRAVVACLRMTPLYNLPLHRAV NLFLQGYNRSWISTEGNNLVEMLVEDLAKGRVTKPWEGEEGKVKEVEEGAKSIDPLLQLI MLFSRSALTESSKLDNDNLYKDYAAIMAKSCRRESQDDAEHEVESFEEKEMEKQKLLYQQ ARLHCRGAPEMVLQAISASSGAMGFMIGPTLKLGIALLNGGNATVQQKMLDYLREKRNVG FFQSMAGHMRSCSVLDLNAFERQNKAEGLGMATDDSSGEKVMPDKDLTCDLFRFLQLLCE GHNSDFQNYLRTQTGNNTTVNIVISTVDYLLRVQESISDFYWYYSGKEVIDPLGQHNFSK AIEVAKQVFNTLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSKQIKLL KELMDLLKDMVVFLLSMLEGNVINGTIGKQMVDMLVESSGNVEMVLKFFDMFLKLKDLTS SEGFREYDPDCKGSICRKDFQKAMENCKYFSQAEIHFLLSCIETNDSEILEYETFVDRFH EPAKDIGFSIAVLLTNLSEHMPKESRLKAFMELAECVLTYFQPSLGRIEIFGSGKRFERV YFEISEYSRTQWEKPQVKESKRQFIFDVVNKGGDKEKMEMFVNFCEDTIFEMQLAAQISG SNSGEMCNGKTELEKSELEEYTSPDHKTWTFIYYWWVMLTCALSVKNLRTLMRMTPKDFL LAAVRFIRFICVLQIHCISAVICHIMYLLYITFVNSGLIEAAKRMKVSDLLGGILEPTLD EVIGVSSTVDQLRTHSASFSSQKELREIRQMASLTFPKEVDILSDIFGLKLKKEGDQYRL VTQDLSDSLTDLFSSTSRTIIDPDVSEEHHTLQFTDHLDKETTEDGKMENLQEKEWKKTE EERRNAKEEKKHRSKKGSHRSKEPQRQHSALWETISSHSKTLLNCFARNFYSMRLLALFV AFAINFILLFYKVAFLPASKEEQVTTSAYGKELLSAMTNTSNGRVYFVLEESSGYMELCL HFLSIAHTIISFCCIIGYYCLKVPLVIFKREKEVARRLEFDGLYVAQQPPEEDIKGQWDR LVINTLSFPSNYWDKFVKRKVMDKYGDFYGRKKISGLLGLDQAALDFSTKRKEQKRLRRD SAWSVLNAVCSRFNSLDAKYQVWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLD IAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVIAFNFFRKFYKHSIGKETEEMK CNDMLTCYMFHMYVGVRAGGGIGDEIQDPAGDEFEVERIVFDITFFFFVIVILLAIIQGL IIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDKIPHGFETHTLQEHNLANYLFFLMYL INKDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQSEDQLG NT seq 14889 nt NT seq  +upstreamnt  +downstreamnt atgttgacatcgagtctccttagatgtgacctatttcagtttcaaaaaatgaccgccaca ggagagggtgaagatgagggacagtttttacgaacgggagatgaggtggttttgcagagc acctttacctcccataacaaacatttgaagctctgtcttgctgctgaaggatttggcagc aggctttgcaggcttgagcccacttcaaactgcaagaatgttcctccagacttgtctgtg tgtggcttcgtcctggctcagtgtctctctgttcgagccctgcaggagatgctggcccac agtgagcaactggcagcagaggcaaaagctggagttgcccatcgcactctgctgtacggc caggcagtgatgttcacacactccttcagtggcatgtatcttagttgcttgtcttcgtct cagacgtcccctgacaagttggcgtttgacgtgggtctgcaagaggacaaagcaggagag gcatgttggtggactgtccatccggcttccaggcagaggtcagagggcgagaaggtgcgt gtcggagatgacctcatactggtcagtgtctcctctgagagatatctgcatctgtccttt ggcactgtatctgacaacaaaagcctgagcgacggtctgattgtcagtgcctccttccag cagactctttggcgtgttgctcccatttgctctggaggtgccattgctcaaggctatcta aaggggggagaaacattgcgcctgctccacagccacagtgatgcttgtctgactattcct tgttcagagcagggagaggagcttcaaagagtgatgcattatgagattggatcagtgtct ggtcatggacggtccctctggaggctggaaattctgcgtgttgcgtggagtgggaggcac acatgttggggcgagccttttcgcctgtgccacgtaacaacggggaggtacctgggtctg atggaggaaaaaggattgcatctagtagatcgggacaaggccgacgtcaagacaacctcc ttctgcttccgatcatcaaaggagaaactcgatgctggcaaaaacacaaatactgattgc atgggaatcccagaaatcaagtatggagactcgatttgttaccttcagcatctgtactca ggactgtggctaacctatcaagctacagatgccaaatgccgcctgggtggaaatctgcgc