Gallus gallus (chicken): 396111 Help Entry 396111            CDS       T01006                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism gga  Gallus gallus (chicken) Pathway gga04020   Calcium signaling pathway gga04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gga00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     396111 (RYR3)    04020 Calcium signaling pathway     396111 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gga04040]     396111 (RYR3) Ion channels [BR:gga04040]  Voltage-gated cation channels   Ryanodine receptor    396111 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 TBK1_ULD Motif Other DBs NCBI-GeneID:  396111 NCBI-ProteinID:  NP_996757 CGNC:  49655 Ensembl:  ENSGALG00000009705 LinkDB All DBs Position 5:complement(30373099..30557874) Genome browser AA seq 4870 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVSSIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLTNTGDNASEGAAQGGHRTLLYGHAILLRHSFSEMYLT CLTSSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSMSNGSIQVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRFFHGHDECLTIPSTDQ NDSQQKKVLYETGGAGVRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGMYLALNDDE GLVMLDREKSDTTSSAFCFRASKELKEKQDSTLKRDIDGMGVPEIKYGDSVCFIQHVASA LWLTYKAPDAKSARLGLLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSLFSQF ISGNNRTLSPIALPVEEMAQTLQDLIKYFQPPGEDLEHEDKQNKLRSLKNRQNLFKDEGM LALVLNCIDRLNDYNSAAHFAEISRVENGTAWKEILNLLYELLAALIRGNRNNCTQFSSN LDWLISKLDRLESSSGILEVLHCILIESPEALNVIAEEHIKSIISLLDKHGRNYKVLDVL CSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWY FELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHLWS GRVPRAVASVNQHLLSSDDVVSCCLDLGVPSISFRINGQPVQGMFENFCTEGFFFPVVSL SAGVKARFLLGGRHGEFKFLPPTGYAPCYEALLPKEKMKLEPVKEYKRDSDGVRDLLGTT QFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRH HPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHANPAAEEDLKKVKLPKNYIMSN GYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVP YALLDERTKKSNRDSLREAVRTFAGYGYNVEPPDQEIADQTVEKVSIDKIRFFRVEQSYA VKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGFFGRS WQPGDVVGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIESGFVPICSLGLSQIGRM NLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIEIWRIDG TIESPPRLKVTHKTFGTQNSNSDMIYCRLSMPIEFRSSFNFGVGVENASSDALQKRKHSQ EFPASSTTCFYSLRIFAGQDPSSVWVGWVTPDYHFYSENFDINKNCTVTVTLGDERGRVH ESVKRSNCYMVWGGDIAANSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCYQVEP NTKLFPAAFVQPTSTNLIQFELGKLKNTMPLSAAIFKSEERNPVPQCPPRLDVQTITPVL WSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMKFHY HTLKLYSSVCALGNTRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLDHAK QAKLMMNNEFIIPVTEETRTIKLYPDETKKHGLPGVGLSTCLKPSFNFSTPCFIVTSEEH QTSSPDIPLDTLKSKAISMLTEAVQCSGSHIRDPVGGHIAFQFVPVLKLIATLLVMGVFD DDDVKQVLILIDPNVFGDHKEEAEEKTEKEEVTQVEEKAVEAGEKAVKETKAPTKGLLQT RLPESVKLQMCHLLNYFCDCELQHRVEAIVSFADHYVSKLQYNQKYRYNELMQALNMSAA LTAKKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIRDELYDFHDDLLIHCGIPLEEEEEE EEDSSLTGKLRSLIYKIKGPPKPEKIEPREEEDKSPTTLKELISQTMVRWSQEDQIQDPE