Gambusia affinis (western mosquitofish): 122845862 Help Entry 122845862         CDS       T07758                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism gaf  Gambusia affinis (western mosquitofish) Pathway gaf04020   Calcium signaling pathway gaf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gaf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122845862    04020 Calcium signaling pathway     122845862  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gaf04040]     122845862 Ion channels [BR:gaf04040]  Voltage-gated cation channels   Ryanodine receptor    122845862 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  122845862 NCBI-ProteinID:  XP_043998308 LinkDB All DBs Position LG16:16814953..16933015 Genome browser AA seq 4895 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGTRGPHRWRLIRKAAHSGGHKTLLYGHAIL LRHSFSSMYLACLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDD LILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGH DEVVSIPGSDQSEEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQSFRLRHLT TGHYLALTDDRGLVLQDRERSDTISTAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSLC FIMHVATGLWLSYQAPDVKSTRLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRN TTLLFNRFIRDLDCLSIKNRTLVALPVEEVLQTLNDLITYFQLPDVELEHEERQIKLRSL KNRQNLFKQEGMLTLVSNCIDRLNVYNSAAHFGESAGSEAGAAWKDILNLLYELLAALIR GNRNNCTQFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKGHIKSIISLLY KHGRNHKILDVLCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLG VSEGSAQYKKWYYELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDL YSFGFDGLHLWSGRIPRAVASLNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENF NTDGLFFPVVSFSAGVKVRFLFGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKR DVEGVRDLLGTTQFTSQASFIPTPVETSQVVMPSHLEKVRDKLAENIHELWGMNKIELGW TYGKRIRDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLAIGCRIVQVNPNAEDSL KKIKLPKNYMMSNSYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQ QDLKSKRNPRLVPYMLLDERTKKSNRDSLREAIRTMIGYGYNIEPSDQEGGQVVERVSID KVRFFRVERTYAVKTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDKLAFVFDGYRGH CLNIGSRLFGRCWHAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIP VCSLGLAQVGRMNLGKDASTFKYYTTCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPK DHNHIAVTRIDGTIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKQNPIVDIN GIHEEDLLKVKHRYPLRSVRHSEESRRVDYSSITTYYHSVRIFAGQDPTGVWVGWVTPDY HYYSNNFNLSKNRTVTVTLGDERGRVHESVKRSNCYMVWGGDMTSCAHASSRSNVDLDIG CLIDLSTGMVTFTVNGKELSTSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNAMPLSS AIFKSEHKNPVPQCPPRLDVQTINTVLWSRMPNIFLKVETARVNERHGWVVQCGEPLQML AVHIPEENRCVDIMELSEQEDMRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYT IDNQYLSGMLREGFYNVLISIHLETAKEARLMMKDEFIIPVSAETRSIRLFSSASKKHSP PGVGLSTSLKPRLNFTPPCFISTKRDYLYSPQIPLDALKKKAISMLTEAVQGGGYHIRDP VGGGVEYQFVPILKLISTLLTMGVLGSEDVQKILLLIDPNVFRDTCEEGVTGRTDKEGLT GTEGKAVEAGEEEAAEEAKQPMKGLLEKRLPEPVKRLMCELLHYFCDCELKHRIEAIASF SDSFVSKLQYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLTFSMGDDCPCP SDIQEELYDFHNQLQLHCGIPMEEDEDERDTSIKGRLLMLVNKIKSQSYKAQEPTEKKQA APSNLKELISQTMVSWAQECHIQDPKLVRKMFSLLRRQYDSIGELLRAMRKTYTISAASV QDTIHLLASLGQIRSLLSVRMGKEEEKLMIDGLSDIMNNKVFYQHPNLMRILGMHETVME VMVNVLGGDKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPA MRGSTPLDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPI EGERYLSFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKI SETPALDLPGSVHRVSSDLSADADDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKG KGEALRIRAILRSLVPTEDLVGIISIPLKTPIINKDGSMTEPDMSASFCPDHKAPMVLFL DRVYGIEDQSFLLHLLEVGFLPDLRTATTLDTEGLCTTETALAMNRYIGSAMLPLLTRCA PLIAGTEHYATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLSICKHLRPSMLQQLLHRL VFDVPLLTEYCKMPLRLLTNHYEQNWKYYCLPSGWGSFGTASEDELLLTKRIFWGVFDSL SQRKYDPELFKMAMPCLSAIAGALPPDYVDASISTAVEKPVSVDAQGNFDPKPINTANIV LPEKLEHLTNKYAEHCHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRIYKALTEKEKEIYR LPIRDSIKSMLAMGWSIDRTKDGESMSLQRENEKMRKISQASQANGFNPSPIDTSIVTLS RELQGMVEVMAENYHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKALDLFR FLQINGYGITRGLKDLEQDSSSMEKRFAYKFLKKLLKYVDSAQDFIAHLEAMAASGKTDR SPHEQEIKFFAKVLLPLIDQYFKNHSLYFLSSPNKNLSSSGYASNKEKEMVASLFCKLAA LVRHRISLFGSDSTTMVSCLHILAHTLDTRTVMKSSSEQVRVGLRTFFENAAEDLEKTFE NLKLGKFTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRI LTSLFALGTGKNIYVERQLPALGQCLATLAGAMPVAFLEPKLNTHNPCSVFNTKSARDRA VLGIRESVEDMCPGMPRIDGLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERG PENQAASGGSTYCTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARA DLLKSHFLPTLEKLKKKTVKVVAEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPM LIRYVDNNRSRWLKEPDSDSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLT GDNKTKMSKSFKEKSGGQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQE LISLAKTRYLMKDTDEEVKDHIHQNLHLREKSEDPAVRWQLNLYKDIVMRIESPPDPERV VDRIQRISAAIFNLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINL FLLAYQSIWIETEEYSFEEKLVQDLAKTQPKVEEEEEEEVRKQPDPLHQLILHFSHNALT ECSSLEEDPLYIAYADMMAKSCAEGEEEEEEKEKTFEEKEMEKQKMLYQQARLHDRGAAE MVLQMISASKGRLGATVTFTLKLGISILNGGNILVQQKMLDYLKEKRDVGFFKSLSGLMM SCSVLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNN DFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSKALSV AKQVFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELL DLQQDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSF KEYDSESKGVISKKDFQKSMENQKQYSQSEIEFLLSCAEADENDMFSYKQFVERFHEPAK