Gallus gallus (chicken): 421508 Help Entry 421508            CDS       T01006                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gga  Gallus gallus (chicken) Pathway gga04020   Calcium signaling pathway gga04260   Cardiac muscle contraction gga04261   Adrenergic signaling in cardiomyocytes gga04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gga00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     421508 (RYR2)    04020 Calcium signaling pathway     421508 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     421508 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     421508 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gga04040]     421508 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:gga04990]     421508 (RYR2) Ion channels [BR:gga04040]  Voltage-gated cation channels   Ryanodine receptor    421508 (RYR2) Domain-containing proteins not elsewhere classified [BR:gga04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    421508 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  421508 NCBI-ProteinID:  XP_025004802 CGNC:  8217 Ensembl:  ENSGALG00000010812 LinkDB All DBs Position 3:complement(37257604..37618417) Genome browser AA seq 4987 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEFAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLLDDKSLLLTDKEKADIKSTAFCFRSSKEKLDVGMRKEVDGMGTPEIKYGDSI CFIQHVDTGLWLSYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGD DLYSYGFDGLHLWSGCVARTVNSPNQHLLRTEDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREY KQDRNYTRDLLGPTLNLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEK VKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRVDMSNG IMEKFRIFRTEKTYAVKSGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGF KAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDG FLPVCSLGPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPQNHEHIEVMRIDGTIDTCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRTAAG GLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLAADRTEREKDATKPELNNHKDYVQEK PSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQ CLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHV DESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSINSECFQFSPEFPLEILKAKTIEMLTEAVQ EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAASLEDE KDLSEKELSSDELKSGEEESRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIE AIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDK TDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDLTIRGRLLYLVEKVTYLKKKQ AEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALP KTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE NSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISK GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL LAAMEEAIQISEDPTRDGPSPNNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRCA PEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPD HKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTA VLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPS MMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRK LFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNP QPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLL SEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDAAHGYSP RAIDMSNVTLSRDVHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEK AKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILE FDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSTGGHASNKEKE MVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFLD NAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTSVALLPVLSSLFEHIGQHQFGEDLI LEDVQVSCYRILSSLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYS IYNTKNARDRAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPML CSYMSHWWEHGPENNPDKVEVCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVF SQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTL ARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQ NEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICA PGDQDLIALAKNRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSS DPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRH RAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPQEEDESLKRVDPLHQLILLFSRT ALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKHDNIKDLRNKF ASLGENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILN GGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVI THERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRV QESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLW DAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVD MLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQS ETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLEL SESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGG EKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEDNEKDKLEEQDPGMGFFSLVTM KSALVALKYNLMTLMKMLSVKSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHFACSV FRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPAETALPTE DLTDLRTLSEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSVAPMPEAQEKV QDQVKEDEKEEKEETKSEPEKAEGEDGEKEEKAKEDRAKQKLRQLHTHRYGEPEIQESAF WKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKEIPVVSTGE NMKLDSLESDSQRVIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIF KREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEF YGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFL YLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYL YTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYE IYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDT VPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRK QYEDQLN NT seq 14964 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgaaggcgaggacgagattcagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaactgttcacaaggagcaacagaaattgtgtcttgctgcggaa ggatttggcaacaggctttgctttttggaatccacatcaaattctaagaatgtgccacct gatttgtccatctgcacctttgtgcttgagcagtctctgtctgtacgagccctgcaggaa atgctggctaacacagaggagaaggcagaagggctagttgatgtggaaaaatggaaattt atgatgaagtctgcacaaggtggtggtcatcgaacacttctctatggacatgcaatcctg ctgcgccattcctacagtggcatgtatctatgctgcctctcaacatctcgatcttcaatg gataagctggcatttgatgtaggattgcaagaggacaccacaggtgaggcatgctggtgg actatccatcctgcttctaagcagcgatcagaaggagaaaaagtgcgtgttggagatgac cttattttagtcagtgtctcttctgaaagatacttgcatctctcctatggcaatggtagc ttacatgttgatgcagctttccagcaaactctttggagtgtagcaccaatcagttcagga agtgaatttgcccaaggatatctgataggtggggatgttctgaggttattgcatggtcac atggatgaatgcttgacagtcccttcgggtgaacatggagaagaacaaagaagaaccgtc cattatgaaggtggtgcagtgtcaattcatgctcgttccctttggcgattagaaactctg agagttgcgtggagtggcagccacataagatggggacagccattcagactaagacatata acaacaggaaaatacttaagtctcctagatgacaagagtcttcttcttactgacaaagag aaagcagatataaaatctacagcattctgttttcggtcttccaaggaaaaattggatgta ggtatgagaaaagaggtagatggaatgggaacacctgaaataaaatatggagattcaata tgcttcatacagcatgtcgacacaggcttgtggctttcataccagtctgctgatgcaaag tctgtaagaatgggttctgtgcaacgcaaggcaataatgcaccatgaaggtcacatggat gatggtttaacattgtccagatctcagcatgaagaatcccgtacagcacgtgtcatccgt agtacagtcttccttttcaacaggtttataaggggccttgatgctctcagcaaaaaagtg