Gavialis gangeticus (Gharial): 109293815 Help Entry 109293815         CDS       T07453                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism ggn  Gavialis gangeticus (Gharial) Brite KEGG Orthology (KO) [BR:ggn00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:ggn04121]     109293815 (UBR4) Enzymes [BR:ggn01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      109293815 (UBR4) Ubiquitin system [BR:ggn04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     109293815 (UBR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 zf-UBR Motif Other DBs NCBI-GeneID:  109293815 NCBI-ProteinID:  XP_019367466 LinkDB All DBs Position Unknown AA seq 5163 aa AA seqDB search MAASGGAAAEPGWEVAVRPLLSASYSAFELKELPQLLASVIESESEILHHDKQYEPFYSS FVALSTHYITTVCGLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGL CTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQ LTSVFNPRVTASPSLAPETQVEGESEDQASTDQASAAKTKSIFIAQNVASLQELGGSEKL LRVCLNLPYFLRYINRFQDAVSANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLP VLEPLTPTRLQDVTVLALSCLYAGVSVATCMAILHVGSTQQVRTGSTSSKEEDYENDAAT IVQKCLEIYEMIGQAISNSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEK DPLAALRVRDIIARTKEGVGSPKLGPGKGHQGFGVLSVVLANHAIKLLTSLFQDLQVEAL HKGWETDGPPAVLNIMAQSTSIQRIQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSM SSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIXXXXXXXAPPPPPPPPP LESSPRVKSPNKQTTGENGNILASRKDPELFLSLASNILNFITSSMLNSRNNFIRNYLSV SLSEQHMATLASIIKEVDKDGLKGTSDEEFAAALYHFNHSLVTSDLQSPTLQNTLLQQLG VAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWERFVSTLKQNALQ GALPNDTEDLNVEHLQLLLLIFHNFSERGRRSILTLCIQTILELTVKMDSQLQSVPLILA RLLLVFDYLLHQYSRVPVYLFEQVQYNLLTPPIGWVSGSQESSRRTAIPIYHGFKEVEEN WTKHCSSDAVPQPRFYCILSPEASEDDLNRLDNTVCEVLFSRIVKYDELYAALTSLLAAG SQFDTLRRKENKNVTALEACALQYYFLILWRILGILPPSKNYMNQLAMNAPDMSECDILH TLRWSSRLRIISYVVWIKDHLIKQGMKAEHAASLIKLASTKCSSVKYDVEIAEEYFARQI SSFCGIDCTTILQLHEIPSLQSIYTLDAAISKIQVSLDEHFSKLAAETDPHKSSEITKNL LPATLQLIDTYATFTRSYLLRSLSEEGSAENKPSEEKLQGYAAVLAIGSSRCKSNTLGPT LVQNLPPAVQTLCESWNNIHTNEFPNIGSWRNAFANDTIPAESYISAVQAAHLGTLCSQS LPLAASLKHTLLSLVRLTGDLIVWSDELNPQQVIHTLLPLLLETSTESVAEISCNSLERV LGPAESDEFLARVYEKLITGCYNILANHSDPNSGLDESILEECLQHLEKQLESSQARKAM EEFFSESGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLRLCGSLAQLA CVEPVRLQAWLTRMTMSPPKDSDQLDVVQENRQLLQLLTTYIVRENSQVGEGVCTVLLST LIPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHSAAVDWLSRCKKYLSQKNVI EKMNANVMQGKHVTILECTCHIVSYLADVTNALSQTSGQGPSHLSVDGEERAIEVDSDWV EELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKV CHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRVPESVIR HATTSPAEKSKVTISEGKGPDEEKPKKSSLCRNVEGCREELQSQANFSFAPLVLEMLNFL MEAIQINFQQASAMGSSSRAQQALNELHAVDKTVEMTDQLMVPTLGSQEGAFENVRMNYS GDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKR KLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLAT GNFIIKAVWLPGSQTELAIVTADFVKIYDLSVDALSPTFYFLLPSSKIRDVTFLFNEEGK NIIVIMSSAGYIYTQLMEEASSAQHGPFYVTNVLEVSHEDLKDSNGQVAGGGVSVYYSHV LQMLFFSYCQGKSFAATISRATLEVQRLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVC CVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGS LRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKAAAITTRTSSQVNFPIDFFEHNQQL TDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEVTNNNSTMVMTGMRIQIGT QAIERAPSYLEIFGRTMQLNMTRARWFDFPFTREEALQADKKLTIFIGASVDPAGVTMMD SIKIYGKTKEQFGWPDEPPEDFPSASVSNVCPPNLNQGNGTGDTEAATPATASGTVLERL VVSSLEALESCFAVGPVNEKEKNKAAAQELATMLLSMPAPSSVQQQTKSLLASLHTSRSA YHNHKDQALLSKAIQYLSSSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQ LEAEAGEEGQEAQKHAEGDGCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHVEATVN ALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPS SPRSNTPMGDKDDDDDDDAEDKMQSSGLANGEHIRQESQEQSEVDHGDFEMVSESMVLET SENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGL QSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESG GSAVDSVAGEHSVSGRSSAYGDTTAEGHPAGPGSVSSSTGAISTTTGQQEGDGSEGEGEG EAEGDVHTSNRLHMVRLMLLERLLQNLPQLRNVGGVRAIPYMQVILMLTTDLDGDDEKDK GALDNLLSQLIAELCMDKKDVSKKNERSPVNEVHLVVMRLLSVFMSRTKSGSKSSICESS SLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSP FFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTNSRIPPPIFDHSWFYFLSEYL MIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIYLRASVVTA SSGSALQYDTLISLMEHLKACAEIATQRTVNWQKFCIKDDSVLYFLLQVSFLVDEGVSPV LLQLLSCALCGSKVLSVASSSGSSTSSTSAPAASGSGQPATQSKSSTKKSKKEEKEKERE GESSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLALHIYRNSN KSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTQQTEKKLKEYSQKAVEILRTQ NHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQ QVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQL TPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGEN VYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTNIN TLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDESGSSGGISSTSASVNRYILQLA QEYCGDCKNSFEELSKIIQKVFASRKELLEYDLQQREAATKSSRTTVQPTFTASQYRALS VLGCGHTSSTKCYGCASAVTEHCITLLRALATNSAIRHILVSQGLIRELFDYNLRRGAAT MREEVRQLMCLLTRDNPEATQQMNDLIIGKVSAALKGHWANPDLASSLQYEMLLLTDSIS KEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVD TLTTVKPYSNEIHAQAQLWLKRDPKASYEAWKKCLPARGIEANGKSPSRTELHQLYLSEK YIWKWKQFMSRRGKRTCPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQ QVLDLLTSYLDELSIAGECAAEYLGLYQKLIKPAHWKVYLAARGVLPYIGNLITKEIARL LALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQR TKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYSLDDYRTPVFIFERLCSIIY PEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALL EDDSGMELLVNNKIISLDLPVAEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLD STTDEEEDEEEVYKMAGVMAQCGGLDCMLNRLTGIKDFKQGRHLLTVLLKLFSYCVKVKV NRQQLVKPEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSE DKGNLLLTGDKDQLVMLLDQINSTFVRSNLSVLQGLLRIIPYLSFGEMEKMQILVDRFKP YCNFDKYDEEHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIP SAKNLDADIWKKFLSRPALPFILRLLRGLATQHPATQVLIGTDSITNLHKLEQVSSDEGI GTLAENLLEALREHPEVNKKIDAARKETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTK TALLKQMEELIEEPGLTCCICREGYKFQPAKVLGIYTFTKRVALEEFENKPRKQQGYSTV SHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHN TYLQECTGQREPTYQLNVHDIKLLFLRFAMEQSFSVDTGGGGRESNIHLIPYIIHTVLYV LNTTRATSREEKNLQSFMEHPKEKWVESAYEVDGPHYYTVLALHILPPEKWKAMRVEILK RLLVTSHARAVSPGGASRLTDKTVKEYSTYRSGLLFWALVDLIYNMFKKVPTSNTEGGWS YSLAEFIRHNDMPIHEAADKALKTFQEEFMPVETFSEFLDVAGLLTEISDPDSFFKDLLN SIP NT seq 15492 nt NT seq  +upstreamnt  +downstreamnt atggcggcgtcgggcggcgccgcggcggagccgggctgggaggtggcggtgcggccgctg ctttccgcctcctactcggccttcgagctgaaggagctgccgcagctgctcgcctcggtc atcgagagcgaatctgaaatcctgcaccatgacaagcaatacgagcccttctactcctcc ttcgttgcactctccacgcattacatcacgactgtgtgtggcctaatacccaggaaccaa ctgcagtcagtggcagctgcttgtaaagtcctgattgaattctcactactgcgacttgaa aacccagatgaagcatgtgctgtttcacaaaaacacttgattctgctaatcaaggggctt tgcactggctgtagccgcctggacagaactgaaatcataactttcacagcaatgatgaaa tcggccaagctgcctcagactgttaaaaccctctctgatgtggaggatcagaaagagctg gcttccccagtgagccctgaactgcgacagaaggaggtgcagatgaacttcctgaatcag ttgacatcggtgtttaaccctagagtgacagcatcaccgtctcttgctccagagacccag gtggaaggagaaagtgaggatcaagcgtctactgaccaagcttctgcagcaaagacaaaa agtatcttcattgcccagaatgtggccagcctgcaagagctaggtggctctgaaaagctg ctgagagtgtgcctgaacctcccttactttttgcgctacataaatcgatttcaggatgcc gtgtcagccaactccttcttcattatgccagccactgtagcagatgccacggcagttcgc aatgggtttcactcgctggtgatagatgtgacgatggcattggatactctgtctcttcct gtattggagcctctcactcccacacgactgcaggatgtgactgttctggccctcagctgc ctctatgcaggtgtgagtgtagcaacatgcatggccatcctacacgttggcagcacacag caggtacgaactggatccactagttctaaggaagaagattacgaaaatgatgctgccact attgtacagaaatgtcttgaaatctatgaaatgattgggcaggccatcagcaactcacgc cgtgcagggggggagcattaccagaatttccagctgcttggtgcttggtgtttgctaaac agcctcttcctcatcttgaacctcagtcctacagccttagccgataagggaaaggagaaa gacccattggctgctcttcgtgtcagagacatcattgctcgaacaaaagagggagttggg tctcccaaactaggccctgggaaagggcatcaagggtttggtgttctgtcagtggtgcta gcaaaccatgctatcaaactcctaacatcgctcttccaggatctgcaagtggaggcacta cacaagggatgggaaactgatgggcccccagcagtgctgaatatcatggctcagagcaca tcaattcaaagaattcagcggttgatcgattctgtgcctctcactaatttgctgctgact ttgctgtccacttcttacagaaaggcttgtgtcttgcagcgtcagaggaagggttccatg agcagtgatgcaagtgcctccactgattctaacacatattatgaggatgacttcagcagc actgaggaggacagcagccaggatgatgacagtgaacccatcctcggccagtggtttgaa gagacaattnnnnnnnnnnnnnnnnnnnnggcccctcctccaccccctccaccacccccc ctggagagttcacctagagtgaaaagccccaacaaacagacgactggggagaatgggaac attctggccagccgcaaagacccagaactgtttttaagcctagcttccaatattctgaac