Gracilinanus agilis (agile gracile opossum): 123250068
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Entry
123250068 CDS
T07702
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
gas
Gracilinanus agilis (agile gracile opossum)
Pathway
gas05012
Parkinson disease
gas05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
gas00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
123250068 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
123250068 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
gas01001
]
123250068 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
gas04131
]
123250068 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
gas04147
]
123250068 (LRRK2)
Enzymes [BR:
gas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123250068 (LRRK2)
Protein kinases [BR:
gas01001
]
Serine/threonine kinases: TKL group
LRRK family
123250068 (LRRK2)
Membrane trafficking [BR:
gas04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
123250068 (LRRK2)
Exosome [BR:
gas04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
123250068 (LRRK2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
COR-A
Ras
LRR_14
Ank_2
LRR_9
LRR_NXF1-5
nSTAND3
Arf
LRR_13
AAA_22
TrwB_AAD_bind
CARF_Card1
T2SSE
AAA_7
MMR_HSR1
AAA_16
Beta-prop_EML_2
Arm
G-alpha
cobW
nSTAND_NTPase5
PduV-EutP
FtsK_SpoIIIE
NACHT
Septin
ABC_tran
TniB
NB-ARC
TsaE
AAA_29
Kdo
MobB
FeoB_N
Motif
Other DBs
NCBI-GeneID:
123250068
NCBI-ProteinID:
XP_044535041
LinkDB
All DBs
Position
5:213187129..213365707
Genome browser
AA seq
2429 aa
AA seq
DB search
MASGSSLEDEENEEGTLEKLTVRLQNVQEGKQIETVIQILEDMMLLTFTDHAAKLFKGKN
VHIPLLLVLDSYMRVAGVQQVGWSLLCKLTEICPDIMQSLMGPQDVGKDWEVLGVHQLIL
KMFTVHNANITLSVIGLKTLDQLLTSDLMALRILEEDCSDVFTLIFDAMHTFTANEEIQK
FGCKVLHVLFEKVSEEQLTEFIENKDYMFLLNALKRFNHEEEVVFHVLHSLHSLALPCNN
VEVLMSGNVRCYNIVVEAMKTFSNSEKIQEVGCCLLHRLTLDNFFNILVLNEVHEVIVKA
VKKYPENAPLQIAALSCLALLTETIILNRDLEEKNENQEEDEDNKLCWLEASYRALTLHR
KNTDVQEAACWALNNLLMYQSNLHENIGDEDDQYPAHREMVLSMLMHSSSKEVFQAAANA
LSTLSEQNDESEFQITAAVLSLPSLNRVLHIHFDYFIGNPGIQICGLKIISSLVNCSGAL
EMFSQQGALDSVLHTLQMYPDDRVIQCLGLSLLGSLITKKNLCTETQDLLANILVSSLQR
FKDVVEVQISGFQTTLAILELSLCFARLLLNYHSYDSLIFYQLSRCFTEQMDHQFQNLCC
KLFAKITSDDDIKNVLLVRACEENNSFMAECLLLLGADINKVNGKTSLICQVCEKESNPK
LVELLLNNGSREQEIRKALMISIKKNNSQVISLLLRKLGLDLANSSICLGGFCIGKIEPS
WLSPLFPDKSSNLRKKTNTGSAMARKILRYQMKSLSEDGTIPSSDGSFPEDHLDKYGDWT
FIPESSIDYVFGDDLDSEGSEGSFLMKKKSSSFNVGDLYKDPALQLGSATLERHSASMET
SFDHEELLKKRRDLFSSDDSVRSSKFHSHLRQSDSVFTLTSERECIKSLDLSANELEDID
DISKKCCLSDHLTRLEKLELHQNSLKRIPQQLCETLKCLKYLDLHSNKITSIPAYFLKMN
CIANLDISRNDIGPTIILDPSIRCPTLKLLNLSYNQLSSVPEFLADVIENLEQLLLEGNK
ISEIHSPLHLKELKILNLSKNHLSSITEDFFETCSKLEVFSARMNLLVTMPRLPSSITIL
NISQNKFTCVPEVILNLPHLRSLDLSSNEIHSLPGPAHWQSLNLRELLFNHNQISILDLS
EKAYAWSRMEKLHLSHNKLKEIPPEIGFLENLTSLDVSYNLELRSFPNEMGKLTKIWDLP
LDELHLNFDFKQIGCKTKDIIRFLQQRLKKAVPYNRMKLMVVGNTGSGKTTLLRQLMKSK
KRELNPPSTTVGIDVKDWFIQVWSKGKKELILNVWDFAGREEFYSTHPHFMTQRALYLAV
YDLSKGYAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKTSISKITKELLNKRG
FPEIRDYHFVNATEECEALVKLRKSIIKESLNFKIRDQPVVGQLIPDCYLELEKKILLER
KNVPTEFPVINQKRLVQLVKESQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFV
EPKWLCKMMAQILTVKVEGFAKYPKGIIQRSDVEKFLSKKSRFPKNYMSQYFKLLEKFQI
ALPIGEEHLLVPSSLSDHRPVIELPHCENSEVIVRLYEMPYFPMGFWSRLISRLLEISPY
MLSGRERALRPNRMYWRQGIYLNWSPEAYCLVESSILDNSSESFLKITAPSCRKGCIILG
QVVDHIDSLMEEWFPGLLEIDVCGEGETLLKKWALYSFNDGEEQQKILLDDLMKKTEEGD
LLINPDQPRLTIPIGHIAPDLILADLPRNIMLNNDDLEFEQAPEFLLGDGGFGSVYRASY
KGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRL
LQQDKASLTRTLQHRIALHVADGLRYLHASMIIYRDLKPHNVLLFTLYPNSAVIAKIADY
GIAQYCCRMGIKTSEGTAGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGSRILEGLK
FPNEFDELAILGKLPDPVKEYGCTPWPKVENLIKKCLKENPQERPTSAQVYEILNSAELI
CLMRYILIPKIFVAECMVATNQSSKNAVIWLGSGNNDAGQLSCLEINSERHTSEDVTESR
ILCLALVCLLVEKESWIVAGTQSGTLLAVKTEDDKKSHTLQRMTDSVTCLYCNSFSKQSK
QKNFLLVGTANGRLAIFEDRSVKDEGAPPLKTLNIGNVSTPLMCLNESIYSSEKNIIWGG
CGTKIFSLSSDFSIQKFIETKTNQLFSYATFSDSNIISIVVDKAIYVAKKNSHFVEVWDK
KTEKLCVLIDCVQFLKERMVILSKESKHKMIYSGRVKTLCLQKNTALWIGTGGGHILLVD
LSTHRIIHIIQNFCDSIRAMMTVQLGSLKNVMLVLGYCQKNSESTQHQKEMESCLSVWDI
NLPHEVENLEKHTGVRKELAEKMRSISME
NT seq
7290 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagcagtctagaggatgaagaaaacgaagagggaaccctggagaagttg
acagttaggctacaaaacgtccaggaaggaaagcagatagaaaccgtgatccaaatccta
gaagatatgatgctgttaacgttcacagatcacgctgccaagttgtttaaaggcaaaaat
gtccatatccccttgctacttgttttggattcctacatgagagttgcaggtgtgcaacag
gtgggttggtcacttctctgtaaattgacagaaatttgccctgatataatgcaaagctta
atgggtccccaggatgttggaaaggattgggaagtccttggtgttcaccaactgattctt
aagatgttcactgttcacaatgctaatataaccctttcagtgattggactgaagacatta
gatcagctcctaacttcagatttgatggctttgagaatcttggaagaagattgcagtgat
gtatttacattaatttttgatgccatgcatacatttacagcaaatgaagagatccaaaag
tttgggtgtaaagttttacatgtgctttttgagaaagtttcagaagaacaactgactgaa
tttattgagaacaaagattatatgtttttgctgaatgcattaaaaagatttaatcatgaa
gaagaagttgtttttcatgttcttcacagtttacattcccttgcactcccatgtaataat
gttgaagttctaatgagtggaaatgtcagatgctacaatattgtggtagaagccatgaaa
acgttttcgaacagtgaaaaaattcaagaagttggttgctgtttgttacacaggcttacg
ttggataatttctttaatatcctggttttaaacgaggttcatgaggtcattgtgaaagct
gttaaaaaatacccagagaatgcgcccttacagattgcagcactaagctgcttggctctc
ctcactgaaaccatcattttaaaccgagatttagaagaaaagaatgagaatcaggaagag
gatgaggacaataaattatgctggttagaagccagttacagagcattgacattgcacaga
aagaacacagatgtgcaggaagctgcatgctgggctttaaacaatctacttatgtatcaa
agcaatttacatgaaaatattggcgatgaagatgaccagtatccagctcacagagaaatg
gtactttccatgctaatgcattcttcatcaaaagaagtatttcaggcagctgctaatgca
ttgtcaactctatcagaacaaaatgatgagagtgagtttcagattacagctgccgtttta
tcccttccttctttgaatagagttttacacatacactttgattattttattggaaatcct
ggaattcaaatatgtggactaaaaatcatttcttctttagtaaattgttctggtgcatta
gaaatgttttctcaacaaggggcccttgattcagtgttgcatactctacagatgtatcca
gatgacagagtaattcaatgcctgggtttgagtctactgggaagtttgattacaaaaaag
aatttgtgcacagaaacacaggatctacttgcaaacattctggtttccagcttacaacga
tttaaggatgttgttgaagtacagataagtggatttcaaacaactttggcaatacttgaa
