Gallus gallus (chicken): 421640 Help Entry 421640            CDS       T01006                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism gga  Gallus gallus (chicken) Pathway gga04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:gga00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     421640 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:gga03036]     421640 (SYNE1) Chromosome and associated proteins [BR:gga03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     421640 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH KASH GP57 Motif Other DBs NCBI-GeneID:  421640 NCBI-ProteinID:  XP_004935689 CGNC:  10146 LinkDB All DBs Position 3:complement(49256951..49538650) Genome browser AA seq 8813 aa AA seqDB search MASSRLVTRSRDIANVMQRLQDEQELVQKRTFTKWINTHLAKRNPPMMVSDLFEDIKDGV MLIALLEVLSGQKLPCEQGRHLKRIHWVANIGTALKFLEGRRSVYRGSPIKLVNINSTDI ADGRPSIVLGLVWTIILYFQIEELTSNLPQLQSLSSSASSVESVVSSETASPPSKRKVVT KVQGSARKALLKWIQYTAARQVGIEIKDFGQSWRSGVAFHSIIHAIRPDLVDMEKVKGRS NRENLEEAFTLAETELGIPRLLDPEDVNVDKPDEKSIMTYVAQFLKYYPDPHHTVADVQE NEKEDKLMLRDLKVWAEQFERDLARAQVAETSLQEKYQSFKHFRIQYEMKRKPIELVTQS LRKDGKLSLDQAIVKQAWDRVSSRLFDWHIHLDKSLPAPLGTIGAWLYRAENALREEVSI QQAHEETANIIHRKLEQLKDLLKNIEGHKKTFHEIHGARSVNGVPVPPDQLEDMAERFNF VVSSSELHLLKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQNYISVIENSK FFEQYEVTYQILKRAAEMYAKANGSVEEVESVMKFMSETTAQWRNLSVEVRSVRSMLEEV IANWDRYSSTVAGLQAWLEDAEKMLNQTEQSKKDFFRHLPHWIQQHTAMNDAGNFLIETC DETISRDLKQQLLLLNGRWRELFMQVKQYARADELDKIQKEYLDGVANLTAFVDGSNRKF SSAIEVSFLDVKMFVQDLENIKQKLPTMEAQYKMVTRTAQLLTKEISQEEVNEMLATLTR MKEQLSKVKEYSSALLYECQHLLSPLEEQEKQITNFYESLEKVNEIISIQDPEAQPTTVL KQKAQDLVAYQENCKKALSLIERNSQSILQCVASSEVLQHFHQSTFQKKVTQVQITFQNM VRKAGDWRKNIEANSRLMKKFEESRAELEKVIQIANCCLKEKGNPEELLRKHSEFFNQLD QRVLNAFLKACDELTDILPEQEQHSLQEAVRKLHRQWKDLQMEAPYHLIHLKIEVQKSKL LVTVEECKAELARQNKVLTREGKERMIEEHKLFFGDKGSYHLCGKRLQRIEELCHKLPVS DPVRATLESSQRILKELKSQIDSTYTKLTEHSDIWKSYTNRFSELANWISSTERDLQRIK ENVSDTAKYEQFKSSTREIRQQINKQGENHSWLKSRLAVITKICTDVEAKKTEDELCKLS SDFKGLLDFLAEIERTLGTVGDCVQYKEEVKSAIEELINNSKEAQAEAEKILDTESLLQA QQLLFHHQQRTRRLRAKRQGVQQQIFQAKQLQIEGGLPSAMQEDLLKLEGTLENMQQTME KREEQLQVTINKWEQFERDKETVVKYLNQASCALERILNFSSLESLSSELDQTKELSKHS EAMAVQAENLVKNSSEIQLGSKSKQALQQQAKAIQEQVKKVDVTLEEDLKRMEMMKNKWD HFGKNFEALSTWIAEKEKELETLETASSPLDIQISQIQVINTEIDGKINGISKLEEEAKS FTQFVTSGECAHIKAKLTHIKRYWEELREHAQRLEGTITGKASAQQKYEESLKQVQKTVS