aaggccattttgcacagcgagggtcacatggacgatggactgacattatctcgctctcag agagaagaatctcacaccgctggactcatccggaacactgtttctttatttactcacatt ataaggaaactcgacggttttagtcatgaaggaagcctttcctcactctgtctgccaatg aagacggtaacctgcagcctccaagatctcatcaagtacttccagtctccacttgatggg caaagccatgaagataaacagaaaaacatggctgctcttaggaagcgccagaatatgttt aaagaagagggtgtaatagatctggtcttagactgcattgatcgtctgcaccactacagt agtgattcttgtataaccgatgctactcagtgggaggccgtcgtctacttgttctacgag ttacttgctgatttgatccgtgggaaccgtgtaaactgtgctcatttctcgagctccgtg gactggctcataggcagactggaccatctagaagcatcttctggagtcttggaagttctg cactgtgttcttgtagagagtcctgaggcaattaatgtcataaaagatggacacattcaa tctattatctcgtttctggaaaagtatggacacaacaacaaggtgctggaggttctgtgc tcactgtgtgtgtgccatggtgtggcggtgcgctccaatcagaacctcatctgtgacagc ttgctgccagacagagatttgctacttcagacgcgactgactaatcaggtcgccagcatg agagcaaacatcttcctggccatgggagagtcctcggctcagcatcggaggtggtactat gagttggtcgttgatcacactgacccgtttctcacggctgaaccgacacacctgcgtgtt ggctgggccttcaccaaaggctacctgcccatgcccacaggaggagagggctgggggggc aatggggttggagatgacctctattcgtttggctttgatgggctacacctgtggtcaggt tgtgtgggccgtaaagtcagttcccccttctctcatctgctgaaagataatgatgtggtt agctgctgtctcgacctcacggttccatgcatctccttccgggtcaacggtctgccggtg cagggcatgctggagaacttcaatgctaatggacttctgtatcctgtggtcagcttctca gctggagtcagggttcgttttctgtttggcgggggacatggagagtttcgcttcctgccc ccaccaggctatgcttcatgctctgaggctttgctccccaaagtcaaactgagggtagag ccgtgtcagaaatacatctcggactgtgaagagggaaaaaaagagctcattggcccctcg gtgccagtcactccagttaccttcacccccactccagtagacatcagcaagattgcgtta cctccacaacttgaagacctccgagaaaaaatggcagaaaattttcatgaactctgggtg aaggatagaattgacctcggatggacaaatggaccagtgaaagacgaagggaagcaacac gacccttgtctcgtggagttctccaagcttccggagcaggagagaaaccagaaccttcaa atggctgaggacatacttaagacggttcttgcccttggtttccacattgttttggcagat ggccacgctgaggaacgcatcaaatacatgagactacacacaaagtatgagttgccctgc ggctacaggcctgcaccaatagatttaagacaaattgctctcagttcagctgacaaggat gtggttaccctgttggcagaaaaccatcataatatctgggccagagagtacatcaaacag ggatggacctatggacctgagcaggatataaagaggaaacggagtcctcatctcgtgcct tacagccttgttgatgaaaggatgaggaaagcaggcatggagagcgtaagagaggccgtc cgtctcctgttggcatttggctacagcctggagtctctaagccaggaacagactccttta tcaaagccatgcctcttctctgtggagaagagcagagtgttcagaccagataaatcctac gcggtgaccatggggaagtggtattttgaatttgaagtactgacagccgggaacatgaga gtgggctgggcccgaccaggctgtactccagataaagagctcggctcagatgaccaggct tatgtctttgatgggtttgaggctcagtggtgccatcagggcggtgagcccctgggacgg cgctggctcagaggcgatgtggtgggttgcctggtggacatgttcgaaggcaccatgatg gtcacgctcaatggagagctactgtttaatgacagaggatcagagctggctgccaagtat ttggatatcagagatggcctgttgcctgtggtcagtgttggggtaaaccaggtggggagg atgaatctgggccgccaggtggagtctctgcagtactttaatgtgtgtggacagcaagag ggttataaaccctttgcttttaatatgaccagagacccacctctgtggatgagttggaaa ctgccccagtttacttcagttctgcctgatgatcacagcttacaggttactcggcatagg ggctcaatggattccttatccagcctgagggtctctcagcgggtgttggtgcaacatggt ggaggaagtgagatgggcttttaccggctcagcatgcccatccaatgtgctgccacactc