LVRIMYTLLRRQYDSIGELLQALRKAYTISAASVKDTINLLAALGQIRSLLSVRMGKEEE LLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQIAFPKMVASCCRFL CYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALEEP DLDKVVTYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENASVV VKLLIRRPECFGPELRGEGGNGLLAAMQEAIRISENPTRDLPSQGYKREGDEEEEEEEEI VHMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLK LSTVNKDGTVNEPDMSANFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASAS LDTVSLSTTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSKGRSL TKAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYY CLPSGMGSYGIAAEDELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYL DTRIRSTLEKQTSVDPEGNFDPKPVNTANLVLPEKLEYIVSKYAEHSHDKWAFDKTNNGW KYGVSLDENTKTHPLIRPFKTLTEKEKEIYRWPVRESLKTMLAMGWSLERTKEGGEGMLH QRENEKLRSISQSSQGNGYSPAPLDLTNVVLSRELQGMVEVMAENYHNIWAKKKKMELES KGGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNGIIISRGLNDMDLDASSMEKRFA FKFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLY FLSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISIFGSDSTTMVSCLHILAQSLD TRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVAL LPVLTSIFEHISQYHFGVDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLAS LAAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDGLIKEINNL AESGARYTEMPHVIEVILPMLCNYLSYWWERGSESVPESAGPCCTMITSEHLSIILGNIL KIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAIKIVMEEEQLR ADSKSDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAE VFILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKAMQVKSGGQDQERKKSKRRG DLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSHRDTDEEVKEHIRNNLHLQ EKSDDPAVKWQLNLYKDILKSDEPPDPEKNVERVQRISAALYHLDQVEQPLRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQNYWIETEEYSFEEKLVQDLATSPK KEEEEEEDTEKEQPDPLHQIILYFSRNALTERSKLEDDPLYIAYAAMMAKSCQEEEEEEE EDKEKTFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAILN GGNTIVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLI VRERGEKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRL QESISDFYWYYSGKDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLW DAVVGFLHVFANMQMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVD TLVESSSNVELILKFFDMFLKLKDLTNSDAFKEHDPDGKGIISKKDFQKSMEAQKQYIQS EIEFLLSCAEADENDMFNYIDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQSLLEP AESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEGG EQEKMELFVNFCEDTIFEMQLASQISESDSAERPEEEEEEEPCYVVDIGDDEEEEKSLES PSAFALACAAVKKNVANFFKMVTVKNLRKQYRKVRKMTVKEMVKVFFSFFWILFVGVFQL FFTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVTEAEKTEGAEH GIRDELVQFVKGEKGETDIISDIFGIPTKKEGGSKHGHDAGLGDIAEILGSDIQSSLENN ARKKKGLQIPETAKEAEAERKVEAEKADMEDGEKQDKAKEEQSEQPEEGKMKKKKRRHGQ KIEKPEAVMANFFKALEIYQTKILHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLD EVEEDSNLWNSFEEEEEEEGMVFFVLEESTGYMAPALRALAVIHTIISFVCVIGYYCLKV PLVVFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEESEPEAASLVSWLSSIDTKYHIWKLGVVFTDN SFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTIPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggggaagatgaaatacagttcctacgaactgatgacgaa gtagtacttcagtgtgtttccagtatacacaaagaacaaaggaagttttgcttggcagct gagggacttggaaatcgcctgtgctttttggaaccaacatcagaagctaaatatgttcct ccagacctttgcatctgtaattttgtccttgaacagtctctgtctgtcagagcccttcaa gagatgctgaccaacacaggggataacgccagtgaaggggcagctcaagggggtcacaga actctgctctatggccacgctatactacttcgacattcgttcagtgaaatgtatttaaca tgtttaacgtcatcaagatcccagacagataaacttgcatttgatgtgggactacgagaa aacgcagcaggtgaggcatgctggtggacaatacaccctgcttctaaacaaagatcagaa ggagaaaaagttcgaataggtgatgatcttatcctggtcagtgtgtcctctgaaagatac ctgcatctctccatgtcaaatggaagcatccaggtggacgcctccttcatgcagacactt tggaatgtacatcctacatgctcaggaagcaatattacagaaggatatcttcttggtggg catgtagtacgctttttccatggtcatgatgagtgtttgacaattccttctacagatcag aatgattcacagcagaagaaagtactttatgaaactggaggggcaggcgttcgagcgagg tctttgtggagagtagaaccccttcgaataagttggagtggaagtaatatcagatgggga cagcctttccgtcttcgacatataacaacaggaatgtacttggctttgaatgatgatgaa ggtcttgtaatgttggacagagaaaagtcagacacaacatcttctgctttttgtttcaga gcatcaaaggaactaaaagaaaagcaggattctactcttaaacgtgacattgatggaatg ggagtcccagaaataaaatacggtgattcagtctgttttattcaacatgtagccagtgcc ttatggttgacttataaagcaccagatgctaaatcagcacgcttaggtctcctgaaaaga aaggttatattacaccaagaaggtcatatggatgatggtctaaccttacaaagatgtcag catgaagaatcacaggctgctcgaatcattcgcaatactacaagcttattcagccagttt ataagtgggaacaacagaacactatcacccattgccctgcctgttgaggagatggctcag actctgcaagacctgatcaagtacttccagcctcccggagaagacctggaacatgaggat aagcaaaacaagcttcggtccctcaaaaacagacaaaatctattcaaagatgagggaatg ctggcactagttttgaattgcatcgatcgtttaaatgactacaacagcgcagctcatttt gcagaaatttcaagagtagaaaatggtacagcatggaaagaaattttaaatctcctttac gaactgcttgctgctctcattcgtggcaacagaaacaattgtactcagttttccagtaac cttgattggttaataagcaaattggacagattagaatcttcctcaggtattttggaagtg ttgcactgtatcttgattgaaagtccagaagctttaaacgtaatagctgaggagcacata aaatctattatttcactgttggacaagcacggacgcaattacaaggttcttgacgtgctt tgctctctttgtgtctgtaatggagttgcagttcgtgccaatcaaaacttgatctgtgac aatctactgccaagaagagacttacttttgcaaacacgtttgattaatgatgtgacaagc ataaggccaaacatatttttgggtgttgctgagggctctgcacaatacaagaagtggtac tttgaattaataattgatcaggttgatccattcttgacggcagaacccacccatttacgg gttggatgggcctctacttcaggttatgccccttatcctggaggtggagaaggatggggt ggtaacggcgttggagatgacctatattcttttggttttgacggccttcatctgtggtct ggtcgagtacccagagctgtggcatctgttaatcaacatttgctgtcatctgatgatgta gttagctgctgcttggatttaggtgtacccagcatttcattccgcattaatggtcagcct gtacaaggaatgtttgagaacttctgtactgaagggtttttcttccctgttgtaagctta tcagcaggtgtaaaagctcgtttcttactgggtggacgtcatggagagtttaaatttctg cctcctactggctatgctccctgctatgaagccttgcttccaaaagaaaagatgaaatta gaaccagtgaaggaatataagagagattctgatggagtgagagatttgctgggtacgaca cagttcctctcccaagcttcatttataccttgtcctatagacacgagtcagattgctctt ccttttcatcttgaaaagatcagggataaactagcggaaaatatccatgaactgtgggga atgaataaaatagaactgggctggacatatggcaagatacgggatgataataaaaggcat catccttgtcttgtggaattctctaaattacctgagacagagaagaattataatctacaa atgtcaactgaaaccctcaaaacgcttttggcccttggatgtcacattgttcatgctaat ccagcagctgaggaagatcttaaaaaagtcaagcttcctaaaaattatatcatgtcaaat ggttataaacctgcccctcttgatctttctgaagtgaaattgttgccttctcaagaattt