EFEAKLAEPLTSCTSSSATYGDLQDCTDFCHTVEKLSSTLASLSACARKAASKEKAAQEV TALQQRYEKVLENAKEKQILLETLLARWQKQEKELCAFQTWLEGCEAAGRPSEQYVSADR VKLEGELQSLQDLRADFESHASIYASLLQLNELLFPTASKQCVKAINEKFKELDERWKAL PQTIDKRINFLQSLVAKHGQFDELLCSFSDWIKQFLAELQSTSEINTADPEVAASHNKKH SVEIESKKQQLQSLKDLVDKLCAFSCPVDQQTLQGKTEDCFQIFQEANQITNQRQEALDQ LQVFLELHNAASRVLHQLRQTVEKTGNIDKAKSELLEKDLHDVIQSLNKLEAIAISLDGS LTKAQYHLKHGISEQRTSCRAVVDHLYLELEAVQNLLGTKQSEAEALATLRRSFMERKEE LLKSIEDTEEKADKEGLREATLQALQQRLRIFNQLDEELNSHQHELQWLMDKAKQIAQKD ITLAPEIDKEINHLASLWEDTKKVIQEKKEQSCILIDLIKEYQGLKSTVMKVIDSVDSAS VLKSIWKDHEDIRRTLSKHEAAKNDLSDKQKDLDTFTNKGKHLLAELKKVQNCDCTVVKT DMNSTVDKWLDVSERIDDNIHRLSSGVSLWDDILKIADEMDGWCTKCISHLNEGISNLSN SQRMEVILKDFQSQVKDKEQKLEQLSSKISELKELTHSQEPPADLQFIESDLRQKLEHAK EMSQTAKETLKEFSTQKMQLQKFIDKMTHWLTETEETLLRCSRNLDPESLNLVKETQKDL QLQQSSIDSTRENLNRLCRKYHSVELETLGGTVTSLIKKYEAVNQLCSRTQANMQECLEK HFLYSMQEFQEWFSDVKAAVKELSDRSGDSKAIEAKLHDLQSVLDSLSEGQNKLDAACKE GENLYTCLPQPVVTHIQEQVTKSNQNFKEFLSQCLNDKQALETCASHLGSFEEQHKKLSL WIHDMEERMSTEALGEIKELIPEKKKEVQKVEKFLEELLASRESCEKLAQIAQALNEEGH GAGREVRLASQHLTNYQNMVKTVKEKLRTCQLALQEHLTLEEALQSMWSWVKEVQEKLAS AESTVGSKAMLERRLAQIQEILLLKGDGEVKLNMAIGKGEQALRSSSEEGQKVIQTELQK LKDVWNDIISTSMSWQSCLESLISQWNEYLERKSQLEQWLEKLDHKVEQPLEPQIGLKEK FAQLDFFQAIVSEIEDHSGDLQQLVEKTAELYEKTEDDSFGAAAQEELKTQFNDITTVAK EKMKKVEDIVKDHLLYLDAVHEFTDWLHSAKEELHRWSDATGDTSVIQKKLAKINELVDS RQIGAGRLGRVETLAPAAKRSTSAGGCQLLAAEMQALQLDWKQWEESAFQSQRSLRDVLS QMAVSEQEFAAQVARLEEAVQRFGGLLADWSQSLAPLDSRHTDAEIVESWRKEKETSDAL IKSEHVIDEIKTQLNDLCRFSRDLSTHSSKVSGLIKEYNSLCLQASKGCQSKEQILQQRF RTSFRDFQQWLVNAKVTTAKCFDVPQDISEASASLQKIQEFLSESENGQHKLNLIASKGE LLCSVLPKEKAKVISDKCAMAKEDWKNFISTLHQKESALENLKIQMKDFEATAEPLTEWL STTEKIVQGSSSRLHDLSSKRREQQKLQSVLEEISCHEHQLNRLKEKAQQLLEEQAVSKS FMRRVSQLSSQYLTLSNLTKEKVSKMDRVLAEHQQFSHGFKDLQDWVADAIHMLESYCHP TADKNVLDSRMLKLEGLLTVKQEKEIQMKIIMTRGESVLQNTSLEGAQVIEQQLHTLKDS WASLLSACIQCKSQLEGALSKWTSYQDDVRQFTSWMDKVEASMHSSERQYAELREKTAAL SKAKLLSEEVLSHSSLLETIEAKGSGMAEHYVTQLELQELQDRYKLLKDRTREAVKKAEE LLNLHQGYQRNLKAFETWLEEEQEKLSCLSHLEGDAQKQEATLRDLQELQVRCAEGQALL NAAVRAREEVIPWGMPQIEDRVLESIRQDWQVYQHNLSEARSQLNATVSRLRLMEKKFQK VNDWITELEEKVAVRTGRQSGRATKEMQLQQMKKWHEEITIYKDDVEEVGILAQQILEEG LTTSGMGSQATQLTSRYQTLLLRILEQTKFLEEEIRSMEESELAFSAYKNWYGATNKDFR NVITKFDVLDKTAMEKKVQKLELLLSDMDIGHSLLKSAREKGERAIKYMEENDADCLRKE IGEHVEQLEDLAGSIRKEHVTSEKCLQLAKEFSDKYRAQTQWLTEYQAMLRTPVEPKCEL