agaagccctgcagagggggggcttcaagtcccctccagctctctaagtccaagttcagtg aggaaggaactggaggacacagactctgactttgaagttctgatgaagtcagcacgcagc tttgccggctcaagagatgagctcgatcacaaggatcacagtcatgacaaaacatctaaa ctgaaacagcggttcatgatgaaaaggagtaaaccaggcttagtcagcagcaactcctct gcacggcttctagaagacgttattgttgaaaaggataactacgatcaccttatccagagc tccagatattattatgcagtgaggattcttcctggccaggagccgttcaatgtgtggata ggctgggtgacctctgactttcatcagcatggctcaacgtttgactctgacaacgttggc acagtaactgtcaccctcggcgacgacagtggcaaagttcaagaaagcgtgaagcgaagc aactgtttcatggtttgtgctggagaagctacgggcttgtctcagagtcgtcggagtgcg gggttggaaattggctgcttgattgatacagtggccggacttctcactttcacttctaat ggcattgagatgtcgacttttttccaactggaggctggtaccaagctgtttccggctgtt tttgtcaagcccaccaccagcaacatgttccagttcgaactggaaagcatcaagaatgcc ttgcctttgtcatcagctttgcttcgcagtcagagaaggaatcagagtcctcagtgcctt ccaaggtttcaggttcagtatctgaaaccagtcacatggacaagggtaccagacagcgga ttaaaggtgtttgttgattggcctgatgaacaccacggctggagagtccaatgctttgac ccccaacaagtgatgacccttcagattcctgatgaaaacaaatgtgttgacattttggag ctgtccgagctcgacgacctcctcgcttttcatcaaaatatcctcctgctctactgctcg ctctgtgccctgggtaacaccagagtttgccacgctctctgcagtcacgttgaccagtcg cagatcctttatgctattcagaatccttacctcccggggccgctccgcttggcatattat cagctgtttattcaggtgtacctaagcagtcacaccacagcgtgcctcacgatgaaccat gaatacatcatcccattgacggaccagaccggagaagcctcattttatcttagccctgtc aatggcgtttcagatggaggggatagtcaaacaccagagggcacttgtagaagcacatgc cttaaaccacagatgcgtttttcatctccttgttttgtcaggggtgatgggacggaagca gaaggtgcagttgaaatagcctgcccagacagcccggaaatccctctggacacactgaga aatttgacagcggacatgctgactgccggggttgtggctgtcggtcaagcaatgagggat cccgcgggaggcagtgttgaactgttgctcgtaccccttttaagattgctgtacaacctt ctggtcatgggggtgtttgaggatgaagaccttgtgagggtgctcaggctaattgaacca aatgtcttctccaaaaatgtcaaaaccgttgaggaagccaaggatggaaaacaactggga aaaagcatcaacaaaaaagatgatgatgccattaaacaaggacttcttcaaatggagctt ccagagcctgtccaactagagctctgtcatctgttgtcctacctgtgtgactgccaggta cgacacagggtcgaagcagtgactgcgttctctggtaactttgtgcgtcagctgcaggag aaccagcgatttcgctacactgaggtcatgcaggcactcaacatgtctgcagcactgacc gctcgcaaaaccaaggagttccgacttcctccgcaagagcagatcaatttgctgctgagc ttcagagaagatgagcaacaggagaactgtccgtgtccggttgaactccaacagctcctg cgcgactttcatcaccacctcaacacacactgtggcactgaaacggtcccagactctgag gaggaagatgataccaagatgtctttgaaagattggctattcagtcgagcagcaaaagca gttggacttaaaaagaaacccactgaagtggagaaatataaatcatccagtctcaagtca ctcagaaggctgatatctgaggtgatggtgtgctgggctcaggagagagagatagaagac cctgggctggtcagggctatcttcaccttgctataccgccagtatcagggcctcgagggc cgaatggaagggtcactctcaaaggcatacgctatcagccagtcttccgtggaggacacc atggcactcctgtcgtctctgggccaaattcgttctctcctgagtgtccgcatggggaaa gaagaagagaagctgatgaacagaagactaggagatattatgaataataaagttttctac caacatcccaatttaatgagagctttgggcatgcatgagacagtgatggaggtgatggtc aatgttctgggagaaggggagtctaaggagattacctttcccaagatggtagccagttgc tgtcgattcctctgctacttttgtcggatcagtcgtcacaatcagggagcgctgttcgac cacctcacatacttactggaaaacagcagagttgggctagcttctccgtccatgcgtggc