DIGFNVAVLLTNLSEHMPHDARLSTFLNLAESVLSYFEPFLGRIEIMGGAKRIERVYFEI SESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPV ERSDEDEDESPNVVENQDEEEEENIMMESSSAFTIACISMRKNLCHFRQLLTLKSMRRQY RKFRKMSVREMVKGFFSFFWMIITGLFHFIYSLIWGFFHILWTTMFGGGLVEGAKNMKVT DILGNMPDPTQFGIHGDVLETEKMEANDASALEEMGQMAQGVAAEADLMAELLNIQPKRE GKHGTEPGLGDVSEVVVGDAPSIASAVKQKKAQMAAKKASNGDYKSDSEKGDSEDGEKKD HDKAKDEAPPQHSIEERRAPKKRLSLRKEPPEAFMASFLAGLEIYQTKMLNYLARNFYNL RFLALFVAFAINFILLFYKVTGEYTEDEDPWNRRGRVGEEEDEGALEYFVLQESTGYMAP TLRCLAILHTIISFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQW DRLVINTLSFPNNYWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEA SLVSWLSSIDTKYHVWKLGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKT LRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSADDDEPDMKCDDMMTC YLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTMQEHNLANYLFFLMYLINKDETE HTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14688 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggagagggagaggatgagatccagttcctcagaactgatgatgaagtg gttctccagtgtgtggcctgcatccagaaggagaatcgtaagttctgcctggctgctgaa gggctgggcaatcgcctatgttacctggagccaacatctgaggcgaagtatgttccccca gacctgtgcatctgtacctttgtgctggagcaatctctatcagtacgggctctacaggaa atgctcgctaaaagtggacagaacagtgaagggacacgcgggccgcatcgatggaggctc ataaggaaggcagcacacagtggaggacacaagactctgctttatggacacgccatcctc ttgcggcattccttcagctctatgtacttggcctgtttgaagacatcaaggtcccagaca gataagctgtcctttgatgttggcctgcaggaggattcaacaggtgaagcctgctggtgg acgatccatcctgcttcaaaacagagatcagaaggagagaaagttcgcattggtgatgac ctcatccttgtcagtgtgtcctcagagagataccttcacttatccatctccaatggcaac atccaggtggatgcttccttcatgcagactctgtggaatgtccaccccatctgttctggt agcaacatagaagaaggctacctgttgggtggccatgtgatgcgtctattccacggtcat gacgaggtggtgagcatcccaggatccgaccagagtgaagaacagcagaggatagtcaac tatgagacgggcaaagcaggtgcaaaggcgaggtccttgtggaggttggaaccactacga atcagttggagtggaagccacatccgctgggggcaatcgtttcgactacgtcacctgaca acaggtcactacctggccttgactgatgacagggggttggtgctgcaggaccgggagagg tcggacaccatttctacagctttctgctttagagcatcaaaggagaagctggagcaaagc cccaagagggacattgagggcatgggggtggcagagattaaatatggagactcgctctgc ttcatcatgcatgtagcaacaggtctgtggctgtcctatcaggcgcctgatgtcaaatct actcgactgggtcccctcaagagaagagcttgtcttcactctgagggtcatatggatgat gggttaaccctgcagcgctgtcaacatgaagagtctcgagccgcaagaatcatccgcaac acaacgctgctctttaaccgattcatcagagaccttgattgcctgagcattaagaacagg acccttgtagccttgcctgtcgaggaagtgctccaaacactcaatgacctcatcacctat ttccaactccctgatgttgagctggagcatgaggaaagacagataaagctgcgttcactc aagaacagacagaacctcttcaaacaagaaggcatgctgacccttgtctccaactgcatt gaccggctaaacgtctacaacagtgcagcccattttggggagtctgctgggtcagaggcc ggagctgcctggaaagacattctcaacttgctttatgaacttctggcggcattaatcaga ggaaaccggaacaactgtacccagttctcaaacaatttagactggcttgtaagcaagttg