ctagttgacaaactagcagaaaatgcacataatgtctgggcaaaagacagaataaagcaa ggatggacctatggcattcagcaggatcttaagaacaaacgtaatcctcggctagtgcca tatgcattactagatgaacgtactaaaaaatcaaacagagatagcctccgtgaagctgtt aggacatttgcaggctatggttataatgttgagccacctgaccaagaaatagctgaccaa acagtggaaaaagtcagcattgacaagatacgttttttcagagtagaacagtcttatgca gtgaagtccggaaagtggtactttgaatttgaagctgtaacaggtggagatatgcgtgtt ggctgggccaggccaggctgtcgacctgacattgaactgggagctgatgaccaagcattt gtttttgaaggaagcaaaggccagcgttggcatcaaggcagtgggttctttggacgaagt tggcaaccaggagatgtggttggttgcatgataaacttggatgacaaatcaattatcttt accctgaatggagagttgcttataaccagtaaaggttcagaacttgcatttgccgacttt ggaatagaaagtggttttgttccaatttgctcactgggtctgtctcagattggacgtatg aaccttggaatggatgccagtacattcaagtattataccatgtgtggccttcaagaaggt tttgaaccttttgcagtgaacatgaaccgagatgttgctatgtggtttagtaaacgttta ccaacatttgttaatgtgccaaaaaatcatcctcacatagagatatggagaattgatgga accattgagagtccacctcggttaaaagttactcacaaaacatttggtacacaaaacagc aattctgatatgatatactgccgtttgagtatgcccattgagttccgttcatcattcaac tttggcgtgggtgtggaaaatgcctcatctgatgctcttcaaaaacgaaaacacagccaa gaatttcctgcttcttctaccacatgtttttattccttgcggatatttgctggccaagac ccatcctctgtctgggttggctgggtaacaccagactatcatttttacagtgagaatttt gacataaataaaaactgcacagtgacagttactttaggagatgagagaggcagggttcat gaaagtgtgaagcgcagtaattgctatatggtttggggaggagatatagctgctaattct cagagatcaggtcgcagtaatgttgatttagaaattggatgctttgttgacctggctact ggaatgttgtcattcactgccaatggaaaagagcttggcacttgttatcaggttgaacca aacacaaaactttttcctgcagcttttgtacagcctacgagcactaacttaattcagttt gaacttggtaaattaaagaataccatgcctttatcagcagcaatttttaaaagtgaggaa agaaatcctgttcctcagtgtccccctcgccttgatgtgcaaacaattacacctgtttta tggagtagaatgcctaacagctttctaaaagtagaaacagagcgtgtcagtgaacgtcat ggctgggttgtgcagtgtttggaacctctgcagatgatggcacttcatatcccagaggaa aacagatgtgttgatattttggaactatgtgaacaagaagatttgatgaagtttcactat cacactttaaaactttatagctcagtttgtgctctaggtaacactagagttgcttatgca ctttgtagccatgtagatatatctcagttattttacacaatagataatcagtatttgcct ggactcctacgttctggattctatgacttgctcattagtattcatttggaccatgccaag caagccaagctcatgatgaacaatgaatttatcattccagttacagaggaaactcgaact attaaattatatcctgatgaaacaaagaagcatggtttacctggagtagggcttagcact tgtctcaaaccaagctttaatttttctactccttgctttattgtaacctctgaagaacat cagacatccagcccagatattccacttgacacacttaaatccaaagctataagtatgttg acagaggcagtacagtgtagtggttctcatatacgagaccctgttggaggacatattgca ttccagtttgttcctgttcttaaactcatagcaacattgcttgtaatgggagtttttgat gatgatgatgtgaagcaggtgttaatcctcattgatcccaatgtcttcggagatcacaag gaagaagcagaagagaagacagagaaggaagaagttacacaagttgaagaaaaagctgta gaagctggagaaaaggcagtaaaagaaacaaaagctcctacaaagggcttattgcagacg agattaccagaatctgttaagcttcagatgtgccacttactcaattatttctgtgactgt gagctgcaacacagagtggaagcaattgtatcatttgcagatcactatgtatcaaaattg caatataatcagaagtacaggtataatgaactcatgcaagccttgaacatgtccgcagct ttgactgccaagaagactaaggaatttcgatctcctccacaagaacagattaacatgctg ctgaactttcaactgggagaggattgtccctgtccagaggagattcgggatgaactatat gacttccacgatgatcttctaattcactgtggtattccactagaagaggaggaagaggaa gaggaagattcctccttgactggcaaacttcgttcattaatatacaaaatcaaaggtcca ccaaaaccagaaaaaatagagcccagggaagaagaagataaatcacctactacactgaag