ttcatcacctcctccatgctaaactccaggaacaatttcattcgcaactacttaagtgtg tctctttccgagcagcacatggccacactggctagcattatcaaggaagtggacaaagat gggctgaagggcacatcagatgaggaatttgctgctgcattgtatcacttcaaccattcc ttggtgacctcagaccttcagtcccctaccttgcagaatacacttctacagcagttggga gtggcccctttctcggaaggaccttggccgttgtacatccatccccagagtctgtctgta ctctcccgccttctcctaatctggcagcataaagccagtgcgcagggagatcctgatgtc ccagaatgcctcaaagtttgggagcggtttgtgagcactttaaaacaaaatgccctgcag ggggcacttcccaatgacacggaagacctcaatgttgaacacctccaactcctcttgctt attttccacaacttctctgagagaggccgcagatctatcttgaccctctgtatccagacc attctggaactgactgtaaagatggattcccagttgcagtctgtaccgctaatcctagct cgcctgctgctggtcttcgactacctgcttcatcagtattccagagttcccgtgtacttg tttgaacaggtgcaatataatctgctaaccccacccataggctgggtcagtggatcccag gagagtagtagacgaaccgctatccctatctaccatggatttaaagaagtggaagaaaac tggaccaaacactgctcatcagatgcagtgccacagcccaggttctactgcatcctgtca cccgaagcttctgaagatgacttgaaccgcctagataacacggtttgtgaggtcctgttt tctaggattgtgaagtatgatgagctttatgcggccctgacctcactacttgcagctgga tcacagtttgacaccctccggaggaaagaaaacaaaaacgtcacagcactggaggcctgt gcacttcagtactacttcttgatactctggaggatcctggggattttgcccccttctaaa aactacatgaatcagctggcgatgaacgcacctgatatgagtgaatgtgatatcctgcat acactgcgctggtcctcccgcttgcgtatcatctcctatgttgtttggatcaaggatcac ttgatcaaacaaggcatgaaagctgaacatgctgcttctctcattaaattggcctccact aagtgcagctcagtgaaatatgatgtggaaatagcagaggaatactttgctcgacagatt tcctctttctgtgggattgactgcaccactattctccagctgcatgagattcccagtttg cagtccatttacacccttgatgctgccatttccaagatccaggtttccctggatgaacac ttctctaagctagctgcagaaactgacccacacaaatcatcagagataaccaagaacctg ctgcctgctactctgcagcttattgacacctatgctacattcactagatcttatttgcta cggagcctgtctgaagaaggctcagctgaaaacaaaccttccgaagagaagctgcagggt tatgctgctgtcctggctataggatcaagccgttgcaagtcaaatactctgggtccaaca cttgtccagaacttgccaccagcggtacagaccttatgcgaatcctggaacaacattcat actaatgaatttccaaacattggatcatggcgcaacgcctttgcaaatgacacaatccca gcggaaagctacatcagtgcagtccaggctgctcacctgggcaccctttgcagccagagt ctacctcttgcagcctccttaaaacacacgctcctttccttggtcagactcactggggac ctcattgtctggtcggatgaactgaacccacaacaggtgatacatactctattgcccctt ctcttggagaccagcacggaaagtgtggcagagatcagctgcaactccctggaaagggtc ctggggcctgcagagtcagatgagttcctggctcgtgtctatgagaaattgatcacgggt tgttataacatactggctaatcactccgatcccaacagtggccttgatgagtctatcttg gaggaatgtttgcagcatctggagaagcagctggagagcagtcaggctcggaaagccatg gaggaattcttttcagagagtggagaactggtccagatcatgatggcaacagccaatgag aacctctcagctaaattctgcaacagagtcctgaaattcttcactaagctcttccagctg actgagaagagccctaaccccagcctcttaagactctgtggctccttggcccagctggct tgtgtggagcctgtacgtcttcaagcctggttaaccaggatgactatgtcacccccaaaa gattcagatcagctggatgttgttcaagaaaatagacaactgctgcaacttctaacaacg tacattgttcgggagaacagccaagttggagaaggcgtgtgcactgttctgctgagtacc ttgataccgatggcaacagaaatgctggccaatggtgatggaacgggctttcctgaactg atggttgtgatggcaactctagctagtgctgggcaaggtgcaggccatctccagcttcac agtgctgcagtcgattggctgagcagatgcaagaaatacctgtctcaaaagaatgttatc