gaaagactagagtcttcttcaggcatcttggaagttctgcactgcatcctaattgagagc cctgaggcactcaatatcattcagaaaggacacattaagtctatcatatcattgctctac aagcatggacgcaaccacaagattttggatgtactttgttcgctgtgtgtgtgcaatgga gtagctgttcggaccaatcagaacctcatttgtgatcacttgctgcccaaaagagatctg ctattgcaaacccaactggtcaatgatgtccagagcatgagaccaaacatcttcttgggg gtcagtgagggctctgctcagtacaagaagtggtactacgaactgatgattgatcaagtg gaccactttgtgaccagtgagccctctcacctgagagtgggctgggccaacaccaaaggt tatgcaccctatcctggaggaggggagggctgggggggcaacggagtgggtgacgacctc tactcatttggctttgatgggcttcatctttggtcaggccgtatcccgcgggctgtcgcg tctctgaaccagcatatcctgacttcggaagatgtggtgagctgttgtctggacctggga gctcccagcatctccttcaggataaatggacagccggtccagggcatgtttgaaaatttt aacacagacggactctttttccccgtcgtcagcttctccgcaggagtcaaggttcgcttt ctgtttggtggccgacatggtgactttaagtttctgccaccgtcaagttatgctccatgt tatgaggctttgctgccaaaagagaagatgaaggtggagccggtgaaagagtacaaaaga gatgtggagggggtccgggatctgcttgggaccacccaattcacctcacaggcctccttc attcccactcctgtagagaccagccaggttgttatgccgtctcacttggaaaaagttcga gacaagctggctgaaaacatacatgaactgtggggtatgaataagattgaattgggatgg acttatggcaagaggataagagatgataacaaacgacagcatccttgccttgttgatttc tctaagctgccagaaacggagaagaactacaacctgcagatgtcaacagaaacactgaaa accctgctagcaataggttgccgtattgttcaagtgaatccaaatgcagaggactccctc aaaaaaataaaattacccaagaactacatgatgtccaatagctataaaccatcccctctg gatctgtccgacatcaaactgacaccaggccaggagctgctagtggacaaactagcagag aatgcacacaatgtttgggccaaagaccgcatcaagcagggatggacttacggcattcag caggatttgaagagcaagcgtaatcctcgtctcgttccctatatgctgctggatgagcgg accaagaagtcaaacagggacagcctgcgagaggctatccgcaccatgattggctatgga tacaacatagagccttcagaccaggaaggaggccaagtggttgaacgagtcagcattgat aaagtccgcttcttcagagttgaaaggacatatgcggtgaagactggaaagtggtacttc gaatttgaggcggtcactggaggagacatgagagtgggctgggccaggcctgggtgcaaa cctgatgtggaacttggaacagataaacttgctttcgtgtttgatggatatagggggcac tgtctgaacatcggtagcagattatttgggcgctgctggcacgctggggatgtagtcggc tgtatgatcaacatggaggacaagtctatgatttttacccttaatggagagatcctgatt acaaccaagggttctgaactctgtttcactgactttgaaactgaggatggatttattcca gtgtgtagtctcggtcttgctcaagtggggcgcatgaatctggggaaagatgctagcact ttcaaatactacaccacatgtggcctgcaagagggattcgaaccatttgcagtcaacatg aaccgggaggtcacaatgtggttcagcaagcgtctgcctacttttgtcaatgtgccaaag gaccacaaccacattgcagtaaccagaattgacggcaccattgacagccccccgtgtctg aaggtcacccacaagacatttggcacccagaacagtaatgctgacatggtgttctgtcgc ctcagcatgccggtagagttccactctttcttcaagcagaaccccatagttgacataaac ggcatacatgaagaggatttgctcaaggttaaacacagatatccactgagatctgttcga cacagtgaggaaagtagacgagtggactacagcagcatcaccacgtactaccactcggtg agaatctttgcaggtcaggaccctacgggtgtgtgggttggatgggttacccccgactac cattactatagcaacaatttcaatctcagcaagaacagaactgtcactgtaaccctgggt gatgaacgtggacgagttcatgaaagtgtgaaaaggagtaactgctacatggtgtggggt ggtgacatgaccagttgtgcacatgcttccagccgcagcaacgttgatttggacattggc