aagtcttccacagtagatttacctattgagtcggtcagtctgagccttcaagacttgatt ggctactttcacccccctgatgaacatttagagcatgaagacaaacaaaacaggctccgc gcactgaagaatcgccagaacctcttccaggaagagggcatgatcaacctcgttcttgaa tgtattgatcgcttgaatgtatacagcagtgcagctcattttgcagatgtagctgggaag gaagctggagaagcatggaaatcgattctgaattccttgtatgaattactagcggctctt attcgagggaatcgtaaaaactgtgctcaattttctggatctcttgattggctgatcagc agattagaaagactagaagcctcttctggaatactagaagttctacactgtgtattggtg gaaagccctgaagctctaaacattattaaggaaggacatattaaatcaatcatctgtctt ttggacaaacatggaagaaaccataaggttttggatgtcttatgttctctctgtgtatgt catggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgccaggaaga gatctgctcttacagacccgccttgtgaaccatgtgagcagcatgcgacctaatattttc ttgggaattagtgaaggctctgctcagtacagaaaatggtactatgaacttatggtggac catctagagccttttgtgactgcagaatcaactcacctacgagtaggctgggcttcaaca gagggctactcaccgtatccggggggaggagcagagtggggaggaaatggtgttggtgat gacttgtattcttatggcttcgatggtctgcatctgtggtcaggctgtgtagctcgaaca gtaaattctccaaaccaacatctgctgagaactgaagatgttattagttgctgtttggat ctgagcgcccccagcatctcttttcggataaatggacagccagttcaaggaatgtttgag aatttcaacatagatggccttttcttcccagttgtcagcttctctgcaggaataaaggta cgtttcttgcttggaggtcgccatggagaattcaagttccttcctccacctggatatgcc ccttgctttgaagctgttctaccaaaagagaaattgaaagtggagcatagccgagagtac aagcaggatcgaaactatacaagggacctgctgggtcctactctcaatctgtcacaagca gctttcacccccgttcctgtagatactagccagattgttttgcctccccacttggaacga attagagaaaagttagcagagaacatccatgaactttgggttatgaataagattgaacta ggctggcagtatggaccagttagagatgacaacaaaagacaacacccatgcttagtggag ttctcaaaattgccggagcaggaaagaaattataacttacaaatgtcgcttgaaacactg aaaacgctgctggcgttaggctgccatgttggaattgctgatgaacgtgctgaagaaaaa gtgaaaaaaatgaaacttccaaagaactaccagttgttgagtggatataagcctgctccc atggatctgagtttcatcaaactgaccccctctcaagaagctatggtggataaactagca gagaatgctcacaatgtgtgggcaagggaccgaatcaggcaaggctggacctatggtatc cagcaggatgtgaaaaatcgacgaaatcctcgtcttgtaccttatgcccttttggatgat cgaacaaagaagtcaaataaagacagtcttcgggaagcagtccgcacccttctaggctat ggctacaatctagaagctcctgaccaagatcatgccacaagagtggacatgagcaatggg ataatggaaaaattccggatcttccgcacagagaaaacttatgcagtgaaatctggaaag tggtacttcgagtttgaggcagttacagcaggagacatgagagttggctggacaaggcct ggttgtctgccagatcaggaacttggctcagatgaagaagcttttgtttttgatggcttt aaggcacagcggtggcatcaaggtaatgagcattttggccgctcatggttggcaggagat gttgttggatgtatggttgacatgaatgaacacactatgatgttcaccttaaatggcgaa atcctgcttgatgactcaggttcagaacttgcatttaaagattttgaggttggtgatgga tttctacctgtgtgcagcctgggtccatctcaagtgggaagaatgaactttggaaaagat gtcagcactctaaaatatttcactatctgtggcttacaggaagggtatgagccctttgct gttaatacaaacagagacattaccatttggctcagtaaaaggctccctcagtttctacca gtgccacaaaatcatgaacatattgaggtgatgagaattgatggaaccatagacacttgt ccttgcctgaaggtcacacagaagtcctttggttcacagaacagtaaaacagatgtcatg ttttttcgattaagtatgcccattgaatgtgctgaggtgttctccagaacagctgcagga gggttaccaggcactggtctttttggcccgaagaatgatttggaagattatgatgctgat tctgattttgaggttctaatgaaaactgctcatggtcatctagcagctgaccggacagag agagaaaaagatgccacaaaaccggagttaaataaccataaagattatgttcaagaaaag ccttcacgtcttaaacaaagatttatgcttaggaggacaaagccagattatagcacaagc cattctgcaaggcttactgaggatgtgctagcagatgatagggatgactatgattatttg atgcaaacttccacgtactattattcagtgagaatatttcctggtcaagaacctgctaat gtttgggtaggctggattacatctgactttcatcagtatgacacaagctttgacttggac agagtgcgtactgttacagtaactctgggagatgaaaaaggaaaggtccatgagagtata aaacgcagcaactgctatatggtatgcgcaggagagagcatgagccctgggcaaggacgt aataataatggtctggagattggttgcttagttgatgctgccagtggcctgctgaccttc acagctaatggcaaagaactgggcacatactatcaggttgaaccaagcacaaagttattt cctgctgtatttgctcaagctacaagccccaatgttttccagtttgagttgggtagaata aagaatgtaatgccattatctgctggcttattcaaaagtgaacacaaaaatccagtttcc