YEKKAQLSKYKSMQQTILSHEPSVKSVIEKGEALFDLVNDVTLKSNIQDLQSDYHELCSA AKAYVETLEVRVKEHEDYNSDLQEGEKWLLHMSSRLVSPDLMENNSLEVITQQLANHKAI MEEIAGFEDCLNKLKSKGDYLINQCTEHLQAKFKQNIQSHLQGTRDSYSAICSTAQRVYQ SLEHELQKHVNHQDTLQQCQTWLTTVQSELKPSTWTPFSLADAVKQVKHFRALQEQANTY LDLLCSMCDLSDATVKSTATDIQQTKQMIEQQIMHSQYLAQGWEEIKQMKAELWIYFQDA DQQLQNLKRRRAELELNIAQNMVLQVKEFSQKLQSKQSALTSVTEKINKLTQGQESPEHK EIGQLSNQWLDLCLQAHSLLIQREEDLQRTVDYHDRMNVVELFLEKLTKEWDNLARSDAE STNVHLEALEKLALTLQERRFALEDLKDQKQKMVEHLNLDDKELVKEQFGHFEQRWTQLE ELVKRKMQISVSTLEEFSLVHSKLQELMEWAEEQQPSISEALKHSPPPDLAQSLLMDHLT ICSELEAKQLVLKTLLKDAERVMTSLGLNERQELQKALSDAQHHVDCLSDLVGQRRKHLN KALSEKTQFLLAIFQATNQIHQHEKKVTFPEHICLLPEDVNKQIRTCKNAQASLKAYQNE VTGLWTQGRDLMKEATEQEKSEVLGKLQELQNIYDTVLQKCTQRLLELEKNIVSRKYFKE DLDKACHWLKQADIVTFPEVNVMNSNSELYTQLSKYQQILEQSPEYENLLLALQRHGQEI LPSLNEVDHSYLDEKLNILPQQFNIVTALAKDKFYKVQEAIYARKEYTSLIELTTKALTE LDDQFINMDKAPASVLAKEVVSLQQAYRDLLGEVMSLGAAVDELNQKKEAFRSTGQPWQP DEMLKLATLYHKLKRQIEQKISLLEDTVEACQEHEKMCTQLEAQLEAVKNEQIKVNEEML PIEEKLKIYHSLVGSLQDSGSLLKRITEHIETLSPQLDPSALETTNHQVLSWQDKLKNLH SAIGDIVMDCENRLVQSIDFQTEICRSLDWLRWVKTELNGKLSLDLKLQSIQEEIRKVQI HQEEVQSSLRVMNALSNKEKERYMKAKELIPADLENTLAELAELDSEVQEAIHMRQATLD KLYSLCQRYYQVIQITNDWLEDAQEFLHLTRNGLDVENSEGNLGNHIEFFSTESQFSNNL KELQGLVSELEPFILATAREQLMQNLASLEEKGKGTKQEAKTQQELLQRCASEWQEYQTA RQKVIEVMNEAEKKLSEFSVAKAASSHEAEEKLQTHKTLVSVVNSFHEKITTLEEKASQL EKVSNDASKATVNRSVTTVWQRWTRLRNVAQEQEKILEDAVQEWKGFNDKIQKATVVIDQ LQDRLPESSVEKASKTELLELLDYHSSFLLEVEHQLSSLGLLKQHALNMLQDVEIKPLSQ EEVPVMQEVKAMQDRCHNMQQKVKKSVKLVKQELKEREDVEAQINVVKTWIQETKEYLLN PDVEVDTQLQELKSLLSEVTTHRQAVEKMAEQQQNKYLGLYTILPSELSLHLAEVGLALV TVQDQIQAKEKETEHIKTLNQEFGQRIQGIANELNAILSKLKRKTNDIVQAKFEQKILGE ELDSCNIKLLELDASVQEFSEQNIPLAKQLANRIGKLTALHQQTIRQAEYRATKLSQATS HLEEYNEMLEFILKWIEKANILVHGSITWNSSSHLRDQFKAYQTMLEESAEIHGDLEAMS ERIEYLASVYSTEGMSQQVLELGRRTEELQQVIKVRLPNLQDAAKDMKKFEVELRALQTA LEQAQATLTSPELGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVCQSALRIPEEVVTSLP ICHSALQLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQMIESAHREIQDKPIA TSNIQELQNQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLSEG MEELDSDLLPAHPAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVAN TDASVNQDIAYYQALSAEQLQTEAAKIQPSTSATQEFYEPGLESAASAKLDDLQRSWETL KNVISEKQRTLYEALERQQKYQDTLQSISTKMETTEMKLNESLEPAKSPESQMAEHQALM DEILMLQEEITELQTSLAEELVSESLDAEAADQLALQSTLTVLAERMATIRMKASGKRQL