ttatcactctgctttgcaaggctgctgctaaactatcattcatatgactcactaattttt
tatcagttatcccggtgtttcactgaacaaatggatcatcagtttcagaatctttgttgc
aagttatttgccaaaataactagtgatgatgatattaaaaatgtactactggtgagagcc
tgtgaggagaataatagtttcatggctgaatgtctcctccttttgggagctgatattaat
aaagtgaatggaaaaacttctttgatctgccaggtttgtgaaaaggaaagcaatcccaaa
ttagtggaactgttgctaaataatggatcacgggaacaggagattcggaaggcactgatg
atcagcataaagaaaaataacagtcaggttatcagtttactattaaggaagcttggcctg
gatcttgccaatagcagcatttgtctcggaggattttgtattggaaaaattgaaccttcc
tggcttagtcctttatttccagataaatcatctaatttaagaaaaaaaacaaacacagga
tctgcaatggcaagaaagatactaagatatcaaatgaaaagtttgtcagaagatggaaca
ataccaagcagtgatgggagttttcctgaagatcatcttgataaatatggtgattggacc
tttatacctgagtcttctatagattatgtatttggtgatgatcttgatagtgaaggaagt
gaaggttcctttcttatgaaaaagaaatcaagctcttttaatgtgggagatctttataaa
gatcctgccttgcagcttggttcagcaactttggaaagacattctgcttcaatggaaacc
agtttcgatcatgaagaattattgaagaaaagaagagacttattttcttcagatgattct
gttcgatcttcaaaatttcactcccatttgaggcagtcagacagcgtttttactctaacc
tcagaaagagaatgtataaagtcattggacctttcagcaaatgaactagaagatattgat
gatataagcaagaaatgctgtttaagtgatcatttgacacgtcttgagaaactggagctt
catcagaattcacttaaaagaattccccaacaactctgtgaaactttaaaatgtttgaaa
tatttggacttacacagtaacaaaatcacatcaattcctgcctatttcttgaaaatgaat
tgcattgcaaatcttgatatctcccgtaatgacattggacctactataattttggatcca
tctatcagatgtccaaccctgaagctgctcaatctctcctacaatcagctatcctctgtc
cctgaatttcttgcagatgtcatagaaaatctagaacagcttcttttggaagggaacaaa
atatcagaaatacattcacctttgcacttgaaggaactgaagattttaaaccttagtaaa
aaccacttatcctcaataactgaagacttttttgagacgtgtagtaaactggaagttttt
agtgccagaatgaatttgcttgttactatgcctcgcttgccttctagcataaccatttta
aatatttcacaaaacaaatttacatgtgttccagaagtaattctcaaccttccacatttg
aggtcattagatttgagcagcaatgaaattcacagtctacctgggcctgcacactggcaa
tcattaaacttaagagaactcttgtttaatcataatcaaatcagcattttggacttaagt
gaaaaagcatatgcatggtcacggatggagaaactacacttgtcccacaataaactgaag
gagattcctccagaaattggttttcttgaaaatttaacatctcttgatgtgagttataat
ttggagctgagatcctttcccaatgaaatggggaaattaactaaaatctgggaccttcct
ttggatgaattgcatctcaattttgattttaagcagataggatgcaagaccaaagacatc
ataaggtttcttcaacagaggttaaagaaggctgtgccctataatcgaatgaaacttatg
gttgtgggaaatactggcagtgggaaaactacattgttacgacagttaatgaaatctaaa
aaaagagagttgaaccctccaagtactacagtaggcatagatgtaaaagattggtttatc
caggtgtggagcaaaggaaagaaagagctgatcctaaatgtctgggattttgcagggcga
gaagagttctacagcactcaccctcattttatgacacaacgagcactgtatcttgctgta
tatgaccttagcaaaggatatgctgaagtagatgctatgaagccatggctcttcaacata
aaggctcgggcttcttcctcaccggtgattctggttggcacccatttggatgtttctgat
gagaaacagcgaaagacttccataagcaaaatcactaaggagctcttaaacaaaagaggg
ttccccgaaatacgagattatcattttgtgaatgctacagaagaatgtgaagcattggta
aaacttcggaaaagtatcataaaggagagtctgaatttcaagatcagagaccagcccgtt
gtaggacagctaattccagactgctacttggaacttgagaagaaaattttattggagcga
aagaatgtacccacagaatttccagtaatcaatcagaagcgattggtacagctggtaaaa
gaaagtcagctacagttggatgagaatgaacttcctcatgcagttcacttcctaaatgaa
tcaggtgtcctgctacatttccaagacccagcactgcagttaagtgacttgtattttgtg