gaactcatatcccagactatggtgcgctggtcccaagaagatcagattcaagatccagaa ttggttcggattatgtacactctcctgcgtaggcaatatgatagcattggtgagctactt caagctctgaggaaagcatacactattagtgctgcctctgtgaaggataccattaatctg cttgctgcactgggccaaattcgctcacttctcagtgtcagaatgggaaaagaagaggaa ctcctaatgattaatggattaggagatataatgaacaacaaggttttttatcagcatcct aacttaatgagagtcttgggcatgcatgagacagttatggatgtgatggtgaatgtgctt ggaggagataaatctcagatcgcttttcctaagatggtggcaagctgttgtcgattcctg tgctacttctgtcgcattagtcgtcaaaaccaaaaagccatgtttgagcatctcagttac ttactggaaaacagcagtgttgggttggcatttccttcaatgagaggttcgacaccacta gatgttgcagcagcctctgtaatggacaacaatgagcttgcactagcactggaagaacca gatcttgataaagttgttacatacctggcgggttgtggcctgcagagttgtccagtattg ctagctaaaggatatccagacatcgggtggaatccaatagagggtgaacgttacctgtca ttcctaagatttgcagtttttgtaaacagtgaaagtgttgaagaaaatgcaagtgttgtt gtaaagctccttattcgacgaccagagtgctttgggccagagcttagaggagaaggagga aatggtttgctggcagctatgcaagaagccatacggatctcagagaatcctactcgtgac cttccctcacaaggatataagagagaaggtgatgaagaggaggaggaggaggaggagatt gtacacatgggcaatgcaatcatgtcattttactctgctctcatagatttacttggacgc tgtgcaccagaaatgcaccttattcaaagtggaaaaggtgaagctattcgaatcagatca atccttcgatctctagtgccaactgaagatttggttgggattataagtataccactaaag ctgtcaacagttaacaaagatggcactgtaaatgagccagacatgtctgcaaatttctgt cctgatcataaggcaccaatggtactcttcttggaccgtgtgtatggtattaaggaccaa agcttcctccttcacctacttgaagttggatttttaccagatttgagagcttctgcctct ctggatacagtttctctaagtaccacagaagcagctcttgcattaaacagatatatttgc tcagctgtgtttccattactcaaaagatgcgctcccctcttttctggaacagaacatcat gcctctcttgttgactccatgcttcacacaatatataggttatccaagggacgttccctt acaaaagcacaacgagacactattgaagaatgcctgcttgctatctgccaccacttacga ccctctatgctccaacagctattgagaaggctagtttttgatgtgcccttactcaatgaa tactgtaaaatgccactcaagcttctgactaatcactatgaacagtgttggaaatattat tgtctgccttcaggaatgggaagctatggaattgcagcagaagatgaattacatttaact gaaaaacttttttggggaatatttgattccttgtctcataagaagtatgatccagagctc tttagaatggccttgccctgtctaagtgctatagctggggctttgcctcctgattattta gatacacgaattagatcaacattagaaaagcagacctcagtggatccagaaggaaatttt gatcccaaacctgtcaacacagcaaaccttgtacttcctgaaaagctggagtatattgtc agcaaatatgctgagcattctcatgataagtgggcttttgataagactaataacggatgg aaatacggtgtttcactggatgaaaatacaaagactcatccattaataagacctttcaaa actttaactgagaaggaaaaagaaatttatcgttggcctgtgagagaatcactgaaaacc atgttggccatgggatggagcctagaaaggaccaaagaagggggcgaaggaatgttacat cagcgtgaaaatgaaaagctccgcagcatatctcagtctagccagggaaatggatatagt ccagcaccacttgatctcactaacgtggtactttctagggaacttcagggaatggttgag gtaatggcagaaaactaccataatatatgggccaaaaagaagaaaatggagttggaaagc aaaggtgggggcagtcatcctttattggtaccttatgacacactcacagccaaggagaaa tcacgggaccgtgaaaaggcacaagagctgtttaaattccttcaagtgaatggcataatc atatctcggggtctgaatgacatggatttggatgcttcatccatggaaaagaggtttgcc ttcaagtttctgaagaaaattttaaaatatgttgattctgctcaagagttcattgcacat ttggaagccattgtaaccagtggaaaaactgaaaaatccccacatgaccaagaaataaaa ttctttgccaaagttcttttaccattagttgatcagtactttacaaatcactgcttgtac ttcctgtcttctccaacaaaaacacttagtagcagtggatatgcatcaaataaggaaaag gaaatggtagcaagcctgttctgcaaactagctgctcttgttagacataggatctcaatt tttggtagtgattctacaacaatggtgagctgcctgcacatcttagctcagtctctggac