LEEKLSEQLEEQRQEQALQRYRCEADELDHWLLNTRATLDTALVTAEEPMDMEAQLVDCQ NMLVEIEQKVVALSELSVHNENLLMEGKAHTKDEAEQLALKLRTLKGSLLELQKVLHDKQ INIQQGSLQEKEESNLDLVSSQSPSVQEWLAQARTTRSQQQQSTLQQQKELEQELEEQKN LLRSVACRGEEILTQQGIPEGLCISEKPEKLSEELCLEGEKSSPEQQLKIKWESLNHKFN TKQKLLQKTLEQEQLQLYSRPNRLISGLPLYKENGQDEEKSSVSPVLVELNQAFEDVSSE AGRVEKESLHLEQKLYNGVASTSLWLDGVEEQVFVATALLPEEETETYLCKQESLAKEIK DITEEMDKNKNLFTQIFPENGDNREVIEDTLDCLLRRLTLLESVVNQRSHQMKERLQEIM TFKNDLKLLFTSLADSKYLVLQKLAEAAEKPETEQIQVIMQAEESLKELDAGINELKKSV DKLQIDQPSAQELSKLQDMYDEVMMIIGSRRSDLNQNLALKRQYERALQDLADLVETGQE KMDGDQKMIVASKEEVQSLLDKHKEYFQGLESHMILTETLFRKMSSFALLKETQSHSELI AQASTVLKLAHKRGVELEYILETWMHLDEAYQELTRQLESVEGNIPAVGLVEETEDKLTE RIKLFQHLRSNLTEYQPKLYQVLDDGKRLLFSVSCSDLESQLNQLGEHWLSNTSKVNKEL HRLETILKHWTRYQSESTELTHWLQSAKERLEFWSQQSLTVPQELETVRDHLSSFLEFSK EVDAKSSQKSSVLSTGNQLLRLKKVDTAALRAGLSQIDSQWTELLTQIPAVQEKLHQLQM DKIPSRHAITEVMSWISLMENVIHKDEESIKNVIGQKAIQDYVQKYKGFKIDLNCKQLTV DFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNRRWQILQGLVTEKIQLLESLQESWTEY ENNVQCLKSWFETQEKKLKKQQRIGDQASVQNALKDCQELEESIRTKEKELESIEQSGLS LIQNKKEEACSAVLNTLQEINHSWANLDHMVSQLKILLQSVLDQWSIYKVTYEELNSYLM EARYSLSRFYLLTGSLEAVKVQVDNLQSLQDELEKQENSLQKFGSVTNQLLKECHPPVTE TLTSTLKEVNMRWNNLMQEIAERLRSSKGLLQLWQRYKDCYQQCSSTVRLREDQTNELLK TATSKDIADDEVTTWIQDCNDLLADIKTAQDSLIVLQELGEELKSRVEASAAAAIQSDQL SLNQNLSALEQALCKQQTVLQAGVLDYQTFAKNLQDLEAWITEAEAKLKGQDPGHTSDLS AIQSRMEELKSQMLKFSSMAPDLEHLNELGYRLPLNDKEIKRIQNLNRQWSLISSQTTER FSKLQSFLLQQQTFLEKCETWMDLLVQTEQKLAAEISGNYQSLLEQQRAHELFQAEMFSR QQILHSIISDGQHLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIHQWQR YREMAEKLRKWLMETSCQPVSGLGNAPIPLQQVRALLDEVQLKEKVLLRQQGSYILAVEA GKQLLLSADSGAEAALQAELTEIQERWKKVSNQLEEQKKQVALLLKDWERSEKGIADSLE KLRSFKKKLSQPLPEHHDELNAEQIRCKELENAVDGWTDDLAHLSLLKESLSTYISADDI SVLNERIELLHRQWEELCHQVSLRRQQVSEKLNEWAVFSEKNKELCEWLTQMESKVSQNG DIVIEEMIEKLRKDYQEEIAVAQENKIQLQLMGERLAKASHESKASEIEYKLGKINDRWQ HLLDLIAARVKKLKETLVAVQQLDKNMSSLRSWLAHIESELSKPIVYETCDSEEIQRKLN EQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATETECDSIQQATRNLDRRWRNICAMS MERRLKIEETWRLWQKFLDDYSRFEDWLKNSERIAAFPSSSGVLYTVAKEELKKFEAFQR QVHESLTQLELINKQYRRLARENRTDSDCSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI GQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNNNKIQQII VQGEQLIEKSEPMDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLTDDEHELSDREV DLDESADLSDIHWHDKSADSVLSPHPSSNLSLPLAQPVRSERSGRDTPASVDSIPLEWDH