gaaaaaatgaatgctaatgtcatgcagggaaagcatgttactattctggagtgcacgtgc catattgtgtcttatttggctgacgtcaccaatgcattgagccagaccagcggccaggga cccagtcatctttcagttgatggagaagaacgggccatagaggttgattcagattgggta gaagagctggctgtggaggaagaagactctcaagctgaagactcggatgaagattctctc tgtaacaaactctgcaccttcaccatcacgcagaaagagttcatgaaccaacactggtac cattgtcacacttgtaagatggtggatggtgttggtgtctgcacagtgtgcgctaaagtt tgccacaaggaccatgagatttcttatgccaaatatggttccttcttctgtgactgtgga gccaaggaagatggcagttgcctggctctggtgaagagaactcccagtagtggtatgagc tccaccatgaaggaatctgcattccagagtgaacccagagtgcctgagagtgtcatccgc catgctaccacctccccagcagagaaatccaaggtcaccatcagtgaggggaagggtccg gatgaagaaaagccaaagaagagcagcctgtgtagaaatgttgagggctgtcgagaggag ctgcaatcccaggccaacttctcctttgctcctttggtgttggagatgctgaacttccta atggaggccattcagattaacttccagcaggcttcagccatgggaagcagcagccgggca cagcaagccctgaatgagctacatgctgtggacaagacggtggaaatgacagatcagtta atggtcccaactcttggctctcaagaaggtgcctttgagaatgtccgaatgaattacagt ggtgaccagggccagacaatccgacagctaatcagtgctcacgtgctgaggcgggtagcg atgtgtgtgctctcctcccctcatgggcgccgccagcatctggctgtgagtcatgagaag ggcaagattacagtgttacagctctcagcattgctgaaacaagcggactccagcaaaagg aaactgactctcacccgccttgcctctgcaccagttccctttactgtgctgagcttaaca ggaaatccttgcaaggaagactaccttgctgtgtgcggactgaaggactgccatgtgcta acgttcagcagctctgggtccgtctcggatcatttggtactgcatccccagctggccaca ggcaacttcatcatcaaggctgtctggcttcctgggtctcagaccgagcttgctattgta actgcagactttgtgaagatttacgacctttcagtagacgccttgagtccaaccttctat ttccttttgccaagctccaaaatcagggatgtcacctttctgttcaacgaggagggaaag aacatcatagtcatcatgtcctctgctgggtacatctacacacagctcatggaggaggca agcagtgcccagcatggaccgttttatgtcaccaatgtgcttgaagtcagtcatgaggat ctgaaggacagtaatggccaggtggcaggaggtggtgtgtcggtgtattactcccatgtc ctacagatgctgttcttcagttactgccaaggcaaatcctttgcagccacaatcagcagg gcaactttggaggtgcaacgtcttttcccgatcaacattaagagctcaaatggtggaagc aagacctccccagcactgtgtcagtggtctgaggtgatgaaccatcctggcttggtgtgc tgtgttcagcagaccacaggtgttcctctggtggtcatggtgaagccagacacttttctc atccaggagattaaaaccctgccagctaaagcaaagatccaggacatggtggccatccgt cacacagcatgtaatgagcagcagaggaccaccatgatcctcctgtgtgaagatggcagc ctgaggatctacatggccaatgtagagaacacatcctactggcttcagccctctctccag cctagcagcgtcatcagcatcatgaagccagttcgcaaacgcaaagcggctgccattaca actcgcacctccagtcaggtgaatttccccattgacttctttgagcacaaccagcagctc acggatgtggagtttggaggcaatgacctattgcaggtttataatgcccagcagataaag caccggctcaattccactggcatgtatgtggccaacaccaagcctggtggcttcaccatt gaagtcacgaacaacaacagtacaatggtaatgacaggcatgcggatccagattggcacc caggcgattgagcgagctccttcctacctggagatctttggccgcaccatgcagctgaac atgaccagggctcgttggtttgacttccctttcactcgagaagaagcccttcaagcagac aaaaagctaaccatctttattggggcctctgtggaccctgctggagtcacaatgatggat tccatcaaaatttatggcaagaccaaagaacagtttggctggcctgatgagcccccggag gatttcccatctgcttcagtgagcaatgtttgtcccccaaacctcaatcagggaaatggt actggagatacagaagctgctacacctgcaactgccagtgggactgtcctggaaaggcta