tgtctaatagatctgtccactggcatggttactttcactgtcaatggaaaggagttatcg acatcctaccaggtggaaccaaacacaaaactctttcctgctgtgtttgtccgacccacc agcccaaacctctttcagtttgagctggctaagataaagaacgcaatgccactgtcatcg gccatctttaagagtgaacacaagaacccggtgcctcagtgtccgccccgactagatgtc cagacaatcaacacagtgctgtggagccgcatgcccaacatcttcctcaaagtggaaaca gccagagtgaacgagcgacacggctgggtggttcagtgtggcgagccactgcagatgctg gcagttcacattcctgaggagaacaggtgtgtcgacattatggagctgtcagagcaggag gacatgaggaagttccactatcacacgttgaagctctactgtgccctttgcgcgctggga aacacccgcgttgcccacgccctctgcagccaccttgatcagtcgcagctattatacacc atagataatcagtacctctctggcatgttacgggagggattctacaatgttctgatcagc atccacttagaaacagccaaggaggccaggctcatgatgaaagatgagttcatcattcca gtctcagctgagacgcgttcaattcgtctcttttccagcgcgtctaaaaagcacagcccg ccaggggtgggacttagcacctccctaaaaccccgcctcaactttaccccgccatgcttc atcagcaccaagagggattatctatacagtccgcagatcccactggatgcacttaagaaa aaagctatttcaatgttgaccgaagctgttcaaggcggtgggtaccacattcgagatcct gttggaggaggcgtagagtatcagtttgtcccaatcctgaagctcattagcaccttgctg actatgggggttttaggtagcgaggatgttcaaaagattttactgctcattgacccgaat gtgttcagagatacttgtgaggaaggggtcacaggacgcacggacaaagagggactcact gggactgagggtaaggcagttgaagcgggagaggaggaggccgcagaggaggccaaacag ccaatgaaaggactgctggagaagaggcttccggagcccgtcaaacgactgatgtgtgag ctgcttcattatttctgcgactgcgagctgaagcaccgtattgaggccattgcgtccttt tcagacagctttgtctccaaattgcagtacaaccagaagtttcgctacaatgagctcatg ctggccctcaatatgtcggcagctgttacagcaaagaagacgaaagagttcagatctcct cctcaggagcagatcaacatgctgctgactttcagcatgggagatgactgtccgtgtcct tcagacatacaggaggagctgtacgacttccacaaccagctgcagctccactgtggaatt ccaatggaagaagatgaagacgaacgggatacatctattaaaggccgcctccttatgctg gtgaacaagattaagagtcagtcctataaagctcaagaaccaacagagaagaaacaagct gcaccatctaatctgaaggagctcatctctcagacgatggtcagctgggcccaggagtgt cacatccaagaccccaaactcgttcgcaagatgtttagccttctgagaaggcagtatgac agcattggggagcttctccgggcaatgaggaagacctacaccatcagtgctgcctcggtt caggacaccatccacctccttgcctccctcggtcaaatcaggtctctactgtctgttcgc atggggaaagaggaggagaagctcatgattgatggactcagtgatatcatgaacaacaag gtgttttaccagcacccaaacctgatgagaatcctgggcatgcacgagaccgtaatggag gtcatggtgaatgtgctgggaggagacaagtctcaggaaattgcttttcctaaaatggta gccagttgctgtcgcttcctgtgctatttttgtcggatcagccgacagaaccagaaggcc atgtttgaccacctcagttacctgctagaaaacagtagtgtgggtcttgcttcaccagcg atgagaggatctacacctctagatgtagccgcatcctctgtgatggataacaacggctta gctctagcactggaggaacctgatctggacaaggtggttacatacctggctggatgtggt ctacagagctgtccgatgcttctcgctaaagggtacccagacattggctggaaccccata gaaggagagcgttatctctccttcttgcgttttgcggtcttcgtcaacggcgagagcgtg gaggagaactcgagcgttgtggtgaagctgctcatccgacgtccagagtgttttggccct gcattgagaggagagggaggaaacggcctactggctgcgatgaaggaggctattaagatc tctgagactcccgctttggacctgccaggctctgtgcatcgagtcagctctgatttgtca