DYDLSRDLETAVSRALHSEEEDGEQEKDFYLRGAASIADVEIPETLEAYVTLTENALKNT SGEPGSLEAHIRQLDKALDTSRFQIQQTENIIRSKTPTGPELDATYKGYMKLLGECSGSI DSVKRLGYKLKEEEEKLSGLINLNSTETQTAGVIDRWELIQAQALSKELRMKQNLQQWQQ FNSDLNSIWAWLGETEEELEKLRRLDLSTDIQTIELRIRKLKELQKAIDNRKAIILSINL CSSEFTQSDSEESKKLQERLSQMNIRWDHVCSMIEEWRCSLQDALMQCQDFHEMSHGLLL WLENIDRRKNEIVPINPNLDSEILQDHHRLLMQIRRELLESQLKVASLQDMSCQLLVNAE GKDCLEAKEKVHVIGNRLKLLLKEVIRHIKDLEKALDISSSQLDLSSWSSADELDTSGSV SPVSGQSTPSRQRTPRGKCSLSQPGPSVSSPHSRSIRGGSGSSPSEAGPAWQHPSFFLRV LRAALPLQLFLLLLIGLACLVPMTEEDYSCAMANNFARSFHPMLKYMNGPPPL NT seq 26442 nt NT seq  +upstreamnt  +downstreamnt atggcctcatcccgactcgtgacaagatctagggacattgccaatgtcatgcaacggctt caagatgagcaagagttggtacaaaagaggacttttacaaaatggatcaatactcatctg gctaagcgcaatcctcccatgatggtcagtgatttgtttgaagacatcaaggatggggta atgctgatagcccttttggaggttctttcagggcagaaactgccttgtgagcaaggacgt catctgaagagaattcactgggttgccaacattggcacagcacttaagtttctagaagga agacggtctgtataccgaggatctccgattaagcttgtcaacataaactcaactgatatt gctgatggtcgaccttctattgtgcttggcttggtgtggacgataatcttatattttcag attgaagaactcaccagcaatcttccacagctgcagtcattgtctagcagtgcttcttct gtggagagcgttgtcagttcagaaactgcaagtcccccaagcaaacggaaggtggtaacc aaggtccaaggaagtgccaggaaggctttgttaaaatggatccaatatacagcagcaagg caagttggaattgaaatcaaagactttggacaaagttggaggagcggtgttgcatttcat tccattatccatgctatccgcccagatttagtggacatggagaaagtaaaaggaagatca aacagggaaaacctagaagaggcatttacactcgcggaaacagagctagggattccgagg ctccttgatccagaagatgtgaatgttgacaagccggatgaaaagtctatcatgacctac gtagcccagtttttgaagtactatcctgatcctcatcatacagtggctgatgtgcaggag aatgaaaaggaagacaagttgatgctgagagacctaaaagtgtgggcagaacaatttgaa agagatttagcacgggcacaggtggcagaaacaagtttacaggagaaataccagtcattt aagcatttcagaatacagtatgagatgaaaaggaaacctattgaacttgtaacccagtcc ttaaggaaagatggtaaattatcacttgatcaagctatagtgaagcaagcgtgggacaga gtttcttccaggctgtttgactggcacatacacctagataaatctcttcctgcacctttg ggtaccataggtgcttggctctatagagcagagaatgctctaagagaagaagtaagcatt cagcaagctcatgaggaaacagcaaatataatacaccggaagctcgaacaacttaaggat ctactgaaaaacatagaaggtcacaaaaagacattccatgagatccacggggcaaggtct gttaatggagtgcctgttccaccggaccaattagaggatatggcagagaggtttaatttt gttgtctcttcatctgagctccatctgttgaaaatggagttcctggaactgaagtaccgt ctactgtcactcttagttcttgcagaatcaaagttaaaatcatggattattaaatacgga agaagagagtcagtggaactactcctgcaaaattacatttctgttattgaaaatagtaag ttctttgagcaatacgaagttacataccagatcttgaaaagagcagctgaaatgtatgcc aaagcaaacggctcagtggaagaagttgagagtgtgatgaaattcatgagtgaaacaaca