actcgaactgttatgaaatcaggatctgagctagttaaagctggattgcgcgcttttttt gaaaatgcagctgaagatctggaaaaaacttcagaaaatcttaaacttggaaaatttacc cattctcgaacacaaatcaaaggtgtttcacagaacatcaattatactacagtagcattg ctacctgtcttgacttcaatttttgagcatatttcacagtatcattttggagttgatttg cttttgggtgatgtacaagtttcatgttacagaattctttgtagcctctattcccttggg actgggaagaacatctatgttgaaaggcaacgtcctgcacttggtgagtgcttagcatct cttgcagcagccattccagtggcgttccttgaaccttctctcaaccactacaacccactg tctgtcttcaacacaaaaagtgcaagagaaagagcaattttaggtatgcctgatacagta gaggagatgtgtccagagatccctcagctggatggactaataaaggaaattaataattta gcagagtctggagcaaggtatactgaaatgccacatgtaattgaggttatcttacccatg ctgtgcaactatttgtcctactggtgggaacgagggtctgagagtgttcctgaaagtgct ggcccttgctgtacgatgataacatctgagcatctgagcatcattctgggaaatattctg aaaatcattaacaacaatctgggaatagatgaagcatcttggatgaagagaattgcagtt tatgctcaacctatcatcagcaaagccagacctgatctgctgaaaactcactttattcca acactggagaaattgaagaagaaagctataaagattgtgatggaagaggagcaactgaga gcagacagtaaaagtgacactcaagaagctgagctacttattcttgatgagtttgctgtt ctttgtagagacctctatgccttctatccaatgctgatacgttacgtagacaacaacaga gccaactggctaaagaaaccagatgcagattctgatgaactgtttcgaatggtagctgaa gtttttatcctgtggtgcaaatcacataatttcaaaagagaagaacaaaattttgtcatt cagaatgaaatcaacaatttggcatttttaactggagataccaagagcaagatgtctaaa gccatgcaagtaaagtctggaggacaagatcaagagagaaagaaatcaaaacgcagaggg gatttgtactccatacaaacatccttgattgtagctgcacttaaaaagatgcttcctatc ggcttgaatatgtgtactccaggagatcaagagctcatctccttggctaagactagatat agccatagggacactgatgaagaagtcaaagagcatatacgtaacaatttacatctgcag gaaaagtctgatgatcccgctgtgaaatggcagttaaatctgtataaagacattctgaag agtgatgagcctcctgaccctgagaaaaatgtggaacgtgtgcagaggatatcagctgct ctgtatcatctggatcaggttgaacagccactgagatcaaagaaagctgtttggcacaaa cttctgtcaaaacaacgcaaaagagctgttgttgcttgttttagaatggcaccgttatac aacctacccaggcaccgttctattaacctcttcctccatggctatcagaactattggata gaaacagaggaatattcatttgaggagaaactagttcaggatttggctacatctccaaaa aaagaggaagaagaagaggaagatacagagaaagaacaacctgacccacttcatcagatt atcctctattttagtcgcaatgctctcacagagaggagcaaactggaagatgatccctta tatatcgcctatgctgccatgatggcaaagagctgtcaggaagaagaagaggaggaggag gaagacaaagagaagacatttgaggagaaagaaatggaaaagcagagaactctttatcag caagctcgcttacatgaccgtggagctgctgagatggtccttcagatgatcagtgcaagc aaaggtcatacaggacccatggttgttgaaacactaaaacttggtattgctattctaaat ggtgggaatacaatagttcaacagaaaatgctagactacttgaaggagaaaaaggatgct ggattctttcaaagtctttctggtttgatgcagtcctgcagtgttcttgacttgaatgcg tttgagagacaaaataaagcagaaggcctgggaatggttactgaagaaggaactctcatc gtacgtgagcgtggtgaaaaagtgttgcagcatgatgaatttactcgagatctatttaga tttttacaactactctgtgaagggcataacaatgattttcaaaattacctacgtactcag atgggcaacaccacaacggtgaatattatcattagtacggtcgactacctcttgcgtctt caggaatcaatcagtgacttctattggtactattcaggaaaagatgttattgatgaatca ggacaacgtaacttctctaaagctttggctgtcaccaaacaaatattcaattcccttact gaatatatacagggaccttgcattggtaaccaacagagcctggctcatagtaggctgtgg gatgcagttgttggatttcttcatgtatttgccaatatgcagatgaaactttcacaggac tctgctcagattgaactgcttaaggaactgctagatctgctaaaggatatggttgtgatg ttgttgtcattacttgaaggtaacgttgtaaatggaacgattggaaaacaaatggtcgat acacttgtagaatcatctagcaacgtagaattgatcttgaagttttttgacatgtttctc