gtagtgagttctttagaagcgctggaaagctgctttgctgtaggaccagtcaacgagaag gagaaaaataaggctgcagctcaggaactggctacaatgctcctgtccatgccagctcct tccagcgtccagcagcagaccaagagcctcctggctagcctgcacaccagccgctcggcg taccataaccacaaggatcaggccttgctgagcaaagccattcagtacttgagctcctct agcaaagaagggaaggatcttgaccctgaagtgtttcagaggttggtcatcactgctcga tccatcgctattatgaggccaaacaacctggttcatttcacagagtcgaagttgccacag ttggaagcagaagcaggtgaagaagggcaggaagcccagaagcatgctgaaggagatggt tgtagttttattacccagctggtcaaccacttctggaagctacatgcgtcaaaacccaaa aatgccttcctggctcctgcctgcctgccaggtctgactcacgttgaagccacagtcaat gctttggtggatattatccatgggtactgcacatgcgagctggattgtatcaatactgca tccaagatctacatgcagatgttactctgtcctgatccagcggtgagcttttcttgcaaa caagctttaatcagagtactgaggccaaggaacaaacggagacatgtgactctgccatct tctccacggagtaacactcctatgggagataaggatgatgatgatgacgatgatgcagaa gacaaaatgcagagctcggggttagcaaatggtgagcatattcgacaggaaagccaggag caaagcgaggttgatcatggggacttcgagatggtgtctgagtcaatggttctggagact tctgaaaatgtgaataatggcaacccttctcccctggaggctcttctggctggagcagag ggattcccacccatgctggacattcctccagatgcagacgatgaaacaatggtggaactg gccattgccctaagcctgcagcaagaccagcaagggagcagcagcagtgcacttggactg cagagcttgggactgtctggtcaagcccccagctcttcttctcttgatgctgggactctc tctgacaccacagcatcagctccagcgtcggatgatgaaggcagcacagctgcgacagat ggctctactcttcggacttcgccagctgaccatggtggcagtgtgggctccgagagtgga ggcagcgcagtggactcagtggctggcgagcatagcgtgtctggccgcagcagcgcatac ggtgacaccacggctgagggccacccagctgggcctggcagtgtcagctcaagtactggt gctattagcaccactacaggacagcaggaaggggatggctcggaaggagaaggggaaggg gaagctgagggagatgtccataccagcaacaggctgcacatggtccgtttgatgctgttg gagagactgctgcaaaacctcccccagctgcggaacgtcggaggagtccgtgccattcct tacatgcaggttattttgatgctcacaacagacctagatggagatgatgagaaggacaag ggtgctttggataatcttctgtcccagctcattgcagaactgtgcatggacaagaaggac gtgtccaagaagaacgaacgctctcccgtgaacgaagttcacttggtagtaatgaggttg cttagtgtgttcatgtccaggaccaagtcaggatctaaatcttccatatgcgagtcctct tccctcatctccagtgctactgcagcggcattgctgagctctggtgctgttgactattgc ctgcatgtgctgaagtctctcctggagtactggaaaagccagcagaatgatgaggagcct gtagccaccagtcagctgctgaaaccccacaccacctcttctcctcctgacatgagcccc tttttcctccgtcagtatgtgaagggtcacgctgcagatgtttttgaggcctatactcag ctgctgactgagatggtgctgcgtttaccctatcagatcaagaaaattgctgacaccaac tcacgcatcccaccgcccatcttcgatcattcttggttctacttcctatctgagtacctg atgatccaacagactccgttcgtacgccgccaagtccgcaagcttctgctcttcatctgc ggctcaaaggagaagtaccgccagctccgagacctgcacactttggattctcatgtccgc ggtattaaaaaactcctggaagaacaaggcatttaccttcgggcaagtgtggtcactgca agctcaggctctgctctccagtatgatacactgatcagcttgatggaacacttgaaggct tgtgcggagattgccacacagcgaacagtgaactggcagaaattctgcattaaagatgac tccgtactctattttctccttcaagttagtttcctggtagatgaaggagtgtcgccagtt ctcctacagctgctgtcttgtgctctttgtggcagcaaagtgctgtctgtggcctcatcc tctggatctagcacctcttccacctctgccccagcagcctctggctccgggcagccagca acacagagtaaatcttccaccaaaaagagcaaaaaggaggaaaaggagaaagagcgagag