gcacagtggaggaacctctcagtagaggtgagaagtgtaagaagcatgttggaagaagta attgctaactgggacagatacagcagcactgtggcaggtctgcaagcctggttggaggat gctgaaaaaatgcttaatcagactgaacagtctaaaaaggatttcttccggcacttacct cactggatccagcagcacacagccatgaatgatgctggtaattttctgattgaaacatgt gatgagaccatttccagggaccttaagcagcaacttcttttactaaatggaagatggaga gaattgtttatgcaagtgaagcaatatgctcgggcagatgaattggacaaaatacagaaa gaatacctggatggtgtggctaatttgacagcttttgttgatggaagcaatagaaaattt tcatcagccatagaagtgtccttcctagatgtgaagatgtttgtacaagatttagaaaat attaagcaaaaattgcctaccatggaagctcagtacaaaatggtcacaagaacagcacaa cttcttacaaaagaaatttcccaagaagaagtaaatgaaatgcttgcaactttgacaagg atgaaagagcagctgagcaaggtcaaggagtattccagtgccctgctgtatgaatgccag catctgctgtctccacttgaagaacaggagaaacaaatcacaaacttctatgaatctctt gaaaaggtcaatgaaataatttctatccaggatcctgaagcacagcctacaactgttctt aagcaaaaagctcaagatttggtagcttatcaagaaaactgcaagaaagctttgtccctc attgagagaaatagtcagagtatcctgcagtgcgtggcttctagtgaagtgttgcagcat ttccatcagtcaacatttcagaagaaagttacacaagttcagatcacttttcagaatatg gtcaggaaagctggtgactggaggaaaaacatagaagcaaatagccgtttgatgaagaaa tttgaggagtctagagcagaactggagaaagtgatacagattgccaattgttgcttaaaa gaaaaaggaaatcctgaagagcttctcaggaagcatagtgaattctttaatcagttggac cagagagtcctaaatgccttcctgaaagcttgtgatgaacttactgacatccttcctgaa caagagcaacacagcctgcaggaagctgtgaggaaactccataggcagtggaaggatctt caaatggaagccccgtatcatttgatccatttgaagattgaagtgcagaaaagcaagctc ctagtcacagtggaggagtgcaaagctgaactagctcgacagaataaggtgctaaccaga gaaggcaaagaaaggatgattgaagagcacaagttgttctttggtgacaagggatcttac catctctgtgggaaaagattacaacggattgaagaactgtgccataaacttccagtttct gatccagtgagggctacattggaaagtagccaacgaatcctgaaggagctcaaatctcag atagacagtacatacacaaaactaacagagcattcagacatctggaagagctatacaaac agattttctgaattggcaaattggatttcgtctacagaaagagacctacagaggataaag gaaaatgtcagtgatactgctaaatatgagcaatttaaatcatctactagggaaatcagg cagcaaattaacaagcagggagaaaatcacagctggctgaaatctagacttgcagttatt actaaaatatgtactgatgtggaagccaagaaaacagaagatgaactctgtaaactttcc agtgacttcaaaggacttctggattttctggctgagattgaaaggacattaggcactgtt ggagattgtgtccaatataaagaagaggttaaaagtgcaattgaagagctaatcaacaac tctaaggaagcccaagcagaagctgaaaagatcctggatacagaaagtttattgcaagct cagcaactactgtttcatcatcagcaaaggacaaggagactccgtgcaaagagacaaggt gtgcaacagcagattttccaggctaaacagttgcagattgaaggtggactgccaagtgca atgcaggaagatttactgaagctagaaggaacactggagaacatgcagcagactatggag aaacgggaagagcaattgcaagtcacaataaataaatgggagcagtttgaaagggacaaa