cagtgtcctccacgtctccatgtccagtttctgactcacgtgctttggagtagagtgcca aaccacttcttgaaagttgatgtctctaggatcagtgaacgtcaaggctggatgatacag tgcctgaatcctttgcagttcatggcccttcacattcctgaagaaaacagaacaattgat attttagagctgacagaacaagaagaactgctgaaatttcactaccatactctccgatta tattcagctgtgtgtgctttaggaaacaaccgcgtggcccatgctatgtgtagccatgtg gatgaatctcagcttctatatgctattgagaataaatatatgccaggactattacgtgca ggatattatgacttactcatagacatccatctcaatacctatgcaactgccaggttaatg atgaataatgaatttattgttccaatgactgatgagaccaagagtattaccctgtttcct gatgaaaacaagaagcatggcctccctggtataggactcagcacttccttaaggccaaga atgcagttctcctcaccgagttttgtaagcattaacagtgaatgctttcagttcagtcct gaattcccactggaaatcttaaaggccaaaacaatagagatgctgactgaagcagttcag gagggcagcctccatgtcagagacccagttggaggttctacagaatttctgtttgtccct ctcatcaagctcttttacaccctcctaattatgggaatcttccacaatggggatctgaaa cacatcttgcagttgattgagccacgggttttcaaagaagctgcgagtctggaggatgaa aaggatctctcagagaaggagctgagttcagatgagctcaagtcaggagaggaagaaagc agaggggagcaagtgccaaaggaaggactccttcagatgaagcttcccgaacctgttaag ctacagatgtgtcatctactccagtacctgtgtgattgccaggtacgacaccggatagaa gccattgtagcattttcggatgattttgtggccaagcttcaagagaatcagcgcttcagg tacaatgaagtgatgcaggccttgaacatgtctgctgccttgacagctagaaaaacaaag gaatttcgatccccacctcaggagcagattaacatgctgctgaactttaaagatgataaa actgattgtccttgccctgaagaaattcgggatcaactcttggatttccatgaagaccta atgacacactgtggaattgaactagatgaagatggaactttggatggaaatagtgattta accattaggggtcgcctactatacttggtggaaaaagttacatatctgaagaagaagcaa gctgagaagccagttgatgatgatgctaagacatcctctactcttcagcaattgatttca gatacaatggtgcgctgggcccaggaatcagtaatagaagacccggagttagtcagggcc atgtttgtactgctacatcgccaatatgatggtattggtggcttggttcgagccctgccg aagacttacaccataaatagtgtgtccgtggaagatacaatcaatcttctggcatccctt ggccaaattcgttccttgctcagtgtcaggatggggaaggaagaagagaaacttatgatt cgtggattaggagacatcatgaataataaagtattttatcaacatcccaatctcatgaga gctttaggcatgcacgagaccgtcatggaagtgatggtaaatgtacttggtggaggagaa tccaaggaaatcactttcccaaaaatggtggcaaactgctgtcgtttcctatgttatttt tgccgcattagtaggcagaatcaaaaagctatgtttgatcatcttagctatttattggaa aatagcagtgttggccttgcctctccttctatgcgaggatctactcctttagatgttgca gcagcatctgtgatggataacaacgaacttgcactagctttaagggagcctgatctggag aaggtggttcgatacttggctggatgtggattgcagagttgtcctttgttgatttctaaa ggctatccagacattggatggaatccagttgaaggagagcgatatttggattttcttcgt tttgctgtattttgcaatggagagagtgtggaagagaatgcaaatgttgtagtgagactg cttattcgtcgaccagaatgttttggtccggctctaagaggagaaggaggcaatggtcta cttgctgccatggaggaagcaatacaaatatcagaagatccaacaagagacggaccttcc ccaaataatggatctagtaaaacccttgaaatggaagaacaagaagatgacactattcat atggggaatgcaatcatgacattttatgctgctttgattgatctcttaggacgttgtgcc cctgaaatgcatctcatacatgctggtaaaggggaggccataagaatcaggtcaattcta aggtctttgattccactggaagatttggtgggcgtaattagcattccgttccacatgccg accatagctaaagatggtactgtggtggaacctgacatgtctgcggggttttgcccagat cacaaggcagccatggttttgttccttgacagggtctatggaattgaggatcaggatttt cttctacatcttcttgaagttggctttctgccagatctccgtgctgctgcttctttagat acagctgctttgagtgctacagatatggctttagctctgaatcgatacctttgcacagca gtcttgcctctgttgaccagatgtgctcctctttttgctggcacagagcaccatgcttcc cttattgactccttattacatactgtgtacagactttcaaagggctgctctcttaccaaa gctcagcgagattccattgaggagtgcttactttctatctgtgggcagttgagaccttct atgatgcagcatttgctgagaagattagtatttgatgttcccctattaaatgaacatgca aagatgcctctcaagttgctgacaaaccattatgaaagatgctggaagtattattgttta ccaggtggatggggtaactttggtgctgcctcagaagaagaacttcatttatccagaaag ttgttctggggtatttttgatgctttgtctcaaaagaagtatgaacaagaactattcaaa ctggctttgccttgtttgagtgcagttgcaggggcattacctccagattatatggaatca aattatgtcaatatgatggagaaacaatcttcaatggattcagatggaaactttaatcct caacctgttgatacttcaaacattacaatccctgaaaagctggaatatttcattaacaaa