gctgatgccgatgatgaagaggaggtggtccacatgggcaatgccatcatgtcattctac tctgccctcattgacctattgggacgctgtgcccctgagatgcatctcatcaacaaagga aaaggtgaagctctgcgcattcgagcaatattacgttctctagtgcccaccgaagacctt gtaggaattatcagcattcccctcaaaacacccatcatcaacaaagatggatcaatgact gagcctgacatgtcagctagcttctgtcctgaccacaaagccccgatggtgctgttttta gacagggtgtatggcattgaagaccaaagttttctgcttcatctgctcgaagtcggcttc ctccccgacctgaggacggctaccactctagatacggagggactctgtacgaccgagact gccctggctatgaatcgctacattggctcagccatgctgcctcttcttacgcggtgtgca cctctcattgctggcacagagcactatgctactcttatcgactccaccctgcacactatc taccggctatccaagggccgctcactgaccaaggcacagagggacgccattgaagagtgt ttactgtctatttgcaaacacctccgcccgtccatgctccagcagctcctgcaccgtctc gtctttgacgtgcccttgctgactgagtactgcaagatgcctctaaggcttctaaccaac cactatgagcagaactggaagtactactgcctcccctcaggatggggcagcttcggcaca gcatctgaagatgaacttctgctcaccaagaggatcttctggggggtgtttgattctctt tcccagaggaagtatgacccagagttatttaagatggccatgccgtgtctcagtgctata gctggagctttgccaccagactatgtggatgcctccattagcacagccgttgaaaagcct gtttctgtggatgctcagggaaactttgaccccaaacccatcaataccgctaacattgtt ttaccagaaaaacttgaacacttgaccaacaagtatgctgagcattgccatgagaaatgg tctgcagagaaggtgctgctggggtggaaatatggggactgtgtggatgagaaagctaaa actcatcctcagttaaggatctacaaagccctaacagaaaaggagaaggagatttacaga ttgcccattagggactcgattaaaagtatgctggccatgggctggagcatcgacaggaca aaggacggagagagcatgtctctgcagagggaaaatgagaaaatgaggaaaatatctcaa gcttctcaggctaatggctttaatcccagcccaatagacacaagtattgtgactttgtcc agagaactgcaggggatggtggaagtaatggctgagaattaccataacatctgggccaag aagaagaaaagtgaccttggaagcagaggtggaggaactcatcctctcctggtgccctat gacacgctgacagccaaggaaaaggcccgtgatcgagaaaaggccctggacctttttcgc ttcctgcaaattaatggctatggcattacaagaggtttgaaggacttggagcaggattcc tcttccatggaaaaaaggtttgcctataaattcctcaagaagctcctgaagtatgttgat tcagcccaggactttatcgcccacttagaggcaatggcagccagtggaaaaacagacagg tcccctcatgaacaagaaatcaagttttttgccaaagttcttctcccactcatcgatcaa tacttcaagaaccactctttgtatttcctctcctctcccaacaagaacctaagcagcagt ggttacgcctctaacaaagagaaggaaatggttgcgagcctattttgtaaactggctgct cttgtcaggcataggatttctctttttggaagtgattccaccaccatggtcagctgtttg cacatcctggcacacactctcgacaccaggacagtgatgaagtcgagctcggagcaggtc agggtggggctgaggacgttctttgagaacgctgcggaggacttagagaagacctttgag aacctgaagctggggaagttcactcactctcgctcccagatgaaaggcgtgtcacagaat atcaactacacaactgtggctttgcttcccatcctaactgctctgtttgagcacatcact caacaccactttggagtagatctgcttttggatgatgtgcaggtgtcctgctatcgaatc ctgaccagcctctttgctcttggcactgggaaaaacatctatgtggaaaggcagctgcca gctctcggtcagtgtctggccactcttgctggcgccatgcctgtagccttcctggagcca aagcttaacacgcacaacccctgctctgtttttaataccaagagtgccagagatcgagca gtgctgggaatacgagaatcagttgaggatatgtgtcctgggatgccgcggattgacggg ctcatgaaagacatcaatgacatggctgagtctggagcgcgctacactgaaatgccccat gtgatcgaggtggtgctgcccatgctgtgcaactacttgtcctactggtgggaaaggggc