gaaacagtagtaaaatatcttaatcaagcaagctgtgcacttgaacgtatcttaaacttt agcagtttagagagtctctcctcagaactggatcagacgaaggaactttctaaacacagt gaagccatggcagtacaagctgaaaacttggtgaagaattcttctgagatacagcttggt tcaaagagcaaacaagccctgcagcagcaggcaaaagctatccaagagcaagtgaaaaaa gtggatgttactctagaagaagatcttaaaagaatggaaatgatgaaaaacaagtgggat cattttggcaaaaattttgaagctctgtccacctggatagctgaaaaagaaaaagaactg gaaactttggaaacagcttcatctcctttggacatacagatcagccaaatccaggttatt aatacagaaatagatggtaaaataaatggaatctcaaaactagaagaagaagccaaatca tttacccagtttgttacctctggagaatgtgcacatattaaagccaaactgactcatatc 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ggagcagcagctcaagaagaactaaaaacacagtttaatgacatcacaactgtagccaag gagaaaatgaagaaagtggaagacattgtgaaggatcatttgctatacctcgatgcagtg catgaattcacagactggctacattctgcaaaggaagagctgcaccgctggtcagatgca actggagatacatcagtgatacagaaaaagctggccaaaatcaatgagctggtagactct cgccagatcggcgcgggccgcctcggccgagtggagacgctagctcccgcagcgaagcgc agcacgagtgccggcggatgccagctcctcgccgctgagatgcaggccctgcaattggac tggaagcagtgggaagaaagcgctttccagagccagcgcagcctgcgggacgtgctgagc cagatggccgtgtcggagcaggagttcgccgcgcaagttgcgcggctggaggaggccgtg cagcggttcggcgggctgctggctgactggtcgcagagcctggctcccctcgacagccgt cacaccgacgccgagatcgtggagagctggcgcaaggagaaagaaacatcagatgctctg ataaagtctgaacatgtgatagatgaaatcaagactcagttaaatgatctttgcagattt tccagagatttgagtacccattcttcaaaagtttctgggttgattaaggagtataacagc ctctgcctgcaagcttcaaagggatgtcagagtaaagagcagatcttgcaacaaagattt cggacaagtttcagggacttccagcagtggctggtcaatgcgaaagtcaccacagccaaa tgcttcgatgtacctcaggatatcagtgaagcttcagcaagtctacagaaaatacaggaa ttcttatcagaaagtgagaatggacaacataaattaaacttgatagcatccaaaggagaa 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gaagcaaaaggcagtggaatggctgagcattatgtcactcagcttgaactccaggagctg caggaccgatataagttgctcaaagacagaacaagggaggcagtaaaaaaagctgaagaa ctgcttaacttacatcaggggtatcaaagaaatctgaaggcatttgaaacatggctggag gaggaacaggaaaaacttagctgcttatcacaccttgaaggtgatgcccagaaacaggag gcaacgctccgagacctgcaggagttgcaggtccgctgtgcagagggacaagcattactg aatgctgctgtccgtgccagagaggaggtgattccttggggcatgccacagatagaagac agagtgttggaatccatacggcaggactggcaagtttatcagcacaatctttctgaagca agaagccaattaaacgctactgtgagcagactgaggttaatggagaaaaaatttcagaag gttaatgactggataacagaactggaggagaaagttgctgtccggactgggaggcagtct ggtagagcaacgaaagagatgcagcttcaacaaatgaagaaatggcatgaagaaataacg atatacaaagatgatgtggaggaagttgggatactagctcaacaaatactagaggaaggt