tccactcctcttgatgtggcagcagcctctgttatggataataacgagctggctttatca ctaaaggaagctgacctagagaaggttgttcagtaccttgctgggtgtggtctccagagc tgttctctgctactggcaaaaggctacactgatattggctggaaccccgtggagggagaa cgctatgtggactttctacggtttgctgtgttctgcaatggcgagagtgtagaggagaat gcatatgtggttttgaggttgctgatccgtcggcctgagtgctttggccctgcactgaga ggcgacgggggagacgggctgctagccgccatgaaggaagccatcagcatctctcaggac ccatctatggacggacctttccccagcagaacaacgaatgcagtccacagcaatgaggat gaccttattcacatggggcacgccatcatgaccttctactcggcacttattgacttactg ggacgctgtgctccagagatgcatttaattcagggcggcaaaggagaagccattcgcatc agggccatcctgagatctctcatcccagtacaggatcttgaaggagtcatcagcatctgc tttcaactcccatccgtgtcagaagatggtgtgttggtggagcctgacctgtccacagtt ttctgtcctgaccacaaggcagccatggttttattcctggatcgcgtttatggtgtggag agtcaaagttttcttctgcacctcctggaagttggctttctgcctgatcttcaggcagct gtttctcttgacactactgacctgggatctactgacatggctcttgccctcaatagatac ttgtgcacagctgtccttcccctgctcaccaaatgttcagccctctttcacgatctagag gatcatgccttgctcgtagattctgtcatccagacaatctaccggctctcaagggctcta agcttgaccagggctcagagagacaccacagacgattgtttgctggctttgtgcaggaaa ctcaagccatctatgatgcagcctctccttcaaaggcttgtgtttgatgttctccagctc tcagatcacagcaaattgcccctgaaaatgttgaccagtcattatgagcagatgtggaag tattactcccacaccggaagtcaggataaacaaaagttagcctctgaaggggagctccag ctgtctaggaagttattctggggtgtgtttaaggccttgacaaaaaagtccttcattcct cagctgctaagtttgtgcgtgcagtgtcttgttgcagttgccaaagccttgcctcctgac tatgtggagcctggctgtttgtctcaagtggacagaataacctcggtggacacagatgga tattttgagccgcaacctgtagatacatcaaatgtctctgtgcctgagacactggacttt gtagttaacaagtacgcagagcacactcatgagaagtggtctctagaaaagtttgccagt ggctgggtacatggcgatcagctgtgtgaaaacaccaaggtccaccctctcctgaagcca tacagggctctggctgaaaaggagaaggattcatatcgctgggccataaaagagacaata aagagcatgttggcctttggatggaccatagaacgtaccaaagaaggagatgcatttggc attcatgcctgtgttcacacggtttctcaggctggtcagctctcatttgaaggagcatcc acctttagccctaaacctttggacatgagcagcatcaccttatcatgggaacagtgtgca atggccgaacagttgggtgaaaactatcataatgcctgggccaagactaagaagttagaa cttgagagcagaggtggaggtcattcgatgctggttccatacgacgctctgactgccaag gagaagaccaagttcagagaaaaagctcaggagatactgaagttttttttgctccatggc tacactgtgtggagagatcgaaaatctgtggaaattgacttccctccttctgcaaactgc tttggacatatttttctccaacgaatgctgtattacactgaggagactcaggagaacatg ctaaagctcgaggtgattcaagccagaggacagatgcctaaaggagaaagggctcaaaat cagcagccaataattttttttcagaaggtcgttcttccactattggagcagtatgtaaaa aggcatcgtctgtattttttgtcctcttctctgaactcaagtgaaagcagaagtcattcc tccaaaagggaaaaggagatggttctatgtctcttctgtaagcttgctgatttggtaaga cacagaatctcactaattggagacgaagcatctgccgttacaagctgcctccgcattctg gctcaggcgcttgatgcaagaatattgacggcagcagcttcagagtccatacagacgtct ctgcattcattttttgaagcagctgcagcagatttggagatgactgtggggaaaatatcg gagaccttgcctcacagcagaggtcagctgtctaaaggagttgtcaacacccttaactat gcaacgtccatcctaatgccaacacttacctccctcttccatcatcttgccaatcaaaac tacggagtggatgttctggtcggtggtatccaggtgtcatgtttcaagattttaaacagc ctctactctctggggaccagtcaaagcttctacatggaggggcagaggtcagcagcaggc