tatgcagaacattctcatgataaatggtcgatggaaaagtttgccaatggatggacgtat ggtgaaacatactctgaatctgcaaaagtgcaaccattaatgaagcagtataaactactc tctgaaaaggagaaagaaatttatcgatggccaatcaaagaatctctaaaaaccatgctg gcatggggatggcggattgaaaggacacgggagggagattccatggcattgtataatcgg acacgtcgcatatctcaaaccagtcaaatctctgtagatgcagcccatggttacagtcct cgagcaattgatatgagcaatgttaccctctccagagatgtgcatgctatggcagagatg atggctgaaaactatcataacatatgggcaaagaaaaagaaaatggagcttgaagcaaaa gtaggaggaggcaaccatccccttcttgttccttatgatacactcacagccaaagaaaaa gctaaggacagagaaaaagcacaggatattctgaaatttctacaaattaatggatacgta gtctccagaggacttaaggacctggaattggacacaccttccattgagaaacgctttgcc tacagtttcctccagcagcttataagatatgtagatgaagctcatcagtacattttggaa tttgatggtggcagcagaggcaaaggagagcatttcccatatgaacaagaaatcaagttt tttgccaaagttgtgctccctttgattgatcagtatttcaaaaatcatcgcttgtatttc ttatctgcagcaagtaggcctctcagcactggaggccatgcctctaataaggagaaagaa atggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatttcactgttt ggaaatgatgcaacatcaatagtcaactgtcttcacatattgggccagaccttggatgcc agaactgtgatgaaaactggtctggagtctgttaagatggcattgagagcatttttggac aatgctgctgaggatctggagaaaacaatggaaaatcttaagcaaggccagtttacacac agcagaaaccagcccaagggagttacacaaatcattaattatacctcagtggctctcctg ccagtgctatcttcgttatttgagcatattggacagcaccagtttggggaagatttgata ttggaagatgttcaagtgtcttgttatagaatattgtccagtttgtatgctctgggaacc agcaaaagtatatatgtagagcggcaacgatcagcactaggagaatgcttggctgctttc tcgggtgcctttccagtggcttttttggaaactcatttgaacaaacataatatctactca atttacaataccaagaatgcaagagacagagcagttcttaatttacctactagtgtagaa gaagtttgcccaaatattccttccttggtgaagctaatggaagaaattgtggaactggca gaatctggtattcgctacacacaaatgccacatataatggaagtgatactgcctatgctg tgtagttacatgtcacactggtgggagcatgggccagaaaacaatcctgacaaagttgaa gtgtgttgtacagccttgacatcagagcacatgaacactctgttgggtaacatattgaaa atcatctataacaaccttggtattgatgaaggagcctggatgaagaggttagcagtgttt tcccagcccatcataagcaaagcgaagccacagctcttaaagacacacttcctgccactg atggataagctaaagaaaaaagcagcagtggttgtatcggatgaagagcatctaagagca gaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccactttg gcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagggca aaatggctgaaagagcccaaccctgaagctgaagaattgttccgcatggtggctgaagtc tttatttactggtcaaagtctcataatttcaaaagggaagagcagaactttgtggtacaa aatgagatcaacaacatgtccttcctgatcagtgacaccaaatctaagatgtctaaggca gcagtttctgaccaagagaggaagaagatgaagcggaaaggtgacaggtactctatgcag acctctctcattgtggcagcgctgaagagattacttcctattggcctaaatatttgtgct cctggagaccaagatctaattgcactggccaaaaaccgattcagcatgaaagatactgag gatgaggtacgagatatcattcgcagtaatcttcatctccagggcaagctggaggatccc gccattagatggcagatggcactttacaaagatttacctaacaggactgaagattcatca gatccagagaagactgtggaaagagttcttgatatagctaatgtactgtttcatctggaa caggttgaacatcctcagcggtccaaaaaagcagtttggcataagctgctgtctaaacag aggaaaagagcagtagttgcttgctttagaatggcaccattgtataacctgccaaggcac cgagctgtgaatctctttcttcaaggatatgataaatcttggattgaaacagaagaacac tattttgaagacaaactgatagaagatttagcaaaacctggagaggaaccacaagaagaa gatgaaagccttaaaagagtggatccattacatcaacttattctgctattcagtcgaaca gccttaactgaaaaatgcaaattggaggaagattttctctatatggcttacgctgacatt atggcaaagagttgccacgatgaagaagatgatgacggtgaagaagaagtaaagagcttt gaagtcacaggatctcaacgcagcaagcacgataatatcaaagatttaagaaacaaattt gccagcctcggcgagaactctctggaaaaagaaatggaaaagcaaaaacttctgtatcag caagccagactgcatgaccggggtgctgctgagatggttcttcagacaatcagtgctagt aaaggtgagatggggccaatggttgcagctaccctgaagctagggattgccatcttaaat ggaggaaattctactgttcagcagaaaatgcttgactacctcaaggataagaaagatgtg ggtttctttcagagtcttgctggtcttatgcagtcctgtagtgttcttgatctaaatgca tttgaacgtcaaaacaaagcagaaggccttggcatggtgactgaagagggatcagtcatc actcatgagcgcggagaaaaggtgatgcaggatgatgagttcacctgtgacctctttcgc