cctgaaaaccaggctgccagtggtggaagcacttactgcactactgttacctcggagcac ctcagcctcatcctcggcaacatcctcaagatcctcaacaacaatttaggcatcgacgag gcctcctggatgaagagaattgcagtttatgtgcaacccatcattagtaaagctcgcgca gacctgctcaagagccacttcttgcccaccctggagaaactaaagaagaagacagtaaaa gtggtggctgaagaggagcttctgaaggccgacagtaaaggagacacccaggaggccgag ctgctcattttggatgagtttgctgtgctctgcagggatctctatgcattttaccccatg ctcatccgctatgtggacaacaacaggtctaggtggctgaaagaaccagattcagactcc aatgagctcttcagaatggttgcagagattttcatcctttggtgcaagtctcataacttt aaaagagaagagcaaaactttgtggttcaaaatgaaatcaacaatctttctttcttgacc ggagataataaaacaaagatgtcaaagtcctttaaggaaaagtctggaggacaagaccag gagaggaaacataagaagaggcgcggtgaattttactccattcagacctcattaattgtg gccgctctgaagaagatgctgccaatcggcctcaacatgtgcacccctggggatcaggag ctgatttctcttgccaagacccgctacctcatgaaagatacagatgaagaggttaaagac catatacatcaaaatttgcaccttcgagaaaagtctgaagaccctgctgtgcggtggcag ttgaacctgtataaggacatcgtgatgagaattgaaagcccccctgaccctgaacgagtg gtcgatcgtatccaaaggatctctgctgccatctttaatctggaacaggtggagcagcca ctgagatccaagaaatgcgtatggcagaagttgctctccaaacagcgaaagcgtgcagtt gttgcctgcttccgaatggctcccctttataatctaccaaggcatcgctctattaacctc ttccttctggcatatcaaagtatatggatagaaacagaggagtactcttttgaggagaag ctggtgcaggacctcgcaaaaacacaacctaaagtggaagaagaggaagaggaggaggtc cgaaagcaaccagaccctttacaccagctcatccttcatttcagccacaacgctctgact gaatgcagttcgttggaagaggaccccttgtatattgcatatgcagatatgatggcaaag agttgtgctgaaggtgaagaggaagaagaagaaaaagagaaaacatttgaagaaaaggaa atggagaaacagaaaatgctgtatcagcaagcccgactgcatgatcgaggtgcagcagag atggtccttcaaatgattagtgccagcaaaggtcgacttggtgccactgtgactttcacc ctcaaactgggcatctccattctcaacggtggaaacatcctggtccaacagaaaatgctg gattatctcaaggagaaaagagacgttgggtttttcaaaagtctatctggattgatgatg tcatgcagtgtcctggatttgaatgcctttgaaaggcaaaacaaagccgaaggcctgggg atggttactgaagagggatcaatcaacgtgagtgagcggggttccaaggttctgcaaaat gatgaattcactaaggatctctttaggtttctgcaacttctctgtgagggtcataacaat gattttcaaaatttcctgaggacccaaacagggaataccaccacagtcaatatcatcatc agcacagttgactacctgctaagactccaggaatccatcagtgatttctactggtattat tctggtaaggatgtcattgatgaggctggccagaggaacttttctaaagcactgtcagtt gccaaacaggtcttcaactctttaacagagtatatacagggtccatgcatcggtaatcag cagagtctggctcacagcaggctgtgggatgcggttgtgggcttcttgcatgtctttgcc aacatgcagatgaaattatcccaggactccagtcagattgaattactgaaggagctcctg gacctgcagcaggacatgattgttatgatgctttctcttctagaaggtaacgttgtgaat ggaactattggcaaacagatggttgacaccttggtggagtcttcaagtaacgtggagatg attctgaaattttttgacatgttcctcaagctgaaggacttgacgacatcagacagtttt aaggaatacgactcggagagtaaaggcgtcatttctaagaaggactttcaaaagtccatg gagaaccaaaagcagtactctcagtctgaaattgaatttcttctctcctgtgctgaggct gacgaaaacgacatgtttagctacaaacaatttgtggagagatttcatgaaccagcaaag gacattggcttcaatgtggctgtattgctcaccaacctctcggagcatatgccccacgac