aaattaaaagatttaactaactcggatgctttcaaagaacatgacccagatggtaagggc atcatttcaaagaaggatttccagaagtcaatggaggctcaaaaacaatatatacaatca gagattgaattcttgctgtcgtgtgcagaagctgatgaaaatgatatgttcaactacatt gattttgtggaaagattccatgaaccagccaaagatattggctttaatgtagcagttttg ctaacaaacctttcagagcatatgcctaatgactcacgccttcagagcttacttgaacct gcagaaagtgttcttaattactttgaaccctaccttggccgtattgaaataatgggtgga gccaagaaaatagaaagagtttactttgaaatcagtgaatccagtagaatgcagtgggag aagccacaggtgaaggaatccaaaaggcaattcatatttgatgttgtaaatgaaggtgga gagcaagaaaaaatggagctcttcgtgaatttctgtgaagacactatctttgaaatgcag ttagcatcacaaatctctgagagtgattcagctgagagacctgaggaagaagaagaagaa gagccttgctatgttgtggatattggagatgatgaggaagaagaaaagtccctggaatct ccttcagcttttgcattggcctgtgctgcagtcaagaagaacgtagccaacttttttaaa atggtcactgtgaagaacctaagaaagcagtacaggaaagttagaaagatgacggtaaaa gagatggtgaaagtgtttttctcttttttctggatcctattcgtaggggtgttccaactg ttctttactatagtgtggggaattttccagattctttggagcaccgtatttgggggtgga ctagttgaaggagccaaaaacattaaagttactaaaatactaggggacatgcctgaccca acgcagtttggaatccatgatgatgttacggaagcagaaaaaactgaaggtgctgagcat ggcattagagatgaacttgtgcagtttgtaaaaggtgaaaagggagaaactgacataatc tcagatatttttggcattcctactaagaaagaaggtggctcaaaacatggtcatgatgct ggacttggagatattgcagaaatacttggctctgatatccagtcttctctggaaaacaat gctcgtaagaaaaaaggactacagatacctgaaactgcaaaagaagctgaagcagaaaga aaagtggaagctgagaaggctgacatggaagacggtgagaaacaggataaagcaaaggaa gaacagtctgagcagccggaagagggaaaaatgaagaaaaagaagcgaaggcatggacaa aaaattgagaaacctgaggctgttatggctaatttcttcaaagccttggaaatatatcaa acaaaaatacttcactacctggcaaggaatttttataacttacggtttcttgctctattt gttgcatttgccattaactttattctgctattttacaaggtgacagaagagccacttgat gaagtggaggaagactctaatctctggaactcttttgaggaagaggaagaggaggaagga atggtattttttgttttggaagaaagtacaggttacatggcacccgctctcagagcactg gcggttattcatactatcatctcctttgtctgtgtgattggatactattgcttaaaggtc cctttggttgtattcaagagagaaaaggaagtagctaggaagctggaatttgatggatta tacataaccgaacaaccatctgaagatgacattaaaggacaatgggatcgcctggttata aacacaccgtcctttcctaacaattactgggataaatttgtaaaacgaaaggttattaac aagtatggagatttgtacggagcagagcgtatagcagaacttttgggtttggacaaaaat gcccttgattttagtcccgtggaagagagcgaaccagaagcagcatctcttgtgtcatgg ttaagttccattgatacaaagtaccacatttggaagctcggtgttgttttcactgataat tcatttttgtatttagcttggtacacaactatgtctatccttgggcactataacaacttc ttttttgctgctcatctgctggacattgctatgggtttcaagacattgcgaaccattttg tcctctgtcactcacaatggcaaacagcttgtgctgactgtaggactcctggctgtagta gtgtatctttacactgttgtggcgttcaacttcttccgcaaattctacaataaaagtgaa gatgaagatgaaccagatatgaaatgtgatgacatgatgacgtgttacctattccacatg tacgtgggtgtaagagctggtggtggcattggggatgaaattgaggatcctgctggagac ccttatgaaatgtatcgaattgtcttcgacatcacatttttcttctttgtcattgtcatc ctactggccattattcaaggtctgattattgatgcttttggtgaactaagagaccagcaa gaacaagtgagagaagatatggagaccaagtgctttatttgtggaattggcaacgactat tttgacacaatcccacatggctttgaaacacatactctgcaggaacacaacttggcaaac tacctattcttcttaatgtacctcataaacaaggacgagactgagcatactggccaggag tcatttgtgtggaagatgtaccaagaaagatgctgggatttcttcccagcaggagactgc ttccggaaacagtatgaggatcaactcggctaa

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