gcatgtgtagcagctctgaccggagcttttcctgtatgcttcctggagccaactctagac cacagcaatccccattctatctacaatgtcatgagtcccaccgagattaaagatcagggt ctgccggaccggatggaggacacgtgtcgcccttttccttcactgggagaggcgctggag aacgtggaggagctggctgctgctggttctgtagctcatcaaatgcagtacatccatgtg gcagaggtcaccttgcccatgttgtgcagctatatttcacactggtgtcgctggggccct gagggacacccagagggcctcagctctgttgttcctcagcatgcgagcgacctgattggc cacatccttcgtatcatccacaaccatgtcggcgctagccagggtgactggatgaaacag cttgcagttttttcgcagccgatcatatgcaaagccgacagcgagctgctgagaagtcac tttctccccctgatggagaagctgaggaagcgggcagagtgtgtccagttagaagaggaa gtgatgaaagcagaagactgctgtagttctgaagcagagctgcagatacaggagaagtac agggttctggtccaggatctctacgccttttatcctcttctcatccagtttgtggatttt aatcgagccagatggctgaaagagacgatccccgaggctgagcagctgttcagcatggtg gcagaggtctttgtattctgggccaaatctcatcatttcaaatgggaagagcagagttat gtggtccagaatcgaatcaacaatttggcttttttgctctctggtgacaacatgctggag tttgaccatataaagaaaggcatgaagatgaagggggatcgttactctgcacacacgtct ctcatagtggctaccataaagaagttggttcctgtgggactcagagtttgttttccatgt gaccagaaccttatcatgttggtgaagaaccgctattctcagaataaccttgaagatgag attcgggagcatattttgagatacctcaaaaatgtttttggtcaggcatcaaacagagtc agccatgggattctgtctgccgatctcccagcacagcttgaggccccagctgacacacaa aggactgtgaacagggttctagaaatagctcgggtgctttattacctggatcaggtagag cacccacagagaagcaaaaaacctgcttggaacaacgttttatccaaacaaagaagacgt gcggtggtggcttgcctgaggatgactcctctctacaatttgccactgcatcgagctgtc aaccttttcctgcaaggttacaacagatcttggatatcaacagagggaaacaacttggta gaaatgcttgtggaggatttagctaaggggcgagtgacaaaaccgtgggaaggtgaggaa gggaaagtaaaggaggtggaagaaggtgccaagtcaattgatcctctccttcagctcatt atgctcttcagtcgaagtgcgctgacggaaagcagcaaacttgataatgacaacctctac aaagattatgctgctattatggccaagagctgccgcagagaaagccaagatgatgcggag cacgaagtagaaagctttgaagagaaggagatggaaaagcaaaagctgttgtaccaacag gccaggctgcattgtcgtggagcccctgaaatggtcctgcaagctattagcgccagtagt ggcgctatgggattcatgattggtcctactctgaaactaggtattgctcttcttaatgga gggaatgcaacagttcagcagaaaatgctggattatctaagagagaagcgcaatgttggc ttttttcagagcatggctggacacatgcggtcatgtagtgttctggatttgaatgcattt gagaggcagaacaaagcagagggattaggcatggccacggatgacagctcaggagagaag gtgatgcctgacaaggacctgacttgtgaccttttccgtttcctgcagctgctctgcgaa ggacacaattctgatttccagaactatttaagaacacaaactgggaacaacaccactgtc aacattgttatatcaacggttgactatttactaagggtacaggaatcgatcagtgatttc tactggtactactctgggaaagaggttattgatcctctgggtcaacacaacttctccaag gccattgaagttgccaaacaggtcttcaacacgctcaccgagtatatacagggtccgtgt attgggaatcagcagagtctggctcacagtcgtctgtgggatgctgtcgtgggattcctc catgtctttgctcacatgcagatgaagctgtctcaggattcaaagcagataaaactccta aaagaactcatggacttactgaaggacatggttgtgttcctcctctccatgttggaagga aatgttatcaatggaacaattgggaagcagatggtggatatgttggtggaatcatcaggc aatgtggaaatggtcctcaagtttttcgacatgttcctcaaactaaaagacctgacttct tctgagggcttcagagagtatgaccctgactgtaagggcagcatatgcaggaaggacttc cagaaagccatggaaaactgtaaatacttctcacaagccgagatccacttcctgctctct