tttcttcaattgctttgtgaaggacacaattcagattttcagaattacttgagaactcag actggtaacaacacaactgttaatattataatttccactgtggattacttattgagagtt caggagtccattagtgatttctattggtattattctgggaaggatgttattgatgaacaa ggacaacgaaatttttccaaagccatccaggttgcgaaacaagttttcaatactctgacg gagtatatccaggggccatgtactgggaatcagcaaagtctggcacacagcaggctatgg gatgctgtagttggttttcttcatgtatttgctcatatgcagatgaagctgtctcaggat tccagtcaaattgaattactgaaagaattaatggatcttcagaaggatatggttgtcatg ttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaagcaaatggttgat atgcttgtggaatcgtccaacaatgtggagatgattctgaagttttttgatatgttcttg aaactgaaagatttgacttcttctgatgcgttcaaagagtatgatcctgatggtaaaggc ataatttcaaaaagggatttccacaaggcaatggaaagccataagcattacacccagtct gaaactgaatttctgctatcatgtgctgaaacagatgagaatgagactctggactatgag gagtttgtgaaacgattccatgagcccgccaaagacattggtttcaatgtcgcggttctc ctgaccaacctctccgaacacatgccccacgatactcgcttgcaaacttttcttgaactg tcagaaagtgtgctgaattactttcagcctttccttggacgtatagaaatcatgggcagt gcaaaacgcattgaacgagtgtattttgaaataagtgagtcaagtcggactcagtgggaa aaacctcaggtaaaagagtcaaagagacagtttatatttgatgttgtaaatgaaggtgga gagaaagaaaagatggagctttttgttaatttctgtgaagataccatctttgaaatgcaa ctggctgcccaaatatccgagtcagatctaaatgaaaggtcagcaaataaagaggacaat gagaaagataagcttgaggaacaggatcctggaatgggtttcttctcacttgtaactatg aagtcagcattagtagcgctcaagtataatttaatgactcttatgaaaatgctcagcgtg aagagcctaaagaaacagatgaagaaggtgaagaaaatgaccatgaaggacatggttatg gctttattttcttcctactggagcattttaatgggtttactgcattttgcctgtagtgtc ttccggggcttctttcgcatcatttgcagtttgcttcttggaggaagcctagtagaagga gcaaagaaaatcaaggtggctgagctattagctaatatgccagatcccactcaggatgag gtgcgtggggaaggagaagagggggagaggaagccagcagaaactgccttgcctactgaa gacttgactgatttgagaactttatcagaggagagtgatctactctcagatatatttggt ttggatttgaaacgagaaggtggacagtataaattgattcctcacaacccaaatgctggt ttgagcgatttactgagcactccttctgtagcaccaatgcctgaggcacaggaaaaagtc caggaccaggtgaaagaagatgaaaaggaagagaaggaagaaacaaaatctgaacctgaa aaagcagaaggagaggatggagaaaaagaagagaaagcaaaggaagacagagcaaaacag aagttaagacagcttcatactcacagatatggagaaccagaaattcaggaatcagctttc tggaaaaaaattattgcatatcaacagaagcttcttaactattttgctcgaaacttttat aacatgcggatgttggcgttgtttgttgcctttgccatcaacttcatcctgcttttctat aaggtctccacctctgctgtgacagaagaaaaggaaattcctgtagtgtctactggagaa aatatgaagttggacagcttggagagtgacagccagagggtcattgcagtgcactatgta ctggaagaaagcagtggctacatggagcccacactgcgaattttggccatcttacacacg gtcatctcattcttctgcatcattgggtattactgtttgaaagtcccactggtaattttt aagagagaaaaggaagtagcaaggaagttggaatttgatgggctgtatatcactgaacag ccctcagaagatgatattaaagggcaatgggatagacttgtaatcaacacacagtctttt ccaaataactactgggacaaatttgtgaaaagaaaggtcatggataaatatggtgagttc tatggccgtgacagaatcagtgagttactaggaatggacaaagctgctctcgatttcagt gatgctagagaaaagaagaaaccaaagaaggatagctccttatctgctgtgctaaactcc attgatgttaagtatcagatgtggaaattaggagttgttttcactgataattctttcctt tacctagcttggtacatgaccatgtcagtccttggccattacaacaattttttctttgct gctcatctccttgacattgcaatgggattcaagacattacgaactatactctcatcagtg acccacaatggcaaacagcttgtcctaacagtgggattactggcagtagtggtatacttg tacacagtagtggcattcaattttttccggaagttctacaacaaaagtgaagatggtgat atgccagatatgaaatgcgatgatatgctaacatgctacatgtttcacatgtatgttgga gtacgtgcaggtggaggtattggtgatgaaatagaggatccagcaggagatgaatatgaa atctatcgaatcatctttgacatcactttcttcttctttgtgattgtcatcctgcttgcc attattcaagggttaattattgatgcttttggtgagctaagagatcagcaagaacaagtg aaggaagacatggagacaaagtgctttatctgtggaataggaaatgactactttgataca gtgccccatggctttgaaactcatacactgcaggagcacaacttggccaattatttgttt tttctgatgtatcttattaacaaagatgaaacggagcatacaggacaggaatcctatgta tggaaaatgtatcaagaacgatgctgggagttttttcctgctggtgattgtttccgaaaa cagtatgaagaccagcttaactaa

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