ctcactaccagtggaatgggaagccaggctacacagcttacatctcgatatcaaactctt cttcttcgtatcttggaacaaacaaagtttttggaagaagagatacgcagtatggaggag tcagaattggcttttagtgcttacaaaaattggtatggagctactaacaaggacttcaga aatgtgatcaccaagtttgatgtgttggataaaacagcaatggagaaaaaagtgcagaaa ctagagctgcttttgagtgatatggacataggccacagtttactgaaatctgcccgtgag aagggggagcgagctataaagtacatggaagaaaatgatgctgattgcttaagaaaagaa attggagaacatgtggaacagcttgaagatttagctggttcaatcaggaaggagcatgtg acttcagagaagtgccttcagctggcaaaggagttctcagacaagtacagggcacaaacc cagtggctcacagagtaccaagccatgttgcgtacaccagtggaaccaaagtgtgaactt tatgagaagaaggcccagttgtccaaatacaagtccatgcagcagaccattttgtcccat gagccttcagtaaaatcggtgatcgaaaagggagaagcactttttgatctggtgaatgat gtgactctaaagagcaacattcaagatcttcagagcgattaccatgaactctgcagcgca gcaaaggcatatgttgaaacattagaggtgagagtaaaagagcatgaggactacaatagt gatttgcaagaaggagagaagtggttattacatatgtctagcaggctggttagccctgac ctcatggagaataacagtcttgaagtaatcactcagcaactagccaaccacaaggctatc atggaagaaattgcaggatttgaagactgtttgaacaaacttaagagtaaaggtgattat ttgattaatcaatgcacagaacatcttcaagcaaaatttaagcaaaatatacaaagccat cttcaaggaacaagggacagctattctgccatatgtagcacagcccaacgggtgtaccag agtttggaacatgaactccagaagcatgtaaatcatcaagataccctacaacagtgccag acttggctgactacagtacagtcagagctaaagccaagtacctggacacctttcagcctg gcagatgcagttaaacaggtgaaacatttccgggctctgcaggaacaggcaaatacatac 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aaggagttacagggcctggtatctgagctggagccctttatacttgccacagcaagagag cagctcatgcagaatctagcttcattggaagaaaagggcaaagggacaaagcaggaagcc aaaactcaacaagaactgttgcaaaggtgtgcttctgagtggcaggagtatcagacagca cgacaaaaggtcattgaagtgatgaatgaggctgaaaaaaagttatctgaattctcagta gctaaagctgcttcttctcatgaagcagaagagaaattgcaaacacataagactcttgtg tctgtagtaaattctttccatgaaaagataacaactcttgaagagaaggcttcacagctg gaaaaagttagcaatgatgccagcaaggcaactgtaaatagatcagtgacaacagtttgg cagcgctggacaaggctccggaatgtagcccaggagcaagagaaaattttggaagatgca gtacaggaatggaaggggtttaatgataagattcagaaagctactgtagtgatagatcaa ctacaggatcgtttaccagaaagctcagtagaaaaagcatctaaaacagagctcctggaa ctcctggattaccacagcagcttccttctggaagtggagcaccagctatcatctttgggt ctgctcaaacagcatgctcttaatatgcttcaggatgtggaaataaaacctctgtcccag gaggaagtaccagtcatgcaagaagtcaaagcaatgcaagatcgatgccacaatatgcaa cagaaagtgaaaaaaagtgtaaagctcgtgaaacaggagctgaaagagcgtgaggacgtt gaagcacaaataaatgttgtgaagacttggatccaggaaacaaaagaatatttattaaac cctgatgtggaagtggatactcaacttcaggagctgaagtctctcctctctgaagtaact 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