gaacctaaatggctatgcaaaatgatggcacagattttgacagtgaaagtagaaggtttt
gctaaatatccgaagggtattattcagcgttcagatgtggaaaagttcctttcaaagaag
agtagatttcccaagaactacatgtctcagtactttaaactcctggaaaagtttcagatt
gctttaccaataggagaggagcatttgctagttccaagcagtttgtctgatcatagacct
gtgatagaacttccccactgtgaaaactctgaagttattgttaggttgtatgaaatgcct
tattttcccatgggattttggtccagactaatcagtcgattacttgaaatttctccttac
atgctttcaggaagagaacgggcccttcgccccaatagaatgtattggagacaaggcatc
tacctgaactggtctcctgaagcctattgcctggtagaatcttcaattctggacaatagc
tcagagagtttcttgaaaattacagcgccttcctgcagaaaaggttgtattattttggga
caagttgtggatcacatagattctctcatggaagaatggtttcctggtttgttggaaata
gatgtttgtggtgaaggagaaacattgttaaagaaatgggctttatatagttttaatgat
ggtgaagaacaacaaaaaatactacttgatgatttaatgaagaaaactgaagaaggagac
ctcttaattaatccagatcaaccaagactcactatcccgataggccatattgctcctgat
ttaattttggctgatctgcctagaaatattatgttgaataatgatgacttggaatttgaa
caagcaccagaatttcttttaggtgatggtggttttggatcagtttatcgagcatcctat
aaaggagaagaagtagctgtgaagatttttaataaacatacatctcttcggctgttaaga
caagagctagtggtgctttgccatctccatcaccccagtctgatatctttgcttgctgct
ggtattcgcccccgaatgttggtaatggaattagcttcaaagggctctctagatcggtta
cttcaacaagacaaagctagcttaaccagaacactccagcacagaatagcactacacgtt
gctgatggcttacgatatctgcatgcatcaatgattatatatcgtgatctgaagcctcat
aatgttctgctttttaccctgtatcctaattctgcagtcattgccaagattgcagactat
ggtattgcacagtactgctgcagaatgggaataaagacatctgaaggaacagcaggattt
cgtgcacctgaagttgccagaggaaatgtaatttacaaccagcaggctgatgtctattca
tttggtttgctgctttatgatattttgacaacaggaagtagaattctagaaggattgaaa
ttcccaaatgaatttgatgagttagctatacttgggaaattaccggatccagtaaaagaa
tatggttgtactccatggcctaaggtagaaaatttaattaagaaatgtctgaaagaaaat
cctcaggaaaggccaacatctgcccaggtatatgaaattttgaactcagctgaattaata
tgtctcatgagatatattttaatacccaaaatttttgtagcagaatgcatggttgctaca
aatcaaagcagcaagaatgcagttatctggctgggtagtgggaacaatgatgctggacaa
ctatcctgtcttgagataaattctgaaagacacacctctgaggatgtgacagagagcaga
atattgtgtcttgcccttgtgtgtcttctggttgaaaaggaaagctggattgtagcagga
acacagtctggtaccctattggcagtgaagacagaagatgataaaaagagccacacactt
caaagaatgactgattctgttacttgcttatactgcaattctttttccaagcaaagcaaa
caaaagaattttcttctggtgggaacagcaaatggcaggttggctatttttgaggacaga
agcgttaaggatgaaggagctcctcctttgaagacattaaatataggaaatgtaagcact
ccactaatgtgtttaaatgaatccatctattcatcagagaaaaacataatctggggagga
tgtggcaccaagattttctcactttccagtgatttctccattcaaaaatttattgagaca
aaaaccaatcaactgttttcttatgcaacattcagtgattccaacatcatttcaatcgtg
gtggacaaagctatctatgtggctaagaaaaacagtcattttgttgaagtatgggacaag
aagacagagaaactttgcgtactcatagactgtgtgcagtttttaaaagagcgtatggta
atattaagcaaggaatcaaaacataaaatgatttattctggaagagtaaagaccctctgc
ctgcaaaaaaatactgccctctggattggtacaggaggaggtcacatcttactggttgat
ctttcaacacatcgcatcatacacataattcagaacttttgtgattctatcagagcaatg
atgacggtccagttagggagcctaaaaaatgtcatgctggttttggggtactgccaaaaa
aatagtgaaagtactcagcaccaaaaagaaatggagtcttgtttgtctgtatgggacatt
aacctaccacatgaggttgaaaacttggagaagcacacaggagttagaaaagaattagct
gaaaaaatgagaagcatttccatggagtaa
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integrated database retrieval system