ggtgagagttctggcagccaagaagatcagctgtgcacggctctggtgaaccagctgaac aaatttgccgataaggaaacgcttattcagtttctgcgctgcttcttgctggagtccaac tcttcctctgtgcggtggcaggcccactgcctggcactccacatctacaggaactctaac aagtctcagcaagaactgctcttagatctcatgtggtcaatatggccagaacttcccgca tatgggcggaaggctgcccaatttgtggatctgctgggctatttttctctgaagacgcaa cagactgagaagaagctgaaggaatactcccagaaggccgttgagattctccgaacccag aaccacatccttaccaaccatcctaactccaacatttacaacacactgtctggcctggtg gagtttgatggctattacctggagagtgatccttgcctagtctgcaataacccagaagtg ccattctgttacatcaagctttcctccatcaaggtagacacccgctacaccaccacccag caggttgtgaagctaattggcagccacacaatcagcaaagtgacggtgaagataggagat ctaaaacgcactaaaatggtccggacaatcaacctctattacaataacaggacagtgcag gccatagtggaattgaaaaacaaacctgctcgttggcacaaagccaaaaaagtccagctc accccaggacagacggaagtgaagattgatttgcctctgcccattgtggcttcaaacctg atgattgaatttgcagatttctatgagaattaccaggcctccacagaaacccttcagtgc cctcgctgcagtgcgtctgtcccagccaaccctggtgtgtgtgggaactgtggcgagaat gtgtaccagtgtcataagtgcagatccattaattatgatgagaaagatcctttcctgtgc aatgcctgtggattctgtaaatacgctcgctttgacttcatgctgtacgccaagccttgc tgcgctgtggatccgatagagaatgaagaggatcggaagaaggcagtaacgaatattaac actcttctggacaaggctgacagagtgtatcatcagctaatgggacaccgaccacagctg gaaaacctgctgtgtaaagtgaatgaagcagcacctgaaaagccacaggatgagtccggt agcagcggagggatcagctctacctcagctagtgtgaatagatacatccttcaactagct caggagtactgtggtgactgcaaaaactcttttgaggagctctccaagatcatccagaaa gtttttgcttctagaaaagagctcttggaatacgatctccagcagagagaggcagcaacc aagtcatcccgaaccactgttcagcccacgtttactgccagccagtatcgagcgctgtct gtcttgggctgtggtcatacatcttcaacaaaatgctatggctgtgcttcagctgtcact gagcactgcatcaccttgctccgtgctctggcaaccaactctgccattcggcacattctt gtgtcccagggccttatccgggagctgtttgactacaatttacgtcgtggagctgccacc atgagggaggaagtccgtcagctcatgtgccttctaaccagagacaatcctgaggccaca caacaaatgaatgacctaatcattgggaaggtgtctgctgctctgaaaggacattgggca aacccagatctggctagcagcctccagtatgaaatgctgctgctgaccgattccatctcg aaggaagacagctgctgggagctgcgattgcgctgtgctctcagcctcttcttgatggca gtaaacattaagactccagtagtagttgagaacatcaccctcatgtgcctgcgaattctg caaaaactgatcaaaccgcctgctccaaccagcaagaaaaacaaggatgtgcctgtcgat actctcaccaccgttaaaccttacagcaatgaaattcatgcacaggctcagctgtggctc aagagggacccaaaggcatcgtatgaagcttggaaaaaatgcctccctgctagaggtata gaggcaaatgggaaatctcccagcagaacagagctgcaccagctctacttgtccgaaaag tacatctggaaatggaaacaattcatgagtcgccgtgggaagagaacctgccctctggat ctcaagctggggcacaacaactggctgcgacaggtactgtttactcctgcaacccaagct gcaaggcaggctgcatgcactattgtagaagctctggccaccatccccagtcggaaacag caggtccttgatctccttaccagctacttggatgagctgagtattgctggggagtgtgct gctgagtacctgggtctgtatcagaaactcatcaagcctgcacactggaaggtctacctt gcagcaagaggggttctgccgtacattggtaacctcatcacaaaggaaattgctcgttta cttgccctggaagaagccactctcagcactgacctgcagcaggggtacgccttgaagagc ctcacagggcttctctcttccttcgtggaggtggagtctatcaaacggcacttcaaaagc cggctggtgggcacggtgttgaacggctatctctgcctgagaaagctggtggtgcagaga acgaagctgattgacgagacccaggatatgctgctggagatgttggaagacatgacaaca