gctcgtctctctacgttccttaacctggctgaaagcgttctgagctactttgagcctttc ttgggtcgtattgaaatcatgggtggagccaaacgcattgagagggtctactttgagatc agcgagtcaagtcgcacgcagtgggaaaagcctcaggtgaaagagtcaaagcggcagttc atattcgatgtggtcaatgagggcggggagagtgagaagatggagctgtttgtcaacttc tgtgaggacaccatctttgaaatgcagctggcttctcagatctcagagccggatcctgtt gagcgttctgacgaagatgaggacgagagcccaaatgtagtagagaaccaggatgaggaa gaagaggagaacatcatgatggagtcttcctcagctttcacaattgcctgcatctcaatg agaaagaacctgtgtcacttccgacaactgctcactctgaagagcatgaggcggcaatat cggaaattcaggaagatgagtgtgagggagatggtgaagggcttcttctcttttttctgg atgatcatcactggtcttttccactttatctacagcctgatttggggtttcttccacatc ttgtggaccactatgtttgggggtggcctggtcgaaggggctaagaatatgaaggtgaca gacattttgggaaacatgcctgaccccactcagtttgggattcatggagatgtcctggaa acggaaaaaatggaggccaacgatgcctcagcattggaggagatgggtcagatggctcag ggcgttgcagcggaggctgacctcatggcggagctgctcaacatacagccaaagagggag ggcaagcatggaactgagccaggcttgggggatgtatcggaggtggtggtgggagatgct ccatcaatagcgagtgccgtcaagcagaagaaggcacagatggctgcaaagaaggcttca aatggagactacaaatcagactcagagaagggagattcagaggatggtgagaaaaaggac catgacaaggccaaggacgaagctccaccacagcattcaatagaggagagaagagcacca aagaagaggctcagcctgaggaaagaaccaccagaggcctttatggccagctttctggct ggcttagaaatctaccagactaagatgctgaactacctggctagaaatttctacaacttg cgcttcttggcactttttgttgcctttgcaatcaacttcatacttctcttctacaaggtg actggtgaatacaccgaagatgaagacccctggaaccggagaggcagagtaggagaggag gaggatgaaggggcactcgagtactttgtcctgcaggaaagcactggttacatggcacca acacttcgttgtctggcaatactacataccatcatatctttcctgtgtgtggtgggatac tactatttgaaggtgcctctggttgtgttcaaacgagaaaaggaaatagctaggaaactg gagtttgcaggcctctatattactgagcagccgtctgatgacgacattaaaggacagtgg gacagactggtcatcaataccctctcctttcccaataactactgggataaatttgtcaaa cgcaaagtgataaaaaagtatggagacctgtatggagcagagaggatagcagagctgctg ggattggacaagagtgctctggatttcaaccccacagaggaaacggttgccaaggaggca tcactagtgtcatggctgagctcaatcgatacaaaataccacgtctggaaattgggagtg gtgtttacagacaattcattcctatatttagtttggtacacaaccatgtccattcttggg cactacaacaactttttcttcgctgcccatctgctggacatcgccatgggtttcaagacc ctccgcacaatcctgtcctccgtcactcataatggcaaacagcttgtgttgacagtcggc ttgctggcagtcgtggtctatctctacactgtggtggcctttaacttcttcaggaagttc tacaacaagagcgcagatgacgatgagccagacatgaagtgtgatgacatgatgacgtgc tacctgttccacatgtacgttggggtgagagcaggaggcggcattggggacgaaattgag gacccggcaggcgatccatatgaactctaccgcatcctttttgacattacgttcttcttc tttgtcattgtcatcctgctggctatcattcaaggtttgatcattgacgcctttggagaa ctaagagatcagcaggaacaagtcaaagaagacatggagaccaaatgtttcatttgcggc attggtaatgactactttgacacaacgcctcatggcttcgagactcacaccatgcaagag cacaatttggccaactacctgtttttcctgatgtacctcatcaataaggatgaaacagag cacactggccaggagtcctatgtgtggaagatgtatcaggagcgctgctgggatttcttc ccagctggagattgcttccggaagcagtacgaagaccagctgggatag

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