tgcattgaaacaaatgacagtgaaatcttggaatacgaaacttttgtggatcgctttcat gagccggcaaaagacatcggcttcagcatcgctgttctcctcaccaatttgtcagagcac atgcccaaagagtccaggctgaaggcattcatggagctcgcagaatgcgtcctgacttac tttcagcccagtcttggacgcattgagatttttggcagcgggaagcgctttgaacgggtc tactttgagatcagtgaatacagtcgcacgcagtgggagaagccacaggtgaaggaatcc aagaggcagttcatttttgatgtggtcaataagggaggcgacaaagagaaaatggagatg ttcgtcaacttctgtgaggacaccatttttgagatgcaacttgcagcccagatatccgga tccaactctggagagatgtgcaacgggaaaacagagttggaaaagagcgagcttgaagaa tatacatcgccagatcacaagacgtggacttttatctactattggtgggtgatgttaact tgtgccctttctgtgaaaaacctgagaacactgatgaggatgacaccaaaggatttcctc ttagcagcagttcgattcattagattcatttgtgtgcttcagatccactgcatttctgct gtcatctgtcacatcatgtacttgctgtacatcacatttgtcaacagtggtctcattgag gcggcaaaaagaatgaaggtgtcagacttgcttgggggtattcttgagccaactcttgac gaggtcattggggtgtcgagcactgtggatcaactgagaacgcactctgctagtttctct tcccagaaagaattgagggagatcaggcagatggcttcattgacctttcccaaggaggtg gacatattgtcggacatatttggtctcaagttgaagaaagagggagatcagtacagactt gtaacgcaagatctctctgacagtttgactgatctgttcagttcaacttccagaacaata atcgacccggatgtttctgaggagcaccacactttgcagtttacagaccacttggacaaa gagacaacagaagatgggaaaatggagaacttacaggaaaaagaatggaagaaaactgaa gaagaacgtaggaatgcaaaagaagagaaaaaacacagatccaagaaaggctctcatagg tcaaaggaaccacagagacaacattctgctctctgggagacgataagctcacatagcaag actcttctgaactgctttgcaagaaatttttatagcatgcgtctgctggcattgtttgtt gcttttgcaatcaacttcatccttctgttctataaggtagcatttttgcctgcatccaaa gaagaacaggtgactacatcggcatatggaaaagaactgctctctgccatgacaaacacc agcaatggcagagtttattttgtgcttgaagaaagcagtggttacatggagctgtgcctc catttcctttccatcgcacacacaatcatctcattctgctgcattattggttactactgc ctcaaggtgccgttggtgatcttcaaacgtgaaaaggaggtggccagaagactggagttt gatggactgtatgtggctcagcagcctcctgaggaagacattaaagggcaatgggaccgc ctggtcatcaacacactatcgtttcccagtaattattgggataaatttgtgaaaaggaag gtgatggataagtatggagacttttatggccgtaagaagatcagtggactgttaggtctg gaccaagctgccttagacttcagcaccaagagaaaagaacagaagaggctcagaagagac agtgcctggagtgtccttaatgctgtttgttccagatttaactcccttgacgcaaagtac caggtctggaagctaggagtggtgttcactgacaactccttcttgtacttggcgtggtac atgaccatgtcggttttgggtcattataacaacttcttctttgctgcccaccttttggac atcgccatgggctttaagacactccgtaccattctttcctccgtcacacacaatggaaaa cagctggtgctgactgtgggtctgttggcggtcgtggtgtatctctacaccgtcatagcc ttcaatttcttcagaaagttttacaaacacagcattggcaaggaaactgaagaaatgaag tgcaatgatatgcttacttgttacatgttccacatgtacgtgggagtgcgagcaggtggc gggattggtgacgagatccaggatcctgctggagacgaattcgaagtcgaacggattgtc tttgatattacgtttttctttttcgtcattgtcatcctgctcgccattatccagggttta ataattgatgcctttggtgagcttcgagaccagcaggagcaggtgaaggaggacatggag accaaatgtttcatatgtggaatcggaagcgagtactttgacaagattcctcacggcttt gagactcacactctgcaggagcacaacttggccaactatctatttttcctgatgtatctt attaacaaggatgaaactgaacacacgggacaggaatcctacgtgtggaaaatgtaccag gagcgttgctgggaattctttcctgtgggagactgtttccgtaagcagtctgaggatcaa ctcggctga

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