ggcacagaatctgaaacgaaagccttcatggcagtgtgcatcgaaaccgctaaacgttac agccttgatgactacaggactcctgtcttcatatttgagagactttgcagtattatctac cctgaagagaatgaagtgacagagttctttgtgacactggagaaggatccccagcaggaa gacttcttgcagggcaggatgccagggaacccctacagcagtaatgagcctggcattggg ccgctcatgagggacatcaagaacaaaatctgtcaagattgtgacctggtggctttgttg gaggatgacagtggaatggagcttctggtgaacaataagatcatcagcttggatctacca gttgctgaggtctacaagaaggtctggtgtcccactaatgagggggagccaatgaggatc atttaccgcatgcgcgggttgctaggagatgcgactgaagaattcatcgagtctctggac tccactacagatgaagaggaagacgaggaagaggtttataaaatggcgggcgtgatggct cagtgtggaggcctggactgcatgctaaacagactgacaggaatcaaggatttcaagcag ggtcgacacctcttaacagtgctgctaaagttgttcagctactgtgtgaaggtgaaagta aaccgtcagcagctggtcaagcctgagatgaacactttgaatgtcatgctggggacgctg aatctggccctggtggctgagcaggaaagcaaggacagtggtggggcagctgtggcagaa caggtgcttagtatcatggagattatactggatgaatccaatgcagaaccactgagtgaa gacaagggcaacctcctcctgactggtgacaaggatcagctggtaatgctgctggatcag ataaacagcacctttgtccgctccaatctcagcgtcttgcaaggcctattacgcatcatc ccttacctgtcctttggggaaatggagaaaatgcagatcctggttgatcgattcaagccc tattgtaactttgacaagtacgatgaagaacacagtggagatgataaagttttcctggac tgtttctgtaaaatagcagctggcataaagaataacagcaacggccatcaattgaaagat ctcatcctccagaaggggattactcaaaatgcccttgactacatgaaaaagcatatccct agtgcaaagaatttggatgcagacatatggaagaagttcttatctcgccctgcacttccc tttatcctgaggctgcttcgagggctggccacacagcaccctgccacacaggtgctaata ggtacagactccattacaaacctgcacaaacttgaacaagtgtcaagcgatgaagggatt gggacactagctgagaacctgctggaggcgctaagggaacatccagaagtgaacaagaag atagacgcagcccgcaaggagacccgtgcagagaaaaagcgcatggccatggcgatgagg cagaaggctttgggcacattgggcatgacgactaatgagaagggccaggtggtgacaaag actgcgctcctcaaacagatggaggagctaatagaagaaccaggactgacttgctgtatc tgcagagaagggtataagtttcagcctgcgaaggtcctggggatttacactttcaccaag cgagttgcgctggaggagtttgagaacaaaccccggaagcagcagggctatagcacggtc tctcatttcaacattgtccattatgactgtcaccttgctgctgtgagactagcccgtggc cgggaggagtgggaaagtgcagctctgcaaaatgccaacaccaagtgcaatgggcttctc ccagtctgggggcctcatgtgccggagtctgccttcgccacttgcttagccagacacaac acttacctccaggagtgcacggggcagcgggaacccacctaccagctcaacgtccatgac attaagctactgtttctccgcttcgcaatggagcagtcgttcagtgtggacaccggagga ggaggaagggagagcaacatacacctcattccatacataattcacactgtgctttatgtc ctcaacacaacccgagcaacttccagggaggagaaaaacctccagagttttatggagcat cccaaggagaaatgggtggagagtgcctacgaggtggatgggccccattactacacagtt ctggccctgcacatcctgcccccggagaagtggaaagccatgcgggtggagatcctgaag aggctcttagttacctcgcacgcgcgtgcagtgtcgccagggggagccagcaggctgaca gacaagacagtgaaggaatactcaacatatcgctctggccttctcttctgggccctcgtc gatctcatttacaacatgttcaagaaggtgcctaccagtaacacagagggaggctggtcc tattctctggctgaatttatacgacacaacgacatgccgatacacgaagctgcagacaaa gccctgaaaaccttccaggaggagttcatgccagttgaaaccttttctgaatttttggat gtggctggactcttaacggaaatcagcgaccctgacagcttcttcaaggatctcttgaac tccatcccctga

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